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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

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Articles 1,063 Documents

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Gelombang Brainstem Evoked Response Audiometry (BERA) pada anak di bawah lima tahun dengan keterlambatan bicara dan bahasa disertai gangguan pendengaran di RSUP Sanglah, Bali, Indonesia Ni Made Ary Wisma Dewi; I Made Wiranadha
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Hearing loss is one factor that influences speech and language development in children, especially in the first five years of life. The detection of hearing loss in a child can be done with an objective Brainstem Evoked Response Audiometry (BERA). This study aims to evaluate the value of BERA waves in children under five with speech and language delays at the ENT outpatient clinic of Sanglah General Hospital Denpasar.Methods: This study is a retrospective descriptive study design by taking secondary data from the medical records of patients with speech and language delays accompanied by hearing loss who were subjected to BERA examination. Samples were taken by consecutive sampling. Data analysis in this study consisted of descriptive statistical analysis, independent T test, and one-way ANOVA. Data were analyzed using SPSS version 24 for Windows.Results: This study involved 65 people as a sample. Based on gender, it was found that male (76.9%) was more than female (23.1%). Most of them were aged 24-35 months (43.1%). The most hearing loss was Moderate SNHL on the right ear (38.5%), while Mild SNHL on the left ear (38.5%). The mean latency time between I-V waves in the left ear of boys was longer, that was 4.96 ms with a variation of 0.56 ms, compared to 4.59 ms for girls with a deviation of 0.64 ms. There was a significant difference in the mean latency between waves I-V of the left ear between male and female toddlers (p=0.033).Conclusion: Based on the research, it was found that the absolute latency time and between waves of BERA on the right ear did not have a significant difference in boys and girls, but on the left ear, there was a statistically significant difference in the mean of latency time between waves IV in boys and girls. Latar Belakang: Gangguan pendengaran merupakan salah satu faktor yang mempengaruhi perkembangan bicara dan bahasa pada anak terutama pada lima tahun pertama kehidupan. Deteksi gangguan pendengaran pada seorang anak dapat dilakukan dengan pemeriksaan Brainstem Evoked Response Audiometry (BERA) yang objektif. Penelitian ini bertujuan untuk melihat nilai gelombang BERA pada anak balita dengan keterlambatan bicara dan bahasa di Poliklinik THTKL RSUP Sanglah Denpasar.Metode: Penelitian ini menggunakan rancangan penelitian deskriptif retrospektif dengan mengambil data sekunder dari catatan medis pasien keterlambatan bicara dan bahasa disertai gangguan pendengaran yang dilakukan pemeriksaan BERA. Sampel diambil dengan cara consecutive sampling. Analisis data pada penelitian ini terdiri dari analisis statistik deskriptif, uji T independen, dan one way ANOVA. Data dianalisis dengan SPSS versi 24 untuk Windows.Hasil: Penelitian ini melibatkan 65 orang sebagai sampel. Berdasarkan jenis kelamin didapatkan jenis kelamin laki-laki (76,9%) lebih banyak dari perempuan (23,1%). Usia terbanyak pada usia 24-35 bulan (43,1%). Gangguan pendengaran paling banyak yaitu SNHL Sedang pada telinga kanan (38,5%), sedangkan pada telinga kiri SNHL Ringan (38,5%). Rerata masa laten antar gelombang I-V pada telinga kiri balita laki-laki lebih panjang yaitu 4,96 ms dengan variasi 0,56 ms, dibandingkan balita perempuan 4,59 ms dengan variasi 0,64 ms. Terdapat perbedaan bermakna rerata masa laten antar gelombang I-V telinga kiri antara balita laki-laki dan perempuan (p=0,033).Simpulan: Berdasarkan penelitian didapatkan bahwa masa laten absolut dan antar gelombang BERA pada telinga kanan tidak ada perbedaan bermakna pada balita laki-laki dan perempuan, namun pada telinga kiri secara statistik terdapat perbedaan bermakna rerata masa laten antar gelombang I-V pada balita laki-laki dengan perempuan.

Faktor risiko yang mempengaruhi outcome pada pasien cedera kepala di RSUP Sanglah, Bali, Indonesia pada tahun 2018-2019 I Gede Sutawan; Sri Maliawan; I Wayan Niryana
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Head injury or capitis trauma is a blunt/sharp force to the head or face resulting in temporary or persistent cerebral dysfunction. From a socio-economic point of view, the prognostic model by looking at baseline data on admission is an important factor in supporting cost-effective clinical decisions. This study aims to evaluate the risk factors that influence outcomes in head injury patients at Sanglah Hospital, Bali, Indonesia, in 2018-2019.Method: Prospective cohort study to see the effect of risk factors for head injury patients (exposure) with the outcome in the form of unfavorable conditions within 7 days. This research was conducted at the Surgery Department and Emergency Room Sanglah Hospital Denpasar- Bali for 6 months from September 2018-February 2019. Data were analyzed using SPSS version 16 for Windows.Results: Some of the factors significantly associated with and risk factors for the unfavorable outcome within 7 days in head injury patients who were treated at Sanglah General Hospital in 2018-2019 were hypotension, initial GCS 3-8, anisocoria pupil reflex, hypoxia, focal lesions, midline shift, and length of time operation ? 6 hours (p<0.05). Hypotensive blood pressure is the most dominant risk factor for the unfavorable outcome within 7 days of head injury patients admitted to Sanglah General Hospital (Adjusted OR: 5.4; 95% CI: 2.47-12.07; p=0.000).Conclusion: Hypotensive blood pressure is the most dominant risk factor for the unfavorable outcome within 7 days of head injury patients treated at Sanglah General Hospital in 2018-2019. Latar belakang: Cedera kepala atau trauma kapitis merupakan kekerasan tumpul/tajam pada kepala atau wajah yang berakibat disfungsi serebral sementara atau menetap. Dari sudut pandang sosioekonomi, model prognostik dengan melihat data awal saat masuk rumah sakit merupakan faktor penting dalam mendukung keputusan klinis yang cost-effective. Penelitian ini bertujuan untuk mengevaluasi faktor risiko yang mempengaruhi outcome pada pasien cedera kepala di RSUP Sanglah, Bali, Indonesia pada tahun 2018-2019Metode: Studi kohort prospektif untuk melihat pengaruh faktor resiko yang dimiliki pasien cedera kepala (exposure) dengan hasil luaran (outcome) berupa kondisi unfavourable dalam 7 hari. Penelitian ini dilakukan di Bagian Bedah FK UNUD/SMF Bedah Saraf RSUP Sanglah, Denpasar-Bali dan Instalasi Rawat Darurat RS Sanglah Denpasar-Bali selama 6 bulan dari bulan September 2018-Februari 2019. Data dianalisis menggunakan SPSS versi 16 untuk Windows.Hasil: Beberapa faktor yang berhubungan secara bermakna dan menjadi faktor risiko terjadinya outcome unfavorable dalam 7 hari pada pasien cedera kepala yang dirawat di RSUP Sanglah tahun 2018-2019 adalah hipotensi, GCS awal 3-8, reflek pupil anisokor, hipoksia, fokal lesi, midline shift, dan lama waktu tindakan operasi ? 6 jam (p<0,05). Tekanan darah hipotensi merupakan faktor risiko yang paling dominan terhadap outcome unfavorable dalam 7 hari pasien cedera kepala yang dirawat di RSUP Sanglah (Adjusted OR: 5,4; 95% IK: 2,47-12,07; p=0,000)Kesimpulan: Tekanan darah hipotensi merupakan faktor risiko yang paling dominan terhadap outcome unfavorable dalam 7 hari pasien cedera kepala yang dirawat di RSUP Sanglah tahun 2018-2019.

Sindroma Bartter pada laki-laki berusia 44 tahun: laporan kasus Anak Agung Ayu Lydia Prawita; Anak Agung Wiradewi Lestari; Sianny Herawati; Ni Kadek Mulyantari; Ni Komang Krisnawati; Ekarini Katharina Yunarti Nabu
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Bartter's syndrome is a hereditary condition characterized by polyuria, hypokalemia, metabolic alkalosis with normal or slightly low blood pressure due to loss of sodium and renal hyperplasia. Most Bartter syndrome occurs in children and is very rare in adulthood, with a prevalence of 1 in 1,000,000 populations. This case report aims to evaluate the laboratory aspects of Bartter's syndrome in a 44-year-old man at Sanglah Hospital, Bali, Indonesia.Case Presentation: A 44-year-old male patient complaining of vomiting and weakness. Other complaints such as diarrhea, fever, shortness of breath, stiffness and seizures are denied. The patient's previous medical history, treatment history, and family history were denied. Physical examination showed a general weakness with hypotension and polyuria. On laboratory examination, there was severe hypokalemia, hypocalcemia, hypomagnesemia, increased urinary potassium levels, increased urinary chloride levels, and metabolic alkalosis. To differentiate with Gitelman syndrome, an examination of the ratio of urine calcium and creatinine is performed. In this patient, the urine calcium and creatinine ratio increased, which indicated Bartter's syndrome. Patients receive electrolyte replacement therapy.Conclusion: Bartter syndrome is very rare in adulthood. Several tests are needed to make the diagnosis in accordance with the diagnostic approach of hypokalemia, namely electrolyte examination in urine serum, urine creatinine, and blood gas analysis. Latar Belakang: Sindroma Bartter merupakan suatu kondisi herediter yang ditandai oleh poliuria, hipokalemia, metabolik alkalosis dengan tekanan darah normal atau sedikit rendah karena kehilangan natrium dan hiperplasia ginjal. Sebagian besar sindroma Bartter terjadi pada anak-anak dan sangat jarang terjadi pada usia dewasa dengan prevalensi 1 dalam 1.000.000 populasi. Laporan kasus ini bertujuan untuk mengevaluasi aspek laboratorium sindroma Bartter pada laki-laki berusia 44 tahun di RSUP Sanglah, Bali, Indonesia.Presentasi Kasus: Pasien laki-laki 44 tahun dengan keluhan muntah dan lemas. Keluhan lain seperti diare, demam, sesak nafas, kaku dan kejang tidak ada. Riwayat penyakit sebelumnya, riwayat pengobatan, dan riwayat penyakit pada keluarga disangkal pasien. Pada pemeriksaan fisik didapatkan keadaan umum lemah dengan hipotensi dan poliuria. Pada pemeriksaan laboratorium ditemukan hipokalemia berat, hipokalsemia, hipomagnesemia, peningkatan kadar kalium urine, peningkatan kadar klorida urine, dan alkalosis metabolik. Untuk membedakan dengan sindroma Gitelman dilakukan pemeriksaan rasio kalsium dan kreatinin urine. Pada pasien ini didapatkan hasil rasio kalsium dan kreatinin urine yang meningkat, yang mengindikasikan sindroma Bartter. Pasien mendapatkan terapi penggantian elektrolit .Kesimpulan: Sindroma Bartter sangat jarang terjadi pada usia dewasa. Beberapa pemeriksaan diperlukan untuk menegakkan diagnosis sesuai dengan alur pendekatan diagnostik hipokalemia yaitu pemeriksaan elektrolit pada serum urine, kreatinin urine, dan analisis gas darah.

Disseminated Intravascular Coagulation (DIC) akibat gigitan ular: laporan kasus Ni Komang Krisnawati; Ida Ayu Putri Wirawati; Sianny Herawati; Ni Nyoman Mahartini; Anak Agung Ayu Lydia Prawita; Ekarini Katharina Yunarti Nabu
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Snakebite cases are cases of emergency that are often found in the Emergency Unit, especially in rice fields, forests, plantations and swamps. There is no definitive data on the number of snakebite cases in Indonesia. Morbidity and mortality of snakebite cases are highly dependent on the type of snake species, the number and type of can that enter the body, as well as the availability of anti-snake serum.In these patients were found Disseminated Intravascular Coagulation (DIC) due to snake bites.Case Presentation: A 5-years female patient complained of pain in the right hand due to snakebite about 30 minutes before entering the hospital. The snake is green with a red tail, a triangular head shape and a length of about 30 centimeters, biting the middle finger of the patient's right hand. Swollen redness and pain are felt spreading to the shoulders. Physical examination of compos mentis patients with a pulse rate of 96 times per minute, breath rate of 20 times per minute and temperature of 36.7oC. There was found edema and bullae in digiti III in the right manus region, palpably warm, and there is press pain. In the antebrachial region to the right humerus also found the presence of edema and press pain. Patients with normochromic normositer anemia with thrombocytopenia as well as lengthening of coagulation physiology decreased fibrinogen and increased D-dimer.Conclusion: Snake venom can be hemotoxic, neurotoxic and cytotoxic. Snakebite cases require rapid and comprehensive management to minimize the possibility of disability and death. Latar Belakang: Kasus gigitan ular merupakan kasus kegawatan yang sering dijumpai di Unit Gawat Darurat terutama di daerah area persawahan, hutan, perkebunan dan rawa. Tidak ada data yang pasti mengenai jumlah kasus gigitan ular di Indonesia. Morbiditas dan mortalitas kasus gigitan ular sangat tergantung dari jenis spesies ular, jumlah dan jenis bisa yang masuk ke dalam tubuh serta ketersediaan serum anti bisa ular.Presentasi Kasus: Pada pasien ini ditemukan Disseminated Intravascular Coagulation (DIC) akibat gigitan ular. Pasien perempuan, usia 5 tahun dengan keluhan nyeri pada tangan kanan akibat gigitan ular sejak sekitar 30 menit sebelum masuk rumah sakit. Ular berwarna hijau dengan ekor merah, bentuk kepala segitiga dan panjang sekitar 30 centimeter, menggigit jari tengah tangan kanan pasien. Bengkak kemerahan dan nyeri dirasakan menjalar sampai ke bahu. Pemeriksaan fisik pasien compos mentis dengan laju nadi 96 kali per menit, laju nafas 20 kali per menit dan suhu 36,7oC. Pada regio manus kanan ditemukan adanya edema dan bullae pada digiti III, teraba hangat dan terdapat nyeri tekan. Pada region antebrachii sampai humerus kanan juga ditemukan adanya edema dan nyeri tekan. Pasien mengalami anemia normokromik normositer dengan trombositopenia serta pemanjangan faal koagulasi, penurunan fibrinogen dan peningkatan D-dimer.Kesimpulan: Bisa ular dapat bersifat hemotoksik, neurotoksik dan sitotoksik. Kasus gigitan ular memerlukan penatalaksanaan yang cepat dan komprehensif sehingga dapat meminimalkan kemungkinan kecacatan dan kematian.

Membedah peran bank sampah guna menilik efektivitas pengelolaan limbah medis B3 rumah sakit I Nyoman Yustra Karna; I Nyoman Rasmen Adi
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: The implementation of the waste bank to reduce the cost of hazardous and toxic medical waste management needs to be optimized so that it is effective to reduce costs and additional hospital income.Aim: The study aims to determine the factors causing the non-optimal management of medical waste at Surya Husadha Hospital through the implementation of the waste bank.Methods: This study applied a qualitative approach with purposive sampling at Surya Husadha Hospital. Data were collected through observation, in-depth interviews and documentation from six informants. Result: Some obstacles cause the implementation of the waste bank at Surya Husadha Hospital in reducing medical waste management costs to be not optimal, such as limited human resources and equipment. This obstacle causes only two of the four types of medical waste according to the Regulation of the Minister of Environment and Forestry of the Republic of Indonesia No. 56 of 2015, which can be managed through waste banks such as used infusion bottles and used hemodialysis fluid packaging.Conclusion: The implementation of the waste bank at Surya Husadha Hospital has met the proper regulation, but it is necessary to evaluate the constraints, and planning for the needs of human resource and equipment in reducing medical waste management costs. Latar Belakang: Penerapan bank sampah dalam membantu beban biaya pengelolaan limbah medis bahan berbahaya dan beracun (B3) perlu lebih dioptimalkan sehingga bisa efektif untuk meringankan biaya sekaligus bisa sebagai pendapatan tambahan untuk rumah sakit.Tujuan: Studi ini bertujuan untuk mengetahui faktor-faktor penyebab kurang optimalnya pengelolaan limbah medis B3 di Rumah Sakit Umum (RSU) Surya Husadha melalui pemberdayaan bank sampah.Metode: Penelitian ini menggunakan pendekatan kualitatif dengan purposive sampling di RSU Surya Husadha. Teknik pengumpulan data yang dilakukan adalah melalui observasi, wawancara mendalam serta dokumentasi dari enam informan.Hasil: Ditemukan adanya beberapa kendala yang menyebabkan penerapan bank sampah di RSU Surya Husadha dalam mengurangi beban biaya pengelolaan limbah medis B3 menjadi kurang optimal. Kendala tersebut berupa keterbatasan sumber daya manusia serta keterbatasan ketersediaan sarana prasarana. Adanya kendala tersebut menyebabkan dari empat jenis limbah medis B3 yang bisa dikelola melalui bank sampah sesuai Peraturan Menteri Lingkungan Hidup dan Kehutanan (LHK) RI No 56 Tahun 2015 hanya dua yang bisa dikelola yaitu botol infus bekas dan bekas kemasan cairan hemodialisis.Kesimpulan: Pelaksanaan pengelolaan limbah medis B3 di RSU Surya Husadha sudah sesuai regulasi, namun evaluasi terhadap kendala-kendala, perencanaan kebutuhan tenaga, dan juga pengadaan sarana prasarana yang dibutuhkan dalam menunjang kegiatan bank Sampah sangat diperlukan untuk membantu mengurangi biaya pengelolaan limbah medis B3.

Adverse skin reactions of healthcare workers using N95 mask and latex gloves at Kasih Ibu Denpasar General Hospital Bali Indonesia during coronavirus disease 2019 (COVID-19) pandemic – a descriptive study Firly Clarissa Suyanto; Ariana Ariana; Ni Made Dwi Puspawati
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Introduction: Corona virus disease 2019 (COVID-19), caused by SARS-CoV-2, was first identified in Wuhan, Hubei Province, China in December 2019. World Health Organization (WHO) then officially declared the disease as a global pandemic in March 2020. It has rapidly spread throughout the world, causing a huge burden to the health sector. With the increasing number of cases, healthcare workers (HCWs) were exposed to the regular use of personal protective equipment (PPE) such as N95 masks, latex gloves, and gowns. As a result of long term use of PPE, many adverse skin reactions may occur. Hence, this study aims to determine the adverse skin reactions among healthcare workers using PPE.Method: This study is a cross-sectional descriptive study conducted at Kasih Ibu Denpasar General Hospital Bali Indonesia. Questionnaires were used for the research. A total of 45 valid questionnaires were collected, with the majority being women (88.9%) and with an age range of 20 – 30 years old (55.6%).Result: The result showed that the most common adverse skin reactions among HCWs wearing N95 masks were indentation and ear pain (73.3%) and nasal bridge scarring (48.9%). The most common adverse skin reactions among HCWs wearing latex gloves were dry skin (46.7%) and skin soaked with sweat (17.8%).Conclusion: Our study explored the adverse skin reactions due to long term use of PPE, N95 mask and latex gloves in particular. These adverse skin reactions are mostly mild because they continue using PPE.

Mechanism of action of metformin as an anti-aging agent: a literature review Aceng Hamudin; Nur Atik
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Aging is a complex process consisting of various mechanisms that can cause damage and decrease the body's extrinsic and intrinsic functions. Metformin has been indicated for the treatment of degenerative diseases. It also has been reported to be used as an anti-aging agent. Various studies reported different mechanisms of action, but human studies are limited. This literature aims to review the multiple mechanisms of action of metformin as an anti-aging agent. Metformin has been reported to exert anti-aging effects by prolonging life in humans and animals. The effectiveness of metformin as an anti-aging agent is influenced by the dosage and age of the subjects studied. Various mechanisms of action of metformin concerning anti-aging have been reported, including autophagy pathways with AMPK activation and inhibition of mTOR, increased antioxidants, inhibition of ROS, inhibition or enhancement of mitochondrial function and inhibition of inflammation. It was found that there were biomarkers in the form of GPx7, Nrf2, PPAR and SREBP, SOD2, TrxR1, NQO1, NQO2, pNF-kB, FOXO, mTOR, AMPK, which could be used as predictors to explain the anti-aging effect of metformin.

The effect of Modified Radical Mastectomy (MRM) with and without latissimus dorsi flap on seroma of Locally Advanced Breast Cancer (LABC) in Sanglah Hospital Anak Agung Chris Tedy Pramana; I Ketut Widiana; I Gde Raka Widiana
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Locally Advanced Breast Cancer (LABC) is defined as breast cancer spread locoregionally and without any signs of metastasis. Stage IIIA breast cancer is one type of LABC that can be removed surgically, and Modified Radical Mastectomy (MRM) remains the first surgical option. Seroma production is one of the most common complications post MRM, with the hypothesis stating that the Latissimus Dorsi (LD) flap technique is responsible for resulting in higher seroma output. This study aims to compare seroma production in LABC patients post MRM with and without LD flap.Methods: This prospective cohort study was conducted in Sanglah General Hospital, Denpasar, between November 2018 and January 2020. The study sample was divided into 2 groups: LABC patients post MRM with and without LD flap reconstruction. Seroma was measured in milliliters (ml) and collected from the first to fifth day post-operation. Data were analyzed using SPSS version 21 for Windows.Results: Forty LABC patients were enrolled in this study. The mean age for the group without latissimus dorsi flap was 48.45±7.01 years and 49.40±10.77 years for the group with latissimus dorsi flap. The mean seroma production in LABC patients who underwent MRM without and with LD flap reconstruction was 696.45±66.37 ml and 490.10±62.11 ml. There was a significant difference in the total of seroma between the treatment group without-LD flap and compared to with-LD flap reconstruction (p<0.001).Conclusion: Seroma production is significantly higher in LABC patients post MRM without LD flap reconstruction than LABC patients with LD flap.

Neutrophil-Lymphocyte Ratio (NLR) as an output-outcome predictor in moderate-severe head injury at Sanglah General Hospital, Denpasar, Indonesia Melissa Krisanty; Tjokorda Gde Bagus Mahadewa; I Wayan Niryana; I Nyoman Semadi; I Gede Suwedagatha; I Gusti Agung Bagus Krisna Wibawa
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: This prospective cohort study aims to determine the best cut point value and the ability to predict Neutrophil Lymphocyte Ratio (NLR), analyze the most dominant factors, and the direct influence of the NLR to output and outcome in moderate and severe trauma to the head injury at Sanglah General Hospital, Denpasar, Indonesia.Methods: This study was an observational analytic with a prospective cohort design. The subjects of this study were head injury patients over 16 years old with Glasgow Coma Scale (GCS) ? 12 who visited and were treated at Sanglah General Hospital, Denpasar, Indonesia. Patients less than 16 years old, history of alcohol intoxication, stroke, metabolic disease, and multiple traumas were not included as research subjects. Data were analyzed using SPSS version 20 for Windows.Results: The research conducted on 49 respondents found that the best cut-off point of NLR was 6.05 has the most significant predictor (OR=7.6; p=0.001) and dominant (OR=64.97; p=0.002) factors to the output-outcome predictor in moderate-severe head injury. In addition, this cut-off value (6.05) also has a direct influence (x-value=0.523) in the occurrence of output and outcome unfavorable in moderate-severe head injury.Conclusion: the cut-off NLR values of 6.05 became the dominant predictor that directly affected the output and outcome unfavorable in moderate-severe head injury.

Perbandingan kadar Thyroid Stimulating Hormone (TSH) dan kadar Free T4 (FT4) antara metode Fluorescence Immunoassay (FIA) dan metode Electrochemiluminescence Immunoassay (ECLIA) di RSUP Sanglah, Bali, Indonesia Ekarini Katharina Yunarti Nabu; Sianny Herawati; Ni Kadek Mulyantari; Anak Agung Wiradewi Lestari; I Putu Yuda Prabawa
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Diagnostic and therapeutic cases of hyperthyroidism can be identified by examining the levels of Thyroid Stimulating Hormone (TSH) and Free T4 (FT4). There are several examination methods, namely the Fluorescence Immunoassay (FIA) and the Electro-Chemiluminescence Immunoassay (ECLIA) method. This study aims to evaluate the difference in TSH and FT4 level in the FIA method and ECLIA method.Method: This study used observational analytic methods cross sectional design, with 45 samples serum patient with hyperthyroid in January-March 2019. Examine level TSH and FT4 levels with FIA methods (NANO ENTEK FRENDTM) and ECLIA method (Cobas e601 ROCHE). Data were analyzed using SPSS version 17 for Windows.Results: Most of the respondents were aged 25-34 years (28.8%) and female (86.7%). There was no significant difference in the mean TSH level on examination using the ECLIA method (0.60±0.79 mIU/L) and the FIA method (0.63±0.76 mIU/L) (p=0.639). In addition, there was no significant difference in FT4 both in the examination using the ECLIA method (1.67±1.05 ng/dl) and the FIA method (1.69±1.72 ng/dl) (p=0.745).Conclusions: There was no significant difference between TSH and FT4 in both ECLIA and FIA methods. Latar Belakang: Diagnosis maupun pemantauan terapi kasus hipertiroid dapat diketahui dengan pemeriksaan kadar hormon Thyroid Stimulating Hormone (TSH) dan Free T4 (FT4). Terdapat beberapa metode pemeriksaan yaitu metode Fluorescence Immunoassay (FIA) dan metode Electro-Chemiluminescence Immunoassay (ECLIA). Penelitian ini bertujuan untuk mengevaluasi perbedaan kadar TSH dan FT4 metode FIA dan metode ECLIA.Metode: Penelitian ini menggunakan metode observasional analitik dengan desain potong lintang pada 45 sampel serum penderita hipertiroid selama periode Januari-Maret 2019. Dilakukan pemeriksaan kadar TSH dan FT4 dengan metode FIA (NANO ENTEK FRENDTM) dan metode ECLIA (Cobas e601 Roche). Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berusia 25-34 tahun (28,8%) dan berjenis kelamin perempuan (86,7%). Tidak terdapat perbedaan bermakna rerata kadar TSH pada pemeriksaan menggunakan metode ECLIA (0,60±0,79 mIU/L) maupun metode FIA (0,63±0,76 mIU/L) (p=0,639). Disamping itu, tidak juga terdapat perbedaan bermakna rerata kadar FT4 baik pada pemeriksaan menggunakan metode ECLIA (1,67±1,05 ng/dl) maupun metode FIA (1,69±1,72 ng/dl) (p=0,745).Kesimpulan: Tidak ada perbedaan yang bermakna antara kadar TSH dan FT4 pada metode ECLIA dan FIA.

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Bali

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

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Phone -

Journal Mail Official -

Editorial Address -

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota denpasar,

Bali

INDONESIA