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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 237 Documents
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FORMULASI SEDIAAN MASKER WAJAH MENGGUNAKAN EKSTRAK ETANOL BUNGA KECOMBRANG (ETLINGERA ELATIOR) TERHADAP KELEMBABAN KULIT WAJAH Pranata, Chandra; Boru Situmorang, Novidawati; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.364

Abstract

ABSTRACT Skin is an essential and vital organ and a reflection of health. Natural antioxidants such as flavonoids, polyphenols and Sapponin are believed to increase moisture on the skin. This ability is the main reason for using Torch Ginger flower extract which is formulated into a form of facial mask in the form of clay facial mask. Objective: To formulate facial moisturizing mask preparations using the extract of Torch Ginger(Etlingera elatior). This study used the Torch Ginger Flower extract facial moisturizing mask formulation method with a concentration of 0 (Blank), 5% and 10%. Evaluation of mask preparations included homogeneity, stability of dosage at temperatures of 80C and 250C, Organoleptic test and pH of preparations. Measurements of skin moisture activity were measured using alar Skin Analyzer which was tested on the face surface 3cm wide. The results showed that the preparation was stable in terms of odor, color and was at a pH of 4.2-6.3 using observations of litmus discoloration. Effectiveness of facial skin moisture with 10% Torch Ginger extract concentration is more effective to produce results at a concentration of 5% and blank. Conclusion: Torch Ginger flower extract can be formulated into preparations of face masks with various concentrations and has the effect of moisturizing the skin and brightening the complexion. Keywords: Torch Ginger Flower Extract, Facial Mask, Clay Facial Mask, Facial Skin Moisture
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L.) TERHADAP BAKTERI Streptococcus mutans Syarifuddin, Aminah Nur; Purba, Rosa Aldora; Boru Situmorang, Novidawati; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.368

Abstract

Introduction: Basil leaf (Ocimum basilicum L.) is one of the most accessible natural plant in Asia such as Indonesia. Basil leaf vegetation contains a lot of flavonoid compounds and essential oils that have the effect as antibacterial because it can inhibit the growth of bacteria Streptococcus mutans cause dental caries. Streptococcus mutans is a round gram-positive bacteria that typically form pairs or chains during its growth. The purpose of this research is to know the antibacterial effectivity of ethanol extract of basil leaves (Ocimum basilicum L.) on the growth of Streptococcus mutans bacteria.This research was conducted with laboratory experimental research method. Basil lean ethanol extract was prepared by using maseration extraction method. Method: The method used in the inhibitory test using diffusion of the disc with 5 samples in each treatment group. The sample consisted of 5 treatment groups, ethanol extract of basil leaves with concentration of 100%, 80%, 60%, 40% and 20%. Result: The result of this study showed that ethanol extract of basil leaves with 100% concentration had inhibitory power of 10,26 mm (strong category), 80% of 9,65 mm (medium category), 60% by 8,12 mm (medium category), 40% by 7,33 mm (medium category), and 20% by 6,90 mm (medium category). Conclusion: The conclusion of this research proves that basil leaf ethanol extract has antibacterial power agains Streptococcus mutans bacteria with effective concentration is 100% with strong category equal to 10,26 mm.
FORMULASI SEDIAAN SABUN MANDI PADAT EKSTRAK ETANOL BONGGOL NANAS (Ananas cosmosus L.) UNTUK KELEMBAPAN KULIT Octora, Debi Dinha; Situmorang, Yuliana; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.369

Abstract

Tanaman nanas dapat diformulasikan menjadi sediaan sabun mandi padat karna berdasarkan penelitian sebelumnya bonggol nanas menggandung antioksidan tinggi karena memiliki senyawa flavonoid dan saponin. Senyawa yang mampu menangkal radikal bebas adalah antioksidan. Penelitian ini menggunakan metode quasi eksperimental. Pengumpulan sampel, pembuatan simplisia, pembuatan ekstraksi secara maserasi menggunakan pelarut etanol dan pembuatan sediaan sabun padat dengan ekstrak etanol bonggol nanas masing-masing dengan konsentrasi 3%, 4% dan 5%. Kemudian dilakukan uji sabun meliputi: pengukuran pH, ketingian busa sabun, dan uji kemampuan sediaan untuk melembabkan kulit pada responden sebanyak 10 orang selama ± 1 jam dengan menggunakan alat skin analyzer. Ekstrak etanol bonggol nanas dapat diformulasikan menjadi sediaan sabun mandi padat dengan hasil uji pH menunjukan konsentrasi 5% lebih tinggi, hasil uji ketinggian busa menunjukan konsentrasi 5% lebih tinggi dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Hasil penelitian menunjukan sediaan sabun mandi padat dari ekstrak etanol bonggol nanas (AnanasCosmosusL) untuk melembabkan kulit dengan variasi konsentrasi yang berbeda dapat diformulasikan menjadi sediaan sabun mandi padatdengan hasil uji pH menunjukan stabil pada kulit dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Diharapkan untuk penelitian selanjutnya agar dapat membuat sediaan lain dari ekstrak etanol bonggol nanas (Ananas cosmosus L.) dalam bentuk sediaan lain seperti sabun cair, lotion, sabun transparan, krim dan sebagainya.
EFEKTIFITAS IMUNOSTIMULLAN DARI EKSTRAK ETANOL DAUN BENALU KOPI (Loranthus ferrugineus Roxb) PADA TIKUS JANTAN DENGAN METODE TITER ANTIBODI Purba, Novandi; Sari, Lasma Novita; Ginting, Radika
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.372

Abstract

The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB.
UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN SALEP DARI EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphylococcus aureus Turnip, Nur Ulina M. Br.; ., Nurdianti; Dwicahya, Cucu Arum
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.373

Abstract

Salah satu penyebab infeksi adalah bakteri, seperti Staphylococcus aureus. Daun kersen telah banyak digunakan untuk mengobati penyakit yang disebabkan oleh bakteri. Daun kersen telah diteliti memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Tujuan penelitian ini: membuat formulasi sediaan salep ekstrak daun kersen, dan melihat apakah sediaan salep memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Metode penelitian yang dilakukan pada penelitian ini bersifat True experimental, meliputi tahapan: pembuatan ekstrak daun kersen dengan metode maserasi menggunakan pelarut etanol 96%, formulasi salep dibuat dengan dasar salep: vaselin, adeps lanae, dan propilen glikol. Dibuat dalam tiga konsentrasi yaitu: F I dengan 100 mg, F II dengan 200 mg, dan F III dengan 300 mg. Selanjutnya dilakukan evaluasi sediaan berupa evaluasi stabilitas fisik dan homogenitas, dan uji aktivitas dengan bakteri Staphylococcus aureus dengan menggunakan metode difusi agar menggunakan kertas cakram. Hasil menunjukkan bahwa salep memiliki kestabilan fisik dan homogenitas yang baik selama 10 hari penyimpanan pada suhu kamar. Uji aktivitas antibakteri sediaan salep menunjukkan bahwa diameter hambat F I memiliki rata-rata 14,35 mm, F II memiliki rata-rata 16,50 mm dan F III memiliki rata-rata 19,29 mm. Berdasarkan hasil yang diperoleh maka dapat disimpulkan bahwa sediaan salep ekstrak daun kersen memiliki daya hambat terhadap bakteri Staphylococcus aureus. Pada peneliti selanjutnya diharapkan agar memperhatikan daerah tumbuh daun kersen yang akan digunakan sebagai sapel penelitian dan melakukan perbandingan pengujian aktivitas antibakteri antara daun kersen dengan daun yang lainnya terhadap bakteri Staphylococcus aureus.
EFEKTIVITAS ANALGETIK EKSTRAK ETANOL AKAR ALANG-ALANG (Imperata cylindrica (L) Beauv ) PADA MENCIT PUTIH JANTAN Kartika, Dewi; Gultom, Veronika Yuliyani; Sitompul, Andelila Suprianti
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.374

Abstract

Pain is an unpleasant sensory and emotional experience due to tissue damage, either actual or potential or described in the form of damage. Provision of therapeutic doses of analgesics relieve pain or suppress. Plants Imperata cylindrica L. Beauv empirically used as traditional medicine. The purpose of this study to know the analgetic effect of root ethanol extract of alang-alangImperata cylindrica L. Beauv. This study was done by infra red (IR) plantar test method with a wavelength of 96 nm. Twenty male mice were divided into 4 groups. Three groups were given ethanol extract of Imperata cylindrica L. Beauv branches at a doses of 15 mg/kg bb, 30 mg/kg bb 60 mg/kg bb and one group was given 0,5% CMC Na (control) orally. After that, the time (second) hold infra red induction of pain every 10 minutes to 60 minutes. The data obtained were processed using one-way analysis of variance (ANOVA) and followed test the level of 95%. The results of phytochemical screening Imperata cylindrica L. Beauv is alkaloid, flavonoid, and steroid/triterpenoid. Ethanol extract Imperata cylindrica L. Beauv dose of 15 mg/kg bb average induction able to withstand pain of 12,86; 14,34; 15,44; 19,2; 17,52; 15,42 second, the dose of 30 mg/kg bb 13,6; 17,08; 19,82; 18,44; 16,9; 16,48 second, and a dose of 60 mg/kg bb 16,96; 18,9; 18,94; 22,14; 18,0; 17,26 second. Pain is an unpleasant sensory and emotional experience due to tissue damage, either actual or potential or described in the form of damage. Provision of therapeutic doses of analgesics relieve pain or suppress. Plants Imperata cylindrica L. Beauv empirically used as traditional medicine. The purpose of this study to know the analgetic effect of root ethanol extract of alang-alangImperata cylindrica L. Beauv. This study was done by infra red (IR) plantar test method with a wavelength of 96 nm. Twenty male mice were divided into 4 groups. Three groups were given ethanol extract of Imperata cylindrica L. Beauv branches at a doses of 15 mg/kg bb, 30 mg/kg bb 60 mg/kg bb and one group was given 0,5% CMC Na (control) orally. After that, the time (second) hold infra red induction of pain every 10 minutes to 60 minutes. The data obtained were processed using one-way analysis of variance (ANOVA) and followed test the level of 95%. The results of phytochemical screening Imperata cylindrica L. Beauv is alkaloid, flavonoid, and steroid/triterpenoid. Ethanol extract Imperata cylindrica L. Beauv dose of 15 mg/kg bb average induction able to withstand pain of 12,86; 14,34; 15,44; 19,2; 17,52; 15,42 second, the dose of 30 mg/kg bb 13,6; 17,08; 19,82; 18,44; 16,9; 16,48 second, and a dose of 60 mg/kg bb 16,96; 18,9; 18,94; 22,14; 18,0; 17,26 second.
UJI AKTIVITAS EKSTRAK ETANOL DAUN KARAMUNTING (Rhodomyrtus tomentosa.) TERHADAP PERTUMBUHAN BAKTERI Salmonella thypi Wulandari, Suci; Pranata, Chandra; Sihombing, Yanna Rotua; Nasution, Muhammad Hamim
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.382

Abstract

Salmonella thypiis a bacterium that causes typhoid fever. Typhoid fever is an infectious disease that is still a health problem, especially in Indonesia. There are several studies on the types of plants that can control bacterial growth. Indonesian plants are often used as medicine, one of which is the karamunting (Rhodomyrtus tomentosa.). Traditionally a number of parasitic species have been used to prevent and treat various diseases such as cough, anticancer, diuretic, anti-inflammatory, antibacterial, wound or infection karamunting (Rhodomyrtus tomentosa.) Has active compounds such as flavonoids, alkaloids, tannins , saponins, and glycosides which have antibacterial abilities. The purpose of this study is to determine the inhibition of extract of karamunting (Rhodomyrtus tomentosa.) at concentrations of 5%, 10%, and 15%. Test samples using Salmonella thypi. This research is an experimental study with a design (posttest). The research methods included the collection of plant material, determination of plant material, making simplicia, phytochemical screening, making ethanol extract from simplicia by maceration, testing chemical compound groups, and antibacterial testing with paper disk diffusion methods. Karamunting is extracted by maceration process, using 70% ethanol solvent. The results of this study indicate that the benalu coffee leaf extract (Rhodomyrtus tomentosa.) has inhibitory capacity as an antibacterial in Salmonella thypi with a mean inhibition of 16.87 mm at a concentration of 5%, 17.24 mm at a concentration of 10%, and 18.21 mm at a concentration of 15%. The greatest inhibition is produced at a concentration of 15%, because the higher the concentration of the extract, the higher the diameter of the inhibition produced, because the more active substances contained in the extract.
UJI EFEK ANTIINFLAMASI KOMBINASI EKSTRAK ETANOL DAUN GYMNANTHEMUM AMYGDALINUM DEL. DAN ELAEIS GUINEENSIS JACQ. Wahyudi, Wahyudi; Masnawati, Masnawati; ., Ismayuni; Rahmi, Sofia; Berkat Waruwu, Syukur
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.377

Abstract

Inflammation is a response from the body to injury or infection, flavonoids contained in African leaves (Gymnanthemum Amygdalinum Del.) And palm oil leaves (Elaeis Guineensis Jacq.) have anti-inflammatory effects. This study aims to examine the anti-inflammatory effects of a combination of ethanol extracts of Gymnanthemum Amygdalinum Del. And Elaeis Guineensis Jacq. on white rat foot edema which is induced by carrageenan 1% subplantar, and effective dosage as anti-inflammatory. The extract was made by maceration method using 96% ethanol solvent. The antiinflammatory effect test was divided into 5 treatment groups. The first group (negative control) was given 0.5% CMC Na suspension, the group (positive control) was given diclofenac Na suspension 2.25 mg / kg bw, and the suspension group was a combination of African leaf extract (Gymnanthemum Amygdalinum Del.) And palm oil leaves ( Elaeis Guineensis Jacq.) Dose 200 + 62.5 mg / kg bw, 400 + 125 mg / kg bw, and 800 + 250 mg / kg bw. Inflammation volume measurements were measured using a pletismometer for 180 minutes at 30 minute intervals after 1% carrageenan was induced. The results showed that negative controls had significant differences with other treatment groups which did not show anti-inflammatory effects. In conclusion, the suspension of a combination of ethanol extract of African leaves and palm oil leaves has an effective anti-inflammatory effect at a dose of 800 + 250 mg / kg bw.
PERBANDINGAN FORMULASI EKSTRAK E PERBANDINGAN FORMULASI EKSTRAK ETANOL BUAH TERONG BELANDA SEBAGAI PEWARNA PADA BLUSH ON DALAM BENTUK SEDIAAN COMPACT Barus, Bunga Rimta; Estevania Kaban, Vera; Octavia Aitonang, Jessi; Berkat Waruwu, Syukur
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.450

Abstract

Blush on is a cosmetic preparation for coloring the cheeks with an artistic touch so that it can increase the attractive impression in makeup (Nurhayati, 2016). Many blush-on preparations come from chemicals, which can cause spotty, black spots and can trigger skin cancer. One alternative that can be used is by making a blush on natural ingredients, namely Tree Tomato. The purpose of this study was to find out the Ethanol Extract of the Tree Tomato Fruit was made as a blush on coloring in compact preparations.The sample used in this study was Tree Tomato, red and had a soft texture taken from the cultivation of Tree tomato in the village of Brastagi, Karo District, North Sumatra Province. Making extracts is done by maceration and the process of making blush. After that evaluation of blush on preparation is carried out. Evaluation test results of blush on ethanol extract of tree tomato fruit include. The results of homogeneity tests are declared homogeneous, pH test averages 6.4, irritation test results stated not to irritate, the test results of the three formulations can be concluded that the three most preferred form of blush on panelists are formulations with a concentration of 15%, because they have a comfortable level of application, clear colors and very soft.Ethanol extract of Tree Tomato fruit can be made as a dye in compact preparations.
UJI EFEKTIVITAS ANTI BAKTERI EKSTRAK DAUN LEUNCA (SOLANUM NIGRUM) TERHADAP DAYA HAMBAT BAKTERI ESCHERICHIA COLI Fahdi, Firdaus; Sari, Herviani; Saulina Lubis, Lisbet
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.472

Abstract

Antibacterial is a compound that can inhibit the growth of bacteria that can be used for the treatment of infections in humans. One of the bacteria that can cause interference with the system is the Escherichia coli bacteria, where the Escherichia coli bacteria is widely spread around us. The spread of the Escherichia coli bacteria can occur by direct contact (shaking hands, touching). Then passed on by mouth. Leunca leaves have chemical contents including alkaloids, flavonoids, saponins, tanins. The purpose of this study was to determine whether Leunca's leaf extract (Solanum nigrum) has antibacterial effects against the inhibitory power of Escherichia coli bacteria with a concentration of 50 mg/ml, 100 mg/ml, 150 mg/ml, 200 mg/ml, 250 mg/ml. The method of this study was the sample of Leunca leaf obtained from West Lumban Rau Village, Habinsaran Subdistrict, Toba Samosir Regency. Sample preparation was done by making thick extract with the maceration method. An anti-bacterial effectiveness test is done by the disk diffusion method. The results showed Leunca's leaf extract containing alkaloid compounds, flavonoids, saponins, tannins. As well as having antibacterial effectiveness against the inhibition of Escherichia coli bacteria. Average inhibition zone area concentration of 50 mg/ml = 6.1 mm, concentration of 100 mg/ml = 7.3, concentration of 150 mg/ml = 8.8 mm, concentration of 200 mg/ml = 10.8 mm, concentration of 250 mg/ml = 12.6 mm. Conclusion: Leunca (Solanum nigrum) Leaf Extract has antibacterial effects against the inhibitory power of Escherichia coli bacteria with a strong category.

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