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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Interlay technique type 1 tympanoplasty, an alternative for closing large central tympanic membrane perforation Anton Budhi Darmawan
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.874 KB) | DOI: 10.32637/orli.v50i1.356

Abstract

Background: Type 1 tympanoplasty or myringoplasty is the most frequently performed procedure in the field of otology. Type 1 tympanoplasty is a surgical procedure to repair and only involves the restoration of the perforated tympanic membrane. There are three most accepted methods often used universally, namely underlay, overlay, and interlay. The interlay method is a relatively new method developed in 1992 for closing tympanic membrane perforation. This method has a high success rate of 96%. Objective: To report the success of type 1 tympanoplasty with an interlay method to close large central tympanic membrane perforations at Margono Soekarjo District Hospital. Case Report: Reporting 3 cases of chronic tubotympanic suppurative otitis media with large central tympanic membrane perforation which were repaired by type 1 tympanoplasty using interlay method. Clinical Question: Does interlay method type 1 tympanoplasty performed on large central tympanic membrane perforation provide better result compared with other methods of type 1 tympanoplasty? Review Method: Studying the evidence-based literatures on type 1 tympanoplasty interlay methods through Cochrane, Pubmed, and Google Scholar databases. Based on the inclusion and exclusion criteria, three journals were relevant with the reported cases. Result: All three journals stated that interlay method type 1 tympanoplasty had high success rate in terms of closing the tympanic membrane perforation and diminishing air-bone gap. Conclusion: Type 1 Tympanoplasty interlay method could be used as an alternative for the closure of a large central tympanic membrane perforation.Keywords: Chronic Tubotympanic Suppurative Otitis Media, large central tympanic membrane perforation, interlay tympanoplasty ABSTRAK Latar belakang: Timpanoplasti tipe 1 atau miringoplasti merupakan prosedur di bidang otologi yang paling sering dilakukan. Timpanoplasti tipe 1 merupakan metode pembedahan yang bertujuan untuk memperbaiki, dan terbatas hanya di membran timpani. Terdapat tiga metode yang paling diterima dan sering digunakan secara universal, yaitu underlay, overlay, dan interlay. Metode interlay merupakan metode penambalan perforasi membran timpani yang relatif baru, dikembangkan pada tahun 1992. Metode ini mempunyai keberhasilan yang tinggi yaitu mencapai 96%. Tujuan: Melaporkan keberhasilan timpanoplasti tipe 1 dengan metode interlay untuk penutupan perforasi membran timpani sentral besar di RSUD Margono Soekarjo. Laporan kasus: Dilaporkan 3 kasus otitis media supuratif kronik tipe tubotimpani dengan perforasi sentral besar, yang dilakukan timpanoplasti tipe 1 dengan metode interlay. Pertanyaan klinis: Apakah metode interlay timpanoplasti tipe 1 yang dilakukan pada perforasi membran timpani yang besar, dapat memberikan hasil yang lebih baik daripada metode lain timpanoplasti tipe 1? Telaah literatur: Telaah berbasis bukti mengenai timpanoplasti tipe 1 metode interlay melalui database Cochrane, Pubmed, dan Google Scholar. Berdasarkan kriteria inklusi dan ekslusi didapatkan tiga jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Ketiga jurnal tersebut menyatakan bahwa timpanoplasti tipe 1 metode interlay mempunyai angka keberhasilan yang tinggi dalam hal penutupan perforasi membran timpani maupun mengurangi air-bone gap. Kesimpulan: Timpanoplasti tipe 1 metode interlay dapat digunakan sebagai alternatif untuk penutupan perforasi membran timpani sentral yang besar
Pengaruh mometasone furoate terhadap kadar Interleukin 6 serum padapenderita hipertrofi adenoid Suheryanto, Rus; Harahap, Surya Parlaungan; Maharani, Iriana
Oto Rhino Laryngologica Indonesiana Vol 49 (2019): Volume 49, No. 2 July - December 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.492 KB) | DOI: 10.32637/orli.v49i20.314

Abstract

Latar belakang: Inflamasi adenoid ditandai dengan ditemukannya pembesaran ukuran adenoid atau hipertrofi adenoid. Telah banyak dilakukan penelitian yang mendukung IL-6 merupakan dasar patofisiologi terjadinya hipertrofi adenoid sehingga dibutuhkan terapi yang dapat mengurangi peran IL-6. Saat ini, kortikosteroid intranasal menjadi pilihan terapi pada hipertrofi adenoid karena memiliki efek anti inflamasi. Terdapat penelitian mengenai manfaat penggunaan kortikosteroid intranasal terhadap penderita hipertrofi adenoid, dimana terjadi penurunan kadar IL-6, tetapi pengaruhnya terhadap kadar IL-6 serum tidak diteliti. Tujuan: Mengetahui pengaruh pemberian mometasone furoate semprot hidung terhadap kadar IL-6 serum pada penderita hipertrofi adenoid. Metode: One group pre and post test design ini melibatkan 16 subjek. Dilakukan pemeriksaan foto polos skull lateral soft tissue dan pengambilan darah tepi untuk menghitung kadar IL-6 serum. Diberikan terapi mometasone furoatesemprot hidung selama 6 minggu. Setelah 2 minggu dan 6 minggu dilakukan pengambilan darah tepi untuk menghitung kadar IL-6 serum, serta evaluasi foto polos skull lateral soft tissue setelah 6 minggu. Hasil:Terdapat perbedaan bermakna antara kadar IL-6 serum sebelum dan sesudah perlakuan baik, pada minggu kedua maupun minggu keenam (p=0.00). Terdapat perbedaan bermakna antara nilai foto polos skull lateral soft tissue sebelum dan sesudah perlakuan (p=0.00). Berdasarkan uji Pearson, nilai kadar IL-6 serum darah berkorelasi secara signifikan yang bersifat negatif (p<0,05) dengan foto polos skull lateral sebelum dan sesudah perlakuan dengan hasil -0,819 dan -0,692. Kesimpulan: Mometasone furoatesemprot hidung dapat menurunkan kadar IL-6 serum pada penderita hipertrofi adenoid secara bermakna, disertai dengan mengecilnya ukuran adenoid, penurunan gejala dan keluhan penderita hipertrofi adenoid. Kata kunci: Hipertrofi adenoid, Interleukin 6, Mometasone FuroateABSTRACT Background:Adenoid inflammation is characterized by adenoid hypertrophy (AH). Numerous studies had stated that Interleukin 6 (IL-6) is the pathophysiological basis for the occurrence of AH, thus, a therapy is needed to reduce the role of IL-6. Intranasal corticosteroid (IC) is the drug-of-choice for AH for its anti-inflammatory nature. Previous research had shown a decrease in IL-6 levels in adenoid tissue after IC administration, but its effect on IL-6 serum level had not yet been studied. Purpose: To find out the effect of Mometasone Furoate (MF) on IL-6 serum level in AH patients. Methods: One group pre and post test design, involving 16 subjects, underwent a soft tissue skull lateral plain x-ray, also a peripheral blood examination for IL-6 serum level. Afterwards, subjects were treated with MF nasal spray for 6 weeks. The IL-6 serum level was evaluated after 2 and 6 weeks, and the soft tissue x- ray was assessed after 6 weeks. Results: There were significant differences between IL-6 serum levels before and after treatment both in the second and sixth week (p = 0.00). There were significant differences between the value of soft tissue skull lateral plain x-ray before and after treatment (p = 0.00). Based on the Pearson test, IL-6 serum levels correlated significantly negatively (p <0.05) with soft tissue skull lateral plain x-ray before and after treatment with results -0.819 and -0.692. Conclusion: MF nasal spray significantly reduce IL-6 serum levels in AH patients, reducing adenoid size and decreasing symptoms of AH patients.  
Impact of Pharmacotherapy to decrease Interleukin-6 in patients with chronic rhinosinusitis without nasal polyp Lina Marlina; Sinta Sari Ratunanda; Teti Madiadipoera
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.035 KB) | DOI: 10.32637/orli.v50i1.350

Abstract

Background: Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinuses mucosa, ongoing for more than 12 weeks. Even now it still creates socioeconomic problem in both developed and developing countries. Pharmacotherapy administration is essential for decreasing the severity of symptom, improving quality of life, and decreasing interleukin (IL)-6 level. Objective: To find out the effect of pharmacotherapy on severity of the symptom, quality of life, and IL-6 level. Method: Randomized clinical trial with pre and posttest design, on 20 CRS without polyp patients, divided into two groups based on skin prick test results. Both groups were equally treated with nasal irrigation, nasal corticosteroid, and antibiotic amoxicillin clavulanate for 14 days. All subjects were assessed for Visual Analog Scale (VAS) score, nasoendoscopy (NE) score, Sinonasal Outcome test (SNOT)-22, and IL-6 level. Statistical analysis was performed with Mann Whitney and Wilcoxon methods. Result: There were significant differences in total analysis results on VAS scores, NE scores, SNOT-22, and IL-6 levels in both groups, with values p<0.05. There was improvement in all variables after pharmacotherapy, but there was no significant difference between the case and control groups, with values p>0.05. Conclusion: Pharmacotherapy in both groups resulte’ in reduced severity of symptoms, improved quality of lives, and decreased IL-6 levels.Keywords: Interleukin-6, pharmacotherapy, chronic rhinosinusitis without polyp, quality of life ABSTRAK Latar belakang: Rinosinusitis kronik (RSK) merupakan inflamasi pada mukosa hidung dan sinus paranasal, yang berlangsung selama lebih dari 12 minggu. Hingga saat ini masih memengaruhi sosioekonomi di negara maju maupun negara berkembang. Pemberian farmakoterapi sangat penting untuk memperbaiki derajat gejala, meningkatkan kualitas hidup, dan menurunkan kadar interleukin (IL)-6. Tujuan: Mengetahui pengaruh pemberian farmakoterapi terhadap perbaikan derajat gejala, peningkatan kualitas hidup, dan penurunan kadar IL-6. Metode: Penelitian kuasi eksperimental, label terbuka pra dan pascaterapi, pada 20 penderita RSK tanpa polip, dibagi dua kelompok berdasarkan hasil uji tusuk kulit. Perlakuan pada kedua kelompok sama, diberikan irigasi hidung, kortikosteroid intranasal, dan antibiotik amoksisilin klavulanat selama 14 hari. Penelitian dilakukan dengan menilai skor Visual Analog Scale (VAS) gejala hidung, skor nasoendoskopi (NE), Sinonasal Outcome test (SNOT)-22, dan kadar IL-6. Analisis statistik menggunakan metode Mann Whitney dan Wilcoxon. Hasil: Didapati perbedaan bermakna pada hasil analisis total pada skor VAS gejala hidung, skor NE, SNOT-22, dan kadar IL-6 pada kedua kelompok dengan nilai p<0,05. Didapati perbaikan pada semua variabel setelah 14 hari pemberian medikamentosa maksimal, namun tidak terdapat perbedaan bermakna antara kedua kelompok dengan nilai p>0,05. Kesimpulan: Pemberian farmakoterapi pada kedua kelompok memberikan hasil berupa perbaikan derajat gejala, peningkatan kualitas hidup, dan penurunan kadar IL-6.
Effectiveness of immediate primary correction and medial canthopexy in bilateral naso-orbito-ethmoid fracture Dolly Irfandy; Al Hafiz; Dolly Irfandy; Bonny Murizky
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.377 KB) | DOI: 10.32637/orli.v50i1.357

Abstract

Background: The naso-orbito-ethmoid (NOE) region is a functionally and aesthetically important area of the face. Traffic accidents are the most often cause of NOE fracture and contribute about 35 to 60% of cases. Clinical symptoms are associated with location and the impact. The best way to make an assessment is by clinical examination combined with 3D CT scan. The management usually required reconstruction of the injured anatomical structures of the face with Open Reduction and Internal Fixation (ORIF) method. Purpose: To report the result of immediate reconstruction surgery in a NOE fracture case. Case Report: A case of bilateral NOE fracture in a 24 years old woman, treated with ORIF. Clinical Question: Does immedate primary correction and medial canthopexy provides good result on face reconstruction of NOE fracture? Review Method: Literature searching through Cochrane database, Pubmed, Clinicalkey and Google Scholar, using keywords of correction procedure in NOE fracture, Open Reduction and Internal Fixation and medial canthopexy. Result: The search obtained 35 literatures published in the last 10 years, and found 21 articles relevant with the topics. Conclusion: NOE fracture is a fracture which often occurs as a result of traffic accidents. The diagnosis is established by anamnesis of patient’s complaints and symptoms, physical examination, and 3D CT scan. Immediate reconstruction in NOE fracture cases gives a better result compared to delayed surgical management, as implemented in this case.Keywords: Naso-orbito-ethmoid (NOE) fracture, Open Reduction and Internal Fixation (ORIF), immediate reconstruction ABSTRAK Latar belakang: Naso-orbito-etmoid (NOE) adalah daerah yang penting pada wajah secara fungsional dan estetika. Kecelakaan lalu lintas merupakan penyebab terbanyak, dan menyumbang 35- 60% angka kejadian dari fraktur NOE. Gejala klinis berhubungan dengan lokasi dan tingkat keparahan cedera. Cara terbaik mendiagnosis adalah dengan pemeriksaan klinis dan CT scan 3D. Penatalaksanaan dilakukan dengan rekonstruksi struktur anatomi wajah yang terluka, menggunakan metode reduksi terbuka dan fiksasi internal (Open Reduction and Internal Fixation/ORIF). Tujuan: Melaporkan keberhasilan rekonstruksi segera pada fraktur NOE. Laporan kasus: Dilaporkan satu kasus fraktur NOE bilateral pada seorang perempuan usia 24 tahun, yang dilakukan reduksi terbuka dan fiksasi internal. Pertanyaan klinis: Apakah rekonstruksi segera dan kantopeksi medial pada fraktur NOE memberikan hasil yang baik? Metode telaah literatur: Penelusuran berbasis bukti melalui database Cohrane, Pubmed, Clinicalkey dan Google Scholar menggunakan kata kunci rekonstruksi pada fraktur NOE, Open Reduction and Internal Fixation, dan kantopeksi medial. Hasil: Diperoleh 35 literatur yang terbit dalam 10 tahun terakhir, dan didapati 21 artikel yang relevan dengan topik. Kesimpulan: Fraktur NOE merupakan fraktur yang sering terjadi akibat kecelakaan lalu lintas. Diagnosis ditegakkan berdasarkan anamnesis mengenai keluhan dan gejala yang dirasakan pasien, pemeriksaan fisik serta pemeriksaan CT scan 3D. Penatalaksanaan pembedahan pada kasus fraktur NOE sesegera mungkin, memberikan hasil yang lebih baik dibandingkan dengan tindakan pembedahan tertunda, seperti yang tergambar pada kasus yang dilaporkan ini.
The effect of local ketamine infiltration on post tonsillectomy pain scale Ade Asyari; Novialdi Novialdi; Elniza Morina; Rimelda Aquinas; Nasman Puar; Hafni Bachtiar
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.333 KB) | DOI: 10.32637/orli.v50i1.351

Abstract

Background: Post tonsillectomy pain is one of the surgery side effects that most disturbing for patient’s comfort and will cause dysphagia, low intake, dehydration, secondary infection and bleeding. Ketamine is an anesthetic drug that has strong analgesic effect and easily available in any hospital at relatively cheap price. Objective: To find out the effect of local ketamine infiltration on the post tonsillectomy pain scale. Method: An experimental study during tonsillectomy with a Post Test Control Group on 12 samples without local infiltration of ketamine and 12 samples with local infiltration of ketamine in peritonsillar pillar. The pain was assessed 2 hours and 24 hours post extubation with pain Visual Analog Scale (VAS). Result: The VAS value from patients who were given local infiltration of ketamine in peritonsillar pillar were lower (5.83 ± 0.72 at 2 hours and 2.83 ± 0.58 at 24 hours post extubation) compared to patients without ketamine infiltration (7.83 ± 0.58 at 2 hours and 3.58 ± 0.51 at 24 hours post extubation). The result showed statistically significant difference (p <0.05) at 2 hours and 24 hours post extubation. Conclusion: The VAS score of the ketamine infiltration group is lower at 2 hours and 24 hours post extubation than the group without ketamine infiltration, showing there was a noticeable effect of local ketamine infiltration on the post tonsillectomy pain scale.Keywords : post tonsillectomy pain, ketamine, local infiltration, visual analog scale ABSTRAKLatar belakang: Nyeri pascatonsilektomi adalah salah satu efek samping operasi yang sangat mengganggu kenyamanan pasien, dan dapat menyebabkan gangguan menelan, kurangnya asupan nutrisi, dehidrasi, infeksi sekunder dan perdarahan. Ketamin merupakan obat anestesi yang memiliki efek analgetik yang kuat dan mudah didapatkan di semua tipe rumah sakit dengan harga yang relatif murah. Tujuan: Mengetahui efek pemberian infiltrasi lokal ketamin terhadap skala nyeri pascatonsilektomi. Metode: Penelitian eksperimental dengan desain Post Test Control Group pada 12 sampel tanpa pemberian infiltrasi lokal ketamin dan 12 sampel dengan pemberian infiltrasi lokal ketamin di pilar peritonsil saat tonsilektomi. Dilakukan penilaian nyeri 2 jam dan 24 jam pascaekstubasi menggunakan skala nyeri Visual Analog Scale (VAS). Hasil: Nilai VAS pasien yang diberi infiltrasi lokal ketamin di pilar peritonsil lebih rendah (5,83±0,72 pada 2 jam dan 2,83 ± 0,58 pada 24 jam pascaekstubasi) dibanding tanpa diberi infiltrasi lokal ketamine (7,83 ± 0,58 pada 2 jam dan 3,58± 0,51 pada 24 jam pascaekstubasi), dan bermakna secara statistik (p<0,05) pada kedua penilaian. Kesimpulan: Terdapat efek nyata infiltrasi lokal ketamin terhadap skala nyeri pascatonsilektomi, dimana nilai VAS kelompok yang diberi infiltrasi ketamin lebih rendah, baik pada 2 jam ataupun 24 jam pascaekstubasi dibanding kelompok yang tidak diberi infiltrasi ketamin.
Characteristics of non-Hodgkin lymphoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Fadhlia Fadhlia; Benny Kurnia; Lily Setiani; Yerni Karnita; Juniar Juniar; Iip Berliananda
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.482 KB) | DOI: 10.32637/orli.v50i1.352

Abstract

Background: Non-Hodgkin’s lymphoma (NHL) is a primary malignancy in the lymphatic system and extranodal lymphoid tissue originating from B lymphocyte cells, T lymphocytes or natural killer (NK) cells. The incidence of NHL continues to increase with various characteristics. Objective: To find out the characteristics of NHL sufferers undergoing treatment in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin Regional General Hospital (RSUDZA), Banda Aceh from January 2015 to December 2018. Method: This was an observational descriptive study conducted at Banda Aceh RSUDZA using retrospective secondary data collection from medical records that met the inclusion criteria, in total sampling method. Result: Found 32 research subjects, dominantly male (20), the highest age range was 56-65 years (10). The main complaints were neck lumps (10) and oropharynx lumps (11). The most common NHL was from B lymphocyte cells (6). The chemotherapy regimens used are cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). The most frequent side effects are anemia, hypoalbuminemia, and leukopenia. Conclusion: The results showed that NHL was most common in men with an increased incidence in the fifth decade. Neck lumps are the most common complaint. The chemotherapy regimen used is CHOP and R-CHOP.Keywords : Non-Hodgkin’s Lymphoma, chemotherapy ABSTRAK Latar belakang: Limfoma Non-Hodgkin (LNH) adalah keganasan primer pada sistem limfatik dan jaringan limfoid ekstranodal yang berasal dari sel limfosit B, limfosit T atau sel natural killer (NK). Kejadian LNH terus meningkat dengan berbagai karakteristik. Tujuan: Melihat karakteristik penderita LNH yang menjalani pengobatan di Departemen THT-KL RSUD dr. Zainoel Abidin (RSUDZA), Banda Aceh pada periode Januari 2015 sampai Desember 2018. Metode: Penelitian deskriptif observasional dengan pengambilan data sekunder secara retrospektif dari rekam medis yang memenuhi kriteria inklusi, dengan metode total sampling. Hasil: Didapatkan total subjek penelitian 32 orang, dominan pada lakilaki (20), rentang usia tertinggi antara 56-65 tahun (10). Keluhan utama terbanyak adalah benjolan di leher (10) dan benjolan orofaring (11). LNH yang berasal dari sel limfosit B paling banyak dijumpai (6). Regimen kemoterapi yang digunakan adalah cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) dan rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Efek samping paling sering adalah anemia, hipoalbuminemia dan leukopenia. Kesimpulan: Hasil penelitian menunjukkan LNH paling sering pada laki-laki dengan angka kejadian meningkat pada dekade kelima. Keluhan yang paling sering adalah benjolan di leher. Regimen kemoterapi yang digunakan adalah CHOP dan R-CHOP.
Correlation of malondialdehyde and hearing threshold level at frequency 4000 Hz post gunshot exposure Nyilo Purnami; Fauzi Helmi; Sri Herawati
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.503 KB) | DOI: 10.32637/orli.v50i1.283

Abstract

Background: The incidence of acoustic trauma after gunshot exposure in students of the SekolahPolisi Negara (SPN) is quite high. Malondialdehyde (MDA) is a compound that can portray oxidativestress due to free radicals. The correlation between the levels of MDA and the hearing threshold frequencypost gunshot exposure could be used as the base for administering antioxidants to prevent acoustictrauma. Objective: To find out the correlation between the levels of MDA and the hearing thresholdfrequency post gunshot exposure, in East Java SPN students. Method: An observational analytic studywith a retrospective cross sectional approach using secondary data of medical records of the East JavaSPN students batch 2017/2018. The samples were selected by simple random sampling. Result: Out of50 students, the mean of age was 19.62 years. All samples were male with mean 559.17 and standarddeviation (SD) 959.86. The calculation of the 4000 Hz frequency threshold value obtained an averagevalue of 31.52 and SD of 13.4. Hearing loss complaint was found in 1 student (2%). No complaints oftinnitus and vertigo were found. Statistical tests with Pearson correlation between serum MDA levels and4000 Hz frequency threshold values showed a correlation coefficient (r) of 0.74 and p = 0.00 (p<0.05).Conclusion: There was a significant correlation between MDA levels and the hearing threshold at 4000Hz frequency after gunshot exposure in East Java SPN students.Keywords: acoustic trauma, malondialdehyde, hearing threshold level at frequency 4000 HzABSTRAKLatar belakang: Insiden trauma akustik pasca pajanan letusan senjata api pada siswa Sekolah PolisiNegara (SPN) cukup tinggi. Malondialdehid (MDA) merupakan senyawa yang dapat menggambarkanstres oksidatif akibat radikal bebas. Adanya hubungan antara kadar MDA dengan nilai ambang dengarfrekuensi 4000 Hertz (Hz) dapat menjadi dasar pemberian antioksidan untuk pencegahan traumaakustik. Tujuan: Membuktikan hubungan antara kadar MDA dengan nilai ambang dengar frekuensi4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur. Metode: Penelitian ini adalahobservasional analitik dengan pendekatan retrospektif cross sectional menggunakan data sekunderberupa rekam medik siswa SPN Jawa Timur angkatan 2017/2018. Sampel dipilih secara simple random sampling. Hasil: Dari 50 siswa, usia rerata adalah 19,62 tahun. Seluruh sampel penelitian adalah laki-laki, rerata=559,17 dan standar deviasi (SD)=959,86. Penghitungan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil nilai rerata=31,52 dan SD=13,4 Keluhan penurunan pendengaran hanya dijumpai pada 1 siswa (2%). Uji statistik dengan korelasi Pearson antara kadar MDA dalam serum dengan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil koefisien korelasi (r) sebesar 0,74 dan p = 0,00 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur.Kata kunci: trauma akustik, malondialdehid, nilai ambang dengar frekuensi 4000 Hz
The correlation between IL-10 expression and histopathological type in nasopharynx carcinoma patients Hamita, Hamita; Yusuf, Muhtarum; Wiyadi, Manshur Shidiq
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.413 KB) | DOI: 10.32637/orli.v50i1.353

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a malignancy originated from nasopharyngeal epithelial cells. NPC therapy response could be predicted from histopathological type, but some patients with the same histopathological type, showed a different therapy response. Interleukin (IL)-10 expression is expected to be able to predict a better response of therapy in NPC patients. Purpose: To find out the correlation between IL-10 expression and histopathological type in NPC patients. Method: An analytic observational study with cross sectional approach towards 33 samples taken from the Oncology Polyclinic of Outpatient Unit of Otorhinolaryngology Head and Neck Surgery Department, Dr. Soetomo General Hospital. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The IL-10 expression was studied with immunohistochemistry using rabbit polyclonal antibody Anti IL-10. Assessment of the staining used Allred scale. The Fisher exact test was utilized to determine the correlation of IL-10 expression and histopathological type of NPC, with p value = 0.05. Result: The result of IL-10 expression in NPC patients with histopathological WHO type I NPC obtained 1 sample (8.3%) with strong positive expression and 2 samples (9.5%) with weak positive expression. In patients with histopathological WHO type II NPC obtained 2 samples (16.7%) with strong positive expression and 12 samples (57.1%) with weak positive expression. In patients with histopathological WHO type III NPC obtained 9 samples (75%) with strong expression and 7 samples (33.3%) with weak positive expression. Conclusion: There was moderate positive correlation between IL-10 expression and histopathological type in NPC patients.Keywords: nasopharyngeal carcinoma, IL-10 expression, histopathological type ABSTRAK Latar belakang: Karsinoma nasofaring (KNF) adalah suatu keganasan yang berasal dari epitel nasofaring. Respon terapi KNF selama ini dapat dinilai berdasarkan tipe histopatologi, namun pada kenyataannya penderita KNF dengan tipe histopatologi sama dapat menunjukkan respon terapi berbeda. Pemeriksaan ekspresi interleukin (IL)-10 diharapkan dapat memberikan prediksi lebih baik mengenai respon terapi pada penderita KNF. Tujuan: Mengetahui hubungan antara ekspresi IL-10 dengan tipe histopatologi pada penderita KNF. Metode: Penelitian observasional analitik dengan pendekatan cross sectional pada 33 sampel yang diperoleh dari Poliklinik Onkologi Unit Rawat Jalan, Departemen THTBedah Kepala Leher, RSUD Dr Soetomo. Ekspresi IL-10 diperiksa dari blok parafin dengan teknik pemulasan imunohistokimia menggunakan rabbit polyclonal antibody Anti IL-10. Ekspresi IL-10 dinilai dengan menggunakan skala Allred. Uji Fisher exact digunakan untuk menentukan korelasi antara ekspresi IL-10 dan tipe histopatologi KNF, dengan p = 0,05. Hasil: Ekspresi IL-10 pada KNF WHO tipe I didapatkan ekspresi positif kuat 1 penderita (8,3%) dan ekspresi positif lemah 2 penderita (9,5%). Hasil ekspresi IL-10 pada KNF WHO tipe II didapatkan ekspresi positif kuat 2 penderita (16,7%) dan ekspresi positif lemah 12 penderita (57,1%). Hasil ekspresi IL-10 pada KNF WHO tipe III 9 penderita (75%) dengan ekspresi positif kuat dan 7 penderita (33,3%) dengan ekspresi positif lemah. Kesimpulan: Didapatkan korelasi positif sedang antara ekspresi IL-10 dan tipe histopatologi pada penderita KNF
Words in noise audiometry in adult subjects with normal hearing Widayat Alviandi; Jenny Bashiruddin; Brastho Bramantyo; Farisa Rizky
Oto Rhino Laryngologica Indonesiana Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.117 KB) | DOI: 10.32637/orli.v50i1.332

Abstract

Background: Patients with hearing disturbance will generally undergo pure tone audiometry andspeech audiometry in a quiet room, but those examinations cannot evaluate the ability to understand speech in daily environment with a noisy background. Words in noise test will provide valuable informationregarding patient’s hearing problem in noise. Purpose: To evaluate the hearing threshold using wordsin noise test in adults with normal hearing. Method: This cross-sectional study was conducted in CiptoMangunkusumo Hospital from January to April 2017. All subjects who fulfilled the inclusion and exclusioncriteria underwent pure tone audiometry, speech audiometry, and words in noise test. Results: A total of71 individuals with normal hearing were recruited for this study. Words in noise test showed the medianvalue of 67 dB and 100 dB for Speech Recognition Threshold (SRT) 50% and Speech DiscriminationScore (SDS) 100%, respectively. The SRT 50% and SDS 100% were significantly higher in the age group40–60 years compared to the age group 18–39 years. There was also a statistically significant differencebetween males and females at SRT 50% assessed by words in noise audiometry. Conclusion: Wordsin noise test showed a statistically significant difference in SRT 50% and SDS 100% between two agegroups, but no difference was found between genders. The result of this study can be used as a referencefor SRT and SDS values of speech audiometry test in noise.Keywords: words in noise, speech audiometry, speech recognition threshold, speech discrimination score ABSTRAKLatar belakang: Pasien dengan gangguan pendengaran umumnya menjalani pemeriksaanaudiometri nada murni dan audiometri tutur di ruangan yang sunyi, tetapi pemeriksaan ini tidakdapat menggambarkan kemampuan pemahaman wicara di lingkungan sehari-hari yang ramai. Testutur dalam bising dapat mengevaluasi masalah pendengaran pasien dalam keadaan bising. Tujuan:Untuk mengevaluasi ambang pendengaran menggunakan tes tutur dalam bising pada orang dewasadengan pendengaran normal. Metode: Penelitian potong lintang ini dilakukan di Rumah Sakit CiptoMangunkusumo dari Januari hingga April 2017. Semua subjek yang memenuhi kriteria inklusi daneksklusi menjalani pemeriksaan audiometri nada murni, audiometri tutur, dan tes tutur dalam bising.Hasil: Sebanyak 71 orang dengan pendengaran normal diikutsertakan dalam penelitian ini. Tes tuturdalam bising menunjukkan nilai median masing-masing 67 dB dan 100 dB pada Speech RecognitionThreshold (SRT) 50% dan Speech Discrimination Score (SDS) 100%. SRT 50% dan SDS 100% secarasignifikan lebih tinggi pada kelompok usia 40–60 tahun dibandingkan dengan kelompok usia 18–39 tahun. Hasil pemeriksaan tes tutur dalam bising menunjukkan perbedaan yang signifikan antara laki-laki dan wanita pada nilai SRT 50%. Kesimpulan: Tes tutur dalam bising menunjukkan perbedaan yang bermakna secara statistik pada SRT 50% dan SDS 100% antara dua kelompok umur, tetapi tidak ada perbedaan signifikan diantara jenis kelamin. Hasil penelitian ini dapat digunakan sebagai acuan untuk nilai SRT dan SDS pada pemeriksaan audiometri tutur dalam bising.
Laryngomalacia: diagnosis and management at Otorhinolaryngology Head and Neck Surgery Department Dr.Soetomo Hospital, Surabaya Muhtarum Yusuf; Puji Utami
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.405

Abstract

ABSTRACTBackground: Laryngomalacia is an abnormality of the larynx that leads to the inward collapse of the supraglottic structure during inspiration. The condition is primarily characterized by congenital stridor in infants and children. Diagnosis is often made based on the larynx visualization during inspiration. Laryngomalacia is generally recovers spontaneously at the age 2-5 years old, surgery is reserved for severe cases. Purpose: To obtain data of the clinical appearance, diagnosis, and therapy of laryngomalacia. Method: An observational study on medical records of all laryngomalacia patients at the Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine Universitas Airlangga /Dr. Soetomo General Hospital, Surabaya from January 1st, 2017 to December 31st, 2018. Data evaluation included clinical symptoms, type of laryngomalacia, comorbid factors, the age range of clinical improvement, and the management. Result: The main complaint of laryngomalacia was inspiratory stridor in 63 patients (82.89%), followed by dyspnea, snoring, hoarseness, and choking. Endoscopy finding mostly was type 1 in 69 patients (90.79%), the others were type 2 and 3. Comorbid factor mostly was neurological disease in 16 patients (21.03%), followed by congenital heart disease, congenital abnormality, prematurity, and laryngopharyngeal reflux. The age group of clinical improvement majority were <12 months, followed by >12-24 months, and no improvement in 56 patients (73.69%). Conservative therapy was conducted in 73 patients (96.05%) and 3 patients were tracheotomized. Conclusion: The main complaint of laryngomalacia was inspiratory noises, mostly found was laryngomalacia type 1.The highest comorbid factor was neurological disease. The most common management was conservative therapy. ABSTRAKLatar belakang: Laringomalasia adalah kolapsnya struktur supraglotik laring saat inspirasi. Laringomalasia umumnya sembuh spontan pada umur 2-5 tahun, pembedahan hanya dilakukan pada kasus yang berat.Tujuan: Memperoleh gambaran klinis penderita laringomalasia, diagnosis dan terapi. Metode: Penelitian observasional pada semua rekam medik yang lengkap penderita laringomalasia  di Departemen THT-KL RSUD Dr. Soetomo, Surabaya, periode 1 Januari 2017 - 31 Desember 2018. Data yang dievaluasi meliputi gejala klinik, tipe, faktor komorbid, usia perbaikan gejala, dan terapi. Hasil: Keluhan utama adalah napas berbunyi pada 63 penderita (82,89%), disusul sesak napas, mengorok saat tidur, suara parau, dan mudah tersedak. Temuan  endoskopik mayoritas tipe 1 pada  69 penderita (90,79%), sisanya tipe 2 dan 3. Faktor komorbid terbanyak penyakit neurologis pada   16 penderita (21,03%), disusul kelainan jantung bawaan, anomali kongenital, prematur, dan refluks laring faring. Usia perbaikan klinis mayoritas <12 bulan, diiikuti >12-24 bulan dan belum membaik 56 penderita (73,69%). Terapi konservatif dilakukan pada 73 penderita (96,05%) dan 3 penderita menjalani trakeotomi. Kesimpulan: Keluhan utama napas berbunyi, mayoritas laringomalasia tipe 1. Faktor komorbid terbanyak penyakit neurologis. Laringomalasia mayoritas diterapi secara konservatif.

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