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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Kadar imunoglobulin A sekretori pada penderita tonsilitis kronik sebelum dan setelah tonsilektomi Indo Sakka; Raden Sedjawidada; Linda Kodrat; Sutji Pratiwi Rahardjo
Oto Rhino Laryngologica Indonesiana Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.18 KB) | DOI: 10.32637/orli.v41i1.61

Abstract

Background: Infection of the tonsils is a fairly common problem in the population. The complaints among others are pain while swallowing, fever, otitis media, until obstructive sleep apnea. Until now tonsillectomy procedure is still a controversy. For those against it, tonsillectomy is considered decreasing the body’s defense mechanism. Purpose: The goal of the research is to analyze the secretory immunoglobulin A level on the chronic tonsillitis patients before and after tonsillectomy.Method: The research was conducted as a comparative analytic study among the chronic tonsillitis patients before  and after tonsillectomy. Result: The result of this study reveals that the level of secretory Ig A in healthy  subjects were 5358.2200 + 1071.23 ng/ml, in chronic tonsillitis patients before tonsillectomy were 7539.6563 + 2293.07 ng/ml, and after tonsillectomy were 5946.4375 + 2133.13 ng/ml. Conclusion:  The level of s-IgA in chronic tonsillitis prior to tonsillectomy was high and 4 weeks post operation the level of s-IgA decreased, close to the level of normal subjects. Keywords: secretory immunoglobulin A, chronic tonsillitis, tonsillectomy Abstrak :  Latar belakang: Infeksi pada tonsil merupakan masalah yang cukup sering dijumpai. Keluhan yang ditimbulkan berupa nyeri menelan, demam, otitis media, sampai obstructive sleep apnea. Sampai saat ini tonsilektomi masih menimbulkan kontroversi. Bagi yang kontra, tonsilektomi dianggap dapat menurunkan sistem pertahanan tubuh. Tujuan: Mengetahui kadar Imunoglobulin A sekretori (s-IgA) pada penderita tonsilitis kronik sebelum dan setelah tonsilektomi. Metode: Analitik komparatif yang dilakukan pada penderita tonsillitis kronik sebelum dan setelah tonsilektomi. Hasil:Kadar s-IgA individu sehat adalah 5358.2200 + 1071.23 ng/ml, s-IgA penderita tonsilitis kronik sebelum tonsilektomi adalah 7539.6563 + 2293.07 ng/ml, sedangkan s-IgA penderita tonsilitis kronik setelah tonsilektomi adalah 5946.4375 + 2133.13 ng/ml. Kesimpulan: s-IgA penderita tonsilitis kronik sebelum tonsilektomi kadarnya tinggi. Empat minggu setelah operasi, kadar s-IgA turun mendekati kadar s-IgA individu normal. Kata kunci: imunoglobulin A sekretori, tonsillitis kronik, tonsilektomi
Peran blok servikal superfisialis pada timpanomastoidektomi dalam anestesia umum Pryambodho Pryambodho; Ruth Evlin Margaretha; Aida Rosita Tantri; Harim Priyono
Oto Rhino Laryngologica Indonesiana Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1779.824 KB) | DOI: 10.32637/orli.v45i1.100

Abstract

Pendahuluan: Blok perifer yang digunakan saat pasien teranestesi akan mengurangi kebutuhan anestesia dan analgesia selama pembedahan. Berkurangnya pemakaian opioid intraoperatif juga akan mengurangi morbiditas pascaoperatif yang berkaitan dengan opioid. Tujuan: Penelitian dilakukan untuk mengetahui peran Blok Pleksus Servikal Superfisialis (BPSS) dalam mengurangi konsumsi fentanil intraoperatif, menstabilkan hemodinamik intraoperatif, dan mempercepat waktu pulih pada timpanomastoidektomi dalam anestesia umum. Metode: Penelitian ini merupakan uji klinis acak tersamar tunggal yang dilakukan di RSCM selama bulan September-November 2013 pada 32 pasien usia 19-65 tahun, ASA I-III dengan berat badan 35-80 kg yang dibagi menjadi dua kelompok. Hasil: Pada kelompok BPSS, dilakukan BPSS sebelum induksi menggunakan bupivakain 0,5%, sedangkan pada kelompok kontrol tidak dilakukan. Anestesia dipertahankan dengan FGF 0,8-1,6 lpm, compress air: O2 (konsentrasi 40%); isofluran ±1 MAC dan atrakurium 0,25 mg/kgBB setiap 30 menit untuk menjaga nilai BIS 45-60. Fentanil diberikan setiap ada peningkatan tekanan darah sistolik atau frekuensi nadi ≥20% dari nilai 5 menit sebelumnya. Saat 30 menit sebelum operasi selesai diberikan parasetamol 1 gram iv dan ondansetron 4 mg iv. Rerata konsumsi fentanil intraoperatif, tekanan darah sistolik, dan frekuensi nadi kelompok BPSS lebih rendah dan bermakna secara statistik dibandingkan kelompok kontrol: 150 mcg vs 262,5 mcg, p<0,001; 104 (90-112) vs 120 (110-130), p<0,001 dan 68 (62-86) vs 80 (68-100), p<0,001. Kesimpulan: Pemberian blok pleksus servikal superfisialis sebelum induksi mengurangi konsumsi fentanil intraoperatif, menekan respon hemodinamik terhadap insisi kulit, dan mempercepat waktu pulih pada timpanomastoidektomi dalam anestesia umum. Kata kunci: anestesia umum, blok pleksus servikal superfisialis, kecepatan waktu pulih, konsumsi fentanil, timpanomastoidektomiABSTRACT Background: The peripheral block combined with general anesthesia reduces intraoperative anesthesia and analgesia requirement. Reduced opioid consumption decreases postoperative morbidity related to opioid. Purpose: The aim of this study was to assess the role of superficial cervical plexus block (SCPB) before induction in reducing fentanyl consumption, stabilizing intraoperative hemodynamic, and speeding up recovery time in tympanomastoidectomy.  Methods: This single blind randomized clinical trial was conducted in RSCM from September to November 2013 on 32 ASA I-III patients, 13-65 years old, with body weight range 35-85 kg which were randomized into 2 groups. Result: SCPB was performed in SCPB group before induction using bupivacaine 0.5%, whereas in the control group was not performed. Anesthesia was maintained with FGF 0,8-1,6 lpm, compress air: O2 with O2 consentration 40%, isoflurane ± 1 MAC, and atracurium 0,5 mg/kgBW every 30 minutes to keep BIS level 45-60. Fentanyl was given when there was an increase in systolic blood pressure or pulse rate ≥20% more than the value of 5 minutes previously. Paracetamol 1 g iv and ondansetron 4 mg iv were given 30 minutes before the end of the surgery. The average intraoperative fentanyl consumption, systolic blood pressure, and pulse rate was lower and statistically significant in BPSS group compared to the control group: 150 mcg vs 262,5 mcg, p<0,001; 104 (90-112) vs 120 (110-130), p<0,001 and 68 (62-86) vs 80 (68-100), p<0,001 Conclusion: Administration of SCBP before induction, reduced the intraoperative fentanyl consumption, suppressed hemodynamic responses to skin incision and speed up recovery time on tympanomastoidectomy in general anesthesia. Keywords: general anesthesia, superficial cervical plexus block, recovery time, fentanyl consumption,tympanomastoidectomy
Hubungan derajat adenoid menggunakan teknik nasoendoskopi dengan tekanan telingah tengah Rosmini, Rosmini; Suheryanto, Rus; Surjotomo, Hendradi
Oto Rhino Laryngologica Indonesiana Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1111.153 KB) | DOI: 10.32637/orli.v46i2.157

Abstract

Latar belakang: Hipertrofi adenoid sering dilaporkan sebagai salah satu faktor penyebab terjadinya disfungsi tuba. Hubungan anatomi antara nasofaring dan adenoid memiliki implikasi terhadap tuba Eustachius yang terletak di sebelah lateral. Akhir-akhir ini telah digunakan secara luas alat diagnostik endoskopi, salah satu di antaranya adalah pemeriksaan nasoendoskopi, yang dapat memberikan visualisasi 3 dimensi secara jelas, sehingga dapat menentukan derajat adenoid terhadap struktur anatomi sekitarnya. Sebagian besar penyakit telinga tengah didahului oleh gangguan fungsi tuba Eustachius. Fungsi ventilasi merupakan fungsi tuba Eustachius yang paling penting, bertujuan untuk mempertahankan keseimbangan antara tekanan gas dalam telinga tengah dan udara di luar membran timpani. Salah satu cara untuk mengukur tekanan telinga tengah secara tak langsung, yaitu dengan timpanometri yang dapat menilai fungsi ventilasi tuba Eustachius. Tujuan: Mengetahui hubungan derajat adenoid menggunakan nasoendoskopi dengan tekanan telinga tengah. Metode: Penelitian observasional analitik dengan desain cross sectional, melibatkan 24 sampel yang diduga menderita hipertrofi adenoid, yang dilakukan nasoendoskopi, dan tekanan telinga tengah diukur dengan timpanometri. Data penelitian dianalisis dengan uji korelasi Spearman. Hasil: Terdapat korelasi yang cukup kuat dan signifikan antara derajat adenoid dengan tekanan telinga tengah dan tipe timpanogram (p=0,027 dan p=0,002). Kesimpulan: Semakin tinggi derajat adenoid maka tekanan telinga tengah semakin turun. Dibutuhkan penelitian lebih lanjut untuk melihat hubungan antara derajat adenoid menggunakan nasoendoskopi dengan gejala klinis dari hipertrofi adenoid.Kata kunci: Derajat adenoid, nasoendoskopi, tekanan telinga tengah ABSTRACT Background: Adenoid hypertrophy has been widely reported as one of the causes of tubal dysfunction. Anatomical relationship between the nasopharynx and adenoid has implications for the Eustachian tube which is located at the lateral wall of the nasopharynx. Recently, endoscopic diagnostic tool has been commonly used, because it provides a clear 3-dimensional visualization, to determine the degree of adenoid hypertrophy with its’ surrounding anatomical structures. Most of the middle ear disease is preceeded by Eustachian tube dysfunction. Ventilation is the most important function of the Eustachian tube which aims to maintain the balance of the gas pressure in the middle ear and the air outside the tympanic membrane. Tympanometry is one of the tools for measuring the pressure of the middle ear which indirectly assesses the function of the Eustachian tube ventilation. Purpose: To determine the relationship between the degree of adenoid using nasoendoscopy with middle ear pressure. Method: The study was observational analytic with cross sectional design. This study involved 24 patients with adenoid hypertrophy underwent nasoendoscopic examination and tympanometry for assessing middle ear pressure. Data were analyzed using Spearman test. Result: There was a fairly strong and significant correlation between adenoid hypertrophy with middle ear pressure and tympanogram type (p=0.027 and p=0.002). Conclusion: The higher the degree of adenoid hypertrophy, the lower the middle ear pressure. Further research is needed to see the relationship of the degree of adenoid with nasoendoscopy with clinical symptoms of adenoid hypertrophy.Keywords: Degree of adenoid, nasoendoscopy, middle ear pressure
Biofilm bakteri pada penderita rinosinusitis kronis: laporan seri kasus berbasis bukti Silvia, S; Munir, Delfitri; Rambe, Andrina Yunita Murni; Simanjuntak, Amran; Chrestella, Jessy; Ashar, Taufik
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.162 KB) | DOI: 10.32637/orli.v47i2.227

Abstract

Latar belakang: Rinosinusitis kronis merupakan penyakit yang sering dijumpai pada bagian telinga hidung tenggorok kepala dan leher. Melalui berbagai macam teknik pencitraan, biofilm dijumpai pada mukosa sinonasal dari pasien rinosinusitis kronis. Beberapa peneliti mengemukakan bahwa biofilm adalah penyebab yang umum dari infeksi persisten kronis. Peranan biofilm pada penderita rinosinusitis kronis dapat membantu menjelaskan manifestasi klinis pada penyakit tersebut. Ketersediaan pewarnaan hematoksilin-eosin yang luas dalam laboratorium patologi klinik membuatnya menjadi metode yang sangat praktis untuk mendeteksi biofilm dalam praktik klinis. Tujuan: Mempresentasikan ekspresi biofilm bakteri pada penderita rinosinusitis kronis yang menjalani tindakan bedah sinus endoskopi fungsional. Kasus: Sebanyak 33 pasien rinosinusitis kronis menjalani tindakan bedah sinus endoskopi fungsional di beberapa rumah sakit di Sumatera Utara selama bulan Januari-Desember 2016. Prevalensi biofilm didapati pada 22 pasien (66,7%) penderita rinosinusitis kronis. Pada penderita rinosinusitis kronis dengan biofilm positif dijumpai jenis kelamin pria lebih banyak, umur lebih tua, lama gejala lebih singkat, keberadaan polip lebih sering, dan keluhan hidung tersumbat lebih sering. Metode: Pencarian literatur melalui Pubmed dengan kata kunci: chronic rhinosinusitis and biofilm. Setelah melalui proses skrining didapati 2 literatur yang dianalisis. Hasil: Penatalaksanaan rinosinusitis kronis dengan medikamentosa, meliputi pemberian antibiotik, dekongestan, kortikosteroid dan mukolitik disertai terapi tambahan irigasi hidung, serta pembedahan. Bila dijumpai biofilm, maka regimen pemberian antibiotik memakai protocol Marshall. Kesimpulan: Prevalensi biofilm pada penderita rinosinusitis kronis cukup tinggi, pemeriksaan biofilm dapat dipertimbangkan pada pasien rinosinusitis kronis yang menjalani tindakan bedah sinus endoskopi fungsional. Kata kunci: Biofilm, rinosinusitis kronis, hematoksilin-eosin, bedah sinus endoskopi fungsional ABSTRACT Background: Chronic rhinosinusitis is a disease that often found in otorhinolaryngology. Its pathogenesis is not fully understood. Using variety techniques, biofilms have been found in the mucosa of chronic rhinosinusitis patients. Some researchers have suggested that biofilm is a common cause of chronic persistent infection. The role of biofilms in patients with chronic rhinosinusitis can help explain the clinical manifestations of the disease. The extensive availability of hematoxylin-eosin staining in clinical pathology laboratories makes it a very practical method for detecting biofilms in clinical practice. Purpose: To present bacterial biofilm expression in chronic rhinosinusitis patients who had underwent functional endoscopic sinus surgery. Cases:About 33 chronic rhinosinusitis patients who had underwent functional endoscopic sinus surgery in several hospitals in North Sumatera during January-December 2016.Biofilms were found in 22 (66.7%) patients with chronic rhinosinusitis. Chronic rhinosinusitis patients with positive biofilms found mostly male, older in age, shorter duration of symptoms, more frequent polyps, and more frequent nasal congestion complaints. Method: Literature study was conducted through Pubmed with keywords chronic rhinosinusitis and biofilm. After screening process, we obtained two articles that were analyzed based on the critical appraisal. Result: Management of chronic rhinosinusitiswas medical treatment with antibiotic, decongestant, corticosteroid and mucolytic, accompanied by additional nasal irrigation therapy, and surgery. If biofilm was found, antibiotic regimen given using Marshal protocol. Conclusion: The prevalence of biofilms in patients with chronic rhinosinusitis was quite high. Biofilm examination should be considered in patients with chronic rhinosinusitis who undergo functional endoscopic sinus surgery. Keywords: Biofilm, chronic rhinosinusitis, hematoxylin-eosin, fungsional endoscopic sinus surgery
Ekspresi gen litik virus Epstein-Barr: manfaatnya untuk penegakan diagnosis karsinoma nasofaring Daniel Joko Wahyono; Bambang Hermani; Purnomo Soeharso
Oto Rhino Laryngologica Indonesiana Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v40i2.9

Abstract

Background: Nasopharyngeal carcinoma (NPC) is endemic in certain geographic regions, such asSoutheast Asia, and is associated with several environmental and genetic factors. Undifferentiated NPCis consistent with Epstein-Barr virus (EBV) infection. NPC is the most common ENT tumor in Indonesiawith high prevalence among native populations and yearly overall incidence estimated 6.2 per 100.000 population. Purpose: To explain the advantage of EBV immediate-early gene expression analysis indetermining of NPC diagnosis and management of NPC.Review: Replication of EBV implies to twocellular reactions, i.e. latentcy and lytic cycle expression of EBV lytic genes which consists of three lyticphases, i.e. immediate-early, early and late phase. Expression of immediate-early genes BZLF1 andBRLF1 are needed to induct of early and late genes, so both genes are known as transactivator genes.BALF1, an early lytic gene, expresses some protein regulating EBV replication in NPC. Expression of BCLF1, a late lytic gene, is essential for EBV replication, particularly in the forming of virion structure inNPC. Switching from latent to lytic cycle in tumor cells can happened spontaneously, particularly whenthe viral immediate early genes are induced via signal transduction after initial activation by anti-IgG,TGF-ß and CD4+. In NPC, the induction of EBV lytic cycle by cisplatin and irradiation gamma leads tothe increasing expression of BRLF1 and BZLF1 which have a correlation with the increasing of tumorprogression. RT-PCR technique is a very useful for detecting mRNA BRLF1 and BZLF1 gene expressionat the site of primary tumor, while real-time RT-PCR technique is used to measure the mRNA level ofthose genes.Conclusion: Expression of EBV immediate-early lytic gene in the biopsy of NPC primarytumour provides a basic clinical information for NPC diagnosis and therapy more accurately. Key words: expression EBV lytic gene, nasopharyngeal carcinoma, NPC diagnosis. Abstrak : Latar belakang: Karsinoma nasofaring (KNF) bersifat endemik secara geografis (di Asia Tenggara)dan berasosiasi dengan beragam faktor lingkungan dan genetik. KNF tidak berdiferensiasi konsistendengan adanya infeksi virus Epstein-Barr (VEB). Prevalensi KNF pada populasi Indonesia cukup tinggisebesar 6,2/100.000 penduduk per tahun. Tujuan:Menjelaskan kegunaan analisis ekspresi gen litikimmediate-early VEB untuk menegakkan diagnosis KNF dan meningkatkan efisiensi dalam penangananKNF. Tinjauan Pustaka: Replikasi VEB pada epitel nasofaring berimplikasi pada dua reaksi seluler,yaitu siklus laten dan litik VEB. Ekspresi gen litik VEB terdiri dari tiga fase, yaitu immediate-early,early dan late.Ekspresi gen immediate-early BZLF1 dan BRLF1 diperlukan untuk menginduksi genlitik fase early dan late, sehingga kedua gen tersebut dikenal sebagai gen transaktivator. Gen faseearlylitik BALF1 mengekspresikan protein replikasi pada KNF. Ekspresi gen fase late BCLF1 berperanpenting untuk replikasi VEB pada KNF, terutama untuk membentuk struktur virion. Perubahan sikluslaten menjadi siklus litik pada sel tumor dapat terjadi secara spontan, terutama melalui transduksi sinyalsetelah aktivasi oleh anti-IgG, TGF-ß dan CD4. Pada KNF, induksi siklus litik VEB dengan cisplatindan radiasi sinar γ menyebabkan peningkatan ekspresi gen BRLF1 dan BZLF1 yang berkorelasi denganpeningkatan progresivitas tumor. Teknik RT-PCR akan sangat berguna untuk mendeteksi ekspresi mRNAgen BRLF1 dan BZLF1 VEB pada lokasi tumor primer, sedangkan teknik real time RT-PCR digunakanuntuk mengukur kuantitas mRNA gen tersebut. Kesimpulan: Ekspresi gen litik immediate-early VEBpada biopsi tumor KNF memberikan informasi klinis dasar yang lebih akurat untuk diagnosis dan terapiKNF.+Kata kunci: ekspresi gen litik VEB, karsinoma nasofaring, diagnosis KNF.
Pewarnaan Toluidin blue sebagai petanda ketepatan biopsi pasca terapi karsinoma sel skuamosa kepala-leher Bambang Hariwiyanto; Camelia Herdini; Inawati Bobot
Oto Rhino Laryngologica Indonesiana Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.44 KB) | DOI: 10.32637/orli.v42i1.41

Abstract

Background: Squamous cell carcinoma (SCC) is the most frequent malignancy in the head and neck. The treatment modalities of SCC are surgery followed by chemotherapy and/or radiotherapy, could also chemotherapy and/or radiotherapy without surgery. The gold standard of assessing success  in SCC treatment is if there no malignant cells found not only in frozen section tissues, but also in  post chemotherapy and/or radiotherapy tissues. Determining the spot of biopsy tissue for malignancy assessment after treatment is not easy. Toluidin Blue (TB) is a staining material, absorbed by intercellular space in epithelial dysplasia, included SCC.   To determine the validity of Toluidin Blue as sign of accuracy for biopsy site in SCC post treatment malignancy, which not only for surgically treated cases, but also after chemotherapy and/or radiotherapy without surgical treatment. Method: Diagnostic test study to determine sensitivity test, specificity test, positive predictive value and negative predictive value of TB to detect malignant cells in post treatment head and neck SCC patients. Result: There were 30 samples biopsy material from 30 post treatment SCC patients. Sensitivity test was 83,3%, specificity  test: 66,7%, positive predictive value: 79.0%, negative predictive value: 72,7%. Conclusion: TB staining is accurate for determining biopsy spot in post treatment head and neck SCC. Keyword : Validity, toluidin blue, squamous cell carcinoma, post treatment.  Abstrak :  Latar belakang: Karsinoma sel skuamosa (KSS) merupakan jenis keganasan kepala dan leher yang paling sering dijumpai dibanding keganasan yang lain. KSS kepala leher dapat dilakukan terapi pembedahan diikuti kemoterapi dan/atau radioterapi maupun kemoterapi dan/atau radioterapi tanpa pembedahan. Penentuan keberhasilan radikalitas pengobatan ditandai dengan tidak adanya sisa tumor secara mikroskopis yang diambil pada jaringan pasca kemoradiasi tanpa pembedahan, atau pemeriksaan jaringan secara frozen section. Untuk menentukan apakah pada jaringan masih ada sisa tumor atau sudah bebas tumor secara makroskopis terkadang sulit. Toluidin Blue (TB) adalah zat pewarna yang dapat terserap pada ruang interseluler epitel yang mengalami displasia seperti yang terjadi pada KSS. Tujuan: Menilai validitas pewarnaan TB sebagai petanda ketepatan lokasi biopsi KSS pasca terapi, baik pasca pembedahan, maupun yang diterapi dengan kemoterapi dan/atau radioterapi tanpa pembedahan. Metode: Uji diagnostik untuk menentukan sensitifitas dan spesifitas pewarnaan, nilai duga positif dan nilai duga negatif TB sebagai salah satu petanda ketepatan biopsi KSS pasca terapi KSS kepala-leher. Hasil: Didapatkan 30 sampel penelitian yang berasal dari 26 penderita KSS yang telah dilakukan terapi baik bedah maupun kemoradiasi tanpa bedah. Sensitifitas pewarnaan TB terhadap hasil biopsi pasca terapi 83,3%, spesifitas 66,7%, nilai duga positif 79,0% dan nilai duga negatif 72,7%. Kesimpulan: Pewarnaan TB valid untuk menentukan ketepatan biopsi keganasan KSS kepala dan leher pasca terapi. Kata kunci: Validitas, toluidin blue, karsinoma sel skuamosa, pasca terapi
Pengaruh deksametason terhadap proliferasi sel, kadar IL-α, dan TNF-α pada biakan kolesteatoma Ratna Dwi Restuti
Oto Rhino Laryngologica Indonesiana Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.098 KB) | DOI: 10.32637/orli.v44i1.78

Abstract

Latar belakang: Kolesteatoma merupakan suatu struktur berbentuk kantung, terdiri atas epitel gepeng berlapis yang selalu mengalami proses keratinisasi. Mengapa kolesteatoma bersifat invasif, hiperproliferatif, agresif, dan residif, hal ini perlu diselidiki. Deksametason merupakan salah satu kortikosteroid sintetik yang memiliki potensi tinggi sebagai preparat anti-inflamasi. Tujuan: Penelitian ini bertujuan untuk membuktikan bahwa pertumbuhan kolesteatoma dapat dihambat secara medikamentosa (dengan deksametason). Metode: Penelitian ini merupakan eksperimen yang dilakukan di laboratorium. Studi ini membandingkan 2 kelompok, yaitu kelompok biakan keratinosit kolesteatoma yang diberideksametason sebagai kelompok perlakuan dan kelompok biakan yang tidak diberi perlakuan. Hasil: Pada penghitungan sel setelah 48 jam kultur dan 24 jam ditambahkan deksametason, terdapat perbedaan bermakna antara kelompok kontrol dengan kelompok perlakuan yang dimulai dengan dosis 10 µg. Pemberian dosis tertinggi, yaitu 100 µg menyebabkan kelompok dosis tersebut berbeda bermakna dengan semua kelompok lainnya. Kesimpulan: Dibuktikan bahwa tingkat reduksi sel berhubungan dengan penambahan dosis deksametason (dose-dependent). Deksametason dapat menghambat proliferasi selpada biakan keratinosit kolesteatoma dengan dosis minimal 10 µg/mL. Kata kunci: kolesteatoma, keratinosit, proliferasi sel, interleukin-1α, tumor necrosis factor-α ABSTRACTBackground: Cholesteatoma is a sac-shaped structure, arise from stratified squamous epithelium which is constantly undergoing process of keratinization. Why the nature of cholesteatoma is invasive, hyperproliferative, aggressive, and recurrent need to be studied. Dexamethasone is a synthetic corticosteroid which has a high anti-inflammatory action. Objective: The aim of this study was to prove that cholesteatoma growth can be inhibited medically by dexamethasone. Methods: This study was conducted as a laboratory experiment. We compared two groups, the first one were cholesteatoma keratinocyte cultures given dexamethasone as the treatment group and the second group were untreated cultures. Results: In cells counting after 48 hours of culture and 24 hours of dexamethasone administration, there was a significant difference between the control group and the treatment group that was started at a dose of 10 µg. The highest dose given gorup, 100 µg caused significant difference with all other groups. Conclusion: The rate of reduction of cells associated with the addition of dexamethasone dose (dose-dependent). Dexametasone can inhibit cell proliferation in keratinocyte with minimal inhibitory dose of 10 µg/mL. Keywords: Cholesteatoma, keratinocyte, cell proliferation, interleukin-1α, tumor necrosis factor-α
Pengaruh tonsiloadenoidektomi terhadap kadar insulin-like growth factor-1 pada anak dengan obstructive sleep apnoea syndrome Al Hafiz; Novialdi Novialdi; Eti Yerizel; Hafni Bachtiar
Oto Rhino Laryngologica Indonesiana Vol 45, No 2 (2015): Volume 45, No. 2 July - December 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.878 KB) | DOI: 10.32637/orli.v45i2.115

Abstract

 Latar belakang: Infeksi kronis pada tonsil palatina disertai pembesaran tonsil palatina, dapat menyebabkan sumbatan pada jalan nafas bagian atas. Gangguan pertumbuhan banyak ditemukan pada kelompok pasien ini. Tujuan: Mengetahui apakah ada pengaruh tindakan tonsiloadenoidektomi terhadap kadar serum insulin-like growth factor-1 (IGF-1) dan nilai body mass index (BMI) pada anak yang menderita hipertrofi tonsil palatina dan adenoid, dengan gejala obstructive sleep apnoea syndrome (OSAS). Metode: Desain penelitian adalah eksperimental dengan studi pre- dan post-trial, dengan membandingkan kadar IGF-1 dan nilai BMI dalam serum anak dengan gejala OSAS, sebelum dan tiga bulan setelah dilakukan tonsiloadenoidektomi. Hasil: Sesuai protokol penelitian terdapat 14 subjek penelitian, menunjukkan peningkatan nilai kadar IGF-1 dan nilai BMI. Tindakan tonsiloadenoidektomi terbukti dapat meningkatkan kadar hormon pertumbuhan, yang tergambar dari peningkatan kadar IGF-1 dan nilai BMI. Kesimpulan: Tindakan tonsiloadenoidektomi berpengaruh terhadap peningkatan kadar hormon pertumbuhan, yang disimpulkan melalui pengukuran kadar IGF-1 dan nilai BMI dalam serum anak dengan gejala OSAS. Kata kunci: tonsiloadenoidektomi, insulin-like growth factor-1, obstructive sleep apnoea syndromeABSTRACT Background: Chronic infection with the enlargement of the palatine tonsil, could cause blockage of the upper airway. Growth disorders are common in this patient group. Purpose: To determine the effect of tonsilloadenoidectomy on the level of serum IGF-1 in children with palatine tonsil and adenoid hypertrophy and obstructive sleep apnoea syndrome (OSAS) symptoms. Methods: The study design was experimental, pre-and post-study, by comparing the serum levels of IGF-1 and the value of Body Mass Index (BMI) in children with OSAS symptoms, before and three months after tonsiloadenoidectomy. Result: According to the study protocol, there were 14 subjects showed increased levels of IGF-1 and BMI values. Tonsilloadenoidectomy was shown to increase the growth hormone levels, which was reflected from the increased levels of IGF-1 and BMI. Conclusion: Tonsiloadenoidectomy affected the increased levels of growth hormone, which was concluded through the measurement of the levels of IGF-1 and the value of BMI in the serum of children with symptoms of OSAS. Keywords: tonsilloadenoidectomy, insulin-like growth factor-1, obstructive sleep apnea syndrome
Radiological anatomy analysis of uncinate process, concha bullosa, and deviated septum in chronic rhinosinusitis Retno Sulistyo Wardani; Arroyan Wardhana; Endang Mangunkusumo; Vally Wulani; Brent Anthony Senior
Oto Rhino Laryngologica Indonesiana Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.002 KB) | DOI: 10.32637/orli.v47i1.191

Abstract

Background: Risk factors of chronic rhinosinusitis include epithelial disease related to disturbanceof mucociliary transport system, anatomical variations obstructing the ostiomeatal complex anddysfunction of neural regulation.Purpose: To find the prevalence of deviated septum, concha bullosa andlateral deflection of the uncinate process in ipsilateral chronic rhinosinusitis.Methods: A retrospectivestudy of computed tomographic (CT) scans of chronic rhinosinusitis patients who were not cured by6 weeks of maximal medical treatment of rhinosinusitis. Pneumatization of the middle turbinate anddeviation of the septum were evaluated on coronal slices, while lateral deflection of the uncinate processwas also assessed by calculating the angle using Osirix software (Pixmeo, Geneva, Switzerland).Results:One hundred ninety-three CT scans comprising 386 nasal sides were analyzed. The prevalence of thecombination of deviated septum, concha bullosa and lateral deflection of the uncinate process occurringconcurrently with ipsilateral maxillary sinusitis was found to be 32,9% (p=0.01, OR=9.1, 95% CI=1.2-69.7). The prevalence of deviated septum with concha bullosa was found in 40.9% with ipsilateral maxillarysinusitis (p=0.03, OR=3.8, 95% CI=1.1-13.3). One single anatomical variation of lateral deflection ofthe uncinate process had a proportion of 71.5% in ipsilateral maxillary sinusitis (p=0.03, OR=2.7 95%CI=1.1-6.9).Conclusion: Deviated septum, concha bullosa and lateral deflection of the uncinate processwere frequently present in the existence of ipsilateral chronic maxillary rhinosinusitis. It suggested greaterassociation compared to one or a combination of two anatomical variation in the role of local factorscontributing to sinonasal epithelial dysfunction.Keywords: chronic rhinosinusitis, deviated septum, concha bullosa, lateral deflection of uncinate process ABSTRAKLatar belakang: Rinosinusitis kronis adalah penyakit inflamasi yang mengakibatkan gangguankeseimbangan homeostasis fungsi hidung dan sinus paranasal. Patofisiologinya terjadi melalui kombinasigangguan transpor sistim mukosiliar, variasi anatomi yang menyempitkan kompleks ostiomeatal sertagangguan regulasi persarafan sensorik, simpatis dan parasimpatis. Tujuan: Untuk mengidentifikasiprevalensi septum deviasi, konka bulosa dan prosesus unsinatus defleksi lateral, serta hubungannya denganrinosinusitis kronik yang terjadi pada sisi yang sama (ipsilateral). Metode: Penelitian retrospektif potonglintang pada tomografi komputer (TK) pasien dengan rinosinusitis kronik yang tidak sembuh dengan terapimedikamentosa maksimal selama 6 minggu. Pneumatisasi konka media dan deviasi septum dievaluasipada potongan koronal, sedangkan defleksi prosesus unsinatus ke lateral dinilai dan diukur sudutnyadengan menggunakan piranti lunak Osirix (Pixmeo, Geneva, Switzerland). Hasil: Analisis dilakukanpada 193 TK yang terdiri dari 386 sisi hidung. Prevalensi kombinasi septum deviasi, konka bulosa danprosesus unsinatus defleksi lateral yang terjadi bersamaan dengan sinusitis maksila ipsilateral adalah 32,9% (p=0,01, OR=9,1, 95% CI=1,2-69,7). Prevalensi septum deviasi dengan konka bulosa ditemukanpada 40.9% sinusitis maksila ipsilateral (p=0,03, OR=3,8, 95% CI=1,1-13,3). Variasi anatomi tunggalyaitu prosesus unsinatus defleksi lateral memiliki proporsi 71,5% pada sinusitis maksila ipsilateral.(p=0,03, OR=2,7 95% CI=1,1-6,9). Kesimpulan: Septum deviasi, konka bulosa dan prosesus unsinatusdefleksi lateral sering ditemukan bersamaan dengan kejadian sinusitis maksila ipsilateral. Kombinasitiga variasi anatomi yang menyempitkan kompleks ostiomeatal (KOM) lebih kuat daripada hanya satuvariasi anatomi atau kombinasi 2 variasi anatomi, sebagai faktor lokal yang berkontribusi terhadapdisfungsi epitel sinonasal serta gagalnya resolusi inflamasi kronik.Kata kunci: Rinosinusitis kronis, septum deviasi, konka bulosa, prosesus unsinatus defleksi lateral 
Tonsilitis difteri dengan sumbatan jalan napas atas Syahrial Marsinta Hutauruk; Fauziah Fardizza; Sevi Aristya
Oto Rhino Laryngologica Indonesiana Vol 48, No 1 (2018): Volume 48, No. 1 January - June 2018
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.373 KB) | DOI: 10.32637/orli.v48i1.260

Abstract

Latar belakang: Difteri adalah penyakit infeksi yang disebabkan oleh kuman bacillus grampositif Corynebacterium diphtheriae. Bakteri ini terutama menyebabkan infeksi pada saluran napasberupa tonsilofaringitis, laringitis, maupun keduanya secara bersamaan, ditandai dengan terbentuknyapseudomembran. Kematian pada anak dengan penyakit ini umumnya terjadi karena sumbatan jalannapas atas, ataupun efek sistemik toksin difteri. Tujuan: Melaporkan dan menganalisis kasus tonsilitisdifteri yang berakhir dengan kematian meskipun telah mendapat tatalaksana sumbatan jalan napas atas.Laporan kasus: Kasus anak perempuan usia 4 tahun, dan anak laki-laki usia 5 tahun dengan tonsilitisdifteri disertai sumbatan jalan napas atas. Metode: Telaah literatur berbasis bukti mengenai tonsilitisdifteri, komplikasi, dan status imunisasi melalui database Cochrane, Pubmed Medline, dan EBSCOHost Medline. Berdasarkan kriteria inklusi dan eksklusi didapatkan 3 jurnal yang relevan dengan kasusyang dilaporkan. Hasil: Studi tersebut menyatakan tonsilitis difteri sebagai penyakit dengan komplikasisumbatan jalan napas dan jantung. Komplikasi jantung adalah penyebab kematian tertinggi pada tonsilitisdifteri. Status imunisasi pada kasus meninggal sebagian besar tidak lengkap, dan cakupan imunisasi totalmasih rendah. Kesimpulan: Tonsilitis difteri merupakan kasus jarang dengan tingkat kematian tinggiakibat komplikasi sumbatan jalan napas dan jantung. Kematian dapat terjadi akibat efek sistemik toksindifteri, meskipun sumbatan jalan napas telah diatasi. Status imunisasi yang tidak lengkap dan rendahnyacakupan imunisasi pada wilayah tempat tinggal penderita meningkatkan mortalitas kasus tonsilitis difteri. Kata kunci: tonsilitis difteri, sumbatan jalan napas atas, imunisasi difteri, toksin sistemik ABSTRACTBackground: Diphtheria is an acute infectious disease caused by Corynebacterium diphthe­riae, a gram-positive bacillus. The organism infects primarily the respiratory tract, where it causestonsillopharyngitis, laryngitis, or both, typically marked by the forming of pseudomembrane. In children,either the upper respiratory tract obstruction or the effects of diphtheria toxin are the most common causeof death. Purpose: To report and analyze tonsillitis diphtheria cases that ended up in fatality, althoughthe upper airway obstruction had been managed. Case report: Two cases of a 4-years girl and 5-yearsold boy with tonsillitis diphtheria with upper respiratory tract obstruction. Method: The evidence basedliterature regarding tonsillitis diphtheria, its complication and diphtheria immunization status wereconducted on Cochrane database, Pubmed Medline, and EBSCO Host Medline. Based on the inclusionand exclusion criteria, three studies were found relevant to our cases. Result: These studies stated thattonsillitis diphtheria is a disease with upper airway obstruction and cardiac complications. Cardiaccomplications are the leading cause of death. Immunization status in fatal cases was largely incompleteand total immunization coverage was still low. Conclusion: Tonsillitis diphtheria is a rare case with highmortality rate due to upper airway obstruction and cardiac complication. Systemic effect of diphtheriatoxin can lead to fatality although the airway obstruction had been managed. The incomplete immunizationstatus and the low immunization coverage increased the mortality of tonsillitis diphtheria. Keywords: tonsillitis diphtheria, upper airway obstruction, diphtheria immunization, systemic toxin

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