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JURNAL FARMASIMED (JFM)
Published by Institut Kesehatan Medistra Lubuk Pakam
ISSN : -     EISSN : 26550814     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal FARMASIMED (JFM) Volume I Nomor 1 Periode Mei - Oktober Tahun 2018. Jurnal ini memberikan ruang bagi akademisi, peneliti dan pengguna hasil penelitian dan pengabdian untuk mendiseminasikan, menginformasikan, mendiskusikan dan menggunakan hasil penelitian dan pengabdian sebagai upaya meningkatkan kualitas kebijakan di bidang farmasi yang berbasis ilmiah dan dapat dipertanggung jawabkan. Jurnal ini menyajikan hasil penelitian, pengabdian masyarakat serta artikel ilmiah di bidang farmasi.
Arjuna Subject : -
Articles 237 Documents
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EFEK EKSTRAK DAUN GAMBIR ( UNCARIA GAMBIR ROXB) TERHADAP TINGKAT STRESS OKSIDATIF DAN EKSPRESI SIRTUIN 3 PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAAN YANG DIINDUKSI D-GALAKTOSA Sinaga, Inda MH; Sari, Mutiara Indah; Ichwan, Muhammad MH
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.473

Abstract

The aging process must be experienced by all living things, there will be a decrease in the tissue ability to maintain its function so that pathological conditions occur. Some things can cause aging, Free radical factors are external and internal factors that can trigger aging. Induce of d-galactose continuously one of the factors that can increase oxidative stress. This study was design to evaluate the effect of gambir leaf extract on oxidative stress and expression of the sirtuin 3 gene in the hippocampus of female mice induced intraperitoneally by d-galactose 150 mg/kgbb. Researchers conducted a post test only control group study with a sample of 24 female mice aged 10 - 12 weeks with the inclusion criteria an average body weight of 25-35 grams, obtained from the same breeding place, maintained at the same place and time and never as research material. Mice were divided into 4 groups with 6 mice each , group (C) female mice induced only d-galactose 150 mg / kg and in sonde aquabidest 0,1%/body weight, mice induced by d-galactose and sonde gambir leaf extract at a dose of 100 mg / kg bw group (C1), group (C2) 200 mg/kgbw, and 400 mg/kgbw group (C3). Blood samples were collected to determine the increase in oxidative stress levels of malondealdehyde (MDA) through spectrophotometry, and hippocampal tissue collected for PCR method so that the expression of the sirtuin 3 gene can be seen. Increased levels of MDA are associated with increased oxidative stress. This study reported the results of MDA levels were not significant ( p value <0.05). The results of the PCR reported an increase in expression 2 times higher than the control at a dose of gambier leaf extract 200 mg / kgbw Keywords:D-Galactose, Malondealdehid,Sirtuin 3,Cathechin.
EFEK EKSTRAK DAUN GAMBIR ( UNCARIAGAMBIRROXB) TERHADAP TINGKAT STRESS OKSIDATIF DAN EKSPRESI BRAIN DERIVED NEUROTHROPIC FACTOR(BDNF) PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAANYANG DIINDUKSI D-GALAKTOSA Sebayang, Julenda Irianti; Sari, Mutiara Indah; Ichwan, Muhammad Indah
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.475

Abstract

Prevalence of premature aging that causes in decreased memory throughout the world of individuals aged 60 years and over is estimated at 5-7%. According to WHO this is caused by progressive dysfunction and neuronal cell death and is related to free radical formation. This study was design to evaluate the effect of gambir leaf extract ( uncariaGambirRocb ) on MDA and expression BDNF in the hippocampus of aging female mice that are induced in D-Galactose. In this study that method is used a post test only control group, the researcher design with 4 groups being treated ( group1 : inject D-Galactose 150 mg/kgbb/ip and sondeaquabidest 0,1%, group 2 : sondecathechins 100 mg and inject D-Galactose 150mg/kgbb, group 3 ; sondecathechins 200 mg and inject D-Galactose 150 mg/kgbb, group 4 : sondecathechine 400 mg and inject D-Galactose150 mg/kgbb) with the inclusion criteria : all female mice (MusMusculus L) were 10-12 weeks old and had not been studied. MDA is examined through blood serum with spektrofotometer. Isolation RNA with Kit Tiangen Kat DP419 and BDNF expression from the hippocampus by RT PCR Increased level of MDA showed increased stress oksidatif. This study the result of MDA levels were not significant ( p value <0.05 ). There was an increase in BDNF expression in the K2 group compared to the other group in the Control, but it was not significant. The dose of 200 mg/kgbb is determine as the most effective dose of gambier beverage to improve the memory of female mice.
UJI AKTIVITAS EKSTRAK ETANOL DAUN LABU SIAM (SECHIUM EDULE (JACQ.) SWARTZ) TERHADAP AKTIVITAS ANTIBAKTERI STAPHYLOCOCCUS AUREUS Cahya, Cucu Arum Dwi; Priasa, Ayunda; M. Br. Turnip, Nur Ulina
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.499

Abstract

Labu siam merupakan tumbuhan jenis labu-labuan yang dapat dimakan buah dan pucuk mudanya. Tumbuhan labu siam mengandung senyawa metabolit sekunder antara flavonoid, alkaloid, saponin. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun labu siam (Sechium edele (Jacq.) Swartz) terhadap pertumbuhan bakteri Staphylococcus aureus. Penelitian ini dilakukan dengan menggunakan metode eksperimental murni. Metode yang digunakan dalam uji aktivitas antibakteri adalah metode difusi dengan kertas cakram. Konsentrasi yang digunakan pada ekstrak daun labu siam terdiri dari konsentrasi 20%, 40%,dan 60%. Hasil skrining fitokimia menunjukkan bahwa ekstak daun labu siam mengandung saponin, flavonoid, dan tanin. Pengaruh pemberian ekstrak daun labu siam terhadap Staphylococcus aureus ditandai dengan terbentuknya zona hambat pada konsentrasi 20%, 40%, dan 60% secara berurutan dengan rerata diameter sebesar 6,6 mm; 8,5 mm; 10,3 mm. Hasil uji One-Way ANOVA didapatkan nilai sig 0,000 (sig<0,05) dan berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh konsentrasi ekstrak daun labu siam terhadap pertumbuhan bakteri Staphylococcus aureus. Konsentrasi 60% yang paling efektif dalam menghambat pertumbuhan bakteri dengan potensi kuat dalam menghambat pertumbuhan bakteri Staphylococcus aureus dengan mengunakan metode difusi. Disarankan pada peneliti selanjutnya untuk melakukan uji aktivitas antibakteri pada bagian tumbuhan yang lain seperti bunga, batang dan akar.
PERBANDINGAN AKTIVITAS ANTIBAKTERI INFUSA DAUN JERUK NIPIS (CITRUS AURANTIFOLIA) DAN DAUN JERUK PURUT (CITRUS HYSTRIX) TERHADAP BAKTERI ESCHERICHIA COLI Siregar, Saadah; Indriani, Indriani; Vincentia Ade Rizky, Vincentia; Visensius Krisdianilo, Visensius; Anna Teresia Marbun, Romauli
Jurnal FARMASIMED (JFM) Vol 3 No 1 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i1.524

Abstract

Plant Lime (Citrus aurantifolia) and Plant Kaffir Lime (Citrus hystrix) including Rutacea family. Part of the plant lemon and lime are used as a drug other than fruit and leaves that can be used as medicine. This study aims to determine the antibacterial activity infuse lime leaves and lime leaves. Examination of the characteristics simplicia macroscopic examination. Phytochemical screening of compounds includes examining alkaloids, flavonoids, tannins and infuse saponin. Ekstrak conducted using distilled water solvent. Test of antibacterial activity against Escherichia coli bacteria carried by the agar diffusion method using a paper disc. Results obtained from macroscopic examination for lime leaves are fresh leaves leaf-shaped single smooth surface and the lower surface of the leaves are light green, the dark green upper surface. If torn, lime leaves produce coarse fibers. The leaves are small with a width of 3-5 cm. For lime leaves are fresh leaves, leaf litter pinnate compound leaves one. Child leaf blade oval to oblong, base rounded or blunt, the blunt end up pointed, 8-15 cm long, 2-6 cm wide, the upper surface colour some what shiny dark green, light green below the surface. Results of phytochemical screening simplicia powder lime leaves and lime leaves that contain a class of alkaloids, flavonoids and tannins. Antibacterial activity test results showed that there were differences between the antibacterial infusion lime leaves and lime leaves kaffir lime leaves which are more effective against the bacteria Escherichia coli compared kaffir lime leaves.
EVALUASI KUALITATIF PENGGUNAAN ANTIBIOTIK CEFTRIAXONE PADA PASIEN DEMAM TYFOID ANAK RUANGAN RAWAT INAP RSUD DELI SERDANG Rahayu, Yayuk Suyudi; Wulandari, Suci; Anjar Pangestuti, Titi
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.567

Abstract

Typhoid fever is a systemic infection caused by the salmonella thypi bacteria which attacks the small intestine with fever for 1 week or more accompanied by disturbances in the digestive tract. This disease is endemic and is a community disease that is transmitted through food and drink contaminated with bacteria. Typhoid fever can be treated using antibiotics, giving antibiotics especially in children and infants must consider the side effects on body systems and organ function that are still not perfect. The purpose of this study was to determine the use of ceftriaxone antibiotics based on the right indication, the right patient, the right drug, the right dose, the right time of administration and the right way of giving antibiotics in the inpatient installation of the Deli Serdang Regional General Hospital in 2019. This study used retrospective data and was analyzed descriptively by purposive sampling method. Data used by pediatric patients (2-12 years). Data according to the inclusion characteristics of 43 cases were evaluated for their quality based on the right indication, the right patient, the right drug, the right dose, the right time of administration and the right way of administration. The results of this study indicate that the percentage of the quality of antibiotic use includes 43 (100%) right indications, 43 (100%) right patients, 43 (100%) right drugs, 30 (73%) right doses, 42 right time of administration ( 97.67%) and the right way of giving was 43 (100%).
FORMULASI SEDIAAN LOTION EKSTRAK ETANOL BIJI KOPI ROBUSTA (Coffea cenephora) Wati, Erda; cahya, uci dwi; Darmirani, Yosi
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.570

Abstract

Bean robusta coffee contains polyphenol compounds which are useful as antioxidants. Antioxidants can inactivate the development of oxidation reactions, by preventing the formation of free radicals. Robusta coffee bean plant (Coffea canephora) is an ingredient that can be formulated into lotion preparations. Cosmetic lotion aims to remove dead skin cells, brighten the skin and soften the skin. This research is to make lotion preparations from robusta coffee bean extract (Coffea Canephora) . This research uses pure experiment. Robusta coffee beans are extracted by maceration process. The lotion formulation is made with variations of robusta coffee bean powder (Coffea Canephora) with a concentration of 2%, 3%, and 4%. The characteristic test includes organoleptic test, homogeneity test, Ph test, and irritation test. The purpose of this study was to determine the lotion formulation for robusta coffee bean extract (Coffea Canephora). The results of the lotion test had a homogeneous concentration of 2%, 3% and 4%, light brown to blackish brown, with a distinctive smell of coffee. The ph lotion test had a PH of 5 in all formulations on the blank had a PH of 6. The irritation test on the lotion preparation showed no erythema and edema in 5 volunteers. From all the tests carried out, the lotion formulation has good characteristics.
EFEKTIVITAS FORMULASI SEDIAAN LOTION DARI EKSTRAK ETANOL DAUN ALPUKAT (PERSEA AMERICANA MILL) SEBAGAI PELEMBAB KULIT Novasari, Hastrina; Pratiwi, Asti; Mahmiara, Nopri
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.571

Abstract

Avocado plant can be formulated into a lotion because preparation based on previous research avocado leavescontain high antioxidant is represented with flavonoid compound. The purpose of this study is to know avocado leaves can be formulated into the preparation of lotion and to know the preparation of lotion from extract etanol avocado leavescan moisturaize the skin. The research uses exsperimental method. Avocado leaves is exstrach by maceration process. Exanination of lotion preparation by this research is phytochemical screening test, pH test,irritation test and skin moisturaise test with concentration 3% and 5%. Extrach ethanol avocado leaves can be formulated into a skin moisturaizing lotion preparation with irritation test results showed no irritation on the skin, skin moisture examination result concentration 5% moist. The result showed that moisturaizing lotion preparation from avocado leaves ethanol extrach (Persea americana Mill) for skin moisture with different concentration can be formulated into skin moisturaizing lotion preparation
DRP EVALUASI DRUNG RELATED PROBLEMS (DRPs) ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP ANAK RUMAH SAKIT UMUM DAERAH DELI SERDANG Monica, Cindy; S, Aminah.; Dalilla, Siti
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.574

Abstract

Background: Infection is one of the top ten diseases in Indonesia, so that antibiotic therapy is quite high. The increasing use of antibiotics may lead to an increase in the use of irrational antibiotics. Drug Related Problems (DRPs) are events that are not expected from the patient's experience or are suspected to be due to drug therapy so that they have the potential to interfere with the desired healing success. Objective: This study aims to determine the number of occurrences of DRPs which include dosage inaccuracy, namely under and over dose, indication without drug, drug without indication, potential interactions and inaccuracy of drug selection in inpatient pneumonia treatment for children at the Deli Serdang Regional public hospital. In 2019 Method: This study is retrospective in which data is obtained through secondary data in the form of patient medical records for the period January-December 2019 with a cross-sectional study design. The data collection technique was in the form of total sampling, obtained 50 samples that fit the inclusion criteria. Results: Drung Related Problems (DRPs) research that occurred in the under-dose category of drugs (4.0%), and excessive drug doses (2.0%) and no DRPs (94.0%). This shows that the role of pharmacists is important in monitoring patient drug therapy to minimize the occurrence of DRPs.
EVALUASI PENGGUNAAN OBAT ANTITUBERKULOSIS (OAT) PADA PASIEN TB PARU DI RUMAH SAKIT GRANDMED LUBUK PAKAM TAHUN 2020 Sinulingga, Amanda Safithri; Boru Situmorang, Novidawati; Gabena Siregar, Mas
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.576

Abstract

Tuberculosis is a disease caused by the bacterium Mycobacterium tuberculosis, a first- line anti-tuberculosis drug, namely Isoniazid (H) and Rifampicin (R). The increase in the number of Tb Lung patients from 2019 to 2020 at the RS Grandmed Lubuk Pakam encouraged researchers to conduct this study. The purpose of this study was to determine the description of the use of antituberculosis drugs and the rationality of the use of anti-tuberculosis drugs in pulmonary TB patients in RS Grandmed Lubuk Pakam in 2019. This study was a descriptive (non-experimental) study with retrospective data collection taken from patient medical records. Pulmonary tuberculosis at RS Grandmed Lubuk Pakam. Data was collected using purposive sampling technique in accordance with the inclusion criteria and exclusion criteria using the Data Collection Sheet. The number of samples used in the study is 76 medical records of patients diagnosed with pulmonary TB. Data analysis was performed using the Univariate with the help of SPSS. Results of the distribution of treatment duration data that most patients underwent treatment for <6 months, as many as 31 people (19.9%). Followed by patients with exactly 6 months length of 30 people (0.39%). Whereas patients from 6 months 16 people (21.1%). And the number of Chronic Disease that suffered by Diabetes Mellitus patients was 24 patients (14.5%). All three have a significant relationship to the patient's treatment outcomes. Whereas at the age range 18-24 years, 44 people (57.9%) were affected by pulmonary TB. and The results of the evaluation of the rationality of pulmonary TB treatment are the exact indications of (97.4%), (74 patients), the right patients by 100% (76 patients), the right drugs by (97.4%) (74 patients), and the correct dosage of 100% ( 76).
EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020 Sebayang, Loraetta Brety; Anna Teresia Marbun, Romauli; Kartika, Dewi
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.582

Abstract

Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs. the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient.

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