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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Technetium-99m-Human IgG Radiopharmaceuticals: Preparation, Biodistribution and Infection Imaging in Mice WIDYASTUTI WIDJAKSANA; ANNA ROSELIANA; AGUS ARIYANTO; SRI AGUSWARINI; MARIALINA MARIALINA; GINA MONDRIDA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Technetium-99m-Immunoglobulin-G preparation and analysis were carried out using human immunoglobulin-G (IgG) which was conjugated with hydrazinonicotinamide (HYNIC) prior to labeling with technetium-99m (99mTc), and the HYNIC-IgG molecules were stabilized with a co-ligand, tricine. Tricine was prepared both in the form of lyophilized kits and in frozen solutions and their stabilities were compared. The effect of pH on the labeling efhciency was also studied. Characterization of native IgG as well as the radiolabeled IgG were carried out using size exclusion HPLC, whereas the labeling efficiency of 99mTc-HYNIC-IgG was determined using thin layer and paper chromatographic methods. The stability of radiolabeled 99mTc-HYNIC-IgG at room temperature as well as in human serum were investigated by observing the radiochemical purity within 4 hours in vitro. The shelf-life of Lmlabeled HYNIC-IgG stored at -40°C and tricine kits stored at 4°C were determined. Biodistribution of 99mTc- HYNIC-IgG in healthy mice and in infection-induced mice and rats were also studied. The HPLC results showed that the native and radiolabeled IgG had similar retention times, which indicated that conjugation and radiolabeling processes did not affect the integrity of the IgG molecules. The radiochemical purity of 99mTc-HYNIC-IgG was high - more than 90% - without purification step, and the preparation was stable up to 4 hours. Tricine kits prepared at pH 3 was proven to produce clear solution and high labeling yield, while pH 4 produced slight opalescence solution which turned to turbid after a few hours. Biodistribution studies in healthy mice showed an obvious uptake in liver but normal distribution in other tissues, while biodistribution in infection-induced mice showed significantly different uptake between infected tissues, i.e higher than normal tissues. Blood clearance was achieved within 2 hours and excretion via urine and faeces were observed within 24 hours. It is concluded that the preparation using human IgG showed high uptake in the infection site, and the 99mTc-HYNIC-IgG can be a promising radiopharmaceutical for infection or inflammation imaging.
Identifikasi Senyawa Kimia dalam Buah Mahkota Dewa (Phaleria macrocarpa), Thymelaceae PARTOMUAN SIMANJUNTAK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Consecutive extraction of Indonesian medicinal plant, fruit of mahkota dewa, Phaleria macrocarpa (Thymelaceae), by n-hexane, aethylacetate, methanol and then Water afforded fatty acids, steroids, benzophenone and carbohydrate. Elucidation of the chemical structure of the isolated compounds was based upon the spectroscopic spectra such as ultra violet, infrared, and nuclear magnetic resonance (proton and carbon).
Pengembangan Getah Pepaya, Ekstrak Pepaya (Carica papaya L.) dan Ekstrak Umbi Bengkuang (Pachyrrhizus erosus (L.) Urb.) untuk Lotion Pencerah Kulit Berdasar Aktivitas Antioksidan dan Inhibisi Tirosinase LEONARDUS BROTO SUGENG KARDONO; LIANDHAJANI LIANDHAJANI; NINA ARTANTI; YETI MULYATI ISKANDAR; SITI MASRURAH BROTO SUTARYO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Whitening or skin lightening products are well known as cosmetic. In this development, papaya latex (Carica papaya L.), papaya fruit extract and yam bean tuber extracts (Pachyrrhizus erosus (L.) Urb.) were combined for skin lightening body lotion formula. Antioxidant and tyrosinase inhibitory activities were evaluated in the starting materials and the products. Antioxidant activity evaluation was conducted using DPPH free radical scavenging activity method. Tyrosinase inhibitory evaluation was performed based on tyrosinase enzymatic inhibitory reaction to tyrosine as substrate. Papaya latex showed the highest antioxidant activity (32.01%), followed by yam bean tuber extract (27.04%) and papaya extract (26.09%). The tyrosinase inhibitory activities of papaya latex, papaya fruit extract and yam bean tuber extracts were 68.42 %, 36.80% and 52.63 % respectively, as compared to that of arbutin (100%). Based on product appearance, color, odor, pH and viscosity, the product were stable for 128 weeks. The expired date calculation on its antioxidant activity, however, the product was stable for 77 weeks. It is recommended that the product should be stored in non transparent bottle at low temperature or at about 25-28oC.
Validasi Metode Kromatografi Lapis Tipis untuk Penentuan Konsentrasi Kurkumin dalam Sampel Disolusi yang Mengandung Ektrak Curcuma longa DEWI SETYANINGSIH; YOSI BAYU MURTI; ACHMAD FUDHOLI; WOUTER L.J. HINRICHS; ROCHMAT MUDJAHID; SUDIBYO MARTONO; TRIANA HERTIANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Curcumin is a lipophilic compound which suffers from the poor bioavailability after oral administration. Increasing its dissolution rate can be a successful strategy to improve the bioavailability. Along with the formulation developments, a rapid and simple analytical method to determine curcumin concentrations in the dissolution medium is required. The aim of this study was to develop and to validate an analytical method based on thin layer chromatography (TLC) to determine curcumin concentrations in a dissolution medium containing 0.5% w/v sodium lauryl sulfate (SLS) and 20 mM sodium phosphate buffer. A polyvinylpyrrolidone K30 based solid dispersion of Curcuma longa extract and its corresponding physical mixture were dissolved in a medium containing 0.5% w/v SLS and 20 mM sodium phosphate buffer (pH 6.0). Dissolution samples were spotted on a normal TLC plate and eluents of various compositions were evaluated. The retardation factor (Rf), resolution (Rs), and asymmetry factor (As0.05) of the optimized method were determined. Using the optimized eluent, proper separation of curcumin peak was achieved with an Rf of 0.50, Rs of 2.62 and As 0.05of 0.87. Linearity (5-30 μg/mL) was demonstrated by r value of 0.9965. The TLC method provided precision with RSD ≤3.50 and accuracy with recovery value of 94-105%.
Isolasi dan Identifikasi Senyawa Bioaktif Ekstrak Aseton Daun Garcinia lateriflora Blume SRI HARTATI; DEDE RAHMAWATI; SUJASWADI WIRYOWIDAGDO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Preliminary studies have been carried out phytochemical test acetone leaf extract Garcinialateriflora Blume., and toxicity test against shrimp larvae (Artemia salina Leach) and murine cell lineP388. Isolates which showed the highest mortality are proceeded further for fractionation, isolation andpurification. The structure identification of active campound carriedout by analyzing the spectrum of IR ,GC-MS (Gas chromatography mass spectrometer) and proton nuclear magnetic resonance spectrometer(1H-NMR ) and (13C-NMR ). The results showed that the most active against the larval shrimp Artemiasalina L. with LC50 value of 18.03 ug/mL is b-asaron, IC50 of test results on cell line murine P-388 is 47.0ug/mL. This compound was isolated first time from the plant Garcinia lateriflora BL.
KINETIKA PERTUMBUHAN BEBERAPA MIKROBA PENGHASIL A - AMILASE MENGGUNAKAN MOLASE SEBAGAI SUMBER KARBON Trismilah Trismilah; Sumaryanto Sumaryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 1 No 2 (2003): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Molasse as a waste product in sugar industry can be used as alternative carbon source in fermentation, which influences the growth of microbes and production process. In this experiment 5% molasses was used as a medium for producing a - amylase using Bacillus subtilis ATCC 6633, Streptomyces fradiae, and Aspergillus niger. The experiment was done in an Erlenmeyer of 125 ml in a shaker incubator with 250 rpm agitation. The temperature was adjusted to 37°C and the initial pH for Bacillus subtilis ATCC 6633: waste pH=8; Streptomyces fradiae: pH=7, and Aspergillus niger : pH=5. The result showed, that the highest growth and enzyme activity were accomplished by Bacillus subtilis ATCC, while specific growth rate (u max)= 0,1501 in 24 hours attained.
Pengaruh 2,4-D (Asam Diklorofenoksi Asetat) dan BAP (Benzyl Amino Purin) terhadap Proliferasi Kalus dan Produksi Metabolit Sekunder dari Kalus Kencur (Kaemferia galanga L.) Anis Shofiyani; Neni Damajanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.329 KB) | DOI: 10.35814/jifi.v15i2.514

Abstract

The aim of this research is to fi nd combination of 2,4-D (diclorophenoxy acetic acid) and BAP (benzyl amino purine) concentration which give the best infl uence to callus proliferation and to know the effect of interaction between 2,4-D and BAP to obtain good growth culture of Kaemferia galanga L callus and able to produce secondary metabolite. The design used for callus proliferation was a combination of 2.4 D (1–3 mg/L) and BAP (0-0.2 mg/L). All were randomly arranged in a complete randomized design (RAL) with three replicates, and each treatment unit used 10 bottles of culture. The combination of eff ective treatment for callus proliferation was 2,4 D concentrations of 1 to 3 mg/L and without the addition of BAP (B0). 2,4 D with 1 mg/L concentration gave the best callus proliferation rate indicated at callus volume, fresh weight of callus, dried weight callus and the weakness high and white light colour with friable nature. The higher concentration of 2.4 D to 3 mg/L in the formation of callus color to green and on the process of organogenesis (shoot and root formation). Based on qualitative analysis test using thin layer chromatography (TLC), extract methanol callus Kaemferia galanga research results contain secondary metabolite compounds in the form of alkaloids, flavonoids, tannins, saponins, steroids and ethyl para-methoxycinnamate.
Analisis Faktor yang Mempengaruhi Pengelolaan Obat Publik di Instalasi Farmasi Kabupaten (Studi di Papua Wilayah Selatan) YOHANES WAHYU WALUYO; UMI ATHIYAH; THINNI NURUL ROCHMAH
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Public drug management is purposed to ensure availability of quality drug with proper type and quantity, distributed well and orderly. Recent problem of public drug management is the level of drug availability which has not been suitable with the health care need since inadequate supply still occur in one part and oversupply in other part. This research was aimed to indentify what factors are influencing public drug management and to identify public drug management function. This is an observational using cross sectional data collection method, presented descriptively in District Pharmacy Installation and descriptive in nature. Result of research showed that public drug management were influenced by factors such as packing and maintenance funds which is not evenly distributed, staff education which have not met the required need, governance which were not yet performed and drug management facility/ tools which were partially incomplete. The description of drug management are as following: drug procurement fund allocation of 114.02%, drug availability with disease pattern of 170.87%, planning accuracy of 114.02%, essential drug of 70.16%, generic drug of 87.87%,drug procurement has not been met all contract books of 77.00%, drug availability of 75.75%, broken and expired drug of 7.01%, drug vacant time mean of 0.37%, drug distribution accuracy of 57.68% and distributed drug deviation of 17.30%.
Mikroenkapsulasi Ketoprofen dengan Metode Koaservasi dan Semprot Kering Menggunakan Pragelatinisasi Pati Singkong Ftalat sebagai Eksipien Penyalut YUDI SRIFIANA; SILVIA SURINI; ARRY YANUAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study was purposed to prepare microcapsules of ketoprofen by coacervation and spray drying methods and to characterize the resulting microcapsules. The microcapsules were prepared using pregelatinized cassava starch (PCS) and pregelatinized cassava starch phthalate (PCSPh) as a coating material. The obtained microcapsules were then characterized, including its recovery, shape and morphology, drug-loading efficiency, particle size distribution, swelling index, functional Groupanalysis, and drug release profile.The used PCSPh had a substitution degree of 0.0541 and soluble in basic aqueous medium. Microcapsules prepared by coacervation method had an irregular shape and a hollow surface and the entrapment efficiency of 20.27% ± 1.82.Whereas, the spray dried microcapsules showed a nearly-spherical-shape with a biconcave surface and the entrapment efficiency was 80.22% ± 9.18. The release study results showed that within 8 hours ketoprofen released from the coacervation microcapsulesat pH 1.2 and pH 7.4 were 8% and 18%, respectively. In addition, ketoprofen released from spray-dried microcapsules within 8 hours at pH 1.2 and pH 7.4 were 5% and 25%, respectively. In conclusion, the microcapsules prepared by both methods could extent the drug released, thus it could be possible to be used for a sustained release device.
Uji Sitotoksik Hasil Fermentasi Kapang Endofit Buah Mahkota Dewa (Phaleria macrocarpa) terhadap Sel MCF-7 Syarmalina Syarmalina; Wan Lely; Nazliah Laupa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

In the development of traditional medicine, there are great demands of medicinal plant. Meanwhile, those demands exceed the capacity of natural resource to provide the raw material. The solution for that problem that has been developed is by utilizing organism that live on plant tissue, which known as endophytic microbe. The preliminary Brine Shrimp Lethality Test based research on the polarity degree of supernatant extracts has proved that it has high toxic activity on Artemia salina Leach. Subsequent to that study, a research to examine in vitro cytotoxic effect of supernatant extract fermented from Mahkota Dewa fruit endophytic mould KVM/a and KIVM/b isolate on breast cancer cell has been conducted. Thin layer chromatographic test was performed to identify the patch pattern from each fraction of KVM/a and KIVM/b isolate. Furthermore, preparative thin layer chromatographic test was tested on MCF-7 cell by using neutral red method. The cytotoxic effect was determined based on ICs, value. The results confirm the cytotoxic test effect of semi polar fraction of both isolates on MCF-7 cell with the ICs, value of 36.26 ppm for KVM/a and 30.48 ppm for KIVM/b.

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