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JCPS (Journal of Current Pharmaceutical Sciences)
Published by Universitas Muhammadiyah Banjarmasin
ISSN : 25982087     EISSN : 25982095     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Current Pharmaceutical Sciences is a scholarly journal and expects to Publish articles related to the science of pharmaceutical science became the main focus of the problem at this time. This journal may publish research results as well as the results of theoretical studies and reviews. JCPS has had an ISSN print version 2598-2087 and has an online version 2598-2095 since Vo. 1 No.1 year 2017.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "vol. 10 no. 2: september 2026" : 6 Documents clear
Phytochemical Screening and Determination of Total Flavonoid Content of Sangkareho (Callicarpa longifolia Lam.) Leaf Extracts Using Sequential Extraction and UV–Vis Spectrophotometry Noor Kamalia; Mi’rajunnisa; Siti Nashihah; Rara Nelia
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1717

Abstract

Sangkareho (Callicarpa longifolia Lam.), a plant in the Lamiaceae family, is utilized as traditional medicine in Kalimantan. Its leaves are rich in flavonoids, known for their pharmacological activities like antimicrobial, anti-inflammatory, and astringent properties. This study aimed to conduct phytochemical screening and to determine the total flavonoid content of sangkareho leaf extracts obtained through sequential extraction using n-hexane, ethyl acetate, and ethanol 96%, analyzed by UV- Vis spectrophotometry. Phytochemical screening showed that the sangkareho leaf extract contains flavonoids, tannins, saponins, steroids/triterpenoids, and alkaloids. Total flavonoid content was quantified using quercetin as the standard and expressed as quercetin equivalents (QE) per gram of extract.The Result was shown that, the average total flavonoid content in n-hexane, ethyl acetate, and 96% ethanol extracts were 43.93 QE/g extract, 65.80 QE/g extract, and 92.21 QE/g extract, respectively. The data processing by One Way Anova with a p value <0.05, indicating a significant influence of multistage extraction methods on determining the total flavonoid content in Sangkareho leaf extracts.
Formulation and Physical Stability Evaluation of a Clay Mask Containing Basil Leaf (Ocimum sanctum L.) Extract with Varying Kaolin and Bentonite Concentrations Rosa riauwati; Najwi Hasani; Wiwin Nadia; Hayatus Sa'adah
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1644

Abstract

Acne is a common skin problem experienced by teenagers and adults. One alternative plant that has the potential to overcome acne is basil leaves which can be formulated into a clay mask preparation. Claymask is used for oily or sensitive skin because of its ability to deeply cleanse the skin, absorb excess oil and detoxify the facial skin. The purpose of this study was to determine whether there were differences in the physical properties of claymask preparations before and after the stability test of physical properties with variations in kaolin and bentonite concentrations in claymask preparations from basil leaf extract. This research method was carried out by extracting basil leaves using the maceration method. The formulation of clay mask preparations from basil leaf extract used variations of kaolin and bentonite bases respectively, namely, F1 (25% and 3%), F2 (30% and 4%) and F3 (35% and 5%). Evaluation of the physical properties of the clay mask preparations included organoleptic tests, homogeneity, pH, spreadability, adhesiveness, viscosity, drying time and physical stability tests of the preparations using the cycling test method which was carried out for 6 cycles. The results showed that all formulas were declared stable because there was no significant difference in the physical properties of the preparations against the stability test carried out on the clay mask preparation from basil leaf extract, and all formulas in each test were declared good because the results showed that they were within the required range
Formulation and Antifungal Activity of Cymbopogon citratus Extract Lotion Against Trichophyton rubrum Syaidati Nur Annisa' Abidin; Nur Fahma Laili; Elsa Mahardika Putri
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1578

Abstract

The background of this study is based on the high prevalence of skin diseases due to fungal infections in Indonesia, which are often caused by unhygienic living habits and unclean environmental conditions. Lotion was chosen as the preparation because of its ease of application and its ability to maintain skin health. This study aims to develop and test the effectiveness of lemongrass (Cymbopogon citratus) extract lotion as an antifungal agent against Trichophyton rubrum fungus. The research method used was an experiment with lotion formulations containing lemongrass extract at various concentrations of 5%, 10%, and 15%. The effectiveness test was carried out using the well diffusion method to measure the fungal growth inhibition zone. The results showed that all lemongrass extract lotion formulas had antifungal activity, with formula 3 (15% concentration) showing the largest inhibition zone of 13 mm, which is included in the strong category. In addition, all lotion preparations met good physical quality test standards, both before and after the stability test. From the results of this study, it can be concluded that lemongrass extract lotion is effective as an antifungal agent against Trichophyton rubrum and can be an alternative natural treatment for fungal skin infections.
Antibacterial Activity of Acne Patch Preparation Combination of Ethanol Extract of Basil Leaves (Ocimum x africanum Lour.) and Binahong Leaves (Andredera cordifolia (Ten.) steenis) Rismayanti Fauziah; Nur Ikhfatul Jannah Rizal; Wa Ode ida Fitriah
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1642

Abstract

Basil leaves (Ocimum x africanum Lour.) and binahong leaves (Andredera cordifolia (Ten.) steenis) are known to have antibacterial activity that can inhibit acne-causing bacteria. The purpose of this study was to formulate an acne patch preparation combining ethanol extracts of basil leaves and binahong leaves and to determine the physical evaluation and antibacterial activity of the acne patch preparation. This study was analytical, using ethanol extracts of basil and binahong leaves obtained through maceration with 70% ethanol. Acne patches were formulated in four variations of extract concentrations, namely F0 (0%), FI (20% basil, 15% binahong), FII (25% basil, 12.5% ​​binahong), and FIII (30% basil, 10% binahong). Antibacterial activity tests were carried out using the well diffusion method, using mediklin as a positive control. The results showed that the acne patch preparation, a combination of ethanol extracts of basil and binahong leaves, met the organoleptic test requirements, pH, moisture content, weight uniformity, thickness, and folding strength. The antibacterial activity test showed a very strong antibacterial activity against S. epidermidis bacteria, with F0 (0.00 mm) as a negative control, FI (26.2 mm), FII (27.3 mm), FIII (27.4 mm), and K+ (medicinal) of 29.6 mm. Activity against C. acnes bacteria was also classified as very strong, with inhibition zones of F0 (0.00 mm), FI (26.3 mm), FII (27.3 mm), FIII (27.5 mm), and K+ (28.1 mm). It is recommended that future researchers conduct further research on physical evaluation tests using more adequate tools and materials. Further in vivo testing is also recommended to determine the biological effects of the acne patch before application to humans.
In Vitro and In Silico Evaluation of Butterfly Pea Flower (Clitoria ternatea) Extract in Fast-Disintegrating Tablets Mohamad Aprianto Paneo; Siti Eka Amalia; Multiani S Latif; Aris Purwanto; Firman Gustaman; Djayadi Azis
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1813

Abstract

Clitoria ternatea flowers contain flavonoids of interest for pharmaceutical development. This study examined a single fast-disintegrating tablet prototype containing a sequential methanol extract and explored quercetin docking against cyclooxygenase-2 (COX-2). Dried flower powder (100 g) was successively macerated with n-hexane, ethyl acetate, and methanol. The methanol extract was selected based on extraction yield and qualitative flavonoid screening. Tablets containing 250 mg extract at a theoretical mass of 490 mg were evaluated for hardness, disintegration, friability, and dissolution. Extraction yields were 2.15%, 7.35%, and 12.80%, respectively. Reported hardness was 4.25 ± 0.09 kg on the instrument scale, disintegration time was 42.8 ± 1.4 s, and friability was 0.41%. The reported UV–Vis dissolution response reached 93.7 ± 1.6% at 30 min. However, analytical marker, wavelength, calibration details, and replicate structure were insufficiently documented, limiting quantitative interpretation. Quercetin was selected from the literature and was not specifically identified or quantified in the extract. Docking scores were −9.7 kcal/mol for quercetin and −6.8 kcal/mol for the diclofenac comparator. Native-ligand redocking and RMSD results were unavailable, and the hardness summary requires verification against individual measurements. These findings describe an initial tablet prototype and a separate computational hypothesis. They do not establish an optimized formulation, quercetin-specific release, COX-2 inhibition, or anti-inflammatory efficacy. Further analytical characterization, process documentation, docking validation, and biological testing are needed.
Antiseptic Activity of A Mouthwash Containing Kelulut Bee (Homotrigona fimbriata) Propolis and Tabernaemontana macrocarpa Against Streptococcus mutans Javier Dzakwan Nuzuly; Tiara Halidah Ratnasari; Paula Mariana Kustiawan
JCPS (Journal of Current Pharmaceutical Sciences) Vol. 10 No. 2: September 2026
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jcps.v10i2.1711

Abstract

Dental caries remains one of the most prevalent oral health problems, with Streptococcus mutans recognized as the primary etiological agent. The prolonged use of synthetic antiseptics may cause undesirable side effects, prompting the need for safer natural alternatives. This study aimed to evaluate the antiseptic activity of a mouthwash formulation containing a combination of stingless bee propolis extract from stingless bees and Tabernaemontana macrocarpa Jack (selutui puka) leaves extract against Streptococcus mutans. The extracts were obtained by maceration using 96% ethanol and subsequently formulated into five mouthwash preparations with different extract ratios. Antiseptic activity was assessed using the disk diffusion method against S. mutans. The results demonstrated that all formulations exhibited inhibitory activity, as indicated by varying diameters of inhibition zones. Among the tested formulations, Formula F3, containing an equal ratio (1:1) of stingless bee propolis and T. macrocarpa leaves extracts, showed the highest antibacterial activity with an inhibition zone diameter of 17.2 mm, categorized as strong. The pH values of all formulations ranged from 5.82 to 6.64, indicating suitability for oral application. In conclusion, the combination of H. fimbriata propolis and T. macrocarpa leaves extracts formulated as a mouthwash exhibits notable antiseptic activity against Streptococcus mutans, with the optimal activity observed in the balanced extract ratio.

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