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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 35 Documents
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Search results for , issue "Vol 4, No 2 (2022): Volume 4 Edisi 2 2022" : 35 Documents clear
Tingkat Pengetahuan Mahasiswa Fakultas Kedokteran Universitas Tanjungpura Tentang Obat Antihipertensi Pada Masa Pandemi COVID-19 Rosita Dewi; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14170

Abstract

During the COVID-19 pandemic, hypertension became a comorbid with the highest number of deaths. As a health student, it is important to have knowledge related to hypertension and antihypertensive drugs as a basis for providing education to the public. The purpose of this study is to evaluate college students level of knowledge regarding antihypertensive drugs during the COVID-19 pandemic. This study used a descriptive observational research with a cross sectional at the Faculty of Medicine, Tanjungpura University. Samples were gathered by purposive sampling with a total of 338 respondents who are active students of the S-1 study program class 2018, 2019, 2020, and 2021. The research instrument is a questionnaire in the form of a google form, with a Guttman scale and analyzed using univariate to describe variables study. The results showed that the level of knowledge of students in the good category was 56.71% with 186 respondents. The level of knowledge in the good category according to the age factor was 58.72% with 101 students in the age range of 19-20 years. According to the gender factor, the level of knowledge of students in the good category was 56.76% with 147 students with the majority being women. The conclusion from the research is that most of the knowledge levels of students at the Faculty of Medicine, Tanjungpura University, show a good level of knowledge about hypertension and hypertension drugs.
Rapid and Simultan Determination of Phenylbutazone in Herbal Remedies Using Infrared Spectroscopy Combined With Chemometric Ardi Nugroho; Mas Muhammad Luqman Imam Al – As’ari; Andi Makkulawu
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14382

Abstract

Phenylbutazone is one of common adulterated drug in herbal remedies. According to legal regulations in indonesia, it is prohibited to adulterate those ingredients in herbal remedies. So, it is an urgent need to develop rapid, and reliable method for detection and determination adulterants in herbal medicine. This study aims for the detection and determination of Phenylbutazone in herbal remedies using ATR-FTIR spectroscopic combined with chemometrics. Stepwise Multiple Linear Regression (SMLR) was used identify the relationship between concentrations and wave numbers. All samples (Unadulterated and adulterated) were classified and discriminated respectively to their added contents with perfect accuracy and precision. The results suggest that existence of the active substance could be successfully determined at the levels in the range of 0.01 to 85 mg in totally 100 mg of herbal remedies with RMSECV 0.016054643 and R2 0.9984 respectively by using ATR-FTIR technique combined with chemometrics.
Formulation and Activity Test of Repellent Spray Marigold Flower Essential Oil (Tagetes erecta L.) in Aedes aegypti Mosquitoes Nur Alfiah Irfayanti; Jasmiadi Jasmiadi; Alda Ta.ri
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14161

Abstract

The purpose of this study was to determine the activity of spray preparations of marigold flower essential oil (Tagetes erecta L.) on the Aedes aegypti mosquito. Marigold flower essential oil using water distillation method using aquadest and rabbits as test animals. The study was conducted by taking five treatments, namely one negative control group K(-), three treatment groups with variations in concentration (P1) 2.5%, (P2) 5%, P(3) 10% and one positive control group K( +). The results showed that repellent spray had repulsion, control (-) was 50.67%, 2.5% concentration was 68.33%, 5% concentration was 78.67%, 10% concentration was 96% and control (+ ) by 100%. The results of the protection test showed that the repellent spray containing marigold flower essential oil had the highest activity at a concentration of 10%. Based on the results of statistical analysis showed that the calculated f is greater than f table 5% and 1% and the results of the follow-up test of SNK (Newman Keuls) showed that the concentration of 10% was not significantly different from the control (+).
Pengaruh Pemberian Hard Candy dari Infusa Kopi Hijau Robusta (Coffea canefora L.) Pada Pasien Diabetes Mellitus Rusman Rusman; Nur Alfiah Irfiyanti
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14183

Abstract

a disease with chronic metabolic disorders characterized by high blood glucose levels as a result of insulin resistance is known as diabetes mellitus. Indonesia is among the 7th of the top 10 countries which are estimated to have a diabetes mellitus sufferer of 5.4 million in 2045 and have a low blood sugar control rate. Robusta coffee is the most popular drink, and contains chlorogenic acid, which has anti-diabetic mellitus properties. This study aims to examine the hard candy formulation of robusta green coffee bean infusion (Coffea canephora L) on blood glucose levels and creatinine levels in patients with type-2 diabetes mellitus. the research method was conducted observational, with the free and post design method. This research was conducted at the Pajjaiang clinic in September-October 2020 on prolanis patients diagnosed with type 2 diabetes mellitus. A total of 25 patients were given Hard candy formulation from robusta green coffee bean infusion for 3-4 weeks. The results of the study based on the SPSS data analysis showed that there was an effect on reducing blood glucose levels in diabetes mellitus patients, and the results of the GFR calculation showed no significant effect on creatinine function in diabetes mellitus patients.
Analisis Tingkat Pengetahuan Penggunaan Obat Generik Pada Mahasiswa Farmasi Dan Non Farmasi Universitas Tanjungpura Pontianak Negi Novriyani; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14393

Abstract

Knowledge of the use of generic drugs in the community, especially students is low, this is due to the lack of further education on the effectiveness of generic drugs. The aims of this study was to determine the level of knowledge of the use of generic drugs in pharmacy and non-pharmaceutical students at UNTAN Pontianak. The research method used is an observational study with cross-sectional. Respondents in this study amounted to 98 respondents, consisting of 49 pharmacy students and 49 non-pharmacy students, who met the inclusion criteria. Normality test data normally distributed (p0.005), then the analysis used was parametric data analysis using the independent T-Test test. The results showed that there was a significant difference between the level of knowledge on the use of generic drugs in pharmacy and non-pharmaceutical students. In conclusion, the percentage comparison of the level of knowledge with the average value on 4 dimensions, namely, pharmacy students is 82.39% and non-pharmacy students are 38.35%. The level of knowledge about generic drugs in pharmacy students was higher than non 0.00 students (p 0.005).
Identifikasi Penggolongan Obat Berdasarkan Peresepan Obat Hipertensi di Instalasi Rawat Jalan Rumah Sakit Ulfa Sri Mandasari; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14028

Abstract

The cause of hypertension is not clearly known, but risk factors that cause hypertension are found, namely the elderly or the elderly, in the form of a family history of hypertension, excess body weight and excessive salt levels. Hypertension is the third leading cause of death in Indonesia with a CFR (Case Fetality Rate) of 4.81%. Causes of the elderly suffer from hypertension due to reduced work functions in the human body. This study aims to determine the characteristics (gender and age) and classes of drugs prescribed to outpatient hypertension patients at RSUD Dr. Achmad Diponegoro Putussibau. This research is an observational study with a retrospective descriptive research design. From the results of the study, it was found that there were 55 hypertension patients with medical record data, based on gender the number of women was 62% and based on the age of 60-74 years by 80%. The class of drugs that are widely used are ACE-Inhibitors by 31%. Comorbidities that often accompany hypertension patients are diabetes mellitus by 40%. The dosage form is tablets by 90%, with the route of using the drug orally by 100%. The conclusion is that the use of drugs in hypertensive patients in the outpatient installation of RSUD Dr. Achmad Diponegoro Putussibau is mostly women. The majority occur at the age of 60-74 years, the most widely used drug class is the ACE-Inhibitor group with tablet dosage form and the oral route of use is the most widely used.
Uji Aktivitas Antibakteri Mikroba Endofit Dari Buah Merah (Pandanus conoideus Lam.) terhadap Bakteri Patogen Andi Dian Astriani; Endah Dwijayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14369

Abstract

Endophyte microbes can produce bioactive compounds that can be used as medicinal raw materials. Red fruit is one of the typical fruits that grow in the Papua area that has a potential bioactive compound content but has not been widely studied. So the study aimed to isolate endophyte microbes from red fruits (Pandanus conoideus Lam.) and determine activity against pathogenic microbes. The study began with the isolation of endophytic microbes from red fruit plants (Pandanus conoideus Lam.) using medium Nutrient Broth and Potato Dextrose Broth to obtain endophyte bacteria and fungi, once isolated and purified, pure microbes are inoculated in a medium to tilt. To maximize secondary metabolites, each microbe is fermented for 14 days. Supernatan fermentation results are tested antibacterial activity against test bacteria by the method of diffusion agar.  The test microbes used are Eschericia coli, Staphylococcus aureus, Salmonella thyposa, Streptococcus mutans, Candida albicans.  Positive endophyte microbes inhibit fermented pathogenic bacteria to maximize the production of their secondary metabolitesMikroba endophyte which has the ability to inhibit pathogenic bacteria characterized macroscopically and microscopically. From the results of the study, 4 endophyte microbes were produced, 2 in the form of molds, and 2 microbes from bacteria. From the results of the study, bakery N2, can inhibit the bacteria E.coli, S. mutans, S, aureus, S. thyposa. Gram staining, indicating N2 is gram negative bacteria. So it can be concluded that the N2 endophyte bacteria of red fruit (Pandanus conoideus Lam.), have bioactive compounds that can inhibit pathogenic microbes.
Characterization of the manufacturing process simplicia Syzygium aromaticum as raw material for wound healing drug preparations Naziella Naziella; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14184

Abstract

Characterization is the first step before standardization. Standardization of a drug substance is a requirement to achieve parameters that will ensure constant quality in a preparation. The main compounds contained in clove leaves have analgesic and antibacterial properties to accelerate wound healing. This study aims to characterize the process of making clove leaf simplicia and Simplicia (Syzygium aromaticum) originating from Lemukutan Island, Bengkayang Regency, West Kalimantan as raw material for wound healing drug preparations. Clove leaf Simplicia was characterized biologically including habitat and morphology, physically including organoleptic, microscopic, moisture content, ash content, and acid insoluble ash content, and chemically, namely phytochemical screening. Making clove leaf Simplicia consists of harvesting, wet sorting, washing, drying, dry sorting, packaging, and storage. The yield of clove leaf Simplicia was obtained as much as 70.90%. The results of the characterization of clove leaves showed that the clove tree grows in the highlands, with a tropical climate, with a temperature range of 25 C-32 C. Clove leaves are oval in shape, tapered tip, pinnate leaf bone, leaf length is approximately 9-12 cm and width 4 cm-4.5 cm. The moisture content, ash content, and insoluble ash content of the clove leaf Simplicia powder were 9.21%, 3.05%, and 0.69%, respectively. The outcomes of the phytochemical screening of clove leaf Simplicia powder have beensuperbfor holding flavonoids, saponins, triterpenoids, and tannins.
Analisis Faktor-faktor yang Mempengaruhi Kepatuhan Penggunaan Obat Tuberkulosis pada Pasien di Puskesmas Novalisa Novalisa; Ressi Susanti; Nurmainah Nurmainah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14195

Abstract

Patient compliance with medication is one of the treatments for tuberculosis that is of concern. The purpose of this study was to analyze the level of compliance and the relationship of factors to drug use adherence in pulmonary TB patients at Sungai Betung Public Health Center. The method used is analytical observational method by designing a cohort study research. Data collection was carried out retrospectively, namely collecting medical data on pulmonary TB patients and measuring compliance using the Medication Possession Ratio (MPR) method. Data analysis used Chi-Square test with SPSS. The results showed that the majority of patients were male (83.3%), productive age (80%), high school education (33.3%), had a job (83.3%), mileage from home to health services 2km (90%), and underwent treatment for exactly 6 months (63.3%). The patient's compliance rate was 86.7% adherent. Chi-square analysis showed that there was no significant relationship between the level of compliance with age (p=0,557), gender (p=1,000), patients who did not attend school as a comparison between primary and tertiary education (p=1,000; p=0,467; p = 0.125; p=1,000), occupation, distance to service and length of treatment (p=1,000). The conclusion is that there is no relationship between the research variables on drug use adherence.
Komparasi Daya Adsorpsi Silika Dari Abu Sekam Padi dan Ampas Tebu Terhadap Adsorpsi Pb2+ Hanandayu Widwiastuti; Riska Yudhistia Asworo
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14910

Abstract

Heavy metals are the main pollutants which numbers are increasing . PB is a heavy metal that has high toxicity when it enters the human body. This is indicated by the LD value of 50 Pb which is 500 mg / kg body weight. Based on Government Regulation No. 82 of 2001, the maximum permissible concentration of Pb2 + in waters is 0.03 mg / L. Therefore, the presence of Pb2 + in the waters needs to be controlled so that pollution in the waters can be reduced. The purpose of this study was to determine the silica adsorption capacity of rice husks and sugarcane bagasse against Pb2 + adsorption. In this study the characterization of each adsorbent was carried out to determine the active functional groups in the bonds that occur. The maximum adsorption capacity of Pb (II) in Si-husk is 126 mg / g at 0.6 g of mass of the adsorbent while the maximum adsorption capacity of Pb (II) in Si-sugarcane is 109.69 mg / g at 0.8 g of adsorbent.

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