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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Pharmacoeconomic Analysis Of Using Cephalosporin Group In Appendicitis Prophylactic In Rumah Sakit Umum Daerah Subang Yulia Wardati; Dytha Andri Deswat; Zainal Muttaqin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.253 KB) | DOI: 10.35814/jifi.v16i2.441

Abstract

The administration of cephalosporin group antibiotics in patients with post-surgical appendicitis is necessary to prevent postoperative wounds. This pharmacoeoconomic study was conducted retrospectively in the period of 1 January to 31 December 2015 in RSUD Subang for the purpose of determining the effectiveness of drugs and the cost of antibiotic use of ceftriaxone, cefotaxime, and ceftizoxime injection by Cost Effectiveness Analysis method. The subject of the patient was 78 people. Based on Average Cost Effectiveness Ratio (ACER), the smallest value is ceftriaxone Rp 729.124 / day, while the result of Cost Effectiveness plane with cefotaxime as standard drug, ceftriaxone occupies quadrant IV and ceftizoxime occupies quadrant I. The result of Incremental Cost Effectiveness Ratio (ICER) calculation obtained by difference of value equal to Rp 106.347 / day hence can be concluded that antibiotic injection of cefotaxime as standard injection antibiotics used by RSUD Subang can be replaced by antibiotic injection of ceftizoxim by adding cost Rp 106.347 / day but need attention to resource especially funds owned and should be selected if sufficient resources are available.
Efek Kurkumin terhadap Aktivitas Enzim Glutation Peroksidase Mitokondria Hati Tikus Syamsudin Syamsudin; Suyatna FD; Ganiswarna S; Sadikin M
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (559.115 KB)

Abstract

This study was conducted to prove the hypothesis that Curcumin could prevent the oxidative damage of rat liver mitochondria induced by t-butylhydroperoxide (t-BHP). The induction of 400 uMt-BHP reduced Gluthatione Peroxidase (GPx) activity from (0.29+0.03) to (0.04+0.01) umol/min/mg protein. Instillation of Curcumin of 1000 uM could elevate GPx activity to (0.16+0.002) umol/min/mg protein.
Isolasi dan Identifi kasi Senyawa Kimia Zat Anti Kanker dari Daun Kopasanda (Chromolaena odorata (L.)) MUHAMMAD FITRAH; HENDIG WINARNO; PARTOMUAN SIMANJUNTAK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1911.218 KB)

Abstract

Isolation and identifi cation of chemical compound as anticancer from the leaves of Kopasanda (Chromolaena odorata L.) had been done. Extraction was conducted successfully with n-hexane, ethylacetate and ethanol by maceration, and by refl ux for water solvent. Fractionation of ethylacetate extract by column chromatography (SiO2). n-hexane-ethylacetate = 10:1 ~ 1:1; ethylacetate). n-hexaneethylacetate = 5:1) gave one pure isolated fraction fr. 5-3 with inhibition activity against leukemia cell line L1210 at concentration 1.515 ppm. Chemical structure determination was done based on spectral data interpretation of Infra Red, 1D NMR (1H, 13C) and 2D NMR (H-H COSY, HMQC and HMBC) and mass spectra (LC-MS). Pure isolated fraction fr. 5-3 was deducted as methyl ether naragenine.
Virtual Screening and Bonding Mode Elucidation of Curcumin Analogue in Cyclooxygenase-2 Enzyme Using EE_COX2_V.1.0 Protocol ESTI MUMPUNI; ARIEF NURROCHMAD; UMAR ANGGARA JENIE; HARNO DWI PRANOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.851 KB)

Abstract

Kurkumin adalah senyawa fenol bewarna kuning yang terkandung dalam Curcuma longa. Kurkumin diketahui memiliki aktivitas biologi antara lain sebagai inhibitor beberapa enzim metabolisme. Modifikasi struktur kurkumin telah banyak dilakukan. Pada penelitian ini dilakukan penapisan virtual dan elusidasi moda ikatan analog kurkumin menggunakan EE_COX2_V.1.0 sebagai protokol skrining virtual berbasis struktur yang telah tervalidasi. Pengaturan simulasi docking dilakukan menggunakan berbagai aplikasi yang terintegrasi seperti SPORES, PLANTS, BKchem, OpenBabel dan Pymol yang dapat mengidentifikasi senyawa inhibitor siklooksigenase-2 (COX-2). Dari hasil penapisan virtual didapatkan senyawa demetoksikurkumin dengan 3 residu asam amino dan 1,7-bis(3-metoksifenil)-1,6-heptadien-3,5-dion dengan 6 residu asam amino aktif in silico sebagai inhibitor COX-2.
Uji Ketersediaan Hayati Tablet Parasetamol dan Tablet Teofilin pada Kelinci DJOKO WAHYONO; ARIEF RAHMAN HAKIM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The objective of this research is to evaluate the bioavailability of paracetamol tablet to Panadol and theophyllin tablet to Bronsolvan in rabbits. The study Was conducted employing a same subject design using male rabbits which were divided into 2 groups (5 rabbits for each group). The group I was given a single oral antipyretic tablet (paracetamol 500 mg) and the group H was given a single oral antiasthmatic tablet (theophyllin 130 mg). After Wash out period, the group I Was given asingle oral Panadol tablet (paracetamol 500 mg) and the group ll Was given a single oral Bronsolvan tablet (theophyllin 150 mg). Serial blood samples were taken at various interval time for HPLC analysis of unchanged form of paracetamol and theophyllin in blood. Based on the data of the concentration over the time, the pharmacokinetic parameters (Cmaks, tmaks, and AUC0- ̴ ) were determined and compared using statistic analysis paired t test with 95% degree of comidence. The results indicated that the bioavailability of antipyretic and antiasthmatic tablet is not significantly difference to the respective controls (P>0,05).
Konstruksi dan Validasi Protokol Skrining Virtual Berbasis Struktur dengan Kode PDB 3MQE, 3NTG, dan 3LN0 untuk Penemuan Inhibitor Siklooksigenase-2 (COX-2) ESTI MUMPUNI; ARGUN WIDARSA; YANTI SUSILAWATI; OISAN OISAN; ARIEF NURROCHMAD; HARNO DWI PRANOWO; UMAR ANGGARA JENIE; ENADE PERDANA ISTYASTONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Cyclooxygenase-2 (COX-2) inhibitors are high demand drugs in the market. However, available COX-2 inhibitors nowadays have many side effects. Therefore, there is still a need to develop more potent selective COX-2 inhibitors and one of the method that has been prove the effectivity and eficiency for new drugs research is in silico. Structure-based virtual screening (SBVS) protocols were developed to find COX-2 inhibitors using the Protein-Ligand ANT System (PLANTS) docking software, SPORES, BKChem and Open Babel. The directory of useful decoys (DUD) dataset for COX-2 was used to validate the protocols retrospectively; the DUD consist of 426 known COX-2 inhibitors and 13289 decoys. Based on criteria value of EF20% and EFmax used in the article from Huang et al (2006) and Yuniarti et al (2011), two validated protocol, AYO_COX2_v.1.1 and AYO_COX2_v.1.2 , showed good results
Efek Anti Diabetes Spirulina Platensis Terhadap Analisis Kadar, Gambaran Histopatologi, Ekspresi Insulin dan Glucose Transpoter 4 Pada Tikus Putih Wistar yang Diinduksi Streptozopin Kintoko Kintoko; Rifqi Ferry Balfas; Nura Ustrina; Sitarina Widyarini; Lintang Cahya Saputri; Anandita Nurwijayanti; Fajar Slamet Riana; Neni Tri Anggraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.578 KB) | DOI: 10.35814/jifi.v16i2.541

Abstract

Based on Basic Health Research, in Yogyakarta the incidence of diabetes mellitus based on doctor's diagnosis is 2.6% and symptoms will increase with age, but will decrease from age> 65 years. In the treatment of diabetes mellitus there are several treatments with synthetic drugs and natural ingredients for natural ingredients such as Spirulina platensis. Spirulina platensis is one of the microalgae that contains the natural spectrum of carotene and xantophyll pigment mixtures, and with fikocyanin has antioxidant activity, and Spirulina platensis can show a decrease in blood sugar. The type of research conducted is an experimental study. Spirulina platensis is made with several doses of 36 mg, 72 mg, and 144 mg. Rats were divided into 6 groups, 5 groups of streptozotosin induced at a dose of 45 mg / kgBW until the mice had DM were characterized by high KGD yield, then given spirulina suspension, measured in sugar levels on days 0-28. After that the mice in the blood and then analyzed the effect of Spirulina platensis on creatinine and urea in blood. The results were analyzed using SPSS ANOVA and Post Hoc Test methods with 95% confidence level. The results of the analysis of levels in various groups showed that in the induction of streptozotocin treated with spirulina plantesis various doses there was improvement in each analysis of the levels obtained, and also at the dose STZ+SP 36 in each analysis can improve the level of analysis. While on histopathology result and insulin expression in pancreas and histology and expression of glucose transporter 4 and histopathology on kidney and liver showed good change at various treatment dose group especially in STZ+SP 36 group. So at STZ+SP 36 dose showing the change both in this study.
Seleksi Mikroba Endofit Curcuma Zedoria dalam Memproduksi Senyawa Kimia Antimikroba Yoice Srikandace; Yatri Hapsari; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

It is well known, that temu putih (Curcuma zedoaria Berg.), a rhizome of the Zingiberaceae, is oftenly used as medicine. In this connection, the potential secondary metabolites as anticancer and antimicrobes are produced by endophytic microbes in the plant. In this research, five endophytic microbes from the Curcuma zedoaria’s rhizome were fermented to produce compounds as antimicrobes.
Pemodelan Statistik Pemberian Air Susu Ibu (ASI) Eksklusif Berdasarkan Faktor Demograli SARAH ZAIDAN; SWASONO R. TAMAT; NURITA ANDAYANI; ANNY VICTOR PURBA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1560.518 KB)

Abstract

Exclusive breastfeeding is defined as giving breast milk to a baby without any additional drink, food or beverages during the first 6 months after birth. Today there is a decline in exclusive breastfeeding, and among others, one reason is the increase in the participation of mothers in the workforce, especially in urban areas. Many factors that affect the regularity of exclusive breastfeeding by working mothers, one of which, is the demographic factor. This study aims to obtain profile data of exclusive breastfeeding by working mothers and statistical modelling of exclusive breastfeeding by working mothers based on demographic factor, by conducting a survey on 384 respondents. This research uses descriptive analysis and logistic regression analysis with SPSS software version 15.0. Descriptive analysis showed that most mothers working in Jakarta (61.2%) did not give exclusive breastfeeding. Logistic regression statistical analysis showed that age, occupation, distance to work, and travel time to the workplace of working mothers are dominant factors that influence exclusive breastfeedings, with the p-value is smaller than the p value (Sig) = 0.05.
Optimasi Proses Pengeringan Tepung Jamur Tiram Putih (Pleurotus ostreatus) Netty Widyastuti; Sri Istini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 1 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study deals with the determination of the nutritional content of oyster mushroom (Pleurotus ostreatus). An attempt is made to attain better physical properties of the powder after drying. The first procedure consists of drying of ground fresh oyster mushroom at 50°C and 60° C during 24, 48 and 72 hours, while according to the second procedure slices of fresh oyster mushroom are first dried at 40°C (during 24 and 48 hours), than powdered. Laboratory analysis shows that the content (% w/w) of fresh mushroom is as follows: fiber 3.44, fat 0.10, protein 3.15, carbohydrate 0.63 and glutamic acid 0.94. The result of the first procedure is a sticky and brownish powder, while that of the second attempt (dried at 40°C during 24 hours) is a white and fine powder, which can be directly capsuled.

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