Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Articles
721 Documents
<![CDATA[Validasi Kuesioner Baru Menilai Pengetahuan dan Persepsi tentang Kombinasi antara Pengobatan Herbal dan Konvensional ]]>
<![CDATA[I. N. FARIDAH]]>;
<![CDATA[M.N. C. PUTRI]]>;
<![CDATA[D. A. PERWITASARI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Indonesia is a country which has great potential of herbal medicine, although combination between herbal and conventional medicine can be benefi cial or harmful. Knowledge and perceptions about that combination are needed to achieve the best treatment eff ect. To validate a new instrument assessing knowledge and perceptions of patients about combination between herbal and conventional medicine. This study used cross sectional study which was conducted in some of pharmacy in Yogyakarta. Inclusion criterias of the subject were people who visited to the pharmacy with ages above 18 years old and below 65 years old, also had used the combination of herbal and conventional medicine for minimal a month to achieve the same goal of treatment. Items of the questionnaire were developedby existing literatures and added some new items. The content validity had been conducted by some experts. Analysis statistic with bivariate correlations was used to determine the validity and reliability of the questionnaire. Subjects who met the inclusion criteria were 30 people, which are consisted of 15 ofhealthy people and the rest are people who use the combination. In the domain of knowledge, there are 16 valid questions over 19 questions. Reliability had been calculated by 16 questions and it was reliable (cronbach alpha 0.863). In the perception domain, there were 8 valid questions. The reliability showed that the questions were reliable (cronbach alpha 0.862). There are 3 invalid questions because all of the answer is similar. Our study provides that this new questionnaire was valid and reliable to a ssessknowledge and perception of the patient who use combination of herbal and conventional medicine.]]>
<![CDATA[Ekspresi VEGF Sel Adenokarsinoma Mamma Pada Pemberian Oral Ekstrak Andrographis paniculata ]]>
<![CDATA[NUGRAHANINGSIH NUGRAHANINGSIH]]>;
<![CDATA[SARJADI SARJADI]]>;
<![CDATA[EDI DHARMANA]]>;
<![CDATA[HERTANTO WAHYU SUBAGIO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Angiogenesis was needed to fulfill nutrition and oxygen demand for tumor growthh and its metastase. Vascular endothelial growth factor (VEGF) was a potential proangiogenic factor of angiogenesis process. In vitro study of Andrographis paniculata extract showed decreasing tend of VEGF level serum on PC-3 cancer cell line. The aim of this study was to prove the effect of oral administered Andrographis paniculata extract on VEGF expression of adenocarcinoma mammae C3H mice. Twenty four mice was transplanted with adenocarcinoma mammae randomly to four groups. Andrographis paniculata extract at dose 5, 10, and 15 mg/day were given on mice group along 14 days. One group another as a control. VEGF expression were examined use immunohistochemistry staining. Anova test showed difference VEGF expression among reseach groups (p=0,000, r=-0,953). The highest of VEGF expression index 24,8 was found on control group, and the lowest 19,4 was found on group which received 15 mg/day. We concluded that oral administration of Andrographis paniculata extract decreased VEGF expression of adenocarcinoma mamme C3H mice.]]>
<![CDATA[Enkapsulasi Propagul Jamur Entomopatogen Beauveria bassiana Menggunakan Alginat dan Pati Jagung sebagai Produk Mikoinsektisida ]]>
<![CDATA[PRIYO WAHYUDI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Negative effects of chemical pesticides experienced by farmers have encouraged researchers to develop bioinsectiscide. Beauveria bassiana is one of entomopatogen fungus that may be used as an active compound of mycoinsecticide. The main constraint of this mycoinsecticide is retaining the viability of Beauveria bassiana propagules. The encapsulation of active propagule of Beauveria bassiana using sodium alginate and corn starch was studied in this experiment. The aim is to get the formula of mycoinsecticide with a high viable propagules contain for long storage period. Liquid fermentation were proceed to produce active biomass of Beauveria bassiana, followed by encapsulation using sodium alginate (Formula I) and corn starch (Formula II). After encapsulation and the 1st, 2nd, and 3th Week of storage in room temperature, viability test was carried out. The result showed that Formula I and II were able to immobilize effectively, but the number of viable propagule was slightly reduced. The number of viable propagule of Beauveria bassiana in Formula I and ll after three Weeks storage was 8.75 x 106 cfu/g and 6.13 x 106 cfu/g respectively. It can be concluded that encapsulation using sodium alginate and corn starch could retain propagule of Beauveria bassiana in viable number.]]>
<![CDATA[Uji Aktivitas Fagositosis Makrofag Fraksi-fraksi dari Ekstrak Metanol Daun Sirih Merah (Piper crocatum Ruiz & Pav.) Secara In Vitro ]]>
<![CDATA[YUSTINA SRI HARTINI]]>;
<![CDATA[SUBAGUS WAHYUONO]]>;
<![CDATA[SITARINA WIDYARINI]]>;
<![CDATA[AGUSTINUS YUSWANTO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Plants can be sources of immunomodulatory agents. Piper crocatum Ruiz & Pav. (red betel) leaves have been used to heal many diseases, especially to increase endurance. The aim of this research was to investigate the imunomodulatory effect of methanolic leaf extracts of Piper crocatum Ruiz & Pav. and its fractions by in vitro phagocytic macrophage activity test. The result showed that methanolic extract of Piper crocatum Ruiz & Pav. 75μg/mL could stimulate phagocytic macrophage activity equal to 100μg/mL product-X® that contained Echinacea extract. Separation of the extract by vacuum liquid chromatography using gradient solvent n-hexane - ethyl acetate yielded 5 fractions. The second fraction showed the highest activity. It contained alkaloid and terpenoid, while the extract also contained flavonoid and essential oil. Alkaloid and/or terpenoid could be the compound in the leaves of Piper crocatum Ruiz & Pav. that responsible increasing phagocytic macrophage activity.]]>
<![CDATA[Efek Stimulansia Infus Lada Hitam (Piperis nigri fructus) Pada Mencit ]]>
<![CDATA[ROS SUMARNY]]>;
<![CDATA[LESTARI RAHAYU]]>;
<![CDATA[NI MADE DWI SANDHIUTAMI]]>;
<![CDATA[LIBERT MORY]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Black pepper (Piperis nigri fructus) has been empirically used to eliminate fatigue and to increase stamina or as stimulant. The aim of this study was to determine the efficacy of black pepper infuse as stimulant on 30 male DDY mice using swimming and rotarod methods. The mice were divided into five groups. First group was given distilled water as control, second group was given caffeine of 0.36 mg/20 g bw. The other three groups were given orally with black pepper infuse of 0.32 mg/20 g bw, 0.65 mg/20 g bw, or 1.3 mg/20 g bw. Observations on mice swimming endurance and mice endurance on a rotarod, were carried out 60 minutes after oral administration of the solutions. Analysis using Kruskal-Wallis showed that there was significant difference in the stimulant efficacy between the black pepper infuse and the negative control (p<0.05). There was no significant difference in stimulant effect between the 0.32 mg/20 g bw of black pepper infuse and the caffeine positive control, however, the infuse dose of 0.65 mg/20 g bw and 1.3 mg/20 g bw have demonstrated stronger stimulant effects (p>0.05) as compared to the caffeine positive control.]]>
<![CDATA[Aktivitas Antioksidan Senyawa Flavonoid Terprenilasi dari Ekstrak Diklorometana Daun Artocarpus communis ]]>
<![CDATA[PUSPA D.N. LOTULUNG]]>;
<![CDATA[SOFA FAJRIAH]]>;
<![CDATA[EUIS FILAILA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[This research investigated the antioxidant activity of prenylated flavonoid compound from the ichloromethane extract of Artocarpus communis leaves on 1,1-diphenyl-2-picryl hydrazyl free radicals scavenging assay. The dichoromethane extract of Artocarpus communis leaves was fractionated by column chromatography techniques on silica gel, and each fraction was assayed for its activity. The active compound, 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl] 1-propanone, showed moderate antioxidant activity with IC50 54.6 μg mL-1.]]>
<![CDATA[Pertumbuhan Trichoderma harzianum pada Medium yang Mengandung Xilan ]]>
<![CDATA[Priyo Wahyudi]]>;
<![CDATA[Untung Suwahyono]]>;
<![CDATA[Sri Mulyati]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 1 (2004): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Xylan is one of the most important components of hemicelluloses, which could be enzimatically hydrolized by xylanolytic enzymes. One of the xylanase producing fungi is Trichoderma harzianum, which growth in a medium requires sufficient nutrient, such as Carbon, Nitrogen, microelements and vitamins. Xylan as a polysaccharide could be used as Carbon source in a growth medium of T. harzianum. The purpose of this experiment is to assess the growth ability of T. harzianum in a medium with xylan as a sole Carbon source. Three media are tested in this experiment, i.e. Medium I, Medium II, and Medium III. The result shows that the best growth of T. harzianum is obtained in Medium III, followed by Medium II and then Medium I. The best medium pH is neutral (+7) to mild acidic (6.2).]]>
<![CDATA[Analisis Mutasi pada Kodon 531 Pada Gen Rpob Mycobacterium tuberculosis Penyebab Resistensi Rifampisin ]]>
<![CDATA[Yatnita Parama Cita]]>;
<![CDATA[Dwi Hilda Putri]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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DOI: 10.35814/jifi.v15i2.504
<![CDATA[Tuberculosis (TB) is a serious disesase in the world. According to the WHO, it is estimated more than 3 million people die every year as a result of this infectious disease. One factor that causes diffi culty handling TB chemoteraphy is not effective against the bacteria Mycobacterium tuberculosis that causes TB . Effectiveness of treatment is often hampered by the emergence of bacterial resistance against M. Tuberculosis chemotherapy agents are given. From some research found that bacterial resistance may occur in more one type of chemotherapy agent also known as multi-drug resistance (MDR). Mycobacterium tuberculosis develop resistance mechanisms that are different from other bacteria in general. In prokaryotes, resistance is generally due to the transfer of genetic, either through plasmids,transposons and other. Reference sequence beta sub unit of RNAP protein M. Tuberculosis with accession number NP_215181.1 and M. tucerculosis rpoB gene with accession number NC_000962.3 used to obtain preliminary information from the data base www.ncbi.nlm.gov and www.uniprot.org . Mutation done according to several studies literature. Analysis of the composition, profi le, location and structure of protein using www.expasy.org, TMHMM and http://bioinf.cs.ucl.ac.uk/psipred. The primer design is done with Primer Design Program. Based on the analysis of mutation in the beta subunit of RNAP protein M. Tuberculosis, codon 531 (Ser ->Leu), it is known that mutations cause changes in some properties and structure of proteins. Possible changes affecting the nature of bacterial resistance to antibiotics rifampicin. However, further analysis needs to be done with the analysis of the docking technique.]]>
<![CDATA[Kejadian Efek Samping Kinin pada Pasien Malaria di RSUD Bontang, Kalimantan Timur ]]>
<![CDATA[NITA RISTIAWATI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Quinine intravenous for severe malaria and complications, is recommended until the patient is able to use the oral formulation. The purpose of this study was to monitor the side effects that arise during the administration of quinine in malaria patients in Bontang Public Hospital and evaluate the use of other drugs that may increase the incidence of quinine side effects. This study was conducted by using descriptive study design. Monitoring of side effects is based on qualitative data, through clinical observation before and after the patients received the drug. The events of side effects were evaluated from the data collectedby usingNaranjo algorithm to determine possible (score 1-4), probable (score 5-8) and certainty (definite) (score 9). From the study, it is found that 32 patients (88.89 %) experienced quinine side effects, 2 patients (5.55 %) did not experience significant side effects. 7 patients (19.44 %) were using cimetidin, 6 patients (16.67 %) had more than 2 side effects. Possible influence of cimetidine on the clearance of quinine that cause the increase of quinine levels in the blood may increase the risk of the events of quinine side effects.]]>
<![CDATA[Skrining Pendahuluan Toksisitas Beberapa Tumbuhan Benalu terhadap Larva Udang Artemia Salina Leach ]]>
<![CDATA[DANTI NUR INDIASTUTI]]>;
<![CDATA[SRI PURWANINGSIH]]>;
<![CDATA[YUANI SETIAWATI]]>;
<![CDATA[NOOR CHOLIES]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[The brine shrimp lethality test (BSLT) is considered as a useful tool for preliminary assessment of toxicity. It has also been suggested for screening of pharmacological activities of plant extracts. The bioactivity of eight methanol extracts of four parasite plants and two host plants were evaluated using the brine shrimp lethality assay. The results showed that all methanol extracts of the host plants did not have any indication of toxicity The LC50 of methanol extract of Moringa pterygosperma stem was 1085.44±84.32 µg/ml, and of Ficus refusal stem was 1240.86±50.71 µg/ml. But methanol extracts of whole parts of parasite plants showed toxicity to Artemia Salina Leach. The LC50 of methanol extract of Loranthus peretandrus herb parasite was 175.66±29,24 µg/ml while that of Elytranthe evenia leaf parasite was 327.15±38.66 µg/ml; of Elytranthe evenia stem parasite was 320.39±39.57 µg/ml; of Elytranthe evenia flower parasite was 456.79±15.69 µg/ml; of Scurulla atropurpurea herb parasite was 176.44±28.46 µg/ml; and of Viscum articulatum parasite was 53.79±10.83 µg/ml.]]>
