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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Potensi Ekstrak Etanol Daun Sirih Merah (Piper crocatum) Sebagai Antimikrobakterium FARIDA JULIANTINA RACHMAWATY; BARMAWI HISYAM; MARSETYAWAN HNE SOESATYO; TRI WIBAWA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

: The incidence of tuberculosis in Indonesia is high. There is a tendency for some people to use herbs for the treatment of tuberculosis. This research aims to investigate the potency of antimycobacterium property of red betel Vine (Piper crocatum) ethanolic extract against Mycobacterium tuberculosis (M. tuberculosis). The red betel vine leaf was extracted using standard ethanol solvent. The extract was tested on Mycobacterium tuberculosis H3 7Rv. The experiment was conducted by using serial dilution method with 50%, 40%, 25%, 20%, 12.5%, 10%, and 6.25% red betel vine ethanolic extract in Middlebrook 7H9 medium and subseqently inoculated into Lowenstein Jensen (LJ) medium. The result was analyzed descriptively by observing the minimum bactericidal concentration (MBC). The experiment was repeated three times to obtain consistent result. There is no bacterial growth in LJ media at concentrations of 50%, 40%, 25%, 20%, 12.5%, and 10% of red betel vine ethanolic extract. The bacteria was able to grow only at the concentration of 6.25% red betel vine ethanolic extract. Thus the ethanolic extract of red betel vine (Piper crocatum) indicates an antimycobaterium activity against M. tuberculosis H37Rv. The MBC is found at the concentration of 10%.
Penentuan Kadar Genistein dan Aktivitas Hambatan Tirosinase Kedelai (Glycine max) Terfermentasi Aspergillus oryzae ESTIKA YUNINDARWATI; EVI UMAYAH ULFA; ENDAH PUSPITASARI; MOCHAMMAD AMRUN HIDAYAT
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Tujuan dari penelitian ini adalah menentukan kadar genistein dan aktivitas hambatan dari ekstrak kedelai terfermentasi dan non-fermentasi. Kedelai difermentasi oleh Aspergillus oryzae selama 4 hari dan dimonitor kadar genistein serta aktivitas hambatan tirosinase setiap hari. Kadar genistein ditentukan menggunakan densitometer-KLT sedangkan aktivitas hambatan tirosinase dievaluasi menggunakan metode spektrofotometri. Hasil penelitian menunjukkan bahwa kadar genistein meningkat pada saat fermentasi hari ke-1 sampai ke-3 (45,645-1256,042 μg/g ekstrak) tetapi pada hari ke-4 kadarnya menurun (54,373 μg/g ekstrak). Aktivitas hambatan tirosinase juga mengalami peningkatan pada saat fermentasi hari ke-1 sampai ke-3 (dilihat pada nilai IC50) dan menurun saat fermentasi hari ke-4. Disimpulkan bahwa kadar genistein berkaitan dengan aktivitas hambatan tirosinase (R2 = 0,949).
Profil Swamedikasi Analgesik di Masyarakat Surabaya, Jawa Timur Stevan Victoria Halim; Antonius Adji Prayitno S; Yosi Irawati Wibowo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.102 KB) | DOI: 10.35814/jifi.v16i1.424

Abstract

Self-medication is one of the patient's efforts to treat the symptoms or health problems with drug without using a prescription. The most often class of drugs used as self-medication is analgesic (36,2-59,0%). Aim of this study is to describe analgesic self-medication profile among East Surabaya communities, especially Mulyorejo subdistrict. This study is an observational descriptive study that involving 225 patients from 9 pharmacies. The data were collected by using validated questionnaire contains sociodemographic profiles, the frequency of using analgesic, and analgesic profiles purchased by the patients. The data analyze was perfomed by comparing the average of analgesic self-medication frequency based on the patients sociodemographic profiles. The results showed that the average frequency of analgesic used as self-medication is 10.71 (95% CI 8.81-12.60) times a month. The average frequency of analgesic used as self-medication may differ based on sociodemographic profiles. Male patients, elderly, low education level, unemployed, low income (< 2 million), living alone/ divorce, having history of smoking or drinking alcohol showed a higher average frequency of self-medication than the other groups. The results of the study related to analgesic profile showed the majority of patients (80.00%) bought 1 type of analgesic. The most common analgesic group (67.03%) purchased by the patient is Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Headache (42.22%) is a symptom that often encourages patients to use analgesic as self-medication. Based on the results of the study, education about the use of analgesic as self-medication can be more focused on groups of patients with a particular sociodemographic background and NSAIDs drug groups. It aims to avoid the less responsible use of analgesic as self-medication.
Ekstrak Propolis sebagai Imunomodulator Irma L. M.; Syamsudin Syamsudin; I. W.T. Wibawan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A study was done to evaluate the effect of propolis on phagocytic activity and capacity of cells phagocyts with induction SGB (Streptococcus Grup B). In vivo methods were used on the study. In vivo study treatments were divided in four groups. Each group was inducted by 109 cell/ml of SGB. The group consists of treatment by given propolis at dosage 25 mg/kgBW, 50 mg/kgBW, 100 mg/kgBW, and group control, not given propolis. The result showed activity dosage value of propolis were significantly different (p<0.01) at dosage 50 mg/kgBW and capacity dosage value of propolis were significantly different (p<0.01) at dosage 100 mg/kgBW.
Rasio Efektivitas Biaya Obat Antimalaria Kombinasi Artesunat Amodiakuin dan Kombinasi Sulfadoksin Pirimethamin Dalam Terapi Malaria Falsiparum di Sumba DELINA HASAN; ASCOBAT GANI; PURWANTYASTUTI PURWANTYASTUTI; INGE SUTANTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Malaria cases continue to increase in Indonesia, and one of the causes is many malaria parasites resistant to antimalarial drugs such as chloroquine and sulfadoxine pyrimethamine. Antimalarial drug combination recommended by the WHO yet widely available. This study aimed to explore alternative antimalarial drugs through examination of drug-effectiveness and cost-effectiveness analysis of antimalarial drug combination artesunate amodiaquine and sulfadoxine pyrimethamine. To assess the effectix eness or antimalarial drug combinations, as many asl64 patients with who meet inclusion and exclusion criteria were divided into 2 groups with 82 patients respectively. First group was given artesunate amodiaquine while the second group was given sulfadoxine pyrimethamine, and observed for 14 to 28 days. Responses to treatment according to the WHO protocol to include clinical response and parasitological response. The cost effectiveness was assessed through the pharmacoeconomic evaluation method. The results showed that fever clearence time and parasites clearence time by the artesunate amodiaquine combination was faster than by sulfadoxine pyrimethamine combination, and the cost effectiveness ratio of artesunate amodiaquine combination was lower than of sulfadoxine pyrimethamine. In conclusion, the antimalarial drug artesunate amodiaquine combination was more effective and more eflicient than the sulfadoxin pyrimethamine combination, and its cost effectiveness ratio was lower than the sulfadoxine pyrimethamine combination (p=0.05).
Isocratic High Performance Liquid Chromatographic Method for Determination of Metoprolol and Its Metabolite in Human Urine PRI ISWATI UTAMI; SUGIYANTO SUGIYANTO; SUDIBYO MARTONO; LUKMAN HAKIM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

An isocratic reversed phase high performance liquid chromatographic (HPLC) method has been developed for the determination of metoprolol (MET) and α-hydroxymetoprolol (α-OH MET) in human urine. Analytes were extracted using dichloromethane. The optimized separations were performed on a Purospher® STAR RP-18e LiChroCART® (250 x 4.6 mm, 5μm) HPLC column within 12 min by an isocratic elution with 25 mmol/L aqueous potassium dihydrogen phosphate buffer (pH 3.0) containing 15% (v/v) acetonitrile and 15% (v/v) methanol, and UV detection at 234 nm. The method was validated for linearity, accuracy, precision and specificity. The calibration curves for both analytes were linear over the range investigated (1.0-64.0 μg/mL) with correlation coefficients of 0.999. Relative standard deviation (RSD) values were below 2%. For all of the analytes, recoveries value from 98.36±1.68 to 101.32±1.36 % and the limits of detection for MET and α-OH MET were 0.22 and 0.14 μg/mL, respectively. The method developed has been demonstrated to be sensitive and reliable for the measurement of MET and α-OH MET simultaneously in human urine.
Uji Aktivitas Isoflavon Tempe terhadap Penghambatan Enzim α-Glukosidase dan Pengaruhnya pada Tikus Hiperglikemik I NYOMAN SUARSANA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 2 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Isoflavone is a bioactive compound found in fermented soy bean or tempe, and found to have beneficial effect on human health. The objectives of this research were to assay the activity of tempe isoliavone in inhibiting the α-glucosidase enzyme in vitro and to determine the dosage of antihyperglycemic activity of isoflavone tempe. inhibitory effects of tempe isoflavone on α-glucosidase enzyme was tested by spectrofotometry method while in vivo evaluation are conducted using rats under hyperglycemic condition. A total of thirty five male Spraque Dawley rats, which is two months old were used in this study. The rats were divided into seven groups: (1) negative control group; (2) positive hyperglycemic group; (3-6) positive hyperglycemic group and treated with tempe isoflavone with dosages of 100, 200, 300, and 400 mg/kg body weight (bw); and (7) positive hyperglycemic group treated with acarbose dosage of 4,5 mg/kg bw. Blood glucose level was evaluated every 0, 30, 60, 120, 180, and 240 minutes following treatment using Blood Blucose Test Meter GlucoDr. The result showed that the inhibitory effect of tempe isoflavone on α-glucosidase enzyme was 11.89%, with IC50 1.4 mg, and this mechanisms are caused by daidzein and genistein. lsoflavone of tempe with dose of 400 mg/kg bw showed an antihyperglycemie effect.
Uji Aktivitas Penghambatan Enzim α-Glukosidase serta Uji Mutu Ekstrak Etanol Batang Brotowali (Tinospora crispa (L.) Miers.) YESI DESMIATY; RISMA MARISI TAMBUNAN; KARTININGSIH KARTININGSIH; LOLA DYAH PITHALOKA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

In attempt to develop Indonesian traditional medicine (Jamu) to become standardize herbal, it is need to examine the extract that can guarantee its efficacy, quality and safety. Brotowali stem (Tinospora crispa (L.) Miers.) known has antidiabetic effect and no toxic activity. In this research, the quality and α-glukosidase inhibitor activity of ethanolic extract of brotowali stem has been determined. In the quality test were determined specific parameters (identity, organoleptic, extractable matter), non specific parameters (loss on drying, water content, total ash content, solvent residue, heavy metal, and microbial contamination), quantification of markers content (total flavonoid content with spectrophotometric UV-Vis and assay of apigenin content with densitometric method). The research showed that the extract was fulfiled the requirement, total flavonoid content was 0.52% and apigenin content was 0.03635%. The result of α-glukosidase inhibitor activity test gave IC50 of 237.26 ppm.
Studi Observasional Kesalahan Pengobatan di Depo Farmasi Rawat Jalan RSUP Dr. Hasan Sadikin Bandung Viki Hestiarini; Lia Amalia; Eni Margayani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.502 KB) | DOI: 10.35814/jifi.v15i2.522

Abstract

Medication error can occur at all stages, starting from prescribing, dispensing and administration of drugs. This study aims to assess the medication errors that occur in the pharmaceutical care process and analyze the cause of failure using the root cause analysis method, to improvement action and decrease the incidence of medication errors. The data were completeness prescription, frequency of dispensing error and completeness of drug information. The number of sample was 1100 prescriptions Prescribing errors were found the potential injury 15.69±11.51% and near missed error 0.5±0.55%. At dispensing stage, occur 427 incidences (9.71%), consist of two incidences (0.04%) for validation assessment regulations, 224 incidences (5.09%) of data entry, 113 incidences (2.57%) of retrieval of drugs, 19 incidences (0.43%) of fi ll in drugs, 69 incidences (1.57%) of fi nal check. At dispensing stage, near missed 330 incidences (7.51%) of near missed and 97 incidences (2.21%) of potential injury. Failure mode and effect analysis calculate of risk priority number, the drug retrieval (RPN 210) and data entry (RPN 126) were analyzed root cause of the analysis for man, material, method, facility and environment.
Identifikasi Senyawa Flavonoid dalam Fase n-Butanol dari Ekstrak Metanol Daun Wungu (Graptophyllum pictum (L.) Griff) Zuhelmi Aziz; Wiwi Winarti; Kona Nate
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Wungu leaves is one of the herbal plants in Indonesia that have been used significantly by the society to cure scare, swollen, ulcer, gall stone, abscess, skin diseases, liver, hearing disfunction, hemorrhoids, bloody cough, fever and laxative, isolation and identification of the type of flavonoid substance found in n-butanol phase of Wungu leaves methanol extract have been conducted by employing identification by UV-visible spectrophotometry, the result of the examination showed that isolate NB-IV was presumably considered as flavonol substance with 3-OH (with or without 5-OH), isolate NB-V was presumably considered as antosianidin substance with o-diOH on ring A, isolate NB-VI and isolate NBVII was presumably considered as flavonol substance with OH on position 3,5,7 and o-diOH on ring B.

Page 18 of 73 | Total Record : 721

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