cover
Contact Name
Aziz Alfarisy
Contact Email
medicahospitalia@rskariadi.co.id
Phone
-
Journal Mail Official
medicahospitalia@rskariadi.co.id
Editorial Address
-
Location
Kota semarang,
Jawa tengah
INDONESIA
Medica Hospitalia
ISSN : 23014369     EISSN : 26857898     DOI : https://doi.org/10.36408/mhjcm
Core Subject : Health,
Medica Hospitalia: Journal of Clinical Medicine adalah jurnal ilmiah yang diterbitkan RSUP Dr. Kariadi dan menerima artikel ilmiah dalam bahasa Indonesia dan bahasa Inggris yang diharapkan dapat menjadi media untuk menyampaikan temuan dan inovasi ilmiah dibidang kedokteran atau kesehatan kepada para praktisi dan akedemisi di bidang kesehatan dan kedokteran.
Arjuna Subject : -
Articles 584 Documents
Pengaruh Threshold Inspiratory Muscle Training Praoperasi terhadap Kebugaran Kardiorespirasi Pascabedah Ganti Katup Jantung Aditya Paramitha; Sri Wahyudati; Wahyu Wiryawan; Sefri Noventi Sofia
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.42 KB) | DOI: 10.36408/mhjcm.v7i1.433

Abstract

Latar Belakang: Penyakit katup jantung memberikan beban kesehatan yang besar di seluruh dunia. Pasien yang menjalani bedah ganti katup jantung di RSUP Dr. Kariadi Semarang pada tahun 2018 adalah sebanyak 111 pasien. Pada pasien pasca bedah ganti katup jantung terjadi penurunan kebugaran kardiorespirasi. Kebugaran kardiorespirasi dapat diukur melalui pengukuran VO2max. Penambahan threshold inspiratory muscle training (Threshold IMT) praoperasi dianggap mampu menaikkan baseline kebugaran kardiorespirasi sehingga hasil keluaran pascabedah menjadi lebih baik, menurunkan risiko dan komplikasi operasi serta mempersingkat waktu pemulihan dan lama perawatan. Tujuan: Mengetahui pengaruh penambahan Threshold IMT praoperasi terhadap kebugaran kardiorespirasi pasien pascabedah ganti katup jantung. Metode: Penelitian ini merupakan penelitian quasi experimental. Pengambilan sampel penelitian dilakukan secara consecutive sampling, subyek dibagi menjadi kelompok perlakuan (n=9) dan kelompok kontrol (n=9). Kelompok perlakuan diberikan latihan rehabilitasi medik konvensional rutin sebelum bedah ganti katup jantung sesuai dengan Panduan Praktik Klinis (PPK) serta ditambahkan Threshold IMT sesuai protokol penelitian. Kelompok kontrol hanya melakukan latihan rehabilitasi medik konvensional. Hasil: Terdapat perbedaan yang bermakna secara klinis antar kelompok perlakuan dan kontrol pascabedah dengan minimal clinically important difference lebih dari 6%. Terdapat perbedaan yang bermakna secara statistik untuk nilai VO2max pra dan pascaperlakuan dalam kelompok perlakuan (p=0,021), serta antar kelompok perlakuan dan kontrol pascaperlakuan (p=0,026). Kesimpulan: Penambahan Threshold IMT praoperasi meningkatkan kebugaran kardiorespirasi pasien pra dan pascabedah ganti katup jantung. Kata kunci: Threshold inspiratory muscle training, VO2max. Background: Heart valve disease presents a huge health burden worldwide. Patients who underwent cardiac valve replacement surgery at RSUP Dr. Kariadi Semarang in 2018 were 111 patients. Cardiorespiratory fitness declined in post-surgical patients. Cardiorespiratory fitness can be measured through VO2max. Additional preoperative threshold inspiratory muscle training (Threshold IMT) is considered to safely increase cardiorespiratory fitness baseline, reduce the risks and complications of surgery as well as shorter recovery time and treatment duration, thus postoperative outcomes will be better. Objective: To determine the effect of additional preoperative Threshold IMT on cardiorespiratory fitness in post heart valve replacement surgery patients. Method: This study is quasi experimental. Sampling was done by consecutive sampling, subjects were divided into two groups, intervention group (n=9) and control group (n=9). The intervention group was given routine conventional medical rehabilitation exercise before heart valve replacement surgery according to the Clinical Practice Guide (PPK) and added Threshold IMT according to the study protocol. The control group only did conventional medical rehabilitation exercises. Results: There was clinically significant difference post surgery between intervention and control groups with minimal clinically important difference of more than 6%. Statistically significant differences were obtained for the VO2max values ??pre and post treatment in the intervention group (p = 0.021) and between the intervention and control groups (p = 0.026) post-treatment. Conclusion: Addition of preoperative Threshold IMT increases cardiorespiratory fitness pre- and post-operative in heart valve replacement surgery patients. Keyword: Threshold inspiratory muscle training, VO2max.
Efektifitas Posisi Dan Ambulasi Dini Terhadap Nyeri Punggung Pada Pasien Post Percutaneous Coronary Intervention Arafat, Husein; Purwanti, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.996 KB) | DOI: 10.36408/mhjcm.v7i1.434

Abstract

Latar Belakang : Percutaneous Coronary Intervention (PCI) adalah prosedur intervensi non bedah dengan menggunakan kateter untuk melebarkan atau membuka pembuluh koroner yang menyempit dengan balon atau stent. Tirah baring yang lama pada pasien PCI menimbulkan komplikasi yaitu nyeri punggung. Mengurangi nyeri punggung dapat menggunakan perubahan posisi dan ambulasi dini setelah tindakan pelepasan femoral sheath. Tujuan dari penelitian ini untuk mengetahui efektifitas posisi dan mobilisasi dini terhadap nyeri punggung pasien post PCI. Metode : Desain penelitian yang digunakan adalah kuasi eksperimen pre dan post test kontrol grup. Intensitas nyeri punggung dalam penelitian ini diukur menggunakan visual analog scale (VAS). Sampel pada penelitian ini masing-masing 30 responden untuk kelompok kontrol dan kelompok perlakuan pasien post PCI di Instalasi Elang RSUP dr. Kariadi Semarang, dengan teknik pengambilan sampel purposive sampling. Hasil : Hasil uji didapatkan nilai p value 0,000 sehingga dapat disimpulkan pemberian posisi dan ambulasi dini efektif untuk menurunkan nyeri punggung pasien post PCI. Simpulan : Pemberian posisi dan ambulasi dini bisa diaplikasikan sebagai salah satu intervensi keperawatan pada pasien post PCI. Kata kunci : posisi, ambulasi dini, nyeri punggung, post PCI Background : Percutaneous coronary intervention (PCI) is a non-surgical procedure by uses coronary catheterizationto treat narrowing (stenosis) of the coronary arteries of the heart found, using a balloon or stents.The impact of prolong bedrest in patient post PCI,can caused complication such as back pain. Positioning and early ambulation can be used to reduce back pain after removal of sheath. The aim of the study is to determine the effectiveness of positioning and early ambulation to reduce back pain of patient post PCI. Methods : The research methodology used in this study is quasy experimental with one group pre test and post test with control.The number of samples in the study was thirty respondents in each groupby the used purposive sampling techniques. Result : The statistical test result was p value 0.000, it means that the positioning and early ambulation effected in reducing back pain of patient after PCI. Conclusion : Positioning and early ambulation can be applied as one of nursing intervention for the post PCI patients. Keywords : positioning, early ambulation, back pain, post PCI
Terapi Antikoagulan pada Kehamilan Trimester Pertama pada Pasien dengan Riwayat Penggantian Katup Mitral Mekanik Dwi Wahyuni, Maria Gita; Yudanto, Aruman
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (894.007 KB) | DOI: 10.36408/mhjcm.v7i1.435

Abstract

Penggantian katup jantung mekanik memerlukan terapi antikoagulan seumur hidup. Sementara itu, risiko trombosis pada katup mekanik diketahui meningkat pada saat kehamilan. Risiko ini menurun dengan terapi antikoagulan pada dosis yang adekuat. Guideline merekomendasikan penggunaan antagonis vitamin K (VKA) seperti warfarin. Namun warfarin memiliki efek teratogenik sehingga kadangkala terapi antikoagulan dialihkan ke heparin karena preparat ini tidak menembus sawar plasenta. Namun penggunaan heparin diketahui kurang efektif dibandingkan warfarin sehingga memungkinkan meningkatnya risiko kejadian trombosis. Guideline menyebutkan dosis warfarin <5 mg/24 jam sebagai alternatif terapi pada trimester pertama. Kasus ini memaparkan pasien dalam kondisi hamil trimester pertama dengan riwayat penggantian katup mitral mekanik. Antikoagulan VKA dipilih untuk tetap diberikan pada kehamilan trimester pertama dengan dosis <5 mg/24 jam disertai pemeriksaan INR setiap dua minggu untuk mencapai target adekuat (2.5-3.5 menurut AHA 2014). Kondisi janin diketahui baik yang dipantau melalui pemeriksaan USG fetal yang dilakukan berkala. Kesimpulan : Kehamilan paska MVR meningkatkan risiko trombosis dan secara mutlak memerlukan terapi antikoagulan dengan dosis adekuat. Terapi VKA pada berbagai kajian sistematik diketahui aman dilanjutkan pada kehamilan trimester pertama, jika diberikan dengan dosis <5 mg/24 jam. Kata kunci : kehamilan trimester pertama, bedah jantung penggantian katup mital mekanik, antikoagulan, warfarin, heparin, LMWH Heart valve replacement with a mechanical valve requires lifelong anticoagulation. The risk of valve thrombosis is markedly increased during pregnancy. The risk is lower with adequate dosing of anticoagulant therapy. Guidelines currently recommend using a vitamin K antagonist (VKA) such as warfarin. Given the teratogenic effects of VKAs, it is often favorable to switch to heparin derived therapies in pregnant patients since they do not cross the placenta. However, these therapies are known to be less effective anticoagulants subjecting the pregnant patient to a higher chance of a thrombotic event. Guidelines currently recommend pregnant women requiring more than 5 mg a day of warfarin be switched to alternative therapy during the first trimester. This case report highlights a patient who was in her first pregnancy after mechanical mitral valve replacement, she continued to use warfarin in her first trimester with daily dose 3 mg/24 hours. Vitamin K antagonist prefer to be given in first trimester of pregnancy with daily dose less than 5 mg and with monitoring of International Normalized Ratio 2.5-3.5 (AHA Guideline 2014). Fetus condition is observed in good condition with fetal ultrasonography. Conclusions : Pregnant women with a mitral valve replacement (MVR) are at a heightened risk of a thrombotic event, and their absolute need for adequate anticoagulation. Vitamin K antagonist based on many systematic reviews is safe for first trimester of pregnancy if prescribed with daily dose less than 5 mg. Keywords : first trimester of pregnancy, mitral valve replacement, anticoagulant, warfarin, heparin, low molecular weight heparin
Karsinoma Ovarii Serosa pada Kehamilan dengan Komplikasi IUGR : Laporan Kasus di RSUP Dr. Kariadi, Semarang Hapsari, Anggiyasti Vidya; Ambari, Ediwibowo; Dewantiningrum, Julian; Ushan, Ery Perdana
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.943 KB) | DOI: 10.36408/mhjcm.v7i1.436

Abstract

Karsinoma ovarium merupakan keganasan ginekologi terbanyak kedua yang terjadi pada kehamilan. Dilaporkan terjadi 1:10.000 sampai 1:25.000 kehamilan. Histopatologi karsinoma ovarium jenis epitelial lebih jarang terjadi dibandingkan germ cell tumor1,2. Kehamilan tidak mempengaruhi prognosis karsinoma ovarium, akan tetapi komplikasi yang mungkin terjadi adalah torsi tumor, ruptur dan meningkatkan kemungkinan terjadinya persalinan prematur16. Tulisan ini melaporkan seorang wanita, 31 tahun, primigravida, hamil 34 minggu, dengan pembesaran abdomen melebihi usia kehamilan, peningkatan kadar Ca-125 darah dan massa solid ovarium sinistra disertai ascites pada pemeriksaan ultrasonografi. Pemeriksaan histopatologi jaringan tumor ovarium, uterus dan omentum menunjukkan diagnosis low grade serous carcinoma ovarii bilateral dengan infiltrasi hingga tuba dan omentum. Pemeriksaan rutin kehamilan dengan ultrasonografi penting dilakukan untuk skrining adanya neoplasma ovarium yang menyertai kehamilan. Penatalaksanaan hamil dengan tumor padat ovarium tergantung dari usia kehamilan. Menurut algoritme dilakukan operasi pengangkatan massa dan dilakukan frozen section (FS) untuk mengetahui sifat tumor jinak atau ganas pada usia kehamilan 18-22 minggu dan dilanjutkan dengan operasi lanjutan setelah kelahiran bayi16. Pada kasus ini dengan mempertimbangkan kehamilan ini merupakan kehamilan pertama dengan tidak adanya keluhan dan secara prinsip tidak adanya perubahan anatomi untuk dapat dilakukan operasi complete surgical staging saat bayi dilahirkan pada usia kehamilan 34 minggu, maka dari hasil rapat medis diambil keputusan untuk dilakukan operasi complete surgical staging bersamaan setelah sectio caesaria. Prosedur operasi ini tidak mudah dilakukan dan banyak dihindari, tetapi dengan kehati-hatian dan identifikasi struktur anatomi yang baik, maka operasi berjalan lancar.
Herpes Zoster Otikus Dengan Paresis Nervus Fasialis (Sindrom Ramsay Hunt) Pada Pasien Imunokompromais Ametati, Holy; Avianggi, Hayra Diah
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.013 KB) | DOI: 10.36408/mhjcm.v7i1.437

Abstract

Latar belakang: Sindrom Ramsay Hunt (SRH) merupakan komplikasi yang jarang terjadi pada herpes zoster. SRH dapat terjadi tanpa adanya ruam kulit (zoster sine herpete). Karena gejala-gejala ini tidak selalu muncul saat onset, sindrom ini sering salah didiagnosis. Insidensi 5/100.000 kasus pada populasi di Amerika Serikat dan meningkat pada kelompok umur di atas 60 tahun dan kondisi imunokompromais. Laporan Kasus: Laki-laki, 66 tahun, timbul plenting-plenting di daerah telinga kiri menyebar ke dada sebelah kiri sejak 8 hari sebelum dikonsulkan. Terdapat nyeri pada telinga, pendengaran berkurang, pusing berputar, wajah sebelah kiri sulit digerakkan dan sulit berbicara. Permeriksaan fisik ditemukan vesikel berkelompok dengan dasar kulit eritem dan edema, bula, erosi, krusta, konfigurasi herpetiformis, distribusi unilateral, segmental setinggi persarafan servikal 2-4. Temuan tzank test menunjukkan sel datia berinti banyak. Penatalaksanaan dengan sistemik asiklovir dan metilprednison. Pembahasan: SRH merupakan hasil reaktivasi virus varicella zoster laten diganglion genikulatum yang menyebabkan vesikel pada aurikula, otalgia dan paresis/paralisis fasialis. Mekanisme pencetus reaktivasi pada pasien ini diduga berhubungan dengan imunokompromais (keganasan). Pasien imunokompromais memiliki resiko 20-100 kali lebih besar. Pemeriksaan Tzank sesuai dengan gambaran herpes zoster. Terapi SRH yang paling disarankan adalah terapi kombinasi antivirus dan kortikosteroid. Kesimpulan: Telah dilaporkan kasus herpes zoster otikus dengan paresis nervus fasialis (Sindrom Ramsay Hunt) pada pasien imunokompromais. Hasil terapi memuaskan. Prognosis qua ad vitam ad bonam, ad sanam dubia ad malam, ad cosmeticam dubia ad bonam. Kata kunci: Sindrom Ramsay Hunt, Herpes Zoster Otikus, Paresis Nervus Fasialis, Immunokopromais. Background; Ramsay Hunt Syndrome (RHS) is a rare complication in shingles. RHS can occur without the presence of skin rash (zoster sine herpete). Because these symptoms do not always appear at onset, RHS is often misdiagnosed. The incidence of 5/100,000 cases in the US and increase in the age above 60 years and immunocompromised. Case: A 66-years-old male complaint of vesicle on the left ear spreading to left chest, since 8 days prior to the consultation. There was otalgia, dizziness, hearing impairment, difficulty in movement and speaking on the left side. Physical examination found clustered vesicle on an erythematosus and oedematous base, bullaes, erosions, crusts, in a herpetiformis configuration, unilateral distribution, in a level of 2-4 cervical nerve innervation. The Tzank test showed multinucleated giant cells. Management with systemic acyclovir and methylprednisolone. Discussion: RHS is the result of reactivation of latent varicella zoster virus in geniculate ganglion which causes vesicles in the auricle, otalgia and facial paresis / paralysis. The mechanism for triggering reactivation in these patients is immunocompromise (malignancy). Immunocompromised have a 20-100 times greater risk. Tzank results in accordance with diagnostic of herpes zoster. The most recommended therapy is combination of antiviral and corticosteroid. Conclusion: The case of herpes zoster oticus with facial nerve paresis (Ramsay Hunt Syndrome) in immunocompromised has been published. The result of therapy was satisfying. The prognosis qua ad vitam ad bonam, ad sanam dubia ad malam, ad cosmetics dubia ad bonam. Keywords: Ramsay Hunt Syndrome, Herpes Zoster Oticus, Facial Nerve Paresis, Immunokopromised.
Serial Case : Unilateral Dan Trilateral Retinoblastoma HIsbulloh, Hisbulloh; Hendara, Farah
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (592.219 KB) | DOI: 10.36408/mhjcm.v7i1.438

Abstract

LATAR BELAKANG Retinoblastoma adalah tumor intraocular pada anak. Insidensi diperkirakan 1 dalam 15.000 pada 34.000 kelahiran. Retinoblastoma trilateral merupakan kombinasi yang jarang dari unilateral atau bilateral retinoblastoma dengan neoplasma intrakranial neuroblastik, biasanya ditemukan di daerah pineal atau daerah suprasellar. Dalam kasus retinoblastoma trilateral , prognosisnya buruk dengan tingkat kelangsugan hidup antara 9 sampai 13 bulan setelah diagnosis. LAPORAN KASUS Kasus 1, anak laki-laki berusia 1 tahun dengan keluhan leukokoria mata kanan, proptosis, kemerahan, kelopak mata bengkak dan juga memiliki riwayat perdarahan di mata kanan. Pemeriksaan CT scan menunjukkan lesi padat dengan kalsifikasi pada aspek posterior mata kiri (AP 1,32 x LL 1,72 x CC 0,7 cm). Kontras CT mata kanan menunjukkan massa jaringan lunak dengan kalsifikasi (AP 3,57 x LL 3,1 x CC 3,1 cm), meluas ke retrobulbar, saraf optik menebal dan massa parasellar yang enhance(AP 2,6 x LL 2,5 x CC 2,2 cm) Kasus 2, anak laki-laki berusia 2 tahun dengan keluhan mata kanan tampak plak putih yang semakin melebar. Pada pemeriksaan CT scan menunjukan lesi pada inhomogen irregular disertai kalsifikasi pada intra bulbus occuli kanan. PEMBAHASAN Retinoblastoma bisa terjadi baik unilateral bilateral, trilateral maupun quadrilateral. Pada kasus ini, pemeriksaan radiologi berperan untuk mendeteksi adanya tumor baik intra ocular maupun ekstra ocular. Diagnosis yang cepat dan tepat dengan menggunakan neuroimaging disertai penatalaksanaan yang agresif dapat menurunkan mortalitas pada pasien dengan retinoblastoma dan tumor intracranial. KESIMPULAN Diagnosis awal dan pengobatan terbukti penting dalam mengatasi perluasan tumor dan metastasis intracranial yang kemungkinan menyebabkan kematian. CT scan dan MRI sangat penting untuk diagnosis awal, perluasan, staging, rencana pengobatan dan follow up pasien retinoblastoma. Kata kunci : retinoblastoma, unilateral, trilateral, CT scan
Efektivitas Ozonated Virgin Coconut Oil Dosis Bertingkat Terhadap Penyembuhan Luka Full Thickness Skin Graft Autolog Ditinjau Dari Jumlah Fibroblas Dan Ekspresi Vascular Endothelial Growth Factor Pada Tikus Sprague Dawley Napitupulu, Johan Rinto Even; Hardian, Hardian; Najatullah, Najatullah
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (747.524 KB) | DOI: 10.36408/mhjcm.v8i1.447

Abstract

Abstract Background: Now, Skin grafts are one of the therapies of choice in the wound healing process. And this is still developing today. The process of formation fibroblas and the formation of vascular endothelial growth factor have an important role in healing skin graft wounds. Ozonated virgin coconut oil has an important role in wound healing. Objective: To prove the effect of ozonated virgin coconut oil in various doses in increasing number of fibroblas and expression of vascular endothelial growth factor of skin graft wounds. Methods: This study is an experimental study with "Randomized parallel study with controlled group design" on 40 Sprague Dawley rats which are performed an autologous skin graft at the same time. Samples were divided randomly into 8 groups (K1 and K2 = without ozonated VCO), (A1 and A2 = ozonated VCO 50,4 mg/ml), (B1 and B2 = ozonated VCO 103,2 mg/ml), (C1 and C2 = ozonated VCO 204 mg/ml). Evaluation of the amount of fibroblas was done by staining hematoxylin & eosin after the 6th day and the expression of vascular endothelial growth factor was done by staining immunohistochemistry after the 12th day after skin graft. Results: Statistical analysis of the amount of fibroblas after the 6th day was found to be significantly different between the K1 vs A1 group (p = 0.029), K1 vs B1 (p = 0.004), K1 vs C1 (p = 0.000), on the 12th day was found significantly different the amount of fibroblast between K2 vs A2 ( p = 0,029 ), K2 vs B2 ( p = 0,010 ), K2 vs C2 ( p = 0,001 ). The expression of vascular endothelial growth factor on the 6th day was found a significant difference between the K1 vs A1 group (p = 0.024), K1 vs B1 (p = 0.005), K1 vs C1 (p = 0.001), on the 12th day was found significantly different the expression of vascular endothelial growth factor between K2 vs A2 ( p = 0,011 ), K2 vs B2 ( p = 0,036 ), K2 vs C2 ( p = 0,004 ) . Conclusion: Ozonated VCO can increase the amount of fibroblas and expression of vascular endothelial growth factor in the wound healing process of autologous skin graft in Sprague Dawley rats. Keywords: Ozonated VCO, full thickness skin graft, fibroblas, VEGF.
PENGARUH EKSTRAK EDAMAME KAYA GENISTEIN TERHADAP KADAR LOW DENSITY LIPOPROTEIN, HIGH SENSITIVITY-C REACTIVE PROTEIN, SERTA RASIO NEUTROFIL LIMFOSIT DAN MONOSIT LIMFOSIT: Studi Experimental pada Tikus Jantan yang Diinduksi Aterosklerosis Pratama, Reza Dian; Maharani, Nani; Bahrudin, Udin
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.892 KB) | DOI: 10.36408/mhjcm.v8i1.450

Abstract

ABSTRACT Background: Atherosclerosis is related to hypercholesterolaemia and inflammation. Edamame is one of the soybeans with high levels of genistein which protects the formation of atherosclerosis. Purpose: This research aimed to evaluate the effects of genistein-rich edamame on LDL, hs-CRP, Neutrophil-Lymphocyte Ratio (NLR) and Monocyte-Lymphocyte Ratio (MLR) on atherosclerosis-induced mice. Method: This research is a true experimental study with posttest only-controlled group design. Thirty male rats were divided randomly into five groups: negative control group without any intervention, positive control group with atherosclerosis induction, first intervention group with edamame extract supplementation, second intervention group with genistein-rich edamame extract supplementation, and third intervention group treated with atorvastatin. After 28 days, serum LDL, hs-CRP, LDL and MLR were measured. Results: There were significant differences (p<0.001) of hs-CRP values between the second intervention group compared to the negative control, positive control and first intervention group. Edamame extract lowered LDL cholesterol levels in the second intervention group compared to positive control, but the difference were not statistically significant. There were significant differences (p<0.05) of MLR values between the second intervention group and the negative control and also the first intervention group, and significant differences between the second intervention group and the negative control and also the first intervention group. There was no significant difference on NLR values between all groups. Conclusion: The administration of genistein rich edamame may reduces the inflammation in the blood vessels better than edamame extract represented by lower hs-CRP and MLR values compared to the edamame extract. Keywords: Genistein rich-edamame, LDL, hsCRP, neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio
Hafidh, THE LEVEL OF KNOWLEDGE OF HEALTH CARE WORKERS WITH THE LATENT TUBERCULOSIS Aji Prasetyo, Hafidh Bagus; Adji, Raden Mas Soerjo; Setiawan, Andreas Arie; Pramudo, Setyo Gundi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.909 KB) | DOI: 10.36408/mhjcm.v8i1.453

Abstract

ABSTRACT Background : Pulmonary tuberculosis is a contagious infectious disease caused by the Mycobacterium tuberculosis. Health workers have an increased risk of contracting tuberculosis, because they are exposed to TB in their workplaces. The absence of hospital control measures against TB infection makes the risk factor becomes high. Health workers often make contact with TB sufferers. In a good body condition, although infected by TB germs, it does not manifest as a disease or called latent TB. However, latent TB sufferers still have the risk of being active in certain conditions, which then becomes a source of new TB transmission. Objective: This study aims to look at the level of knowledge of health workers towards the incidence of Latent TB in the Hospital. Method : The research method is cross-sectional using a sample of health workers who work in hospitals. The sample size of this study was 46 people using purposive sampling. This study has a variable Health worker knowledge about TB disease and Latent TB incidence. The method of data analysis using Chi Square Test. Result : The results were not significant between the level of knowledge and the incidence of Latent TB in health workers (p = 0.584). While the use of masks with the incidence of latent TB had a significant relationship (p=0,001). Conclusion : There is no significant relationship between the level of knowledge with the incidence of Latent TB in health workers. While the use of masks with the incidence of latent TB has a significant relationship. Keywords : Tuberculin Skin Test, Awareness, Incident, Workplaces.
Manajemen Perioperatif pada Pasien COVID-19 Widya Istanto; Erik Maruli Tua
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (648.276 KB) | DOI: 10.36408/mhjcm.v7i1A.455

Abstract

Kemunculan dan penyebaran severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) menyebabkan krisis kesehatan yang mengancam dunia. Infeksi yang disebabkan SARS-CoV-2 disebut coronavirus disease 2019 (COVID-19). Laporan WHO per tanggal 30 Mei 2020, terdapat 5.817.385 kasus dengan 362.705 kematian secara global dengan 249.525 kasus dan 7.157 kematian di wilayah Asia Tenggara. Cara penularan COVID-19 dari manusia ke manusia telah diidentifikasi melalui droplet dan kontak langsung atau secara tidak langsung melalui sentuhan benda. SARS-CoV-2 pertama kali ditularkan dari hewan ke manusia di pasar basah Wuhan dan akhirnya mempertahankan penularan dari manusia ke manusia. Penyebaran virus ini semakin meluas sehingga menimbulkan pandemi. Kondisi pandemi menimbulkan banyak tantangan bagi sistem kesehatan terutama dalam pengendalian infeksi dan penatalaksanaan penyakit. Ahli anestesi memainkan peran penting dalam epidemi, karena kasus yang dicurigai atau dikonfirmasi mungkin memerlukan anestesi untuk tindakan pembedahan, serta keahlian manajemen jalan napas dalam kasus yang kritis. Pada kasus yang memerlukan tindakan pembedahan, ahli anestesi berperan dalam penilaian pasien COVID-19 pre-operasi, intraoperasi, dan pascaoperasi.