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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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Perbedaan hitung trombosit, Mean Platelet Volume (MPV), dan Platelet Distribution Width (PDW) antara pasien dengan infeksi Helicobacter pylori positif dan negatif di RSUP H. Adam Malik, Medan, Indonesia Fauzan Indra M Lubis; Ricke Loesnihari; Taufik Sungkar
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: H. Pylori cause one of the most common human infections, being present in the gastric mucosa of more than a half of the world population. H. pylori infection can be detected by testing antibodies (IgA and IgG) in serum or saliva. Platelets play an important role in the pathogenesis of abnormalities associated with local or systemic inflammation through the release of thrombotic and inflammatory agents. Mean Platelet Volume (MPV) has long been known as a marker of inflammation and this role has been shown previously in various gastrointestinal disorders. Platelet distribution width (PDW) is a platelet index that reflects variations in platelet size.Methods: Thirty-two consecutive dyspepsia patient who fulfilled the criteria were included. Platelet levels, MPV, PDW, are promising in each patient. We changed the differences in platelets, MPV, PDW patients, dyspepsia with positif and negatif H. pylori infection. Data were analyzed using SPSS version 20 for windows.Results: Most of respondents were females (71.9%) and 56Â±17.45 years old for the average age. The mean of hemoglobin level was 13.47Â±1.59 g/dL, followed by 11,33Â±1,71 fL for MPV, 10,7Â±0,75fL for PDW, and positif H.pylori infection in 56,3% of respondents. There were no differences in platelets, MPV, PDW significantly between the population groups of H. pylori positif and H. pylori negatif (P>0.05)Conclusion: There were no differences in platelets, MPV, PDW significantly between the population group H. pylori positif and H. pylori negatif.

Hubungan kadar TNF-Î± dengan HOMA-IR pada pasien diabetes mellitus tipe-2 di Rumah Sakit Umum Pusat Haji Adam Malik, Medan, Indonesia Poltak Poltak; Santi Syafril; Ratna Akbari Ganie
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: The homeostatic assessment (HOMA) of the first cell-Î² (B) and insulin (IR) function is used to determine insulin sensitivity and cell-Î² function of insulin plasma concentrations and fasting glucose. High extracellular glucose levels will trigger an increase in ROS production (which in turn will increase the formation of Reactive Oxygen Species) expression of TNF Î± (Tumor Necrosis Factor-Î±) and exacerbate oxidative stress. The study aimed to determine the relationship between TNF Î± and HOMA-IR in type 2 DM.Method: A cross sectional study was conducted at the H. Adam Malik General Hospital Medan from December-February 2018 in 43 patients with type 2 DM. Fasting insulin levels were examined using Celuminescence Microparticle Immunoassay and fasting glucose levels with Enzymatic and TNF Î± methods with the Elisa method. The relationship of the characteristics of TNF Î± levels with HOMA-IR in type 2 DM using the Kolmogorov Smirnov test used the Spearman's rank correlation test with SPSS version 20 for windows.Results: The total sample was 43 samples of patients with type 2 diabetes mellitus. Most of the respondents were male (62.8%) and had a median age of 57 (39-87) years. In this study, the TNF-alpha levels were 87.28 (18.43-846.05) pg/ml. While the HOMA-IR level was 3.36 (0.41-25.82). There was no significant correlation between serum TNF Î± levels and HOMA-IR in type 2 DM patients (P> 0.05).Conclusion: There is no significant relationship between TNF Î± levels and HOMA-IR in type 2 DM patients.

Hubungan hipertensi dengan stroke pada pasien Poliklinik Neurologi RSUP Sanglah Denpasar I Made Fermi Wikananda; Ida Bagus Kusuma Putra; I Wayan Widiantara
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Introduction: Stroke is a disease which has a fairly high morbidity and mortality caused by the cessation of blood supply to the brain. The most common risk factor for stroke is high blood pressure or hypertension. In patients with hypertension, blood vessel damage can be occured which triggers thrombosis and atherosclerosis, leads to non hemorrhagic stroke and also weak and thin blood vessels with aneurysms can be found that induce hemorrhagic stroke. This study aimed to determine the relationship of hypertension and stroke in patients at the Neurology Clinic in Sanglah General Hospital, DenpasarMethod: This study was a cross-sectional study involving 100 patients. Secondary data were taken from the medical records of hypertensive and/or stroke patients in the Neurology Clinic of Sanglah General Hospital, Denpasar, from January 1, 2017 to December 31, 2018.Result: The results of bivariate analysis showed a strong and significant relationship between hypertension and stroke (PR = 2.37; 95% CI PR: 1.03 â€“ 8.21; p = 0.04). There was a significant relationship between hypertension and stroke after being controlled by confounding variables (Î² = 1,267; odds ratio = 3,549; 95% CI: 10,801 - 1,166; p = 0,026). Diabetes mellitus, dyslipidemia, arrhythmia, smoking, obesity did not have a significant relationship with stroke.Conclusion: There was a significant relationship between hypertension and stroke in patients at the Neurology Clinic in Sanglah General Hospital, Denpasar.Â Latar Belakang: Stroke adalah sebuah penyakit yang memiliki morbiditas dan mortalitas cukup tinggi yang diakibatkan oleh terhentinya suplai darah ke otak. Faktor resiko dari stroke yang paling sering dijumpai adalah tekanan darah tinggi atau hipertensi. Pada pasien dengan hipertensi dapat terjadi kerusakan pembuluh darah yang memicu adanya trombosis dan aterosklerosis yang memicu stroke penyumbatan dan ditemukan pula pembuluh darah yang menjadi lemah dan menipis disertai aneurisma yang memicu stroke pendarahan. Penelitian ini bertujuan untuk mengetahui hubungan hipertensi dengan stroke pada pasien di Poliklinik Neurologi RSUP Sanglah Denpasar.Metode: Penelitian ini merupakan studi potong lintang dengan melibatkan sampel sebanyak 100 orang. Data sekunder diambil dari rekam medis pasien hipertensi dan/atau stroke di Poliklinik Neurologi RSUP Sanglah Denpasar periode 1 Januari 2017 sampai 31 Desember 2018.Hasil: Hasil analisis bivariat menunjukkan hubungan yang kuat dan bermakna antara hipertensi dan stroke (RP = 2,37; IK 95% RP: 1,03 â€“ 8,21; p = 0,04). Hubungan antara hipertensi dengan stroke setelah dikontrol dengan variable-variabel perancu didapatkan hubungan yang signifikan (Î² = 1,267; odds ratio = 3,549; IK 95%: 10,801 - 1,166; p = 0,026). Diabetes melitus, dislipidemia, aritmia, merokok, obesitas tidak memiliki hubungan yang bermakna dengan stroke.Simpulan: Terdapat hubungan yang bermakna antara hipertensi dengan stroke pada pasien yang datang ke Poliklinik Neurologi RSUP Sanglah Denpasar.

Karakteristik profil pasien urtikaria akut di poliklinik kulit dan kelamin Rumah Sakit Umum Pusat (RSUP) Sanglah periode Oktober 2017- 2018 Gede Mahadika Pradipta Atmaja; Nyoman Suryawati; Luh Made Mas Rusyati
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Acute urticaria is a skin disorder that is often encountered that can cause redness to respiratory obstruction so that emergency emergencies and urticaria lesions that last more than 72 hours are indicative of hospitalized patients. This study aims to describe the characteristics of acute urticaria at Dermato-Venerology Polyclinic, Sanglah General Hospital during October 2017-2018 period.Methods: A cross-sectional study was conducted using secondary data from medical records of patients with urticaria in Sanglah General Hospital in the October 2017-2018 period. Data retrieval was taken by the Total Sampling method. Distribution of research variables namely, gender, age, genetic, causative factors, were collected. Data analysis is described in the form of tables and narratives using SPSS version 20 for Windows.Results: The results showed that there were 23 acute urticaria patients in this study, the age of the most research samples was in the Adult age category with a large percentage of 60.87%, the most gender-based study sample was female gender with a percentage of 78.3%, research genetic samples most of them are in the absence of genetics, with a percentage of 91.3%, the work of most research samples in housewives with a percentage of 34.8%, the most common cause of acute urticaria is in food allergies with a percentage of 56.5%.Conclusion: The incidence of acute urticaria is most common in adulthood, female sex, housewives, and food allergies.

Correlation between extracurricular activities and academic performances among preclinical medical students in Udayana University, Bali, Indonesia Muhammad Faisal Putro Utomo; Ida Ayu Dewi Dhyani; I Gusti Agung Ayu Andra Yusari; I Putu Hendri Aryadi; Ni Putu Diah Utami Darmayanti; I Gde Haryo Ganesha
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Medical students are required to develop ability and clinical skill to carry out the profession. Soft skill is also important to enhance the studentsâ€™ performance when facing real-life situation in community. It can be developed through extracurricular activity which trains positive behavior, time management, and social aspect. This study was aimed to explore the correlation between extracurricular activities and academic performances among medical students in preclinical phase.Summary of Work: A cross-sectional study with total of 221 medical students of Udayana University in preclinical phase. Data were taken from data collecting by Student Executive Board for Credit Point of Participation which was the indicator of extracurricular activities and grouped into active and not active. Data were also taken from Academic Affairâ€™s registered data (Grade Point Average (GPA) and gender). GPA was the indicator of academic performance and grouped into good and average. Data were analyzed using univariate and bivariate analysis (Chi Square Test with Cramerâ€™s V).Summary of Results: From 221 medical students (males 43.9%; females 56.1%), 48% are active participants of extracurricular programs. Fifty-nine medical students had good GPA and 162 medical students had average GPA. The mean score of Credit Point of Participation are 116.545Â±65.79 and GPA is 3.3781Â±0.282 (out of possible 4). Our study showed a positive correlation between extracurricular activities and academic performance (r=0.2; p=0.003).Discussion & Conclusions: Medical students who are active participants in extracurricular programs have better academic performance than those who are passive. This finding may have similar result to some previous studies. Extracurricular activities lead to positive impact in academic achievement, because it can decrease any academic stress and tension, which lead into more productivity in their learning.

Perbedaan rasio neutrofil-limfosit terhadap lama rawat anak dengan pneumonia di Ruang Kaswari, RSUD Wangaya, Denpasar, Bali, Indonesia I Kadek Serisana Wasita; Putu Andrie Setiawan; I Wayan Bikin Suryawan; Anak Agung Made Widiasa
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Pneumonia is one of the most common causes of lower respiratory tract infections and ranked second to the cause of infant mortality (23.8%) and toddlers (15.5%) in Indonesia. The neutrophil-lymphocyte ratio (NLR) can be used as an indicator of the systemic inflammatory response due to pneumonia infection. This study aims to determine the difference in the value of RNL and the outcome of pediatric pneumonia.Methods: Analytical observational study with cross-sectional study design was conducted among 40 children with pneumonia who were admitted to the Kaswari Room at Wangaya Hospital in Denpasar City from January 2018 - March 2019 and fulfilled the inclusion criteria and exclusion criteria. The sample is determined by consecutive sampling. In this study, data regarding complete blood count were obtained from medical record register books (documentation). Data were analyzed using SPSS version 24 for Mac OSX.Result: There was no significant difference between patients with pneumonia who were hospitalized â‰¤ 4 days with those hospitalized> 4 days (P>0.05). Most of the samples were between 1 month to 1 year (62.5%) and more were male samples (55). There is a significant difference in the value of NLR (1.18 (0.07-13.83); p = 0.028) for the length of stay.Conclusion: There are significant differences in the value of the neutrophil-lymphocyte ratio in the length of stay of pediatric patients with pneumonia in the Kaswari room of Wangaya Hospital, Denpasar City.Â Latar Belakang: Pneumonia merupakan salah satu penyebab infeksi saluran napas bawah terbanyak menduduki peringkat kedua penyebab kematian bayi (23,8%) dan balita (15,5%) di Indonesia. Rasio neutrofil-limfosit (RNL) dapat digunakan sebagai salah satu indikator terhadap respon inflamasi sistemik akibat infeksi pneumonia. Penelitian ini bertujuan untuk mengetahui perbedaan nilai RNL pada luaran penyakit pneumonia anak.Metode: Penelitian observasional analitik dengan rancangan penelitian cross sectional dilakukan terhadap 40 pasien anak dengan pneumonia yang dirawat di Ruang Kaswari RSUD Wangaya Kota Denpasar sejak bulan Januari 2018 â€“ Maret 2019 serta memenuhi kriteria inklusi dan kriteria eksklusi Sampel ditentukan dengan cara consequtive sampling. Data tentang darah lengkap pada penelitian ini diperoleh dari buku register rekam medis (dokumentasi). Data dianalisis dengan SPSS versi 24 untuk Mac OSX.Hasil: Tidak terdapat perbedaan bermakna antara pasien pneumonia yang dirawat inap â‰¤ 4 hari dengan yang dirawat inap > 4 hari (P>0,05). Sebagian besar sampel berusia antara 1 bulan hingga 1 tahun (62,5%) dan lebih banyak yang sampel berjenis kelamin laki-laki (55). Terdapat perbedaan nilai RNL yang signifikan (1,18 (0,07-13,83); p=0,028) pada lama rawat inap.Simpulan: Â Terdapat perbedaan bermakna nilai rasio neutrofil-limfosit pada lama rawat pasien anak dengan pneumonia di ruang Kaswari RSUD Wangaya Kota Denpasar.

Profil anak dengan ketergantungan internet di SMPN 2 Denpasar I Gusti Ngurah Agung Jayadhi Widyakusuma; I Made Darma Yuda; I Gusti Ngurah Made Suwarba
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: The internet is technology that developed is very fast in recent years. Development of internet may occur positive and negative effect. Survey that conducted in 2017 in Indonesia, according to gender showed that males (51,43%) are more than females in using the internet. The purpose of this research was to know internet addiction profiles and relationship between internet addiction and gender in SMPN 2 Denpasar students.Methods: The study design was a cross sectional study with total sampling. The data were taken from students by using questionnaire at SMPN 2 Denpasar. The result was analyzed by univariate and bivariate method using chi-square test.Results: There are 366 subjects included in this study. 198 samples were males, and 168 samples were females. Based on the analyzed result, it confirmed that the internet addiction relates significantly with gender (p-value = 0.048) (p < 0.05). Univariate analysis showed that 21,8% were suffer mild internet addiction and 4,3% were suffer moderate internet addiction. Males were suffering internet addiction more than females. Internet was mainly used to play game online and chatting were smartphone are the most device-used to access the internet. Basic needs were the most activities that can stop internet access. The most duration of internet usage are 2-4 hours/day and <40 hours/week.Conclusions: From the result of this study, can be concluded that there is a significant relationship between internet addiction and gender in SMPN 2 Denpasar students.Latar Belakang: Internet merupakan teknologi yang berkembang pesat dalam beberapa tahun terakhir. Perkembangan internet dapat menimbulkan berbagai dampak positif dan negatif. Survei tahun 2017 di Indonesia, komposisi pengguna internet di Indonesia berdasarkan jenis kelamin menunjukkan bahwa laki-laki (51,43%) lebih banyak dibandingkan perempuan (48,57%). Tujuan penelitian ini adalah mengetahui profil kejadian ketergantungan internet dan hubungan ketergantungan internet terhadap jenis kelamin pada siswa SMPN 2 Denpasar.Metode: Desain penelitian adalah cross-sectional study dengan total sampling. Data bersumber dari kuisoner yang diisi oleh siswa SMPN 2 Denpasar. Analisa data dilakukan secara bertahap yaitu analisa univariat dan analisa bivariat menggunakan chi-square test.Hasil: Terdapat 366 subjek yang diteliti. Didapatkan 198 sampel laki-laki, dan 168 sampel perempuan. Hasil penelitian menunjukkan ketergantungan internet berhubungan secara bermakna dengan jenis kelamin p=0.048 (p<0.05). Sebanyak 21,8% responden mengalami ketergantungan internet ringan dan 4,3% mengalami ketergantungan internet sedang. Berdasarkan jenis kelamin, laki-laki lebih banyak mengalami ketergantungan internet. Penggunaan internet terbanyak adalah untuk bermain game online dan chatting. Smartphone merupakan gawai terbanyak yang digunakan untuk mengakses internet. Kebutuhan dasar merupakan kegiatan yang paling dominan menghentikan kegiatan berinternet. Durasi menggunakan internet terbanyak adalah 2-4 jam dalam sehari dan <40 jam dalam seminggu.Simpulan: Berdasarkan hasil penelitian ini dapat disimpulkan bahwa terdapat hubungan yang bermakna antara kecanduan internet dengan jenis kelamin pada siswa SMPN 2 Denpasar.

Pola Mikroba dan Sensitivitasnya Terhadap Antibiotik pada Pasien dengan Infeksi Saluran Kemih di RSUD Prof. Dr. W.Z. Johannes, Kupang Periode Januari-Desember 2017 Vivi Anggelia; Clarissa Oktavia; Heri Sutrisno; Hermi Indita
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Urinary tract infection (UTI) is a serious public health problem which involves infection of any parts of the urinary tract. In the past few years, treatment of UTI becomes very challenging due to increase emergence of antibiotics resistance in uro-pathogens. This study was performed to determine microbial patterns and its sensitivity to antibiotics.Methods: This was an observational descriptive study. The data were collected from 130 urine samples in RSUD Prof. Dr. W.Z. Johannes during period of January-December 2017. Patients were diagnosed UTI by using Vitek 2.Results: We obtained 130 samples of urine culture in RSUD. Prof. Dr. W. Z. Johannes during period of January-December 2017. From 130 samples of urine culture, 83 samples showed growth of bacteria and fungi (63,85%) whereas 47 samples showed no growth (36,15%). From 83 growth samples, we identified 20 types of bacteria which include 4 types of gram positive bacteria, 16 types of gram negative bacteria and 1 type of fungi. The most common causes of UTI were E. coli (22,89%), Candida albicans (10,84%), Klebsiella pneumoniae ss pneumoniae (9,64%) and Acinetobacter baumanii (6,02%). Meropenem, gentamycin and amikacin were still sensitive to uropathogen. The most common antibiotics which were resistance to bacteria were ampicillin and ceftriaxone.Conclusion: Escherichia coli is the most prevalence contribute to UTI in outpatient and inpatient. There were only three types of non-resistant antibiotic to uropathogens.Â Latar Belakang: Infeksi saluran kemih (ISK) merupakan salah satu masalah kesehatan serius. Beberapa tahun belakangan ini, pengobatan ISK menjadi tantangan tersendiri bagi para klinisi karena tingginya angka resistensi antibiotik. Penelitian ini bertujuan untuk mengetahui pola mikroba dan senstivitasnya terhadap antibiotik.Metode: Pada penelitian deskriptif observasional ini, didapatkan 130 sampel urin di RSUD Prof. Dr. W.Z. Johannes dari bulan Januari-Desember 2017 dimana pasien didiagnosis ISK melalui pemeriksaan dengan Vitek 2.Hasil: Sebanyak 130 sampel urin yang dikultur, 83 sampel menunjukan perkembangan bakteri dan jamur (63,85%) dimana 47 sampel menunjukan tidak adanya pertumbuhan (36,15%). Dari 83 sampel yang tumbuh, teridentifikasi sebanyak 20 tipe bakteri dimana 4 tipe merupakan gram-positif dan 16 tipe gram negatif serta 1 tipe jamur. Penyebab terbanyak ISK adalah E. coli (22,89%), Candida albicans (10,84%), Klebsiella pneumoniae ss pneumoniae (9,64%) dan Acinetobacter baumanii (6,02%). Dimana antibiotik jenis meropenem, gentamisin dan amikasin masih sensitif untuk uropatogen. Sedangkan ampisilin dan seftriakson adalah jenis antibiotik yang memiliki angka resistensi tertinggi.Kesimpulan: Escherichia coli adalah penyebab tersering ISK dan hanya ditemukan tiga jenis antibiotik yang masih sensitif untuk uropatogen.

Hubungan antara perilaku duduk pengrajin ukir kayu dengan nyeri punggung bawah di Kecamatan Tegallalang, Gianyar, Bali Pande Nyoman Dhandy Wirakesuma; Anak Agung Sagung Sawitri; Komang Ayu Kartika Sari
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Low back pain is one of the health problems that are often encountered in workers. Some risk factors for low back pain are non-ergonomic sitting position, duration of work, working period, and rest breaks. Woodcarving craftsmen in Pupuan Village have a risk to experiencing low back pain complaint. The purpose of this study is determine whether sitting behaviors is related to low back pain.Methods: An analytical observational study, designed in the form of a cross sectional study to determine the relationship between sitting behaviours with low back pain in Pupuan Village. Samples selected by a non-random consecutive sampling produced 69 samples and analysed using SPSS version 17.Results: Most respondents complained of back pain (89.1%), especially in the lower back (85.5%), after work (95.2%), and improved with changes in sitting position (95.2%). The results of the bivariate analysis showed a significant relationship between age, sitting position, duration of work, length of work, and rest periods with complaints of low back pain (P <0.05).Conclusion: There is a significant relationship between age, sitting position, duration of work, working period, and rest breaks with of low back pain complaint in wood carving craftsmen in Pupuan Village.

Karakteristik Penderita Kusta Multi Basiller (MB) dengan Reaksi Erythema Nodosum Leprosum (ENL) di Poliklinik Kulit dan Kelamin RSUP Sanglah selama Tahun 2016-2018 Putu Ayu Saraswati; Luh Made Mas Rusyati; IGAA Dwi Karmila
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Introduction: Leprosy is still a burden on endemic countries such as Indonesia. As well as leprosy reaction is a problem associated with the cessation of treatment from leprosy patients. The purpose of this study was to do a description of the characteristics of leprosy patients with ENL reactions in the Skin and Sex Polyclinic of Sanglah Hospital Denpasar.Method: This study used a descriptive design with a retrospective approach conducted at the Skin and Sex Polyclinic of Sanglah General Hospital. A search related to the characteristics of leprosy patients who experienced an ENL reaction, then the data was presented in descriptive form.Results: Female gender tend to have more severe leprosy reactions (50%) compared to men. High income (50%), non-endemic area origin (44.8%), elementary school education level (44.4%), and active working (31.0%) tended to experience more severe leprosy reactions. And in this study more severe leprosy reactions were found in the multi-bacillary leprosy group (65.7%), whereas mild leprosy reactions were higher in the pauci-bacillary leprosy group (34.2%).Conclusion: The high rate of severe leprosy reaction requires special attention from both the government and health practitioners, so that there is an integrated management of leprosy, so that the population in Indonesia becomes healthier.

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