Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Majalah Patologi Indonesia

patologi
Website

Published by Perhimpunan Ahli Patologi Indonesia

ISSN : 02157284 EISSN : 25279106 DOI : https://doi.org/10.55816/

Core Subject : Health,

Health Professions Public Health

Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.

Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan

Articles 384 Documents

23 24 25 26 27

Hubungan Ekspresi IGF-1R dan HER-2 Terhadap Jumlah Mitosis dan Derajat Histopatologik pada Karsinoma Payudara Invasif Tidak Spesifik Yessy Setiawati; Aswiyanti Asri; Rosfita Rasyid
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe IGF-1R signaling pathways have cross-talk with HER-2 signaling pathways and was thought to be one of the resistance mechanism intrastuzumab therapy. This research was proposed to analyze the correlation between IGF-1R and HER-2 expression with mitosis count andhistopathological grade in invasive breast carcinoma of no special type.MethodsThis research was a cross-sectional design. A total of fifty-five invasive breast carcinoma of no special type cases diagnosed in theAnatomical Pathology Centre Diagnostic of Medical Faculty of Andalas University in a period of 2014-2015 were collected and stainedimmunohistochemically with IGF-1R and HER-2 antibodies. IGF-1R and HER-2 expression were examined and their correlation with mitosiscount and histopathological grade were statistically analyzed with T-test, Oneway Anova and Chi-Square test.ResultsIGF-1R cytoplasm and membranous expression were found positive in 18.2% and 34.5% cases respectively, meanwhile, HER-2 expressionswere found positive in 23.6% cases of invasive breast carcinoma of no special type. There were significant correlations between IGF-1Rcytoplasm expression with mitosis count (p=0.049). There were no significant correlations between IGF-1R membranous expression withmitosis count (p=0.641) with histopathological grade (p=1.00). There were no significant correlations between HER-2 expression withmitosis count (p=0,495) and histopathological grade (p=1.000).ConclusionIGF-1R expressions have a significant correlation with mitosis count rather than HER-2 expressions. Inhibition it’s signaling pathways mayhave therapeutic value in breast carcinoma. Combination therapy of anti-HER-2 and anti-IGF-1R are expected to overcome resistance withtrastuzumab in HER-2 positive breast carcinoma

Analisis Ekspresi BRAF dan TERT pada Kasus Papillary Thyroid Carcinoma Berdasarkan Stratifikasi Risiko ATA Cempaka Harsa Sekarputri,; Etty Hary Kusumastuti,; Gondo Mastutik
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundPapillary thyroid carcinoma (PTC) is the most common malignancy in thyroid, accounting for more than 80% of all thyroid cancer.Rrecurrences of the disease reach 30% cases. It has been widely observed that BRAF and TERT is associated with aggressivenessbehaviors in human cancer. Both are involved in the pathogenesis of PTC that may be used as targets for new therapies. AmericanThyroid Association (ATA) risk stratification can define the risk of recurrence in PTC. No marker has been found to determine therisk of PTC recurrence. The purpose of this study is to analyzed BRAF and TERT expression in ATA risk stratification system inPTC classic variant samples.MethodsThe methods of this study is an analytical observational study with cross sectional approach, conducted on 56 samples of PTCclassic variant selected from Department of Anatomical Pathology Dr. Soetomo General Hospital between January 2015-December2017 by determined criteria in ATA risk stratification groups of low risk, intermediate risk and high risk. The expression BRAF andTERT observed using immunohistochemical staining of Santa Cruz monoclonal antibody.ResultsThe result for each group based on ATA risk stratification groups of low risk were 13 samples (23.20%), intermediate risk were 25samples (44.62%) and high risk were 18 samples (32.12%).The correlation was assessed with Spearman’s rho correlation test. There is significant correlation BRAF (p=0.004) with a value ofr=0.374 and TERT(p=0.032) with a value of r=0.287 for ATA risk stratification.ConclusionBRAF and TERT expression showed significant correlation to ATA risk stratification in classic variant PTC.

Karakteristik Klinikohistopatologik dan Profil Imunofluoresensi Kasus Pemfigoid bulosa di Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo Tahun 2011-2018 Fetisari Kurniawan; Riesye Arisanty
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundBullous pemphigoid is the most common autoimmune bullous disease. It is characterized by the presence of autoantibodies againsthemidesmosomal proteins in dermo-epidermal junction. Immune complexes subsequently induce skin blisters formation clinically, which willappear as subepidermal cleft histopathologically, and revealed as immune depositions immunologically. These three findings are required inorder to estabilsh the diagnosis of Bullous pemphigoid. This study was aimed to asses the clinico histopathological characteristics andimmunofluorescence studies of bullous pemphigoid in Anatomical Pathology Department, Cipto Mangunkusumo General Hospital.MethodsA cross sectional study was conducted in Anatomical Pathology Department ,Cipto Mangunkusumo General Hospital from January 2011 toDecember 2018. Clinical, histopathological, and direct immunofluorescence results were evaluated.ResultsDuring the last 8 years, bullous pemphigoid was the second most common form of autoimmune bullous diseases. The mean age of thesample was 60 years old. Women were affected more common than men (61.6%). Majority of patients present with blisters eruption (67.4%)and most commonly found in the lower extremities (48.8%). Histopathological examinations showed mostly a subepidermal cleft (89.5%)containing infiltrates of eosinophil, neutrophil, and lymphocyte. DIF staining demonstrated 31 cases (36.0%) with immune depositscharacteristic for bullous pemphigoid.ConclusionThe diagnosis of bullous pemphigoid is relied on a combination of clinical, histopathological, and direct immunofluorescence findings.

Ekspresi AgNOR dan Ekspresi Ki-67 pada Grading Adenokarsinoma Prostat Roza Rita; Delyuzar; Lidya Imelda Laksmi
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundProstate cancer is the second most common cancer and fifth most common cancer cause of death in males. Tissue biopsy is a goldstandard examination to diagnose prostate cancer. One of the hallmarks of cancer is increased activity of cell proliferation. Thisactivity can be detected with Ki-67 and AgNOR (Argyrophilic nucleolar organizing region). The aim of this study is to analyzedcorrelation between AgNOR and Ki-67 expression in grading of prostated adenocarcinoma.MethodsThis analytic cross-sectional study was held in Laboratory of Anatomical Pathology of Medical Faculty of USU/ RSUP H. AdamMalik Medan. Thirty paraffin blocks diagnosed with prostate adenocarcinoma were stained with H&E and p63 immunohistochemistrythen evaluated based on Gleason’s histopathological grading and stained with Agnor and Ki 67.ResultsAgNOR expression yang diperoleh pada grading adenokarsinoma prostat group 1, 2, 3, 4, dan 5 berturut-turut adalah 43; 32,40(±14,54); 64,29 (±28,2); 59,5 (±28,32); 69,22 (±29,26). Ekspresi Ki-67 pada setiap grading adenokarsinoma prostat group 1, 2, 3, 4,dan 5 secara berurutan adalah 43; 32,4 (±14,53); 64,29 (±28,2), 59,5 (±28,31); 69,22 (±29,26). Statistical analyses showed thatthere was no significantly correlation between grading of prostate adenocarcinoma and AgNOR expression (p=0.065), and Ki-67expression (p=0.18). Nevertheless, a significantly correlation between KI-67 expression and grading of prostate adenocarcinomawas found (p=0.34).ConclusionKi-67 could be used as prognostic indicator for prostate adenocarcinoma.

Hubungan Kepadatan Infiltrasi Sel Radang Limfosit dengan Klinikopatologik Karsinoma Kolorektal di RSUP Dr. Mohammad Hoesin Palembang Calvin Ienawi; Suly Auline Rusminan; Zen Hafy
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundColorectal carcinoma has become one of primary problem that caused mortality and morbidity around the world. This malignancyhas contributed almost more than 9% of all cancer incidence. Lymphocyte infiltration density (TILs) is one of prognostic factors toevaluate colorectal cancer. Although some studies have found that there still have variations in sassociation lymphocyte density withclinicopathology of colorectal carcinoma which related to patient prognosis. This study was aimed to identify and analyze theassociation of lymphocyte density with clinicopathological colorectal carcinoma patients in Dr. Mohammad Hoesin General HospitalPalembang.MethodsA total of 41 HE stained slides which were diagnosed as colorectal carcinoma were observed under the light microscope.Lymphocytes were counted in five different areas that showed the highest lymphocytes density. The mean values of the lymphocytewere received from those five different areas. Determination of cutoff point was counted from the median of all mean value of thelymphocytes and being classified to become two categories, high-density lymphocytes and low-density lymphocytes.ResultsOut of 41 subjects, most patients have tumor size more than/or equal to 5 cm (63.4%), the tumors are often found in the left-sided ofcolon (39.0%), have moderate differentiated degree (65.9%), are included into T3 in tumor staging (48.8%), and no regional lymphnodes metastasis (39.0%). The most histopathological classification is adenocarcinoma (41.5%). Bivariate analysis showed thatlymphocyte density has correlation with tumor differentiation degree (p=0.021) and histopathological classification (p=0.004).ConclusionLymphocyte infiltration density has correlation with degree differentiation and histopathological classification of colorectal carcinomain Dr. Mohammad. Hoesin General Hospital-Palembang

Ekspresi Programmed Death Ligand-1 (PD-L1) pada Seminoma Testis sebagai Potensi Faktor Prognostik Freciyana Boedijono; Budiana Tanurahardja; Ria Kodariah
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe prognosis of testicular seminoma cases which failed to be cured with conventional therapy is poor. Several recurrent eventsafter chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infiltrating lymphocytes (TILs)and its role is known as a prognostic factor. This study was conducted to determine the role of PD-L1 expression seminoma indetermining overall survival (OS) and progression free survival (PFS).MethodsThis is a retrospective cohort study with survival analysis. Clinical data were obtained from medical record in RSUPN CiptoMangunkusumo since January 2011-December 2016 and observed for 2 years. Histopathological data were obtained fromAnatomical Pathology Department and PD-L1 immunohistochemical staining were performed.ResultsA significant correlation between PD-L1 expression in tumor cells with 2-year OS (p=0.023) and PFS (p=0.002) in testicularseminoma was found. No significant correlation between PD-L1 expression in TILs with 2-year OS (p=0.235) and PFS (p=0.111).We also found significant correlations between PD-L1 expression of tumor cells and TILs with PFS (p=0.019). A significantcorrelation between stage with 2-year OS (p=0.010) and PFS (p=0.000) and lymph node metastases with 2-year OS (p=0.010) andPFS (p=0.000).ConclusionPD-L1 expression of testicular seminoma cells were significantly correlated with OS and PFS. There were no statistically significantassociations between PD-L1 expression in TILs with OS and PFS.

Aspek Klinik dan Karakteristik Tipe Histopatologik Timoma Maria Mayella Vianney; Lisnawati Rachmadi
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThymoma is the most common neoplasm found in thymus gland and is classified into 5 main histopathological types, A, AB, B1, B2,and B3. Thymomas are most commonly found in the anterior mediastinum and accompanied with myasthenia gravis. The aim of thisstudy was to find out clinical feature and histopathological characteristics of thymomas in Department of Anatomical Pathology, Facultyof Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital (FKUI/RSCM) in 2014-2018.MethodsThis is a descriptive study, using a cross-sectional design. Clinical and histopathological data obtain from the medical records andarchives of the Department of Anatomical Pathology of FKUI/RSCM. Clinical data consists of age, sex, tumor location, clinicalsymptom, concomitant disease, metastasis, and treatment. Histopathological assessment consists of histopathology type using WorldHealth Organization criteria and staging using Masaoka-Koga staging system.ResultsThere were 31 thymoma cases matched the inclusion criteria. Nineteen (61.3%) of 31 cases were women. The mean age of thesubjects was 46.7 years old. A total of 12 cases (37.5%) had muscle weakness due to myasthenia gravis as chief complaint and 21cases (67.7%) of tumor mass in the anterior mediastinum. There 9 cases of type AB and 2 cases of type B2.ConclusionThymoma is more common in women with an average age of 46.7 years. The most common paraneoplastic syndrome is myastheniagravis and mostly found in the anterior mediastinum. The most common histopathologic type is type AB, while type B2 is the least.

Uji Diagnostik Ekspresi CK19 dan HBME-1 pada Lesi Jinak dan Ganas Tiroid Indah Yati; Henny Sulastri; Aspitriani
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThyroid carcinoma is the most common malignancy of the endocrine system. Some cases histopathologically have overlappingmorphological features among papillary thyroid carcinoma follicular variants and follicular adenomas; beetween nodular hyperplasiaand protruding papillary protrusion; nuclear feature and thyroid papillary carcinoma. The combination of CK19 and HBME-1imunohistochemical staining have been proven as specific and sensitive markers to distinguish benign and malignant lesions thyroid.The purpose of this study was to determine the differences in CK19 and HBME-1 expression in benign and malignant Thyroid lesions.MethodsThis study used a diagnostic test of 50 cases (16 cases of nodular hyperplasia, 8 cases of follicular adenoma, 21 papillary thyroidcarcinomas and 5 cases of thyroid follicular carcinoma) clinicopathological data were noted. Immunohistochemical staining wasperformed using CK19 and HBME-1antibodies and the their expression assessed. Data were analysed by SPSS version 22.0.ResultsBased on the four histopathological diagnoses, the majority patient, were females between 20-50 years.Fifty percent of macroscopicsample size was more than 5 cm. The expression of CK19 and HBME-1 has a sensitivity value of 76.9% and 92.3% and a specificityvalue of 79.2% and 79.2%, consecutively. While positive predictive value 80% and 82.8% and negative predictive value 76% and90.5%, accuracy of 78% and 86%, respectively.ConclusionHBME-1 expression could be used to distinguishing benign from malignan lesions of thyroid with high diagnostic sensitivity thanCK19 expression.

Hubungan antara Ekspresi Epidermal Growth Factor Receptor (EGFR) dengan Derajat Histopatologik dan Invasi Perineural pada Adenokarsinoma Prostat Ria Oktavia; R. Zuryati Nizar; Yenita; Tofrizal
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.458

ABSTRAKLatar belakangEpidermal Growth Factor Receptor (EGFR) berperan penting pada karsinogenesis beberapa karsinoma termasuk karsinoma prostat.Overekspresi EGFR pada adenokarsinoma menyebabkan sel tumor menjadi resisten terhadap terapi hormonal. Tujuan penelitian iniuntuk mengetahui hubungan antara ekspresi EGFR dengan derajat histopatologik dan invasi perineural pada adenokarsinomaprostat.MetodePenelitian ini merupakan penelitian observasional dengan desain cross sectional dengan sampel penelitian sebanyak 60 kasusadenokarsinoma prostat yang telah didiagnosis di 5 Laboratorium Patologi Anatomik di Sumatera Barat periode Januari 2015 sampaiDesember 2017. Sampel diperoleh dari blok parafin yang berasal dari jaringan hasil operasi transuretral resection of prostat (TURP)dan prostatektomi kemudian dilakukan reevaluasi terhadap derajat histopatologik dan invasi perineural. Ekspresi EGFR pada seltumor dilihat dengan pewarnaan imunohistokimia. Analisis statistik menggunakan uji Chi-Square.HasilEkspresi EGFR positif ditemukan pada 38 kasus (63,33%) dan kasus terbanyak dengan EGFR positif adalah poorly differentiated(57,9%). Kasus adenokarsinoma prostat dengan invasi perineural paling banyak ditemukan dengan ekspresi EGFR positif (42,1%).Analisis statistik menunjukkan terdapat hubungan bermakna antara ekspresi EGFR dengan derajat histopatologik (p=0,003) dan tidakterdapat hubungan yang bermakna antara ekspresi EGFR dengan invasi perineural (p=0,129).KesimpulanTerdapat hubungan yang bermakna antara ekspresi EGFR dengan derajat histopatologik pada adenokarsinoma prostat dan tidakterdapat hubungan antara ekspresi EGFR dengan invasi perineural.

Hubungan Ekspresi Interleukin-17 dan Indeks Proliferasi Ki67 pada Karsinoma Payudara Ika Kartika,; Theodorus; Citra Dewi; Nyiayu Fauziah Kurniawati
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundTumor cells have the ability to change the phenotype of inflammatory cells in the tumor environment into protumoral factors. One ofthe mediators produced such as interleukin 17 (IL-17) also plays a role in increasing tumor proliferation and invasion. Similar to IL-17,Ki67 has generally been used as a marker to assess the extent of breast carcinoma proliferation. This is the first study to determinethe relationship of IL-17 expression with Ki67 proliferation index of breast carcinoma patients.MethodsThis is a case series study using 38 paraffin block samples of breast carcinoma patients. The clinicopathological characteristicsdocumented are age, histopathological subtype and grade, TILs (tumor infiltrating lymphocytes) and molecular subtypes. Interleukin17 and Ki67 expressions were assessed using immunohistochemistry examination and data were analysed using the Pearson andSpearman test to assess correlations between the two variables.ResultsGeneral characteristics of the sample in this study were breast cancer patients aged >40 years (73.7%), histopathological subtypesof non-specific invasive carcinoma (84.2%), high tumor rates (78.9%), non-dominant TILs (94.7%) and molecular subtype luminal B(55.3%). There is no relationship between IL-17 expression and Ki67 proliferation index (p 0.72 and OR of 1.417), even though lowerexpression of IL-17 showed a higher Ki67 proliferation index.ConclusionExpression of IL-17 cannot describe the Ki67 proliferation index in breast carcinoma. Studies using another analytical techniques andlarge sample size are suggested to obtain more accurate results.

Page 25 of 39 | Total Record : 384

23 24 25 26 27

Filter by Year

2010 2025

Filter By Issues

All Issue Vol. 34 No. 3, September 2025 Vol. 34 No. 2, Mei 2025 Vol. 34 No. 1, Januari 2025 Vol. 33 No. 3, September 2024 Vol. 33 No. 2, Mei 2024 Vol. 33 No. 1, Januari 2024 Vol. 32 No. 3, September 2023 Vol. 32 No. 2, Mei 2023 Vol. 32 No. 1, Januari 2023 Vol 31. No. 3, September 2022 Vol. 31 No. 2, Mei 2022 Vol 31 No 2 (2022): MPI Vol 31 No 1 (2022): MPI Vol. 31 No. 1, Januari 2022 Vol 30 No 3 (2021): MPI Vol. 30 No. 3, September 2021 Vol 30 No 2 (2021): MPI Vol 30 No 1 (2021): MPI Vol. 30 No. 1 (2021): MPI Vol 29 No 3 (2020): MPI Vol 29 No 2 (2020): MPI Vol 29 No 1 (2020): MPI Vol. 29 No. 1 (2020): MPI Vol 28 No 3 (2019): MPI Vol 28 No 2 (2019): MPI Vol 28 No 1 (2019): MPI Vol 27 No 3 (2018): MPI Vol 27 No 2 (2018): MPI Vol 27 No 1 (2018): MPI Vol 26 No 3 (2017): MPI Vol 26 No 2 (2017): MPI Vol 24 No 3 (2015): MPI Vol 24 No 2 (2015): MPI Vol 26 No 1 (2017): MPI Vol 25 No 2 (2016): MPI Vol 25 No 3 (2016): MPI Vol 25 No 1 (2016): MPI Vol 23 No 2 (2014): MPI Vol 24 No 1 (2015): MPI Vol 23 No 3 (2014): MPI Vol 23 No 1 (2014): MPI Vol 21 No 3 (2012): MPI Vol 21 No 2 (2012): MPI Vol 21 No 1 (2012): MPI Vol 20 No 3 (2011): MPI Vol 20 No 2 (2011): MPI Vol 20 No 1 (2011): MPI Vol 22 No 3 (2013): MPI Vol 22 No 2 (2013): MPI Vol 22 No 1 (2013): MPI Vol 19 No 2 (2010): MPI Vol 19 No 1 (2010): MPI More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Jaya Pramana

Contact Email
jayapram@gmail.com

Phone
-

Journal Mail Official
support@majalahpatologiindonesia.com

Editorial Address
Departemen Patologi Anatomik, Fakultas Kedokteran Universitas Indonesia Jl. Salemba Raya 6, Tromol Pos 3225, Jakarta 10002

Location
Unknown,

Unknown

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Jaya Pramana

Contact Email jayapram@gmail.com

Phone -

Journal Mail Official support@majalahpatologiindonesia.com

Editorial Address Departemen Patologi Anatomik, Fakultas Kedokteran Universitas Indonesia Jl. Salemba Raya 6, Tromol Pos 3225, Jakarta 10002

Location Unknown, Unknown INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Jaya Pramana

Contact Email
jayapram@gmail.com

Phone
-

Journal Mail Official
support@majalahpatologiindonesia.com

Editorial Address
Departemen Patologi Anatomik, Fakultas Kedokteran Universitas Indonesia Jl. Salemba Raya 6, Tromol Pos 3225, Jakarta 10002

Location
Unknown,

Unknown

INDONESIA