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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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KLIREN DAN VOLUME DISTRIBUSI Aluwi Sani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 1 No 2 (2003): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The concept and terminology of pharmacokinetics might be forgotten already by pharmacists. Therefore, the writer plans to present a series of article explaining the meaning and significant important pharmacokinetics terms. This article will deal with Clearance (CL) and Volume of Distribution (Vd), which are the two most important primary pharmacokinetic parameters. Other parameters such as t' and AUC are derived from these two parameters. Definition, function and measurement will be discussed in this article.
Faktor yang Mempengaruhi Ketersediaan Obat Program Rujuk Balik (PRB) di Fasilitas Pelayanan Obat PRB Wilayah Eks Karesidenan Kediri (Studi pada Ketersediaan Obat Hipertensi) Sri Dias Tuti; Umi Athiyah; Wahyu Utami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1989.081 KB) | DOI: 10.35814/jifi.v16i1.437

Abstract

PRB drugs service was given to chronically patients who still need long term treatment therefore there was need to guarantee the availability of medicines for their therapeutic needs. The objectives of this research were to know about PRB drug management, to know drug management support, policy, the availability of PRB drugs, and to analize the effects of drug management, drug management support, and policy on drug availability in PRB drug facility in Ex Karesidenan Kediri. Study on the availability of drugs hypertension due to prevalence of hypertension disease tends to increase from 7.6% in 2007 to 9.5% in 2013. This research used cross sectional approach by giving questionnaires to 18 respondents of PRB drug managers who had fulfilled the inclusion criteria. Those respondents were measured on the capability in PRB drug managements and assessment of PRB drug management support and policy. The questionnaires were valid and reliable. The management, management support, and policy score were tested for effect on PRB drug availability for Hypertension by using multiple linear regression. From this research, it was known that PRB Drug Management, PRB Drug Management Supporting Assessment, and PRB Policy by PRB drug managers in drug service facilities in Ex Karesidenan Kediri were mostly categorized as good enough. The availability of PRB drugs at PRB drugs facility with stock calculations indicated the ability to provide PRB medication to serve PRB prescription of hypertension was 28.71%. While the facilitieas that were able to serve an average of 72.67, thus providing substitution drugs beyond the average of PRB stock of 43.95%. The efforts were done for examples, borrowed similar drugs from regular supplies, medicines administered when they were available, or established the similar drugs at prices closed to e-catalogue. The results of the analysis showed that simultaneously PRB Drug Management factors, PRB Drug Management Supports, and PRB Policy have significant effects on PRB Drug Availability (p<0.10). PRB drug management had the greatest effects on the availability (p<0.10), especially in the case of Drug Selection (p<0.10). Selection of drugs was the first step to be done from a cycle of drug management, where the early step was the step that most determine the next steps. The pharmaceutical management framework affected the availability of PRB drugs, particularly the Drug Management factor, especially in the drug selection step. Drug selection was an early step of the drug management cycle that determined the next step.
Efektivitas Gel Anti Jerawat Ekstrak Etanol Rimpang Jahe Merah (Zingiber officinale Rosc. Var. Rubrum) terhadap Propionibacterium acnes dan Staphylococcus epidermidis SYF. OCTY NOVY FISSY; RAFIKA SARI; LIZA PRATIWI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Acne can be caused by bacteria, such as Propionibacterium acnes and Staphylococcus epidermidis. Red ginger (Zingiber officinale Rosc. var. rubrum) has been studied for its antibacterial activity. The aims of this research was to determine the minimum inhibitory concentration of red ginger rhizome ethanol extract against P. acnes and S. epidermidis bacteria and the effectiveness when the extraxt formulated into gel. The simplicia was extracted by soxhlet using 96% ethanol. Diffusion method was used to measure the minimum inhibitory concentration (MIC) of extract. Afterwards, the extract was forrmulated into gel by using three variation of HPMC 4000 and carbopol 934 as gel base with ratio of 70:30 (Formula I), 50:50 (Formula II) and 30:70 (Formula III). Gel evaluation included organoleptic, spreadability, adhesive property, pH and antibacterial effectiveness. The data was analyzed by R-Commander program 2.14.1 Version. The results showed MIC values are 0.45% against P. acnes and 0.5% against S.epidermidis. The results of evaluation for 30 days of storage showed that the gels had stable pH and adhesion, homogenous, whereas the spreadablity of gels increased. Antibacterial evaluation showed that formula I give the best effectiveness with 16,11 mm zone of inhibition against P. acnes and 14,00 mm against S.epidermidis.
Uji Aktivitas Enzim Xilanase Ekstraselular dan Intraselular Bakteri Endofitik Tanaman Brucea javanica (L.) Merr. Shirly Kumala; Wibowo Mangunwardoyo; Diah Dethriani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Assay for xylanase enzyme activity of endophytic bacteria from Brucea javanica (L.) Merr. has been carried out. Parts of the plants used in this study were stem, leave and fruit. Samples were collected from Bogor, Cianjur and Tawangmangu. To evaluate the enzyme activity the fungi were shakefermented for 14 days. The supernatant were used to examine the extracellular enzyme and biomass for intracellular enzyme, using DNS methode to test the activity of enzyme. The results showed that from ten isolates only four isolates produced xylanase enzyme. Isolate 2.3.1 and 2.3.6 produced extra and intracellular enzyme, while isolate 2.1.15 and 2.3.13 only produced extracellular xylanase enzyme.
Karakterisasi Sediaan Granul Biji Sirsak (Annona muricata L.) dan Uji Efektivitas terhadap Larva Aedes aegypti L. sebagai Kandidat Biolarvasida SARAH ZAIDAN; RATNA DJAMIL; SUPRIYONO SUPRIYONO; SITI Nuraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A. aegypti mosquito is a vector of virus caused dengue fever. The effort to control A. aegypti vector has been done so many times, including chemical, physical and biological method. A biological control against this vector can be performed by utilizing soursop seeds which are known to have larvicidal effect against the larva. Previously, it has been proven that the extract of soursop seed demonstrated larvicidal activity against A. aegypti. In this research, the extraction of soursop seed has been carried out by kinetic maceration with the solvent 70% of ethanol. Furthermore, the wet granulation of the obtained extract was used for the preparation of granules which were then tested its larvicidal activity against A. aegypti. Based on the activity test against the larva of Aedes aegypti, the granules showed LC50 values of 295.434 ppm smaller than temephos as a positive control that has larvicidal activity of 1 ppm cause 100% mortality A. aegypti.
The Activities of Antifertility Ethanol Extract Guava Leaves (Psidium Guajava L.) based on The Analysis Of Cement and Display of Immunohistochemistry Cyclooxygenase-2 In Testis Of Mice (Mus Musculus L.) RICA VERA BR TARIGAN; M. PANDAPOTAN NASUTION; SRY SURYANI WIDJAJA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Population growth increase, without support from good economic conditions, requirer population control. One of the program to control population growth is family planning program (KB). The participation of men in family planning programs is very important. Male contraception can utilize natural materials derived from plants. One of the herb is guava leaves (Psidium guajava L.) which contains many active substances that can inhibit the process of spermatogenesis. The purpose of this study was to determine the effect of ethanol extract guava leaves to the quality (concentration, viability, morphology, and motility) of spermatozoa and the expression of Cyclooxygenase-2 (COX-2) in the testes of mice (Mus musculus L.). The research used experimental design with completely randomized sampling method. Four treatment groups, namely P0 using aquadest as a control 0,5 mL, P1 using 15 mg/25g body weight extract orally, P2 using 20 mg/25g body weight extract orally, and P3 using 25 mg/25g body weight extract orally. Data were analyzed using One Way ANOVA followed by Bonferroni Post Hoc test 5%. The results showed that ethanol extract guava leaves with a dose of 15mg/25g body weight had significantly decreased sperm quality and increased expression of COX-2 in the testes of mice. This research indicates that guava leaves have a potential to be used as a herbal contraceptive.
Desain, Sintesis Dan Uji Sitotoksitas analog UK-3A: Hidroksipikolinil Dioktil Glutamat Ester YULIA ANITA; MUHAMMAD HANAFI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 1 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Antibiotic UK 3A had been isolated as a minor component from the mycelium of Streptomyces sp. 517-0. It was elucidated as a nine-member dilactone ring derivative. To produce an analog of UK-3A, i.e. hydroxypicolinil dioctyl glutamic ester, was synthesized from L glutamic acid and octanol, and the product was then reacted with 3-hydroxypicolinic acid and dioctyl glutamic ester. The tinal product was identified by 1H and 13C FT NMR, FT-IR spectrophotometry, and LC-MS. The it was tested for cytotoxic activity against P388 Murine Leukemia cells. The results showed that the 3-hydroxypicolinyl dioctyl glutamic ester has higher inhibition activity against P388 leukemia cells with IC50 value of 9.80 µg/mL than the activity of UK 3A with IC50 value of 38.4 µg/mL.
Studi Pendahuluan Mikroba Endofitik Penghasil Senyawa Terpen dari Tanaman Artenisia annua Titi Parwati; Bustanussalam Bustanussalam; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 1 No 1 (2003): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Some endophytic microbes were isolated from medicinal plant Artemisia annua collected of Tawangmangu and Cibinong. Microbe isolate were made on corn meal malt agur supplemented with chloramphenicol and nutrient agar supplemented with nystatin from tissue subjected after the triple surface sterilization procedure. The potencies of these isolates to produce-terpene compounds were screenned by phytochemistry analysis, thin layer chromatography (tlc) and high performance liquid chromatography (hplc) after fermentation in four different medium. The results showed that 6 isolates from 17 microbe isolates can produce terpene compounds.
FORMULASI CREAMBATH DENGAN VARIASI KONSENTRASI SARI BONGGOL PISANG AMBON (Musa acuminata Colla) Teti Indrawati; Nabhilla Sofia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1988.72 KB) | DOI: 10.35814/jifi.v16i1.462

Abstract

Ambon banana (Musa acuminata Colla) humps contain anthraquinone compounds that effectives This research aims to take advantage of the hump to be confectionary cream bath as hair growth. Water extracts of Ambon banana humps were blended and filtered, and then, this water extracts of Ambon banana was made into cream bath using concentration of 8%, 10%, and 12%. The method that is used to make cream bath is dissolution and mixing methods at a temperature of 75oC–80oC and the water extract was add at 40oC. These cream bath products weres evaluated by organoleptic, homogeneity, emulsion type, pH, spreading ability, viscosity and flow character. All formula cream bath preparations had white to ivory white, odourless bananas, emulsion type o/w, homogenized, pH 6.05 to 6.38, spreading ability 4862.05 mm2-3672.67 mm2, has a viscosity of 12000 cps-145000 cps, and showed the flow properties pseudo-plastic thixotropic.
Pengaruh Pemanasan Berulang terhadap Sifat Fisikokimia dan Kandungan Asam Palmitat pada Minyak Goreng Yunahara Farida; Irene Frederika Siregar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Determination of physicochemical properties and contents of its palmitic acid of cooking oil have been done. The treatment of physicochemical properties of cooking oil was carried out after heating on temperature 150, 170, 200 and 225°C for 7 days and then it was stored. The result showed that physicochemical properties from the refractive index, specificic gravity, acid values, peroxide values, total carbonil and thiobarbituric acid, are increased but iodine values is decreased by treated on temperature and time stored. The content of palmitic acid from palm oil which determine by gas chromatography decreased on the third days of storing.

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