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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Efektivitas Krim Anti Jerawat Kayu Secang (Caesalpinia sappan) Terhadap Propionibacterium acnes pada Kulit Kelinci SITI SA’DIAH; LATIFAH KOSIM DARUSMAN; WULAN TRIWAHYUNI; IRMANIDA BATUBARA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sappan Wood extract (Caesalpinia sappan) is potential as an anti-acne due to its ability as an antioxidant, lipase inhibitor and anti Propionibacterium acnes. The potency is influenced by the quality of simplicia and extracts. To elevate the application, semisolid dosage formulations were made in cream forms using a standardized extract of Sappan Wood. Creams were formulated with the same base composition but different extract concentrations (range of 1-10%). In vivo assay were carried out on rabbit skin induced by intradermal injection of P. acnes. Sappan Wood was collected from Semarang and the resulting extract has met the Materia Medika Indonesia requirement with brazilin level in extract of 224.675 mg / g. In vivo tests showed that all Sappan Wood extract formulations have potency as anti-acne as indicated by curative percentage for 15 days were significantly different from the formula base. Curative effect of all formula were not significantly different with the Mediklin® positive control. Formula with the lowest concentration of the extract was the most effective and efficient with the curative percentage of more than 96% in 15 days.
Kecukupan Penggunaan Garam Beryodium di Provinsi Kalimantan Tengah Berdasarkan Hasil Tes Cepat NYOMAN FITRI; SUNARNO SUNARNO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Kekurangan yodium merupakan penyebab keterbelakangan mental pada anak-anak tertinggi di dunia. Pengadaan dan penggunaan garam beryodium merupakan strategi yang aman, cost-effective dan berkelanjutan untuk memastikan asupan yodium yang memadai untuk semua masyarakat. Penelitian ini bertujuan untuk memperoleh gambaran penggunaan garam beryodium oleh rumah tangga di Provinsi Kalimantan Tengah. Penelitian dilakukan dengan cara menganalisis data sekunder yang didapat dari Riset Kesehatan Dasar (Riskesdas) pada tahun 2013. Hasil penelitian menunjukkan bahwa persentase rumah tangga yang mengkonsumsi garam beryodium di Provinsi Kalimantan Tengah adalah 90,5%, jauh lebih tinggi dari persentase konsumsi nasional yang hanya 77,1%, tetapi dengan penyebaran yang tidak merata antar kabupaten/kota serta antara pedesaan dan perkotaan. Kecukupan konsumsi garam beryodium dalam rumah tangga berhubungan dengan tingkat pendidikan kepala keluarga dan tingkat sosial ekonomi keluarga.
Efek Peningkat Respon Imun dari Ekstrak Etanol Pegagan (Centella Asiatica Urban) pada Tikus SRI NINGSIH; AGUNG ERU WIBOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This research had been conducted to verify the activity of ethanolic extract of Pegagan or Centella asiatica Urban (CA) from Indonesia as immune enhancing with the activity and capacity of peritoneal macrophages as parameters tested. Sprague Dawley male rats were divided into 4 groups of 5 rats each. Dose 1, dose 2 and dose 3 groups were treated with extract at the dose of 10, 20 and 40 mg/200 g b.w. p.o. for 15 consecutive days, respectively, and the control group was supplemented with carrier. One day after the last treatment, all rats were sacrificed after induced by Staphylococcus epidermidis (109 CFU per rat) i.p. and then the activity and capacity of peritoneal macrophages were examined with giemsa staining microscopically. The results showed that the immune-enhancing effect of the extract was a dose dependent manner. Based on statistical analysis (ANOVA, p < 0.05), the administration of CA extract at the dose of 40 mg/200 g bw demonstrated the highest result and differed from control group significantly (96% of macrophage activity and 61 bacteria of macrophage capacity). From these experiments could be concluded that the ethanolic extract of CA had potential to be developed as immune-enhancing agent. However, it was still needed to conduct further study for elaborating the mechanism of immune enhancer completely.
SISTEM UBIQUITIN-PROTEASOM DAN HUBUNGANNYA DENGAN KARSINOGENESIS YANG DIINDUKSI OLEH PAPILLOMAVIRUS MANUSIA Khie Khiong
JURNAL ILMU KEFARMASIAN INDONESIA Vol 1 No 2 (2003): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Certain types of human papillomaviruses (HPV) have been etiologically associated with malignant lesion, most notably with cervical cancer. The major oncoproteins of these cancerassociated viruses are encoded by the viral E6 and E7 genes and characterization of these oncoproteins has shown that both E6 and E7 exploit the ubiquitin-proteasome system to degrade the cellular proteins.
Formulasi Sediaan Nanopartikel Ekstrak Bonggol Nanas (Ananas Comosus (L).(Merr) sebagai Antimikroba Dian Eleveny Martha Flareyanti; Fahleni Fahleni; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (496.189 KB) | DOI: 10.35814/jifi.v15i2.513

Abstract

Pineapple stem contains bromelain enzyme with highest concentration compared to the other parts. The aim of the research was to formulate an anti dandruff creambath containing nanoparticles of pineapple stem which was physically and chemically stable and could inhibit the growth of Pityrosporum ovale. The pineapple stem extract was then formulated into nanoparticles prepared by cross-linking method using chitosan. The resulting nanoparticles were dried using freeze drying. The dried powder of extract was used to determine the minimum inhibitory concentration (MIC) against Pityrosporum ovale. The zone of inhibition of extract and nanoparticles were measured at the MIC. The extracts were then formulated into anti dandruff creambath. The creambath in the concentration of 3% (MIC) whereas the nanoparticles were formulated in the consentration of 1, 2, 3 fold MIC. Each formula was evaluated for its physical characteristics including organoleptics, homogenity, viscosity and flow properties, spread ability and for its chemical characteristic pH value. The stability was performed for one month at temperature of 25 oC and 40 oC. The results showed that the nanoparticles have particle size of 860.03 nm and zeta potensial of 18.63 mV. The best formula was formula IV with inhibitory zone of 17 mm, and had stable organoleptic properties, homogenity, viscosity and flow properties, and pH value, as well as capaability of spreading with diameter of 4817.53 mm. Accordingly the nanoparticlesin creambath could increase the antimicrobial activity.
Pengembangan Pewarna Rambut dari Ekstrak Kental Gambir (Uncaria gambir Roxb.) dalam Sediaan Setengah Padat LATIRAH LATIRAH; TETI INDRAWATI; ANNY VICTOR PURBA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Gambier (Uncaria gambir Roxb.) is one of the alternatives used as a natural colouring agent in foods and drinks. The aim of this research was to develop extract gambier as a hair dye. Gambier extract was obtained by macerated with water in base condition (pH 8-10). The resulting extract was evaluated for hair adhesion, organoleptic, physical, chemical and irritation test to rabbit’s skin. Viscous gambier extract has 0HUE value of 338.73 ± 0.116 (purple), can be processed into permanent hair colour cream with 0HUE value of 42.167 ± 0.231 (red), pH 8, ammoniac odor, produce red yellowish hair with 0HUE value of 53.43 ± 0.060, fulfil requitment for microbiology, not iritant to rabbit's skin has density of 0.903 0.006 g/L and viscosity of 13,100 ± 0.000 cP.
Aktivitas Minyak Ikan dalam Menghambat Preneoplasia Kolon Mencit yang Diinduksi Azoksimetan dan Dextran Sodium Sulfate KUSMARDI KUSMARDI; BAMBANG PONTJO PRIOSOERYANTO; EVA HARLINA; SANTOSO CORNAIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Epidemiologic studies of dietary marine n-3 fatty acids and risk of colorectal cancer have been inconsistent. The study was conducted to understand the inhibitory effect of fish oil in mice with colorectal preneoplasia induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). In this study, Balb/c mice was induced by AOM 10 mg/kg body weight followed by administration of 1 % DSS during a week. Fish oil administrated orally at a dose of 1.5, 3, and 6 mg per day. Histopathological examination of the colon tissue (hematoxylin-eosin staining) was done by counting the number of inflammation, and hyperplasia foci, the number of mitosis epithelial cells, and the scores of dysplasia in ten visual fields. In the second month, decreasing in the number of inflammation foci occurred between the control and low dose groups with medium and high dose groups (p<0,05). While in the third and fourth month, decreasing in the number of inflammation foci were observed in all treatment group (p<0.001). The number of mitotic colonic crypt epithelial cells was statistically significant between control group and treatment groups, initially observed since the second month. In the second month to the fourth month, generally increasing of doses of fish oil has decreased the number of hyperplasia foci. Our research indicates that fish oil also inhibits the occurrence of dysplasia. In the third and fourth month, dysplasia was found in the control group. Dysplasia was found only in the fouth month in the treatment group.
Fraksinasi Ekstrak Butanolik Kaldu Fermentasi Isolat Kapang Tanah Banjarmasin Biomcc-F.T.3762 Berbasis Uji Aktivitas Penghambatan Dihidroorotat Dehidrogenase Plasmodium falciparum AMILA PRAMISANDI; HARMITA HARMITA; ANIS HERLIYATI MAHSUNAH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Butanolic extract of soil fungus BioMCC-F.T.3762 fermentation broth exhibited inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a fl avin dependent mitochondrial electron transport chain, an essential enzyme in de novo pyrimidine biosynthesis pathway of the parasite. The crude butanolic extract exhibited PfDHODH inhibition of 97% at a concentration of 413 μg/mL, and showed no inhibitory activity against its human homolog. Bioassayguided fractionation was performed on butanolic extract of microbial fermentation broth to isolate the active compounds. The active fraction was isolated using liquid–liquid partition, silica gel column chromatography, octadecylsilane (ODS) column chromatography and was purifi ed by preparative high performance liquid chromatography (HPLC). Major peak of active fractions, FS10-2-12 and FS10-2- 13, were detected by PDA HPLC, which showed a retention time of 12.6 minute and 13.9 minute at 254 nm, respectively. The active fractions exhibited 75% and 40% inhibitory activity against PfDHODH, respectively, at a concentration of 100 μg/mL. In comparison, atpenin A5, a known potent mitochondrial complex II inhibitor exhibited 75% inhibitory activity againts PfDHODH at 366 μg/mL.
Formulasi Nanopartikel Losartan dengan Pembawa Kitosan AKHMAD KHARIS NUGROHO; NURI ARI EFIANA; RONNY MARTIEN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Nanoparticle formulation is important for systemic drug delivery via several routes. This research was aimed to establish optimal formation of chitosan nanoparticle formulation with losartan, an antihypertension known as an angiotensin II receptor antagonist. Ionic gelation method was used. Formulation was established in 2 steps. Firstly, determination of the best losartan and chitosan concentrations which can produce physically stable nanoparticles without precipitation, at room temperature within 25 days. Secondly, optimization of the process by factorial design method of two factors, including pH (4.0 and 5.0) and the stirring rate (350 and 700 rpm), with the loading capacity of the nanoparticle as the observed response. The obtained nanoparticles were evaluated further for its particle size and zeta potential. The physichal stability tests indicated that two nanoparticle formulations containing losartan-chitosan of (14 mg% : 35 mg%), and losartan-chitosan of (21 mg% : 35 mg%) were stable. The factorial design studies suggested that pH 4 and the stirring rate of 350 rpm were the optimal conditions which produced the highest loading capacity (47,7%). The particle size and zeta potential of the stable nanoparticle were 290.3±52.6 nm and +50.8 ±4.8 mV respectively.
Formulasi Serum sebagai Penyembuh Luka Bakar Berbahan Baku Utama Serbuk Konsentrat Ikan Gabus (Channa striatus) SITI MARDIYANTI; EFFIONORA ANWAR; FADLINA CHANY SAPUTRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ikan gabus (Channa striatus) diketahui dapat menyembuhkan luka karena mengandung kadar tinggi protein, asam amino esensial dan asam lemak yang berperan dalam proses penyembuhan luka. Tujuan dari penelitian ini adalah membuat serum sebagai penyembuh luka bakar yang mengandung serbuk konsentrat ikan gabus (Channa striatus) yang telah dibuat gelasi ionik dengan kitosan dan natrium tripolifosfat sebagai zat aktif. Serbuk konsentrat ikan gabus dengan kosentrasi 7,5% (formula 1), 10% (formula 2) dan 12,5% (formula 3). Selanjutnya dibuat menjadi serum dengan menggunakan kolagen dan gelatin sebagai bahan pengental. Sediaan serum yang dihasilkan dikarakterisasi in vitro dan dievaluasi secara in vivo penyembuhan luka bakar derajat dua (deep partial thickness) pada kelinci. Suspensi dan serum yang dihasilkan dikarakterisasi secara fisik maupun kimia. Hasil pengukuran suspensi formula 1, 2 dan 3 adalah sebagai berikut: ukuran partikel berturut–turut 42,67-204,23 nm, 70,81-257,11 nm, 128,86-323,68 nm; nilai potensial zeta (+)16,9 mV, (+)18,3 mV, (+)8,4 mV; ketiga formula memiliki partikel berbentuk sferis. Dari hasil uji in vivo dan analisa histologi sediaan serum serbuk konsentrat ikan gabus-kitosan tripolifosfat dapat digunakan sebagai penyembuh luka bakar derajat dua dalam.

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