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Jurnal Farmasi Higea

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Published by Sekolah Tinggi Ilmu Farmasi Padang

ISSN : - EISSN : 25413554 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 10 Documents

Search results for , issue "Vol 7, No 1 (2015)" : 10 Documents clear

Uji Efek Ekstrak Etanol Daun Sirsak (Annona muricata L.) terhadap Aterosklerosis Arteri Koroner Burung Puyuh Jantan Zet Rizal; Surya Dharma; Rusmayanti Rusmayanti
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Has been research about influence of ethanol extract of leaves of soursop (Annona muricata L.) on the formation of coronary artery atherosclerosis of male quail induced high fat feeding and propylthiourasil. Male quail were divided into five groups , each group getting treatment. Negative controls given standard diet, a positive control was given high fat feeding and propylthiouracil, doses of 50, 100, 200 mg / kg BW ethanol extract administered orally soursop leaves. The treatment is done for 60 day, then take heart, be making preparations histopathology and staining haematoxyllin-eosin. The results showed that the ethanol extract of leaves of soursop dose 50 mg / kg BW selective in preventing atherosclerosis in male quail, when compared with the positive control ( P < 0.05 ). While the administration at a dose of 100 and 200 mg / kg showed no selective in preventing atherosclerosis in male quail, when compared with the positive control .

Karakterisasi Kompleks Inklusi Simvastatin – Β-Siklodekstrin Metoda Co-Grinding dengan Variasi Waktu Penggilingan Maria Dona Octavia; Auzal Halim; Monica Afrinda
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Characterization of simvastatin - b-cyclodextrin inclusion complexes by co-grinding method had been studied. Solid state simvastatin - b-cyclodextrin inclusion complex prepared by co-grinding method in 1:1 mol ratio. Simvastatin, b-cyclodextrin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes were characterization by X-ray Diffraction (XRD), Fourier Transformation Infra red (FTIR), Differential Thermal Analysis (DTA), scanning electron microscope (SEM) and dissolution studies. X-Ray Diffraction results showed decreasing peak intensity diffractogram very sharp compared to pure simvastatin and differential thermal analysis (DTA) were showed the interaction between simvastatin and b-cyclodextrin. In vitro dissolution rate studies of simvastatin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes. Simvastatin - b-cyclodextrin inclusion complex showed increasing dissolution rate significant compared to simvastatin - b-cyclodextrin physical mixture and pure simvatatin. The results showed the formation of inclusion complex between simvastatin and b-cyclodextrin by co-grinding method.

Pengaruh Ekstrak Etanol Daun Sukun (Artocarpus Altilis (Parkinson Ex F.A. Zorn) Fosberg) terhadap Kadar LDL (Low Density Lipoprotein) pada Mencit Putih Jantan Hiperkolesterol Helmi Arifin; Zet Rizal; Meri Susilawati
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The research has been about effect of ethanol extract of breadfruit leaves (Artocarpus altillis (Parkinson ex F.A. Zorn) Forsberg) to cholesterol levels in white male mice. Mice used 45 individuals were divided into 5 groups of animal that group I as a negative control group was given only the standard diet food. Group II is the positive control induced hight-fat foods and suspension PTU. Group III, IV and V are given foods containing high fat and suspension PTU with extract variations along with dose of 100, 300, and 900 mg/kg body weight once a day for 7,14 and 21. Then LDL levels measured on day 7, 14, and 21. The results of resarch showed that there are variations influence the dose and duration of administration of the decreased levels of blood LDL white male mice. The highest levels decrease at a dose of 900 mg/kg for 21 day.

Pembuatan Kalsium Laktat dari Batu Kapur Bukit Tui Padang Panjang Zulharmita Zulharmita; Roslinda Rasyid; Wessi Anhar
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v7i1.115

A study concerning the manufacture of calcium lactate from the limestone hills Tui Leopold. Limestone sample of 30 g was dissolved in 6 M HCl, filtered and the filtrate was added 6 M NH4OH to pH 10. Then added lactic acid 1 M. The precipitate is filtered, washed, dried in an oven at a temperature of 1050 C. The results obtained calcium lactate as 6. 2084 g. To determine the calcium content in limestone identification and assay of calcium, limestone is used as much as 1 g of calcium levels and obtained percentage is 36.08 %. Examination of limestone calcium lactate include organoleptic examination, solubility, qualitative identification, examination and the melting point of the assay by the method complexometry. The third difference in the weight of calcium lactate calcium percentage of the results obtained, for a weight of 1 g as much as 77.13 % w/w , weight of 2 g as much as 90.28 % w/w, while the weight of 3 g as much as 81.42 % w/w. From the data of calcium lactate assay with a sample of 7.93 g drying results have calcium levels that the percentage purity 82.94 % w/w, and the results of testing the melting point is 2280 C calcium lactate. So natural limestone hill Tui Leopold has a high purity calcium levels that can be made of calcium lactate.

Pengaruh Pemberian Gambir dari Uncaria gambir (Hunter) Roxb terhadap pH dan Tukak Lambung pada Tikus Putih Jantan Suhatri Suhatri; Zet Rizal; Debhi Mutiara Iryanda
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The effect of gambir Uncaria gambir (Hunter) Roxb on pH and gastric ulcers in male rats induced by 1 mL/200 gram body weight by oral admistration. The parameter taken to asses antiulcer activity were change of gastric acid pH and ulcer index to normal condition. The result indicate that the gambir Uncaria gambir (Hunter) Roxb at doses of 20 mg, 40 mg and 80 mg/Kg BB body weight significantly decreases the ulcer index with curative ratio were 51.93 %, 55.98 % and 63.90 % (Gambir of two days) and 68.43 %, 77.69 % and 82.61 % (Gambir of four days) with respect to control group. The gambir at 20 mg, 40 mg and 80 mg/Kg BB body weight also significanthy decrease the gastric acid pH to its normal value (P<0.05).

Pembuatan dan Karakterisasi Ekstrak Kering Daun Salam (Syzigium polyanthum (Wight) Walp.) Harrizul Rivai; Andi Heriadi; Humaira Fadhilah
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The research on preparation and characterization dried extract of bay leaves (Syzigium polyanthum (Wight) Walp.) has been done. The dry extract is made by adding various ratio of lactose, which is the ratio of the extract and drying with lactose ½x heavy viscous extract (F1), lactose 1x heavy viscous extract (F2), 1½ x heavy viscous extract (F3) and lactose 2x heavy viscous extract heavy (F4). Dried extract mode with F4 has better characteristics than the other formulas. The name of the extract is Extractum Syzigium polyanthum (Wight) Walp. Siccum. The extract was in the form of dry powder, light green, odor like bay leaves with a bitter flavor. Levels of water soluble extract was 80.4343% ± 3.5790%, while levels of ethanol soluble extract 26.3056% ± 3.1693%, flavonoid levels of the dried extract was 0.4198% ± 0.2767%.

Analisis Pengawet Nitrit Pada Daging Sapi Dengan Spektrofotometri Uv-Vis Rusdi Rusdi; Zulharmita Zulharmita; Izzatus Salaafia Nurrohmah
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The study about analysis of preservative sodium nitrite in beef by Spectrophotometry method has been done. The study was conducted by using which obtained from two supermarket and three traditional markets in Padang city, there are samples A, B, C, D and E. The levels of sodium nitrite in beef was determined by qualitative and quantitative analyzing. The result showed that preservative sodium nitrite found in samples A and B, which levels in samples A was 11,325 mg/Kg and samples B was 0,575 mg/Kg. While sodium nitrite was not found in samples C, D and E. It can be concluded that the levels of sodium nitrite in samples A and B are comply with requirements of Regulation of The Head of The National Agency of Drug and Food Control of Republic Indonesia No. 36 year 2013 which is concerning about food additives, which levels of preservative nitrite is maximum of 30 mg/Kg.

Pengaruh Pemberian Ekstrak Etanol Daun Ketepeng Cina (Cassia Alata L.) Terhadap Waktu Pendarahan, Pembekuan Darah dan Jumlah Trombosit Mencit Putih Jantan Sri Oktavia; Selvina Pebryantika; Surya Dharma
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Research on the effect of ethanol extract of ketepeng cina (Cassia alata L.) on bleeding time, blood clotting and platelet count male white mice. Extracts ketepeng cina (Cassia alata L.) given to male white mice that had been induced with phenytoin natrium. Animal experiment is divided into 4 groups, each group consisted of 5 mice. Group 1 (control) was given phenytoin natrium at a dose of 100 mg/kg BW, group II given ketepeng cina extract dose of 100 mg/kg BW, group III given ketepeng cina extract dose 300 mg/kg BW, group IV given ketepeng cina extract at a dose of 900 mg/kg BW. Before given phenytoin natrium, groups 1 to 4 were measured prior bleeding time, blood clotting and platelet counts on day 0 as control, then given phenytoin natrium from day 0 to day 14 and continued with the administration of the test substance to-8 to day 21. Effect observased day-to-7, 14,and 21. The results showed the extract of ketepeng cina (Cassia alata L.) at a dose of 100, 300, and 900 mg/kg BW orally can affect shorten bleeding time, blood clotting and increase the number of platelet male white mice day-to-21 and the most effective dose is the dose of 900 mg/kg BW.

Pemeriksaan Kualitatif Hidrokuinon dan Merkuri dalam Krim Pemutih Roslinda Rasyid; Eva Susanti; Rieke Azhar
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Studies have been conducted to analyse the hydroquinone and mercury content in beauty whitening creams from parlor and on the market in Padang city. Beauty whitening cream samples were A, B, C, D,E and F, then were observed using FeCl3, Ag-ammoniacal, Sodium Hydroxide, Potassium Iodide, and amalgam reagents. Hydroquinon was determined using Thin Layer Cromatography (TLC) and UV spectrophotometer. The results showed that six samples from three samples whitening cream B, D and F identified containing hydroquinone and two samples B and F contain mercury. So from the six samples of beauty whitening cream, three samples of the products do not contain hydroquinone and mercury.

Perbandingan Kemampuan Polimer HPMC dengan Gom Arab dalam Meningkatkan Kecepatan Disolusi Tablet Karbamazepin Rina Wahyuni; Auzal Halim; Eka Syuryani
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The effect of HPMC and gom arabic to do dissolution ability of carbamazepine tablets made by wet granulation has been. There are 5 formulas of carbamazepine granules, mind each formula was containing 40% w/w of carbamazepine. Carbamazepine wese coated by HPMC polymers and gom arabic by spray drying process. formula 0 countain carbamazepine with coanted HPMC and gom arabic witle formula 1 and 2 is countain carbamazepine coated by HPMC polymers with concentration 5% w/w and 10% w/w respectively. Formula 3 and 4 is countain carbamazepine which counted by gom arabic with concentration 5% and 10% respectively. The result shows that formula 2 show the highest dissolution rate 134.7133%.

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