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Hirowati Ali
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Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 792 Documents
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Dapur Makanan Pendamping-Air Susu Ibu (MP-ASI) di Daerah Bencana Malampah, Pasaman Barat Amalfi, Hendra; Masnadi, Nice Rachmawati
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p235-244.2024

Abstract

Indonesia legislation number 24 of 2007 at 55 concerning disaster management states that children (babies and toddlers) are a vulnerable group when a disaster occurs.1 Children are a vulnerable population and have special health problems that must be considered when a disaster occurs. One of them is the very limited availability of complementary foods (MP-ASI) and this condition will worsen the nutritional status of children in disaster areas.2,3,4 The provision of food menus for toddlers in natural disaster conditions is limited because public kitchen do not prepare special menu for toddlers so that children consume food that is also consumed by adults, including instant food. The availability of MP-ASI ingredient can be achieved from public kitchens with the help and cooperation of various parties including volunteers by setting up MP-ASI kitchen so that nutritional intake for toddlers is fulfilled in disaster conditions.5 This was a activities report on establishing MP-ASI in the disaster area, Malampah, Pasaman. It has been expected to be a reference for establishing MP-ASI kitchen in disaster area, as consideration in creating operational standards for establishing MP-ASI kitchen in disaster area, and assist in managing public MP-ASI kitchen in natural disaster area.
Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat Agustian, Dede Rahman; Putra, Andani Eka; Arisanty, Dessy
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p163-172.2024

Abstract

Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies.
Pengaruh Pemberian Ekstrak Daun Kelor (Moringa Oleifera) Sebagai Antioksidan Terhadap Kadar Malondialdehyde Pada Tikus Model Hiperglikemia Sari, Asti Marian; Yerizel, Eti -; karmia, Hudila Rifa
Majalah Kedokteran Andalas Vol. 48 No. 1 (2025): MKA January 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i1.p63-70.2025

Abstract

Tujuan: Mengetahui pengaruh pemberiak ekstrak Moringa Oleifera terhadap kadar malondialdehyde pada tikus wistar model hiperglikemia. Metode: Penelitian ini melibatkan 20 ekor tikus strain wistar betina yang berumur 8-12 minggu dengan bobot 200-250 gram yang memenuhi kriteria inklusi maupun ekslusi. Tikus dibagi menjadi kelompok empat, yaitu Kelompok kontrol negatif (K-), Kontrol positif (K+), Perlakuan 1 (P1) dan Perlakuan 2 (P2). Kelompok P1 hanya diberikan makan dan minum standar saja, tanpa perlakuan. Kelompok K+ diinjeksi aloksan secara Intraperotoneal dengan dosis 100 mg/kgBB sehingga tikus menjadi hiperglikemia, P1 diberi injeksi aloksan menjadi hiperglikemia dan diberikan ekstrak moringa oleifera dengan dosis 250 mg/kgBB dan P2 injeksi aloksan menjadi hiperglikemia dan diberikan ekstrak moringa oleifera dengan dosis 500 mg/ kgBB selama 21 hari, Pada hari ke-22 semua kelompok diambil darah untuk dilakukan pemeriksaan kadar malondialdehyde. Hasil: Rerata kadar malondialdehid pada K-, K+, P1 dan P2 berturut-turut, yaitu 1,81±0,06 nmol/mL, 3,81±0,24 nmol/mL, 2,55±0,30 nmol/ mL, 2,09±0,21 nmol/mL, dengan nilai p=0,01. Kesimpulan : Pemberian ekstrak moringa oleifera sebagai antioksidan berpengaruh terhadap penurunan kadar malondialdehid
The Relationship Of Therapy Frequency, Food Intake, And Nutritional Status With Quality Of Life In Breast Cancer Patients At The Andalas University Educational Hospital Coloay, Yuliany Christy; Purnakarya, Idral; Lipoeto, Indrawaty
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p252-259.2024

Abstract

Breast cancer is a non-communicable disease, the development of cancer cells affects a series of organ functions. Treatment for breast cancer is generally divided into three, namely mastectomy, chemotherapy and radiotherapy. Objective: To determine the relationship between frequency of therapy, food intake and nutritional status with the quality of life of cancer patients. Results: Cancer cell activity in the body is characterized by pain, especially in the cancer area. The frequency of therapy >3 months has an effect on decreasing nutritional status, the therapy undertaken has side effects, both chemotherapy and radiotherapy, resulting in side effects such as nausea and loss of appetite. Conclusion: Patients who undergo therapy for 3 months tend to be underweight, if the food intake they receive according to their needs will reduce the risk and disruption of a series of body system functions. Regulating the types of food with a regular eating pattern increases the body's physical defenses. Maintaining normal nutritional status while undergoing therapy can maintain physical quality that is related to quality of life.The Relationship Of Therapy Frequency, Food Intake, And Nutritional Status With Quality Of Life In Breast Cancer Patients At The Andalas University Educational Hospital
Biscuit Formulation With Substitution Of Mackerel Fish Meal (Rastrelliger Sp.) And Black Rice Flour (Oryza Sativa L. Indica) As An Alternative Snack For Diabetes Mellitus Sufferers Lubis, Rizka Adelia; Syahrial, Syahrial; Elnovriza, Deni
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i3.p265-275.2024

Abstract

Objective: This research aims to develop a biscuit formulation with the substitution of mackerel fish flour and black rice flour as an alternative snack for diabetes mellitus sufferers.Method: This research was an experiment with a Completely Randomized Design (CRD) consisting of four treatments, namely 0% (F0), 25% (F1), 50% (F2), and 75% (F3). Organoleptic tests were carried out on 7 trained panelists. The organoleptic test data was tested for normality using the Shapiro Wilk test. The results of the data distribution are normally distributed, so to determine whether there are real differences in each treatment, the data is processed using the ANOVA test at the 5% level, if it is known that there are significant differences (p value <0.05), followed by the Duncan New Multiple Range Test (DNMRT) at the 5% level to see which treatments are different. Results: The biscuits selected based on organoleptic tests were F1 biscuits with a water content of 3.1%, ash 1.5%, protein 5.2%, fat 3%, magnesium 117 gr, anthocyanin 14.88 mg. Conclusion: Biscuits substituted for mackerel fish flour and black rice flour can be used as an alternative snack for diabetes mellitus sufferers.Keywords: diabetes mellitus, biscuits, mackerel flour, black rice flour 
Uncontrolled diabetes and nephropathy diabetic: implication from retrospectively studied at RSUP Dr. M. Djamil Padang Amanda, Dela Sasqia
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1780-1789.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kontrol glikemik dengan kadar kreatinin serum pada pasien diabetes melitus tipe (DMT2); Metode: Penelitian cross-sectional ini dilakukan pada bulan November 2022 hingga Januari 2024. Sebanyak 1.130 rekam medis pasien DMT2 yang melakukan pemeriksaan kadar HbA1c dan kadar kreatinin serum di Instalasi Laboratorium Patologi Klinik RSUP Dr. M. Djamil Padang pada tahun 2019–2021 diikutsertakan. Uji Mann-Whitney digunakan untuk menganalisis hubungan antara kontrol glikemik dan kadar kreatinin serum; Hasil: Sebanyak 52,7% pasien DMT2 adalah laki-laki dengan rata-rata usia 55,8 tahun. Lebih dari separuh (52,7%) pasien DMT2 memiliki kontrol glikemik yang buruk dan ditemukan bahwa median kadar kreatinin serum pada pasien DMT2 dengan kontrol glikemik buruk adalah 5,3 (1,3-15,3) mg/dL, sedangkan pasien dengan kontrol glikemik baik adalah 4,2 (0,4-8,0)mg/dL. Hasil analisis bivariat menunjukkan terdapat hubungan bermakna antara kontrol glikemik dengan kadar kreatinin serum pada pasien DMT2 (p<0,05); Kesimpulan: Temuan pada penelitian ini menunjukkan adanya hubungan antara kontrol glikemik dengan kadar kreatinin serum pada pasien DMT2.
Probiotic and Its Fundamental Role In Gastrointestinal Health: A Literature Review Yansen, Fatridha
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1851-1861.2024

Abstract

The gastrointestinal tracts are hosts to a wide variety of microorganisms known as intestinal microbiota. This gut microbiome may get disrupted that will influence the human health. Probiotics can restore the balance of gut microbiota by changing its composition and promoting its stability. Objective: This review aims to compile the role of probiotics in maintaining gastrointestinal health based on evidence-based through the modulation of the human gut microbiome.  Method: This article is structured based on a literature review method by collecting and reviewing papers published in PubMed, Scopus, ScienceDirect, Springer, and Google Scholar.  Results: The administration of probiotics have successfully shown evidenced beneficial health effects to prevent or treat for several main these several diseases including diarrhea, lactose intolerance and intestinal bowel diseases. Conclusion: Probiotics have been demonstrated to play key functions in the digestive system and to considerably reduce the symptoms of a variety of illnesses.
Glycemic control and serum albumin in type 2 diabetes patients: What does observational study say? Yosa, Nelvia Okta
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1790-1800.2024

Abstract

Glycemic control is important to prevent organ damage in Type 2 Diabetes Melitus (T2DM) Patients, especially liver and kidney. One of parameter used to see the decreasing function of both organs is serum albumin. Aim : The aim of this study was to identify the association between glycemic control and serum albumin level on T2DM patoents. Method :  This is an observational analytical study using cross sectional design. This study was conducted at RSUP Dr. M. Djamil Padang using T2DM patients medical records on 2019-2021. The level of HA1c <7% was cathegorised as good glycemic control and Hb1c >7% was cathegorised as poor glycemic control. Results : The results showed that there was an association between glycemic control and serum albumin level on T2DM patients at RSUP Dr. M. Djamil Padang. Conclusion : Glycemic control was inversely associated with serum albumin levels in patients with T2DM in RSUP Dr. M. Djamil Padang
Organoleptic and Nutrient Tests of Bareh Randang Formula with the Addition of Curd to Reduce Hypercholesterolemia Asrya, Lastrie
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1801-1816.2024

Abstract

Objective: This study aims to determine the organoleptic test and nutritional content of the Bareh Randang formula with the addition of curd to reduce hypercholesterolemia. Method: This type of research is experimental by conducting direct experiments using a Completely Randomized Design (CRD) with four levels of curd addition, namely 0 gr, 15 gr, 25 gr and 35 gr per dough formula which is carried out in two repetitions. Organoleptic tests were carried out by 25 panelists. Data were analyzed using the Kruskal Wallis test and Mann Whitney advanced test. Laboratory tests carried out proximate nutrient content tests and BAL tests. Results: Based on organoleptic tests, the best formula was obtained with the addition of 25 grams of curd. The results of the Kruskal Wallis test showed that there was a significant difference of P<0.05 in color, taste and texture, while in aroma there was no significant difference of P>0.05. From testing the LAB content, it was found that the bareh randang product contained LAB 108 CFU/g which is useful as a probiotic food. Conclusion: When making bareh randang products, it is best to add 25 grams of curd.
THE EFFECTIVENESS OF THE HEALTHY KITCHEN PROGRAM TO OVERCOME STUNTING IN IMPROVING THE NUTRITIONAL STATUS OF STUNTING TODDLERS Sridefi, Fadhilla Puja
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1817-1824.2024

Abstract

Stunting is a problem of chronic malnutrition which is caused by a lack of nutritional intake for a long time. One of the programs initiated by the BKKBN to reduce stunting rates is the Healthy Kitchen to Overcome Stunting (DASHAT) program. One of the DASHAT programs is providing local supplementary food to stunted toddlers. The aim of this research was to determine the effectiveness of DASHAT on weight gain and nutritional status of stunted toddlers during the program and after 3 months of completion of the program. This research uses a Quasy Experiment approach. The population in this study were all stunted toddlers who received the DASHAT program, while the sample in this study was 34 toddlers taken by random sampling in three areas of the South Padang District Health Center, Padang City. The results of this research show that the DASHAT program is effective in increasing the weight of toddlers with a p-value of 0.000 during the program and 0.048 after the program, but is not effective in changing nutritional status (TB/U) after the DASHAT program ends. Maximum monitoring is needed from various parties regarding stunting toddlers after the DASHAT program is completed.

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