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Published by Perhimpunan Ahli Patologi Indonesia

ISSN : 02157284 EISSN : 25279106 DOI : https://doi.org/10.55816/

Core Subject : Health,

Health Professions Public Health

Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.

Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan

Articles 384 Documents

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Analisis Karakter Klinikopatologik pada Kasus Karsinoma Payudara Subtipe Luminal A Like Andi Susanto; Birgitta Maria Dewayani,; Bethy Surjawathy Hernowo
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundMolecular subtypes of breast carcinoma, luminal A like has the best prognosis, but in the previous studies there were cases thatshowed poor clinical outcomes. This study attempted to investigate the clinicopathological characteristics in luminal A like subtypebreast carcinoma.MethodsThis study is a cross sectional study. The samples used were 67 medical records of patients with luminal A like subtype breastcarcinoma in January 2014 to June 2019 period from Hasan Sadikin Hospital, Bandung. According to estrogen receptor (ER) andprogesteron receptor (PR) expression status by adding both intensity and distribution scores, the data were divided into twosubgroups: low histoscore (<7) and high histoscore (≥7). Clinicopathological characteristics (age, TNM stage, treatment, location,histologic type, grading and metastasis) were evaluated for each subgroup.ResultsFrom 67 luminal A like subtype breast carcinoma patients, 73.13% were in the high histoscore subgroup, with higher percentage oflow grade histopathologic features (63.27%). There were no significant differences in age and TNM staging between the twosubgroups. Among 67 breast carcinoma patients, 43 were diagnosed in advanced stages. There were significant differences inlymph nodes metastasis between the two subgroups (p-value 0.013), however, there were no significant difference in metastasis toother organs.ConclusionThis study shows that 73.13% of patients with luminal A like subtype breast carcinoma have a high histoscore of hormone receptor.Low histoscore subgroups luminal A like subtype breast carcinoma will metastasize to lymph nodes.

Hubungan Tingkat Ekspresi Fibroblast Activation Protein (FAP) Terhadap Faktor Klinikopatologi Karsinoma Tiroid Papiler Herlina; Heni Maulani; Nursanti Apriyani
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundPapillary thyroid carcinoma is the most common subtype among thyroid cancers. The interaction between cancer cells and tumormicroenvironment plays roles in cancer proliferation and invasiveness. One of important components of tumor microenvironmentthat could stimulate tumor proliferation and invasiveness is activated fibroblast, known as carcinoma associated fibroblasts (CAFs).The aim of this research is to analysed FAP expression is associated with clinicopathologic characteristics.MethodsThis retrospective descriptive observational study with serial cases design was conducted in 40 samples of the paraffin blocks oftissues registered in Department of Anantomical Pathology Faculty of Medicine University of Sriwijaya/Dr. Moh. Hoesin PalembangHospital from January 1st, 2017 to October 31st, 2019. All samples were immunostained with FAP antibody. The expressions of FAPwere evaluated in accordance with the results of the previous study. Statistical test was performed by using Chi-square andSpearman-rho statistical test. Statistical analysis was performed by using SPSS version 23.0.ResultsOur data indicated that patients who were ≥45 years old (21 cases; 52.5%), women (31 cases; 77.5%) suffered from this cancer themost. The stromal type found in ten classic, follicular, solid and columnar variance were pauci (25 cases; 62.6%), desmoplastic (8cases;20%), sclerosis (5 cases; 12.5%) and inflammatory (2 cases; 5%). The expression of FAP in tumor stroma has a significantcorrelation with histopathology subtypes (p=0.028) and stromal type (p=0.000).ConclusionFAP was expressed in tumor epithelial cells and fibroblast stromal tumour of papillary thyroid carcinoma. FAP expression in stromaltumor between histopathologic subtype and stromal type showed significant correlation

Ketepatan Pemeriksaan Imunohistokimia CK19 Dibandingkan dengan PDX-1 pada Tumor Pankreas dan Anak Sebarnya Bayu Perkasa Rosari; Michelle Linggodigdo; Yan Cahya Wijaya; Marini Stephanie; Nur Rahadiani
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundMetastatic adenocarcinoma of unknown origin remains a serious problem in oncology. Pancreatic cancer is often diagnosed when ithas already metastasized. Therefore immunohistochemistry (IHC) examination for detecting metastases of pancreatic origin is veryimportant IHC marker of Pancreatic duodenal homeobox-1 (PDX-1) has a good accuracy for detecting metastases of pancreaticorigin, however it is not readily available in many centers in Indonesia. Instead, IHC marker that is often being used is CK19. Thismarker is not specific, because it is also expressed by gastrointestinal and hepatobilliary tumors. This evidence-based case reportaims to determine the accuracy of CK19 compared with PDX-1 IHC for detecting pancreatic tumor and its metastases.MethodsLiterature searches were conducted on Pubmed/MEDLINE®, Scopus®, Cochrane®databases. Four articles about PDX-1 and 5 articlesabout CK19 that are relevant were found. Those articles were critically appraised.ResultsAll articles are considered valid, as they fulfilled the important criteria for journal validity. A study of CK19 IHC found that this markerhas 100% sensitivity and 6% specificity for diagnosing liver metastases from well-differentiated pancreatic ductal adenocarcinoma.Studies of PDX-1 IHC have different results; a study found that 27 out of 67 were PDX-1 positive in metastases of pancreaticadenocarcinoma origin, while another study found that PDX-1 has 72% sensitivity and 93% specificity for pancreatic neuroendocrinetumor, with 100% sensitivity and 75% specificity for pancreatic neuroendocrine tumor metastases.ConclusionCK19 IHC is highly sensitive for detecting adenocarcinoma metastases of pancreatic origin, thus it can be utilized as a screening test.However, CK19 IHC specificity for detecting adenocarcinoma metastases of pancreatic origin is low compared to PDX-1 IHC

Perbandingan Ekspresi PD-L1 dan TILS pada Karsinoma Payudara Triple Negative dan HER2 Enriched Muhammad Asprianto; Krisna Murti; Citra Dewi; Erial Bahar
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundTriple negative and positive HER 2 subtype breast carcinoma are aggressive subtype that have worst prognosis among othersubtype. High level of tumor infiltrating lymphocytes (TILs) is associated with longer disease free survival and overall survival.Breast cancer is also influenced by the presence of ligation between PD-1 and PD-L1, expressed by activated CD8+ T cells andtumor cells, consecutively. To analysed the comparison of PD-L1 expression levels in triple negative breast cancer and HER2enriched subtype.MethodsA cross sectional study was conducted with 35 samples, which were immunostained with an anti-PD-L1 antibody. TILs weremeasured on HE slides, and together with PD-L1 expression were calculated using image J. Clinicopathological data were obtainedfrom medical record. All data were analysed by SPSS V25.0ResultsA significant difference was observed between PD-L1 expression in HER2 enriched and triple negative samples, where the HER2enriched subtype had a possibility to express PD-L1 3.3 times higher than those of triple negative (p = 0.021; OR = 3.3). There wereno significant differences in clinopathological characteristics or TILs density in both subtypes. Likewise, no significant differenceswas found among PD-L1 expression, and intratumoral and stromal TILs expression.ConclusionMajority patient of both subtypes are mostly older than 40 years old, with positive LVI and higher histological grading. The HER2expression showed a higher level of PD-L1 than triple negative. There was no significant difference of TILs expression betweenthese two subtypes of breast cancer.

Korelasi Ekspresi PD-L1 dengan TILs CD8+ pada Kanker Paru Jenis Karsinoma Bukan Sel Kecil Erisca Ayu Utami; Ika Kartika Ika Kartika; Suly Auline Rusminan; Erial Bahar Erial Bahar; Krisna Murti Krisna Murti
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundNon-small cell lung cancer (NSCLC) is an epithelial carcinoma of the lung which consists of adenocarcinoma, squamous cellcarcinoma (SCC), and large-cell carcinoma (LCC). In a microtumor environment, PD-L1 and PD-1 bonds are immune checkpointsthat act in suppressing the activity of CD8+ TILs, thus affecting the prognosis of NSCLC. Aims of this study is to determine thecorrelation between PD-L1 expression with CD8+TILs in NSCLC.MethodsThis was a cross-sectional study of NSCLC registered in Department of Anatomical Pathology Faculty of Medicine University ofSriwijaya/Dr. Moh. Hoesin Palembang Hospital since 1 January 2017 to 31 January 2020 with a total of 24 samples. All sampleswere immunostained using PD-L1 and CD8 antibodies. PD-L1 expression was assessed in tumor mass and CD8 expression inintratumoral and peritumoral TILs.ResultsOnly two subtypes, adenocarcinoma and SCC, were found in this study. Adenocarcinoma was the most frequent subtype (54.1%),sample group is dominated by <60 years old and was the subtype that expressed the PD-L1 most strongly (TPS ≥50%). There wasnot significant correlation between PD-L1 expression with CD8+ TILs in NSCLC (p=0.679 and p=0.826) but based onclinicopathological characteristics, there was a significant relationship between PD-L1 with disease stage and between intratumoralCD8+ TILs density with disease stage (p=0.048 and p=0.017).ConclusionAdenocarcinoma subtype had stronger expression of PD-L1 compared to SCC. There was no correlation between PD-L1 and CD8+TILs density in NSCLC.

Hubungan antara Profil Histomorfologik dengan Gambaran Endoskopi Esofagitis Refluks pada Dewasa Intan Nevita Oktamia Bernanthos; Diah Rini Handjari
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundEarly diagnosis of GERD is very important because chronic reflux esophagitis is a major risk factor for Barrett esophagus, which is aprecursor lesion for esophageal adenocarcinoma. The aim of this study is to determine the frequency, demographic characteristics,histomorphological profile based on Esohisto criteria and endoscopic features of reflux esophagitis in FKUI/RSCM in 2016-2018.MethodsA cross-sectional study was conducted in Anatomical Pathology Department, Cipto Mangunkusumo General Hospital from January2016 to December 2018. Assessment criteria include demographic characteristics, histomorphological profiles, and endoscopicfeatures. Histomorphological assessment of reflux esophagitis in this study used the Esohisto criteria, by assessing basal cellhyperplasia, elevated papillae, dilated intercellular spaces and intraepithelial eosinophils. Assessment of the lesion severity isclassified as normal mucosa, mild lesion and severe lesion.ResultsThere were 65 cases of reflux esophagitis in adults over a period of 3 years in the Department of Anatomical PathologyFKUI/RSCM. Reviewing demographic data in January 2016-December 2018. The assessment criteria included demographiccharacteristics, histomorphological profiles, and endoscopic features. Histomorphological assessment of reflux esophagitis in thisstudy used the Esohisto criteria, by assessing basal cell hyperplasia, elevated papillae, dilated intercellular spaces in 65 casesfound 33 cases (50.8%) in men and 32 cases (49.2%) in women, with an average sample age of 56 years. The location of the mostlesions was distal esophagus in 30 cases (46.2%). Clinical manifestations in 13 cases (20%) were esophagitis. The most commonclinical symptoms were dysphagia in 21 cases (32.3%). Most endoscopic features were laryngopharyngeal reflux in 12 cases(18.5%), followed by grade C esophagitis in 9 cases (13.8%). The lesion severity of reflux esophagitis lesions based on Esohistocriteria found 37 cases (56.9%) mild lesion followed by severe lesion as many as 28 cases (43.1%)ConclusionThe Esohisto criteria can be used to help diagnose the lesion severity of reflux esophagitis with endoscopic pictures

Ekspresi New York Esophageal Squamous Cell Carcinoma-1 (NYESO-1) pada Sarkoma Sinovial dan Non Sarkoma Sinovial Lainnya Sebagai Dasar Pemilihan Pemberian Imunoterapi Ros Nirmawati,; Nurjati Chairani Siregar; Evelina Kodrat
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundSynovial sarcoma is a rare high grade soft tissue sarcoma. Nowdays, the available therapeutic modalities has not given asatisfactory result yet. Currently, there is a promising therapeutic strategy through immunotherapy targeting NY-ESO-1 which isexpressed on tumor. The aim of this study was comparing NY-ESO-1 immunoexpression between synovial sarcoma and itshistologic mimics i.e. malignant peripheral nerve sheath tumor (MPNST) and dermatofibrosarcoma protuberans (DFSP)MethodsA cross sectional study was done in 28 cases of synovial sarcoma, 10 cases of MPNST and 17 cases of DFSP from archievalmaterial in Department Anatomical Pathology, FMUI/RSCM from January 2013 to June 2019. Immunohistohemical stainning wasperformed using an antibody NY-ESO-1 and it was described positive if it was expressed in more than 50% of tumor with moderateto strong positive intensity.ResultsThere is a significant difference (p<0.001) in NY-ESO-1 immunoexpression among synovial sarcoma (18/28), MPNST (2/10) andDFSP (1/17). Furthermore, synovial sarcoma showed a significantly higher immunoexpression compared to MPNST (OR 7.2;p=0.016; power 68.7%) and DFSP (OR 28.8; p<0.001; power 98.9%).ConclusionSynovial sarcoma showed a higher expression of NY-ESO-1 thus makes it as a good candidates for immunotherapy. There aredifferences in the expression of NY-ESO-1 in synovial sarcoma against MPNST and DFSP.

Hubungan Antara Derajat Histopatologik Sarkoma dengan Respon Radioterapi Eny Soesilowati; Afiati; Herry Yulianti; Hermin Aminah; Bethy Surjawathy Hernowo, PhD, SpPA(K)
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundSarcomas are rare, aggressive tumors originating from mesenchymal tissue. Radiotherapy is currently accepted as thestandard adjuvant to the treatment of high-grade sarcomas, whereas low-grade sarcomas are controversial, but the response ofradiotherapy to sarcomas is up to 50%. The aim of this study was to determine the association between the histopathologicalgrade of sarcoma and the radiotherapeutical response.MethodsThe research design was a cross-sectional study, with retrospective analysis. The sample consisted of 80 paraffin block tissuesfrom biopsy and surgery specimens of sarcoma from January 2013 to December 2019 at Hasan Sadikin Hospital in Bandung,consisting of 45 radiosensitive samples and 35 radioresistant samples. All samples were assessed for histopathological gradeaccording to the FNCLCC. Statistical analysis used the Chi-Square test with a significant value of p <0.05. Data were processedusing SPSS version 24.0 for windows.ResultsIn the radiosensitive group, 15 (33.3%) samples were low grade sarcomas and 30 (66.7%) samples were high grade sarcoma.There was no statistically significant association between histopathological grade and radiotherapeutical response in sarcomasp> 0.05 (p = 0.304).ConclusionIn this study, the radiotherapeutical response was not associated to the histopathological grade of sarcoma. This is because ofthe sensitivity of radiotherapy is influenced by other factors including molecular characteristics.

Perbedaan Profil Histomorfologik Jaringan Hati Resipien dan Donor Pascatransplantasi Hati Anak antara Kelompok Pasien Rejeksi dan Tidak Rejeksi di Departemen Patologi Anatomik FKUI/RSCM Periode 2010-2019 Alif Gilang Perkasa; Marini Stephanie; Nur Rahadiani; Diah Rini Handjari; Ening Krisnuhoni; Hanifah Oswari
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences

Karakteristik Klinikopatologik serta Hubungan Derajat Keganasan dengan Subtipe Molekular Luminal B pada Pasien Karsinoma Payudara di RSUP Mohammad Hoesin Palembang Tahun 2014-2016 Reihan Putri Awaliah; Citra Dewi; Riana Sari Puspita Rasyid
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundBreast carcinoma is the second highest malignant disease that causes death in Indonesia with 58,256 new cases in 2018. LuminalB has more aggressive clinical behavior and is considered as having unfavorable prognosis. This study aimed to determine theclinicopathological characteristics and the relationship histological grade with breast carcinoma subtype molecular luminal B.MethodsThis is a descriptive analytic study with cross sectional design using secondary data of breast carcinoma patients registered atRSUP Mohammad Hoesin Palembang during the period of January 1st, 2014 to December 31st, 2016.ResultsFrom 903 breast carcinoma patients in Mohammad Hoesin Hospital Palembang during 2014 to 2016, 43.63% had luminal Bmolecular subtype. The highest incidence and prevalence washappened in year 2016, whichwere 4.7 and 4.4 per 10 breastcarcinoma patients, respectively. The majority of breast carcinoma of luminal B molecular subtype occurs in the group of patientsaged ≥40 years (81.7%), female (98.7%), Malay race (100%), marital status (98.8%), housewives (68.3%), histopathologicalcarcinoma of invasive non-specific type (75.9%), high grade/ grade III (63.7%), localized (60.6%), no metastases (60.0%), rightsided tumor laterality (50.8%) and with negative HER2 (65.2%). There was a significant relationship between the histopathologicalgrade and breast carcinoma luminal B molecular subtype (p=0.009).ConclusionThe incident of breast carcinoma molecular subtype luminal B at Mohammad Hoesin Hospital Palembang has increased in the lastthree years with the poor clinicopathological characteristics.

Page 27 of 39 | Total Record : 384

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