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Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya
Published by Universitas PGRI Banyuwangi
ISSN : -     EISSN : 26857065     DOI : https://doi.org/10.36526/jc
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering
Jurnal crystal merupakan jurnal yang diterbitkan oleh program studi kimia Universitas PGRI Banyuwangi. Jurnal ini memuat dan menerbitkan jurnal yang sesuai dengan bidang ilmu kimia murni dan terapannya yang terbit dua kali dalam setahun yaitu bulan maret dan september. adapun penerbitan jurnal didasari dengan komitmen pada kelayakan penulisan artikel ilmiah, prosedur dan format penulisan, dan kontinuitas publikasi.
Arjuna Subject : -
Articles 151 Documents
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XYLOKETAL DERIVATIVES FROM XYLARIA SP. AS STRUCTURAL LEADS FOR DUAL MYC/BCL2 AXIS MODULATION FOR DOUBLE-HIT HIGH-GRADE B-CELL LYMPHOMA: A DOCKING-BASED INVESTIGATION Rizki Rachmad Saputra; Retno Agnestisia; Reny Rosalina; Siti Sunariyati; Yohanes Edy Gunawan
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7402

Abstract

High-grade B-cell lymphoma with concurrent MYC and BCL2 rearrangements, known as double-hit lymphoma, shows rapid tumor growth, strong resistance to apoptosis, and poor response to current therapies, largely because available treatments fail to target both oncogenic drivers at once. This study aimed to identify potential dual modulators of the MYC/BCL2 axis by evaluating xyloketal derivatives using a structure-based pharmacoinformatic approach. A total of twenty-one natural and semi-synthetic xyloketal compounds were prepared and analyzed through molecular docking against BCL2 at the BH3-binding groove (PDB: 4MAN) and the MYC/MAX heterodimer at the leucine zipper interface (PDB: 1NKP). Binding affinity, interaction profiles, and structure–activity relationships were examined using AutoDock Vina and Discovery Studio. The results showed that Xyloketal A achieved the strongest BCL2 binding affinity (−9.1 kcal/mol) while maintaining stable interactions with the MYC/MAX interface (−7.0 kcal/mol), supported by hydrogen bonding with Arg143 and Asp108 and hydrophobic contacts within the BH3 groove. Xyloketal J displayed the highest MYC/MAX affinity (−7.4 kcal/mol) with consistent BCL2 engagement, indicating a MYC-biased but still dual-target profile. Several derivatives, including Xyloketal A, Xyloketal J, and Xyloketal B cinnamyl ether, demonstrated balanced activity across both targets. These findings confirm that xyloketal scaffolds can engage both the BCL2 hydrophobic pocket and the MYC/MAX protein–protein interface, suggesting their potential as dual-target inhibitors. This study provides a clear computational foundation for the design and optimization of multi-target therapeutics aimed at overcoming the aggressive biology of double-hit high-grade B-cell lymphoma.
PENGARUH DOPING CUO DAN ZAT ADITIF MONOETHANOLAMINE (MEA) PADA SINTESIS TIO2 MENGGUNAKAN METODE SOL-GEL TERHADAP BAND GAP ENERGY atifaturahmah; Hary Sanjaya; Trisna Kumala Sari; Fajriah Azra
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7415

Abstract

Titanium dioxide (TiO₂) is a semiconductor material that is widely used for photocatalytic applications, but it has a relatively large band gap value so that its activity in the visible light region is limited. This study aims to analyze the effect of CuO doping and the addition of monoethanolamine (MEA) additives on the band gap value of TiO₂ synthesized by the sol-gel method. CuO doping was carried out using CuCl₂·2H₂O precursor with concentration variations of 5%, 10%, 15%, 20%, and 25%. The optimum concentration was then combined with variations in MEA volume of 1 mL, 2 mL, and 3 mL. The synthesized material was characterized using UV-DRS and the band gap value was calculated using the Kubelka-Munk approach. The results of the study showed that the addition of CuO doping caused a decrease in the band gap value of TiO₂ from 3.33 eV to 3.29 eV at an optimum concentration of 15%. The addition of MEA further reduced the band gap, with the lowest value being 3.27 eV at 3 mL MEA volume. This decrease indicates that CuO doping and MEA additives play a role in modifying the electronic structure of TiO₂, thereby narrowing the energy band gap. Thus, the combination of CuO and MEA doping has the potential to enhance the optical response of TiO₂ in the visible light region, namely the range 400 – 800 nm
SURFACE AREA DRIVEN CRYSTALLINITY CHANGES OF HYDROXYAPATITE DURING SIMULATED BODY FLUID IMMERSION Agung Prabowo; Ahmad Fadli; Heni Sugesti; Muh Irwan
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7420

Abstract

The bioactivity of hydroxyapatite (HA) powders is strongly influenced by surface area and crystallinity. This study evaluates the effect of surface area and Ca/P ratio on the bioactivity of HA through immersion in simulated body fluid (SBF) for 3–21 days. Structural and chemical changes were analyzed using XRD, BET, SEM–EDX, and XRF, with bioactivity assessed from XRD peak intensity at 2θ ≈ 30°, degree of crystallinity, Ca/P ratio, calcium ion concentration, and pH variation. The results show that HA maintained its crystal phase during immersion, with the degree of crystallinity varying between 82% and 96%. An initial decrease in crystallinity and peak intensity indicated early HA dissolution, followed by an increase due to apatite layer formation at intermediate immersion times. Prolonged immersion resulted in reduced crystallinity, attributed to calcium depletion and partial re-dissolution. Higher surface area accelerated calcium ion consumption and enhanced apatite formation, confirming improved bioactivity of HA in SBF
A LOW-COST COLORIMETRIC DETECTION OF HG2+ USING PAPER-BASED SENSOR WITH EUCLIDEAN DISTANCE APPROACH Muh. Supwatul Hakim; Tety Wahyuningsih Manurung; Mokhamat Ariefin; Dwi Hermayantiningsih
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7434

Abstract

Mercury (Hg) is a highly toxic heavy metal that poses significant risks to human health and aquatic ecosystems. The development of rapid and low-cost detection methods is urgently needed. In this work, the paper-based colorimetric sensor was developed by immobilizing dithizone onto Whatman No. 41 filter paper for the detection of Hg2+. The sensor utilized the color change of the sensor from green to orange with the color formation of Hg–dithizone complex. FTIR analysis confirmed the successful immobilization of dithizone with characteristic absorption of C=N and C=S vibrations. For quantification, digital images captured by a smartphone were analyzed using the Euclidean Distance (ED) approach. The sensor demonstrated a linear response in the concentration range of 1–5 mg/L (R2 = 0.991), with a limit of detection (LOD) and limit of quantification (LOQ) of 0.50 mg/L and 1.67 mg/L, respectively. Furthermore, the sensor exhibited high precision with a %RSD of 4.39%. Selectivity tests under acidic conditions confirmed that Hg2+ yielded the highest ED value compared to other metal ions such as Cu2+, Pb2+, Co2+, Ni2+, and Zn2+. This paper-based sensor provides a simple, portable, and cost-effective tool for the on-site monitoring of mercury in environmental samples
PENENTUAN INHIBITOR SELEKTIF DALAM MENGHAMBAT KERJA ENZIM SIKLOOKSIGENASE-2 dan EFEK MUTASI RESIDU ASAM AMINO SECARA IN SILICO Aga Adi Masyhuri
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7471

Abstract

The development of selective inhibitors for Cyclooxygenase-2 (COX-2) enzymes is a strategic priority in molecular pharmacology to address the pathophysiology of inflammation without triggering gastrointestinal side effects. This report synthesizes research findings on the binding efficacy of four specific inhibitors—Celecoxib, Rofecoxib, Valdecoxib, and Etoricoxib—using an in-silico methodology based on AutoDock 4.0 docking algorithm. The primary finding reveals that Etoricoxib exhibits the highest selectivity with a ratio of 133, supported by molecular interactions at the methyl sulfone and pyridine groups. Residue mutation analysis identifies Tyrosine 385 (Y385) on COX-2 and Phenylalanine 518 (F518) on COX-1 as critical residues determining the dynamics of active site accessibility through catalytic volume change mechanisms. This report makes a significant contribution by validating computational methods as an accurate predictive tool for mapping ligand-receptor interactions on the COX-2 enzyme
ANALISIS KANDUNGAN TIMBAL PADA MINUMAN SUSU CAIR KEMASAN KALENG DI TONDANO MENGGUNAKAN SPEKTROFOTOMETRI SERAPAN ATOM Elsa Sangian; Abdon Saiya; Stefan Marco Rumengan
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7474

Abstract

Canned liquid milk is a popular product because it is convenient, readily available, and has a long shelf life. Cans have the potential to cause lead contamination, which poses a risk to consumer health. This study aims to determine the lead Pb content in canned liquid milk. The qualitative analysis method in this study used HCl reagent, while quantitative analysis employed Atomic Absorption Spectrophotometry on the three canned liquid milk samples labeled A, B, and C. Qualitative test results indicated that all three milk samples tested positive for Pb, as evidenced by the formation of a white precipitate. Quantitative analysis results showed Pb levels of 0.014 mg/kg in sample A, 0.008 mg/kg in sample B, and 0.007 mg/kg in sample C. All samples remained below the limit specified by SNI 8984 of 2021, which is 0.02 mg/kg.
ANALISIS BIBLIOMETRIK PENELITIAN HIDROGEL KONDUKTIF SODIUM ALGINAT DENGAN VOSVIEWER Tsalsa Romadona; Siti Aisyah
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7531

Abstract

This study aims to analyze research trends and scientific developments in alginate-based conductive hydrogels and their applications in sensor technology using a bibliometric approach. Data were retrieved from the Scopus database for the period 2014–2026 using the keywords “alginate,” “sodium alginate,” “alginic acid,” “hydrogel,” and “sensor.” A total of 281 publications were analyzed using VOSviewer to evaluate keyword co-occurrence, research clusters, and thematic evolution. The results show that “sodium alginate” and “hydrogel” are the main nodes in the research network, with strong linkages to topics such as biosensors, drug delivery, and wound healing. Cluster analysis identifies major research focuses, including conductive and flexible sensors, biomedical applications of alginate, and biopolymer-based sensing materials. In addition, publication trends indicate a significant increase in research output during the 2022–2024 period, reflecting growing scientific interest in this field. Overall, this study provides a comprehensive overview of the research landscape, highlighting key themes, collaboration patterns, and emerging trends in alginate-based conductive hydrogel research. These findings offer valuable insights for guiding future research directions based on observed publication trends.
UJI AKTIVITAS BROMELIN DARI ANANAS COMOSUS DAN PAPAIN DARI CARICA PAPAYA TERHADAP PH MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Zahrotun Nafisah; Dermawan Saro Halawa; Eka Miranda Silaban; Sonia Tri Mart Hutapea; Nasa Natalia; Nia Hana Pratiwi; Kamelia Fahmiati
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7624

Abstract

Protease enzymes such as bromelain from Ananas comosus and papain from Carica papaya are cysteine ​​protease enzymes that have great potential in various applications in the food, pharmaceutical, and biotechnology industries. This study aims to characterize the activity of bromelain and papain enzymes against pH variations using a casein-based spectrophotometric method and a tyrosine standard curve. Enzyme activity is determined based on the amount of tyrosine produced from casein hydrolysis and measured at a wavelength of 280 nm. One unit of enzyme activity is defined as the amount of enzyme that produces 1 µmol of tyrosine per mL per unit reaction time. The yields of bromelain and papain enzyme extraction in this study reached 38% and 32% with protein levels of 10.04 and 21.89 mg/mL, respectively. The activity values ​​of bromelain and papain are significantly affected by changes in pH. Bromelain showed optimum activity at pH 6, amounting to 25.4 U/mL, while the activity decreased drastically at acidic pH. The papain enzyme also has an optimum activity of 17.1 U/mL at pH 6, which decreases drastically at alkaline pH. This activity pattern is consistent with the general characteristics of cysteine ​​protease enzymes, which are sensitive to changes in the ionization of their active groups. The differences in response to pH variations indicate the specific characteristics of each enzyme, influenced by the structure and conformational stability of its protein. The results of this study provide important information regarding the optimum working conditions of both enzymes as a basis for developing industrial applications based on local biological resources.
PENGARUH VARIASI KOMPOSISI TERHADAP KARAKTERISTIK BIOBRIKET BERBAHAN BAKU BIOMASSA MELALUI METODE KARBONISASI Meita Rezki Vegatama; Eka Megawati; Junety Monde
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7698

Abstract

Energy is classified into two groups: the first is non-renewable energy, such as coal, petroleum, and natural gas. While the second is renewable energy, for example, solar, geothermal, water, wind, and biomass. Biomass is organic material derived from plants or animals that includes wood waste such as sawdust, bark, forest residues and agricultural waste such as rice husks, straw, animal manure and others. Briquettes are categorised as solid fuels from alternative energy sources to replace fuel oil through a carbonisation process and forged through pressure with or without adhesives. This study aims to determine how the effect of composition variations on the characteristics of biobriquettes made from biomass through the carbonisation method affects calorific value, volatile matter, ash content, and water content. The experimental method is the method used in this study, with stages of material preparation, material combustion, briquette making, and briquette testing with variations of coffee grounds and rice husks, 25:75, 50:50, and 75:25. The tests carried out were proximate tests, including calorific value, water content, ash content, and volatile matter. Based on the results of research and testing of coffee grounds and rice husk briquettes, the calorific value of sample A was 2,692.66 cal/g, sample B was 3,402.81 cal/g, and sample C was 4,089.19 cal/g. The volatile matter content in sample A was 50.2921%, sample B was 64.9598%, and sample C was 83.1159%. The ash content of sample A was 43.4975%. Sample B was 29.0613%, and sample C was 14.711%. The water content in sample A was 4.3336%, sample B was 5.2663%, and sample C was 1.3438%.
PERBANDINGAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN COCOK BEBEK (Kalanchoe pinnata) DENGAN METODE DPPH DAN ABTS Boima Situmeang; Weny JA Musa; Nurhayati Bialangi; Nani Yulianti
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 8 No. 1 (2026): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v8i1.7746

Abstract

Kalanchoe pinnata leaves are known as a medicinal plant containing secondary metabolites with potential antioxidant activity. This study aimed to compare the antioxidant activity of the ethanol extract of Kalanchoe pinnata leaves using DPPH and ABTS methods. Extraction was carried out by maceration using ethanol as a solvent from 50 g of dried leaf simplicia, yielding 7.2 g of thick extract with a yield of 14.4%. Antioxidant activity was evaluated at concentrations of 20, 40, 60, 80, and 100 ppm. The results showed that the percentage of inhibition increased with increasing extract concentration in both methods. In the DPPH method, the highest inhibition value was 51.1605% at 100 ppm, while in the ABTS method it was 47.7203%. The IC₅₀ values obtained were 93.54 ppm for the DPPH method and 103.01 ppm for the ABTS method. Based on these values, the antioxidant activity of the ethanol extract of Kalanchoe pinnata leaves was categorized as strong in the DPPH method and moderate in the ABTS method. In conclusion, the DPPH method showed higher antioxidant activity compared to the ABTS method. The ethanol extract of Kalanchoe pinnata leaves has the potential to be developed as a natural antioxidant source in pharmaceutical and functional food applications.

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