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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
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Articles 493 Documents
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Correlation of EGFR, RAS, ERK and Ki-67 as predictor of inverted papilloma malignancy transformation Sonny Soebjanto; Pudji Rahayu; Hendradi Surjotomo; Aris Satria Hardika
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.343

Abstract

ABSTRACTBackground: Inverted papilloma (IP) is benign tumor of the nasal cavity and paranasal sinuses epithelium. Sinonasal squamous cell carcinoma (SCC) is epithelial malignancy of nasal cavity and paranasal sinuses. HPV increases epidermal growth factor receptor (EGFR) expression mediated by E5. RAS is part of the RAS-RAF-MEK-ERK pathway that regulates various cell functions. Ki-67 serves as a molecular marker of tumor proliferation. Early malignant transformation often goes unnoticed. It is important to know the roles of EGFR, RAS, ERK and Ki-67 as predictor for tumor markers in IP and Sinonasal SCC. Objective: To find out the correlation of EGFR, RAS, ERK expressions towards Ki-67 expression as predictor of sinonasal IP transformation into sinonasal SCC. Method: A cross sectional study taking samples from the medical record of Dr.Saiful Anwar Hospital. The expression of EGFR, RAS, ERK and Ki-67 were examined with immunohistochemistry. Result: The estimated inner model results for direct influence of EGFR, RAS, ERK and Ki-67 towards IP and SCC were 2.352, 2.019, 2.625, and 2.213. The estimated inner model results for direct influence of EGFR, RAS and ERK towards Ki- 67 were 2.386, 3.811, and 3.00. Discussion: Previous research had reported an increase in Ki-67 index indicated the role of Ki-67 in cell tranformation of IP with dysplasia into SCC. Conclusion: EGFR, RAS and ERK expressions related to Ki-67 on IP and SCC. Increased expressions of EGFR, RAS, ERK and Ki-67 on IP indicated risk of malignant transformation. EGFR, RAS, ERK and Ki-67 could become predictors of IP transformation into SCC. ABSTRAKLatar belakang: Papiloma inverted (PI) merupakan tumor jinak epitel kavum nasi dan sinus paranasal. Karsinoma sel skuamosa (KSS) sinonasal merupakan keganasan yang berasal dari epitel mukosa kavum nasi dan sinus paranasal. HPV meningkatkan ekspresi EGFR yang dimediasi oleh E5. RAS merupakan bagian dari jaras RAS–RAF–MEK–ERK yang mengatur berbagai fungsi sel. Ki-67 berfungsi sebagai penanda molekuler proliferasi tumor. Diagnosis dini transformasi keganasan pada papiloma inverted seringkali luput dari pengamatan. Penting mengetahui peran EGFR, RAS, ERK dan Ki-67 sebagai cikal bakal penanda tumor pada IP dan KSS sinonasal. Tujuan: Mengetahui hubungan ekspresi EGFR, RAS, ERK terhadap Ki-67 sebagai prediksi transformasi keganasan PI sinonasal menjadi KSS sinonasal. Metode: Penelitian cross sectional, sampel penelitian diambil dari arsip rekam medis rawat jalan yang masih didapatkan preparat histopatologi papiloma inverted dan karsinoma sel skuamosa sinonasal di laboratorium Patologi Anatomi, dan dilakukan pemeriksaan ekspresi EGFR, RAS, ERK dan Ki-67 dengan imunohistokimia. Hasil: Hasil estimasi inner model untuk pengaruh langsung EGFR, RAS, ERK dan Ki-67 terhadap PI dan KSS sebesar 2,352, 2,019, 2,625 dan 2,213. Hasil estimasi inner model untuk pengaruh langsung EGFR, RAS dan ERK terhadap Ki-67 sebesar 2,386, 3,811 dan 3,00. Diskusi: Penelitian terdahulu membuktikan peningkatan indeks Ki-67 merupakan pertanda adanya peran Ki-67 pada perubahan PI dengan displasia menjadi SCC. Kesimpulan: Ekspresi EGFR, RAS dan ERK berhubungan terhadap Ki-67 pada IP dan KSS. Peningkatan ekspresi EGFR, RAS, ERK dan Ki-67 pada PI menandakan adanya risiko terjadi transformasi keganasan. EGFR, RAS, ERK dan Ki-67 dapat menjadi cikal bakal prediktor transformasi keganasan PI menjadi KSS.
Mometasone furoate effect on interleukin-6 of adenoid surface and serum in adenoid hypertrophy patients Zainul Mujahid; Rus Suheryanto; Iriana Maharani
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.362

Abstract

Background: Adenoid hypertrophy is one of the most common problems in children resulting in obstruction of the posterior nasal cavity. Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a role in acute and chronic infections, hematopoesis, T cells and B cells formation. Purpose: To determine the effect of intranasal mometasone furoate administration on IL-6 level of adenoid surface and serum and the adenoid size in patients with adenoid hypertrophy. Method: A one group pre- and post-test design involving 17 patients aged 5 to 12 years. The subjects underwent nasoendoscopic examination to determine the adenoid size, also measurement of IL-6 level of adenoid surface and serum before and after 6 weeks treatment with intranasal mometasone furoate. Results: There were a significant decrease of the adenoid surface IL-6 level, serum IL-6 level, and adenoid size with p value <0.05. There was a significant positive correlation between the levels of adenoid surface IL-6 and serum IL-6 (r=0.517; p=0.033). A significant positive correlation was obtained between the decrease of adenoid surface and serum IL-6 levels with the decrease of adenoid size (p<0.05). Conclusion: The use of intranasal mometasone furoate could decrease the IL-6 levels of adenoid surface and serum, and the adenoid size in patients with adenoid hypertrophy.ABSTRAK Latar belakang: Hipertrofi adenoid merupakan salah satu masalah tersering pada anak-anak yang mengakibatkan obstruksi pada rongga hidung posterior. Interleukin-6 merupakan sitokin pleiotropik yang berperan pada infeksi akut maupun kronis, hematopoesis, pembentukan sel T dan sel B. Tujuan: Mengetahui pengaruh pemberian mometason furoat intranasal terhadap kadar IL-6 permukaan adenoid dan serum, serta ukuran adenoid pada penderita hipertrofi adenoid. Metode: Suatu one group pre- and post-test design melibatkan 17 subjek berusia 5 sampai 12 tahun. Subjek menjalani pemeriksaan nasoendoskopi, pengukuran kadar IL-6 serum, dan IL-6 permukaan adenoid sebelum dan setelah pemakaian mometason furoat intranasal selama 6 minggu. Hasil: Didapatkan penurunan kadar IL-6 permukaan adenoid, IL-6 serum, dan penurunan ukuran adenoid yang bermakna dengan nilai p<0,05. Didapatkan korelasi positif yang signifikan antara kadar IL-6 permukaan adenoid dengan IL-6 serum (r=0,517; p=0,033). Didapatkan korelasi positif yang signifikan antara penurunan kadar IL-6 permukaan adenoid dan IL-6 serum dengan pengecilan ukuran adenoid (p<0,05). Kesimpulan: Penggunaan mometason furoat intranasal dapat menurunkan kadar IL-6 permukaan adenoid dan IL-6 serum, serta ukuran adenoid pada penderita hipertrofi adenoid. Kata kunci: hipertrofi adenoid, interleukin-6, mometason furoat intranasal
Pathophysiology and management of gustatory rhinitis Shally Adhina Putri; Nina Irawati
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.404

Abstract

ABSTRACTBackground: Gustatory rhinitis is a syndrome that causes symptoms of annoying rhinorrhea, occurring immediately after consuming solid or liquid foods which are hot and /or spicy. Usually starts within a few minutes after the ingestion of the foods involved, and is not associated with itching, sneezing, nasal congestion or facial pain. Purpose: To discuss the pathophysiology and proper management of gustatory rhinitis. Literature Review: Recent studies suggest that gustatory rhinitis is likely associated with phenomenon of neurogenic inflammation. The ingestion of spicy foods  caused  the  stimulation of trigeminal sensory nerve endings located in the upper part of the aerodigestive track. Sensory   nerve stimulation seems to be correlated with an activation of post ganglionic cholinergic muscarinic parasympathetic fibers and sensitive to atropine. Conclusion: The initial management of gustatory rhinitis is avoiding the trigger foods. Using combination of topical steroid and anticholinergic intranasal had been proven more effective to treat the rhinorrhea caused by gustatory rhinitis than administration of single drug. ABSTRAKLatar belakang: Rinitis gustatori adalah sindroma yang menimbulkan gejala rinore yang mengganggu, sesaat setelah mengonsumsi makanan padat atau cair, yang bersifat pedas dan/atau berempah. Biasanya dimulai dalam beberapa menit setelah menelan makanan tersebut, dan tidak disertai dengan gatal, bersin, hidung tersumbat atau nyeri wajah. Tujuan: Untuk membahas patofisiologi dan tatalaksana yang tepat pada rinitis gustatori. Tinjauan Pustaka: Sejumlah studi terbaru mendapatkan rinitis gustatori berkaitan dengan fenomena inflamasi neurogenik. Proses menelan makanan pedas dapat menyebabkan stimulasi ujung saraf sensorik trigeminal yang terletak di jalur aerodigestif bagian atas. Stimulasi saraf sensorik tersebut berkaitan dengan pengaktifan serabut saraf parasimpatik muskarinik kolinergik post ganglion yang sensitif terhadap atropin. Kesimpulan: Tatalaksana awal yang dapat dilakukan untuk mengatasi rinitis gustatori adalah menghindari makanan pemicu. Kombinasi penggunaan antikolinergik intranasal dan steroid topikal, secara profilaksis atau sebagai terapi telah terbukti lebih efektif untuk mengatasi rinore akibat rinitis gustatori dibandingkan pemberian masing- masing obat tersendiri.
The correlation of MMP-9 and VEGF expressions towards nasopharyngeal angiofibroma clinical stage Yuli Tetriana Sari; Rizalina Asnir; Ashri Yudhistira; Izry Naomi Lumbantobing
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.406

Abstract

ABSTRACTBackground: Nasopharyngeal angiofibroma (NA) is a benign tumor with a destructive tendency, commonly affecting male adolescents. The management of NA could become quite a challenge because it is highly vascularized, and localized in an intricate area. Recently, the role of molecular biology in the development of NA is the research target for a better prognosis. Purpose: To analyze the correlation between expressions of matrix metalloproteinase (MMP-9) and vascular endothelial growth factor (VEGF) with clinical stage, and the correlation between these two markers and nasopharyngeal angiofibroma. Method: This was a descriptive analytic study using cross sectional method. Twenty-four postoperative NA cases were categorized into early and advance stages according to Chandler classification. Evaluation of MMP-9 and VEGF expressions were examined by immunohistochemistry. The correlation of VEGF and MMP-9 towards clinical stage, was analyzed using chi-square or Fisher’s exact test (α = 0.05). Result: No significant correlation between MMP-9 expression and clinical stage (p = 0.204), whereas VEGF expressions and clinical-stage showed a significant correlation (p<0.001). Statistical analysis on correlation between MMP-9 and VEGF expressions showed no significant result (p = 0.099). Discussion: MMP-9 produces pro-angiogenic and anti-angiogenic factors. MMP-9 expression does not affect the growth of NA. VEGF is a pro-angiogenic growth factor that has the most important role in tumor pathophysiology and induces vasculogenesis and angiogenesis. VEGF secretion is affected by pro-angiogenic and anti- angiogenic activities of MMP-9. Conclusion: VEGF expression is related to the clinical stage of NA. Anti-VEGF could be further investigated as an alternative treatment for NA. ABSTRAKLatar belakang: Angiofibroma nasofaring (AN) merupakan suatu tumor jinak dengan kecenderungan destruktif. Penatalaksanaan AN merupakan tantangan karena banyaknya vaskularisasi, anatomi yang kompleks dan terjadi pada usia muda. Peranan biologi molekular pada pertumbuhan AN menjadi sasaran penelitian untuk mencari prognosis yang lebih baik. Tujuan: Mengetahui hubungan ekspresi matrix metalloproteinase-9 (MMP-9) dan vascular endothelial growth factor (VEGF) dengan stadium klinis, dan hubungan kedua marker tersebut pada AN. Metode: Studi analitik deskriptif menggunakan metode potong lintang. Dua puluh empat kasus AN pasca operasi, ditentukan stadiumnya berdasarkan klasifikasi Chandler, dan dikelompokkan menjadi kategori awal dan lanjut. Evaluasi ekspresi VEGF dan MMP-9 diperiksa secara immunohistokimia. Korelasi VEGF dan MMP-9 terhadap stadium klinis dianalisis menggunakan Chi-square atau Fisher’s exact test (α =0.05). Hasil: Tidak terdapat hubungan yang bermakna antara ekspresi MMP-9 terhadap stadium klinis (p = 0,204), sebaliknya ekspresi VEGF terhadap stadium klinis menunjukkan hubungan yang bermakna (p < 0,001). Analisis statistik antara hubungan MMP-9 dan VEGF menunjukkan hasil tidak bermakna (p = 0,099). Diskusi: MMP-9 memiliki kemampuan menghasilkan faktor-faktor pro-angiogenik, dan anti-angiogenik, sehingga ekspresi MMP-9 tidak mempengaruhi pertumbuhan angiofibroma nasofaring. VEGF merupakan pro-angiogenic growth factor yang memiliki peranan paling penting dalam patofisiologi tumor dan menginduksi vaskulogenesis dan angiogenesis. Sekresi VEGF dipengaruhi oleh kemampuan pro-angiogenik dan anti-angiogenik dari MMP-9. Kesimpulan: Ekspresi VEGF berhubungan dengan stadium klinis AN. Anti-VEGF dapat diteliti lebih lanjut sebagai alternatif pengobatan pada AN.
Hearing Loss in Treacher-Collins Syndrome Fezzan Athama Fuadi; Wijana -
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.375

Abstract

Background: Treacher Collins Syndrome (TCS) is a craniofacial disorder that has a dominant autosomal disorder in facial development, found 1 in every 50.000 births. The most often manifestations could be mandibulofacial disorder, microtia, atresia of the ear canal, and hearing loss. This syndrome is also accompanied by bone malformations of the ossicular chain in the middle ear, which can lead to conductive hearing loss up to 50% of cases, besides sensory neural hearing loss. Purpose: To report one case of Treacher Collins syndrome who came to the Audiology-Vestibular Clinic, Dr. Hasan Sadikin General Hospital Bandung. Case report: The patient came with symptoms of micrognathia and microtia with bilateral hearing loss. The right ear is smaller than the left ear, and compliant with 3rd grade microtia. He had undergone reconstruction ear surgery of the right ear, and had an improvement in audiological examination after the second stage of reconstruction. There was TCOF 1 (Treacle Ribosome Biogenesis Factor 1) gene mutation involved in this case. Clinical question: What is the best management for TCS with micrognathia, microtia and severe bilateral hearing impairments? Review method: Literature search was performed with keywords Treacher Collins Syndrome AND microtia AND hearing loss. Result: The search obtained 263 literatures published in the last 10 years, and found 12 articles relevant with the topics. Conclusion: TCS is a rare inherited disorder, but the diagnosis could be easily established. Early intervention with hearing rehabilitation, audio-verbal rehabilitation, and reconstruction ear surgery should be carried out for a better quality of life.ABSTRAK Latar belakang: Sindroma Treacher Collins adalah kelainan kongenital auotosom dominan pada kepala dan wajah, yang ditemukan pada 1 dari 500,000 bayi lahir. Manifestasi yang paling sering didapati adalah kelainan mandibulofasial, mikrotia, atresia liang telinga, dan gangguan pendengaran. Pada sindroma ini terjadi malformasi rangkaian tulang-tulang pendengaran di telinga tengah, yang mengakibatkan tuli konduktif pada 50% kasus, dan dapat juga disertai tuli sensorineural. Tujuan: Melaporkan satu kasus sindroma Treacher Collins yang datang ke poliklinik Audiology-Vestibular, Rumah Sakit Umum Dr. Hasan Sadikin, Bandung. Laporan Kasus: Keluhan utama pasien adalah mikrognatia dan mikrotia disertai gangguan pendengaran kedua telinga. Bentuk telinga kanan lebih kecil daripada telinga kiri, yang sesuai dengan mikrotia derajat 3. Pasien menjalani bedah rekonstruksi telinga kanan, dan memperoleh perbaikan hasil pemeriksaan audiogram pasca tahap kedua bedah rekonstruksi. Pada kasus ini didapati ada mutasi genetik TCOF 1 (Treacle Ribosome Biogenesis Factor 1). Pertanyaan klinis: Bagaimana penatalaksanaan terbaik untuk kasus STC dengan mikrognatia, mikrotia dan gangguan pendengaran berat kedua telinga. Telaah literatur: Penelusuran literatur melalui Google Scholar dilakukan dengan kata kunci Treacher Collins Syndrome DAN microtia DAN hearing loss. Hasil: Didapatkan 263 literatur mengenai STC yang terbit dalam 10 tahun terakhir, dan 12 literatur yang sesuai dengan topik. Kesimpulan: Sindroma Treacher Collins adalah kelainan bawaan langka yang merupakan penyakit keturunan, namun diagnosisnya tidak sulit ditegakkan. Perlu dilakukan intervensi dini berupa rehabilitasi pendengaran, rehabilitasi wicara, dan bedah rekonstruksi telinga untuk memberikan kualitas hidup yang baik bagi penderita.Kata kunci: sindroma Treacher Collins, mikrognatia, mikrotia, gangguan pendengaran
Analysis of the correlation between post intubation laryngeal injury with the risk factors Indriati Purwasari; Lisa Apri Yanti; Abla Ghanie; Erial Bahar
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.330

Abstract

ABSTRACTBackground: Post intubation laryngeal injury varies in each individual. The occurrence could not be predicted, but it might be related to age, gender, smoking, comorbidities, duration of intubation, re- intubation, the type and size of endotracheal tube, the volume and duration of cuff inflation. Knowing the risk factors could prevent and decrease the occurrence of post intubation laryngeal injury. Objective: To find out the risk factors associated with the incidence of laryngeal injury after intubation. Method: This study was a cross sectional design. The samples were taken from medical records of Intensive Care Unit/ High Care Unit patients at Dr.Mohammad Hoesin Hospital Palembang, from January to December 2019. Result: There were 59 ICU/HCU patients suffered post intubation laryngeal injuries. The injuries were varied, with laryngeal edema being the most common injury (89.8%), followed by widened posterior gap (52.5%), and subglottic ulcer (32.2%). Based on the Classification of Acute Laryngeal Injury (CALI), the most common post intubation laryngeal injury was severe injury (42.4%). Multivariate analysis found that intubation more than 7 days had 4.7 times probability of experiencing severe laryngeal injury. Discussion: In our study, there was no significant correlation between post intubation laryngeal injury with gender, comorbidities, smoking, diameter of ETT, and re-intubation. There was a significant correlation between post intubation laryngeal injury, with age, duration of intubation, and kinking type of ETT. Conclusion: There was a significant relationship between severe post intubation laryngeal injury and duration of intubation. ABSTRAKLatar belakang: Cedera laring pasca intubasi endotrakeal bervariasi antara satu individu dengan individu lain. Penyebabnya belum diketahui pasti, tetapi mungkin berhubungan dengan usia, jenis kelamin, riwayat merokok, komorbid, lama intubasi, riwayat intubasi berulang, ukuran dan jenis pipa endotrakeal, volume cuff dan lama cuff dikembangkan. Diketahuinya faktor risiko dapat mencegah dan mengurangi angka kejadian cedera laring pasca intubasi. Tujuan: Mengetahui faktor risiko  yang berhubungan dengan kejadian cedera laring pasca intubasi. Metode: Penelitian observasional menggunakan rancangan potong lintang (cross sectional). Dilakukan melalui data rekam medik pasien Intensive Care Unit/High Care Unit RS Dr. Mohammad Hoesin Palembang periode Januari-Desember 2019. Hasil: Didapati 59 pasien ICU/HCU yang mengalami cedera laring pasca intubasi. Cedera yang terjadi bervariasi, edema laring adalah cedera yang paling banyak terjadi (89,8%), diikuti posterior gap yang melebar (52,5%) dan ulkus subglotis (32,2%). Berdasarkan Classification of Acute Laryngeal Injury (CALI), derajat cedera laring pasca intubasi terbanyak adalah cedera derajat berat sebanyak 25 pasien (42,4%). Hasil analisis multivariat menunjukkan bahwa lama intubasi >7 hari berpeluang 4,7 kali mengalami cedera laring derajat berat. Diskusi: Pada penelitian ini tidak didapati hubungan yang bermakna antara kerusakan laring pasca intubasi dengan jenis kelamin, penyakit penyerta, merokok, diameter pipa endotrakeal dan intubasi berulang. Didapati adanya hubungan yang bermakna antara kerusakan laring pasca intubasi dengan umur, lamanya intubasi dan pipa endotrakeal tipe kinking. Kesimpulan: Terdapat hubungan yang bermakna antara cedera laring pasca intubasi derajat berat dengan lamanya intubasi. 
Diagnostic of lingual tonsil hypertrophy with lateral soft tissue cervical X-ray on laryngopharyngeal reflux Ade Asyari; Novialdi -; Bonny Murizky; Wahyu Julianda; Esmaralda Nurul Amany; Tuti Handayani; Hafni Bachtiar
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.381

Abstract

Background: Lingual tonsil hypertrophy (LTH) evaluation could be performed by flexible fiberoptic laryngoscopy, lateral soft tissue cervical X-ray, CT scan, and magnetic resonance imaging (MRI). Lateral soft tissue cervical X-ray examination is considered as a procedure-of-choice for diagnostic testing of LTH, which, aside from being low cost, the examination could also be conducted in all hospitals and easy to be performed on children. Objective: To compare the lingual tonsil enlargement with examination procedure using lateral soft tissue cervical X-ray as an LTH diagnostic measure compared to the flexible fiberoptic laryngoscopy examination as the gold standard examination. Methods: A retrospective analytic study with cross-sectional design on 30 respondents of laryngopharyngeal reflux (LPR) patients who came for routine ENT physical examination, followed by flexible fiberoptic laryngoscopy examination along with lateral soft tissue cervical X-ray. Results: The sensitivity level of 65.38% was acquired from the statistical tests, along with specificity level of 100%, positive predictive value (PPV) of 100%, and negative predictive value (NPV) of 30.37%. Conclusion: Based on sensitivity and specificity, lateral soft tissue cervical X-ray examination could be used as a diagnostic measure and have an accurate capability to diagnose LTH.ABSTRAK Latar belakang: Evaluasi hipertrofi tonsil lingual (HTL) dapat dilakukan menggunakan laringoskopi serat optik fleksibel, foto Rontgen cervical soft tissue lateral, CT scan, dan magnetic resonance imaging (MRI). Foto Rontgen cervical soft tissue lateral dapat dipertimbangkan sebagai pilihan pemeriksaan diagnostik HTL, karena selain biayanya terjangkau, pemeriksaan ini dapat dilakukan di semua rumah sakit serta mudah dilakukan pada pasien anak. Tujuan: Membandingkan hasil pemeriksaan pembesaran tonsil lingual menggunakan foto Rontgen cervical soft tissue lateral dengan pemeriksaan laringoskopi serat optik fleksibel sebagai pemeriksaan baku emas. Metode: Penelitian analitik retrospektif dengan desain potong lintang pada 30 pasien laryngopharyngeal reflux (LPR) yang dilakukan pemeriksaan fisik THT rutin, diikuti dengan pemeriksaan laringoskopi serat optik fleksibel serta foto Rontgen cervical soft tissue lateral. Hasil: Didapatkan tingkat sensitivitas dari uji statistik sebesar 65,38%, dengan tingkat spesitivitas sebesar 100%, dan didapatkan nilai prediksi positif (NPP) sebesar 100% serta nilai prediksi negatif (NPN) sebesar 30,37%. Kesimpulan: Berdasarkan sensitivitas dan spesifisitas, foto Rontgen cervical soft tissue lateral dapat digunakan sebagai alat diagnostik dan memiliki kemampuan yang akurat dalam diagnosis HTL. Kata kunci: hipertrofi tonsil lingual, laryngopharyngeal reflux, laringoskopi serat optik fleksibel, foto Rontgen cervical soft tissue lateral 
Characteristics of mastoid carcinoma patients in Otorhinolaryngology-HNS Department Zainoel Abidin General Hospital Banda Aceh Benny - Kurnia; Baluqia Iskandar Putri
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.419

Abstract

Background: Mastoid carcinoma is a rare case of an aggressive tumor with a poor prognosis. Purpose: To identify the characteristics of mastoid carcinoma patients in Otorhinolaryngology Head and Neck Surgery Department of dr. Zainoel Abidin General Hospital, Banda Aceh. Method: This was a descriptive study using medical records data from January 2012 to July 2019, and from the histopathological data as a confirmation. Result: There were 9 cases consisted of 4 male and 5 female patients with the ratio 1:1.2, between the age of 12-72 years old, and the majority was in 41-60 years group of age. Clinical symptoms obtained are otalgia (100%), otorrhea (100%),facial paresis (100%), hearing loss (100%), ear canal mass (100%) and retroauricular mass (44.4%). The histopathological type of all cases was squamous cell carcinoma (100%). Based on CT scan examination results, there were 55.6% cases in stage IV and 44.4% in stage III. Chemotherapy was given to 89% of patients, and 11% received radiotherapy. Conclusion: Mastoid carcinoma is a rare case. In our study, there were 4 male and 5 female patients with mastoid carcinoma. The histopathological type of all patients was squamous cell carcinoma, in stage III and IV. Chemotherapy was given to 9 patients, and 1 patient received radiotherapy.ABSTRAKLatar belakang: Karsinoma mastoid merupakan kasus yang jarang namun serta bersifat agresif dan memiliki prognosis buruk. Tujuan: Mengetahui karakteristik pasien karsinoma mastoid di Bagian Telinga Hidung Tenggorok Bedah Kepala Leher, Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. Metode: Penelitian deskriptif dengan menggunakan data rekam medik RSUD dr. Zainoel Abidin Banda Aceh periode Januari 2012 sampai Juli 2019 dan data hasil pemeriksaan histopatologi sebagai konfirmasi. Hasil: Didapatkan 9 kasus terdiri dari 4 pria dan 5 wanita dengan perbandingan 1:1,2. Sebaran usia pasien dari 12 sampai 72 tahun dengan insiden puncak usia 41-60 tahun. Gejala klinis yang didapatkan adalah otalgia (100%), sekret telinga (100%), paresis fasialis (100%), penurunan pendengaran (100%), massa di liang telinga (100%) dan massa retroaurikular (44,4%). Tipe histopatologi seluruh kasus adalah Squamous Cell Carcinoma (100%). Stadium IV sebesar 55,6% dan stadium III sebesar 44,4% ditentukan berdasarkan CT Scan. Dilakukan kemoterapi pada 89% pasien dan radioterapi pada 11% pasien. Kesimpulan: Karsinoma mastoid merupakan kasus yang jarang. Pada penelitian kami didapati 4 pasien laki-laki dan 5 pasien perempuan penderita karsinoma mastoid dengan usia terbanyak pada 41-60 tahun. Histopatologi seluruh pasien merupakan karsinoma sel skuamosa stadium III dan stadium IV. Kemoterapi diberikan kepada 9 pasien, dan 1 pasien mendapat radioterapi.Kata kunci: karsinoma mastoid, karakteristik, gejala klinis, histopatologi, terapi
Endoscopic transsphenoidal resection of craniopharyngioma Dolly Irfandy; Esmaralda Nurul Amany; Bestari Jaka Budiman; Dolly Irfandy; Hesty Lidya Ningsih
Oto Rhino Laryngologica Indonesiana Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v50i2.338

Abstract

ABSTRACTBackground: Endoscopic surgery techniques had been advancing in this last two decades. Transsphenoidal approach endoscopic surgery to the skull base provides better visualization of the operation field compared to microscopic surgery, and also brought lower morbidity than other techniques. Purpose: To report a transsphenoidal endoscopic skull base surgery for craniopharyngioma resection. Case Report: A case of craniopharyngioma in a 47-year-old man. The tumor resection was performed with transsphenoidal endoscopic approach, in collaboration with a neurosurgeon. Clinical Question: Is transsphenoidal endoscopic skull base surgery approach, the appropriate surgical procedure for craniopharyngioma management? Review Method: Evidence based literature study of skull base surgery with transsphenoidal endoscopic approach in craniopharyngioma through database Cochrane library, Pubmed Medline, and hand searching. Result: Skull base surgery with transsphenoidal endoscopic approach was minimally invasive with maximally invasion compared to transcranial surgery, and  also provided better view, and could reduce complication rate. Conclusion: Skull base surgery with transsphenoidal endoscopic approach offers more advantage in skull base lesion management compared to other techniques. Collaboration between neurosurgeon and otorhinolaryngologist using this technique could reduce complication and morbidity rate.  ABSTRAKLatar belakang: Teknik operasi endoskopi mengalami perkembangan pesat dalam dua dekade terakhir. Bedah basis kranii dengan pendekatan endoskopi transfenoid memberikan kualitas visualisasi lapang pandang operasi lebih baik dibanding menggunakan mikroskop, dan juga mengakibatkan morbiditas lebih rendah dibanding teknik lainnya. Tujuan: Melaporkan keberhasilan bedah basis kranii dengan pendekatan endoskopi transfenoid pada kraniofaringioma. Laporan kasus: Seorang laki-laki 47 tahun dengan diagnosis kraniofaringioma yang dilakukan tindakan reseksi tumor dengan pendekatan endoskopi transfenoid berkolaborasi dengan ahli bedah saraf. Pertanyaan Klinis: Apakah bedah basis kranii dengan pendekatan endoskopi transfenoid merupakan teknik operasi yang tepat untuk tatalaksana kraniofaringioma? Telaah literatur: Telaah literatur berbasis bukti mengenai bedah basis kranii dengan pendekatan endoskopi transfenoid pada kraniofaringioma melalui database Cochrane library, Pubmed Medline, dan pencarian manual. Hasil: Bedah basis kranii dengan pendekatan endoskopi transfenoid memberikan akses minimal dengan invasi maksimal, visualisasi lebih baik, dan dapat menurunkan angka komplikasi. Kesimpulan: Bedah basis kranii dengan pendekatan endoskopi transfenoid merupakan teknik operasi lesi basis kranii yang lebih unggul dibandingkan teknik lainnya. Kolaborasi antara ahli bedah saraf dan THT dapat mengurangi angka komplikasi dan morbiditas tindakan ini.
Oropharyngeal dysphagia in extrapyramidal syndrome ferdinand simanjuntak; Rery Budiarti; Muyassaroh -
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.366

Abstract

Background: Dysphagia could be caused by mechanical or motoric problems. Dysphagia is associated with neurological disorders in extrapyramidal syndrome (EPS), including tardive dyskinesia caused by long-term chronic use of antipsychotic drugs. Dysphagia in EPS about 9.4% occurs in young adults. Dysphagia in EPS could be a single symptom or as an concomitant symptom. Purpose: To discuss a case of oropharyngeal dysphagia in EPS due to the effects of antipsychotic drugs on a patient who was treated under multidisciplinary management. Case report: A 32-year-old male patient came to Emergency Unit of Dr.Kariadi Hospital with chief complaint of a sudden onset of difficulty in swallowing liquid and solid food. He had a history of longterm use of Chlorpromazine. The diagnosis of oropharyngeal dysphagia was established with Fiberoptic Endoscopic Evaluation of Swallowing (FEES). Clinical question: What is the proper management for dysphagia in EPS? Method: Literature search through database Pubmed and Google Scholar found 88 journals. Results: There were 4 journals relevant with the case. Those journals reviewed the diagnosis and disclosed the management of EPS with dysphagia was discontinuation of the analogous antipsychotic drugs and swallowing practice physiotherapy. Conclusion: Dysphagia in this case was an EPS due to chlorpromazine use, and made a good respond after drug replacement.ABSTRAK Latar belakang: Disfagia dapat disebabkan oleh gangguan mekanik maupun motorik. Disfagia dapat berhubungan dengan kelainan neurologis pada sindrom ekstrapiramidal (SEP), antara lain tardive diskinesia yang disebabkan pemakaian obat antipsikotik jangka panjang. Disfagia pada SEP sekitar 9,4 % terjadi pada usia dewasa muda. Disfagia pada SEP dapat merupakan gejala tunggal atau sebagai gejala penyerta. Tujuan: Membahas kasus disfagia orofaringeal pada SEP akibat efek obat antipsikotik pada pasien yang diterapi secara multidisipliner. Laporan kasus: Seorang laki-laki usia 32 tahun datang ke IGD RSUP Dr. Kariadi dengan keluhan utama mendadak tidak dapat menelan sama sekali, baik cairan maupun makanan padat. Didapatkan tanda gejala SEP dengan riwayat pemakaian chlorpromazine jangka panjang. Diagnosis disfagia orofaringeal ditegakkan dengan pemeriksaan Fiberoptic Endoscopic Evaluation of Swallowing (FEES). Pertanyaan klinis: Bagaimana penatalaksanaan yang tepat untuk kasus disfagia pada sindrom ekstrapiramidal? Metode: Penelusuran kepustakaan melalui database Pubmed dan Google Scholar diperoleh 88 jurnal. Hasil: Didapatkan 4 jurnal yang relevan dengan kasus. Empat jurnal tersebut menyatakan tatalaksana disfagia dengan SEP ialah dilakukan penghentian obat antipsikotik tipikal dan latihan menelan. Kesimpulan: Disfagia pada SEP akibat penggunaan chorpromazine memberikan respon baik setelah dilakukan penggantian obat.Kata kunci: disfagia orofaringeal, sindrome ekstrapiramidal, chlorpromazine 

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