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Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 792 Documents
 44   45   46   47   48 
Variasi Arteri Koronaria Dominan pada Jantung Kadaver di Laboratorium Anatomi Fakultas Kedokteran Universitas Andalas Gusti Revilla
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p130-136.2023

Abstract

Coronary arteries have a variable distribution in the myocardium of the heart. This condition is also known as dominant coronary arteries. The research that has been done knows that the most common coronary artery variation is the right dominant variation and the co-dominant variation. Objective: to describe the variation of the dominant coronary arteries in the cadaveric heart at the Anatomy Laboratory of the Faculty of Medicine, Andalas University. Method: This study used a descriptive method of looking at the variation of the dominant coronary arteries in the cadaveric heart at the Anatomy Laboratory of the Faculty of Medicine, Andalas University. The population was all existing cadaveric hearts and the entire population was sampled according to the inclusion and exclusion criteria. Results: The number of samples found was 26 hearts. The results obtained were 80.8% were hearts with a right dominant coronary artery, which was the most varied, 7.7% a heart with a left dominant coronary artery, and 11.5% a heart with a co-dominant coronary artery. Conclusion: Variations of  the dominant  coronary arteries  found ptovides information for the need to increase awareness of these risky variations so that morbidity and mortality can be reduced.
Penggunaan ponsel pintar sebagai faktor risiko terjadinya nyeri kepala primer pada mahasiswa kedokteran Untan Kim Liung; Ery Hermawati; Willy Handoko
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p57-67.2023

Abstract

Headache is one of the common symptoms found in nervous system disorders. The incidence of headache in the world in adult humans is 50% in the population with various headache categories. Previous research has shown that there is a relationship between smartphone use and musculoskeletal disorders in the neck, shoulders and hands in young adults. One of the groups involved in the use of smart phones is students. Objective: The purpose of this study was to determine the relationship between the use of smart phones and other factors that cause primary headaches, with the incidence of primary headaches in medical students of Untan. Methods: Observational analytic study of cross-sectional type. The research population is the students of the Untan Medical Study Program, who were selected using a side stratified random technique. Bivariate analysis using contingency coefficient test. Results: The results of the contingency coefficient analysis test showed a p-value of 0.038 (Sig <0.05) for the relationship between the intensity of smartphone use and primary headache, and a p-value >0.05 for the relationship between all other factors and primary headaches. Conclusion: There is a relationship between the intensity of smartphone use on primary headaches in Untan medical students.
Hubungan status hidrasi dengan penurunan massa lemak selama puasa ramadhan Eka Febriyanti; Huwainan Nisa Nasution; Fitri Nur Malini
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p169-171.2023

Abstract

Tujuan : Penelitian ini bertujuan untuk menilai hubungan status hidrasi dengan penurunan massa lemak selama puasa Ramadhan; Metode : Penelitian ini merupakan studi longitudinal terhadap 67 subjek laki-laki yang menjalani puasa Ramadhan penuh. Status hidrasi dinilai dengan pemeriksaan warna urin sewaktu pada minggu ke-2 bulan Ramadhan sedangkan penurunan massa lemak didapatkan dari selisih massa lemak pada 1 minggu sebelum puasa dan minggu ke-2 puasa Ramadhan. Data yang didapat dilakukan analisis bivariat menggunakan Kruskal-wallis; Hasil: tidak terdapat hubungan bermakna antara status hidrasi dengan penurunan massa lemak selama puasa Ramadhan dengan nilai p=0.828; Kesimpulan: status hidrasi tidak berhubungan dengan penurunan massa lemak selama puasa Ramadhan namun diperlukan penelitian lebih lanjut untuk menilai interaksi berbagai faktor yang ikut memengaruhi penurunan massa lemak selama puasa.
Characteristic of Cataract Patients from the Opthalmology Department of RSUP Dr. M.Djamil Padang in 2018-2019 Emery Wynne Emilza
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p19-36.2023

Abstract

Background: Cataract is an eye lens transparency disorder in the form of cloudiness. The purpose of this study was to determine the characteristics of cataract patients in the opthalmology department of RSUP dr. M Djamil Padang Hospital in 2018-2019. Method : This study was a retrospective descriptive study with total sampling and 181 samples were met the criteria. Result: The patients consisted of senile cataract (72.4%), presenile (14.4%), juvenile (11%), and congenital (2.2%). With bilateral (74%), no family history of cataracts (98.8%) and female (56.4%). Obtained risk factors were eye traumas (16%), local eye diseases (7.2%) and metabolic diseases (31.5%). The morphology obtained in congenital and juvenile were totalis (41.2%) and nuclear (35.2%) while in presenile and senile were posterior subcapsular (47.5%) with 81.8% of them were immature. Surgical management was performed with ECCE (97.1%). Conclusion : Most of the characteristics were senile, bilateral, no family history of cataracts and female. The most common risk factor was metabolic disease namely diabetes melitus. In patients with congenital and juvenile cataracts, the totalis and nuclear forms were most commonly found while in presenile and senile cataracts was posterior subcapsular forms with immature level. Surgical management is mostly handled by ECCE.
Hubungan Motivasi Dan Alasan Masuk Ke Fakultas Kedokteran Dengan Prestasi Akademik Cindy Eka Wijaya; Pieter Pieter; Erwin Handoko; Rico Alexander
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p96-103.2023

Abstract

Tujuan: Untuk mengetahui hubungan antara motivasi akademik, identitas profesional dan prestasi akademik; Metode: Penelitian deskriptif potong lintang dilakukan. Dari 279 mahasiswa kedokteran, 188 berpartisipasi dalam riset ini. Pengumpulan informasi memakai 2 kuesioner: kuesioner SMMS dan IPMK dengan kuesioner elektronik. Data yang terkumpul dianalisis melalui program paket SPSS 26.0 dengan metode analisis deskriptif. Skor dibandingkan dengan menggunakan korelasi non-parametrik Spearman's rho, uji Kruskal-Wallis dan Mann Whitney, tingkat signifikansi 0,05 diterima; Hasil: Uji korelasi Spearman’s rho menampilkan terdapat ikatan yang signifikan antara tingkatan motivasi dengan IPMK ialah moderate serta positif. Pada Uji Kruskal-Wallis, terdapat perbedaan motivasi akademik antar semester pada mahasiswa kedokteran. Dalam uji Mann-Whitney, tidak ada perbedaan antara jenis kelamin dan motivasi serta identitas profesional mahasiswa kedokteran di Universitas Prima Indonesia; Kesimpulan: Studi ini mengatakan bahwa motivasi masuk ke fakultas kedokteran memainkan peran penting dalam meningkatkan profesionalisme mahasiswa kedokteran, tetapi tidak pada prestasi akademik.
Korelasi antara kadar gula darah puasa dengan stress oksidatif dan aktivitas katalase pada tikus model diabetes melitus tipe 1 yang diterapi dengan MSC-WJ Endrinaldi Endrinaldi
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p137-144.2023

Abstract

Objective: This study was conducted to investigate the involvement of oxidative damage in type 1 diabetes mellitus rats treated with Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) and to explain the correlation between fasting blood sugar levels and MDA levels as an indicator of oxidative stress and catalase activity.Methods: This research is experimental research with a Posttest-Only Control Group Design. It consisted of 3 groups, namely group 1 was healthy rats, group 2 was DM rats and group 3 was DM rats treated with MSC-WJ. This study conducted in vivo experiments on alloxan-induced diabetic rat models by testing fasting blood glucose (FBG), serum MDA levels, and catalase activity. Malondialdehyde (MDA) was measured by the Ohkawa method, and catalase activity (CAT) was measured by a modified Sinha method.Results: The results showed the correlation analysis between fasting blood sugar levels and MDA levels (r = 0.697) and catalase activity (r = -0.850) in type 1 DM rats after being treated with Mesenchymal Stem Cell Wharton's Jelly.Conclusion: This study shows a strong positive correlation between fasting blood sugar levels and oxidative stress and a very strong correlation between fasting blood sugar levels and catalase activity of type 1 DM rats treated with MSC-WJ.
Efek Protektif Ekstrak Etanol Umbi Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) terhadap Gambaran Histopatologi pada Sel Tumor Payudara Tikus Putih (Rattus norvegicus) Betina Galur Sprague Dawley Diinduksi 7,12 Dimethylbenz(α)Anthracene Afifah Nurkarnia
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p45-56.2023

Abstract

Objective: To determine the effect of ethanol extract of dayak onion bulb on histology of mammary tumor cells in female Sprague Dawley rats strains that were induced by 7,12 dimethylbenz(α)anthracene (DMBA). Methods: The design of this study was a post-test only control group. DMBA (20 mg/kgBW) was given peroral twice a week for five weeks. In this research 30 female Sprague-Dawley rats  were used and divided into 6 groups. Normal group weren’t treated DMBA; negative control group were treated DMBA and DMSO 5%; positive control group were treated DMBA and tamoxifen; treatment I group were treated DMBA and extract 180 mg/kgBW; treatment II group were treated DMBA and extract 360 mg/kgBW; and  treatment III group were treated DMBA and extract 720 mg/kgBW. Results: There was significant difference between treatment I and negative control group (p=0,015); treatment II and negative control group (p=0,011); treatment III and negative control group (p=0,015). Conclusion: Ethanol extract of dayak onion bulb  have an effect on histology of mammary tumors in female Sprague Dawley rats that were induced by 7,12 dimethylbenz(α)anthracene (DMBA).Keywords: Eleutherine bulbosa; Anti-cancer; Histopathology; Mammary tumor; 7,12 Dimethylbenz(α)anthracene
Profil Klinis dan Kejadian Kardiovaskular Mayor Selama Rawatan pada Pasien IMA-EST Usia Muda Fitri Khairani Yusran
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p10-18.2023

Abstract

Tujuan: Mengetahui profil klinis dan kejadian kardiovaskular mayor (KKM) selama rawatan pada pasien infark miokard akut dengan elevasi segmen ST (IMA-EST) usia muda di RSUP Dr. M. Djamil Padang. Metode: Penelitian dengan metode deskriptif retrospektif. Sampel adalah pasien IMA-EST usia < 45 tahun yang dirawat di RSUP Dr. M. Djamil Padang. Data diambil menggunakan rekam medis. Variabel berupa usia, jenis kelamin, faktor risiko, onset gejala, lokasi infark, karakteristik angiografi, arteri terkait infark, terapi, komorbid, klasifikasi Killip dan KKM selama rawatan. Hasil: Dari 100 pasien ditemukan rerata usia pasien 39 tahun dengan rentang usia 24 – 44 tahun, 95% berjenis kelamin laki-laki, 89% memiliki faktor risiko merokok, 80% dengan onset gejala < 12 jam, 60% lokasi anterior, 45% single vessel disease, 48% arteri left anterior descending, 96% mendapat terapi reperfusi dengan 75% mendapat intervensi koroner perkutan (IKP), 21% komorbid pneumonia dan 80% Killip I. KKM selama rawatan dialami oleh 4 orang pasien dengan semuanya kematian. Kesimpulan: Pasien IMA-EST usia muda pada penelitian ini paling banyak laki-laki, merokok, memiliki onset gejala < 12 jam, memiliki lokasi anterior dengan arteri left anterior descending dan single vessel disease, mendapatkan terapi reperfusi berupa IKP dan mengalami KKM selama rawatan berupa kematian.
Preliminary Screening of Phytochemical Compounds of Jeriangau (Acorus calamus) from West Sumatra Refa Rahmaddiansyah; Muhammad Abi Ghoffari Siregar; Rauza Sukma Rita
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p88-95.2023

Abstract

Indonesia's biodiversity is able to meet the needs of human life in various sectors, especially in the utilization of potential plants. Jeriangau (Acorus calamus) is a rhizome plant that is widely used as traditional medicine in various ethnicities, especially in West Sumatra. This is because jeriangau contains bioactive compounds that have the potential to treat various diseases. This research method is an experimental study to qualitatively confirm the bioactive components contained in the rhizome of Jeriangau. The test results of jeriangau simplicia samples showed positive results for the active group of secondary metabolites of flavonoids, tannins, and saponins which have potential as antioxidants. Flavonoids can reduce the risk of chronic disease, especially cardiovascular disease and cancer. Tannins have antioxidant properties and can protect the skin from damage caused by UV radiation. Saponins are known to act as antiviral, antimicrobial, and anti-inflammatory. Therefore, Acorus calamus extract can be used as an antibacterial, antiviral, antiseptic, antifungal, and acts as an antioxidant. Further research is needed on studies of inflammatory activity, either in vitro, in vivo, or in human treatment.Keywords: jeriangau; phytochemicals; West Sumatra; antioxidant.
Pengaruh pemberian ekstrak centella asiatica terhadap kadar gula darah sewaktu tikus (rattus novergicus) model cedera otak traumatik Nafiisah Nafiisah
Majalah Kedokteran Andalas Vol 46, No 1 (2023): Online Januari 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i1.p145-149.2023

Abstract

Hyperglycemic is common in traumatic brain injury (TBI). Centella asiatica (CA) has antioxidant and antihyperglycemic effects. Objective: To determine the effect of CA on GDS in rat with TBI models. Methods: true experimental design with post test only controlled group design. The study used 35 experimental animals randomly divided into 5 groups. P1 was healthy rat, P2 was sick rat, P3, P4, and P5 were the model group TBI and given CA with dose of 150, 300, and 600 mg/kgbb/day. Administration of CA which was given orally and measurement of GDS levels was done after 7 days of treatment. The statistical test used the One Way ANOVA test, the Post Hoc LSD test. Results: Mean GDS at P1 = 94.78 ± 42.47; P2 = 90.97 ± 06.44; P3 = 110.21 ± 3.70; P4 = 122.35 ± 4.91; and P5 = 128.57 ± 3.90. The One Way ANOVA test results show the fact that there is a statistically significant population (p = 0.000). The results of the LSD Post Hoc Test showed that there was a difference between P1 and P3, P4 and P5; P2 with P3, P4 and P5; P3 to P5. Conclusion: the effect of CA on GDS levels in rat with TBI models

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