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Biomolecular and Health Science Journal
Published by Universitas Airlangga
ISSN : -     EISSN : 26208636     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.
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Articles 140 Documents
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Clinical Profile and Outcome of Mechanically Ventilated Children in a Pediatric Intensive Care Unit Surabaya Qorri Aina; Arina Setyaningtyas; Atika Atika
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22143

Abstract

Introduction: Ventilator is used as one of the most frequent life-supportive technology in Pediatric Intensive Care Unit (PICU). There are only few studies from Asian Countries, especially Indonesia regarding the use of ventilator in PICU. The aim of this study was to describe the demographic, indications, length of use, complication, and outcome of patients with ventilator in PICU Dr.Soetomo Hospital, Surabaya.Methods: This is a descriptive study. Collecting data was done retrospectively using medical records of patients using ventilator in PICU Dr. Soetomo General Hospital from January-December 2017 . Statistical analysed was performed using Microsoft Excel 2016.Results: 59 patients met the inclusion criteria. Of the 59 patients, 34 (57.63%) were female and 27 (45.76%) were infant (1-12 months). Common indication of ventilator were status epilepticus and shock that happened in 17 (28.81%) patients. 44 (74.58%) patient was using ventilator >48 hours. There are only 4 (6.78%) of 59 patients that happened to had Ventilator Associated Pneumonia (VAP) as a complication of using ventilator. Mortality occurred in 40 (67.80%) patients and mostly happened in female (60%) and infant (50%). Mortality occurred in 10 (90%) of 11 patients with cardiac failure as the indication of ventilator and in 11 (73.33%) patients who used ventilator ≤48 hours.Conclusion: Status epilepticus and shock was the most common reason for ventilation. Incidence of VAP as the complication of ventilator is relatively low. Relatively high mortality found in age group infants, patients with cardiac failure as indication of ventilator and in patient with short duration use of ventilator.
Factors Associated with Acid Fast Bacilli and Sputum Culture Conversion in Patients with Multidrug-Resistant Tuberculosis in Surabaya Naomi Rahmasena; Isnin Anang Marhana; Muhammad Yamin Sunaryo Suwandi; Tutik Kusmiati; Tuksin Jearanaiwitayakul
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.29763

Abstract

Introduction: Indonesia is a high incidence country of multidrug-resistant tuberculosis. There are approximately 11,000 MDR TB cases, 2.8% of them are new cases and 16% of them are relapse cases. Although guidelines for MDR-TB are frequently designed, medication freely provided, and centers for treatment duly expanded, studies on time to sputum culture conversion have been very limited in Indonesia. Therefore the aim of the study is to identify risk factors that effect on sputum and culture conversion.Methods: Data on short-term regimen for MDR TB in Dr. Soetomo General Hospital from January 1st – December 31st, 2018 were collected with a total sampling approach, and fulfill the inclusion and exclusion. Data were analyzed by computer software IBM SPSS Statistic 24 for windows. Results: Male is more likely to have delayed sputum conversion and culture conversion but no statistical difference is observed (p>0.05). Smoking history is more likely to have delayed sputum and culture conversion but only in sputum smear test shows a significant difference (p≤ 0.05). Alcohol consumption has delay effect on sputum and culture conversion but there is statistically difference in only culture conversion (p<0.05). The high baseline smear test also affects delay the sputum and culture conversion but only in sputum smear reveals a significant effect (p<0.05).Conclusion: In this present study, we identified sex, smoking history, high bacillary loads as significant factors on sputum conversion. In addition, we revealed that alcohol-consumption history is a significant factor affecting on culture conversion.
Caregiver Burden And Psychosocial Factors In Mothers With Autism Spectrum Disorder Children Izzatul Fithriyah; Magdeline Elizabeth Carrasco
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.28875

Abstract

Introduction: Burden experienced by mother can delayed the success of therapy to ASD children. This study aims to determine the correlation of psychosocial factors and caregiver burden in mothers with ASD children.Methods: This study was a cross-sectional analytic study on mothers with ASD children at the Children's Daycare Dr.Soetomo General Hospital. The research instrument used sociodemographic questionnaire and a Caregiver Burden Assessment (CBA). Results: This study was followed by 26 mothers with ASD children. Results: The results showed that 50% of mothers experienced moderate burdens and 34% experienced severe burdens. The results of the correlation analysis showed a significant relationship between caregiver burden and maternal age (p<0.05, r=0.316) and child age (p<0.05, r=0.274). Support and assistance from others in caring for GSA children also correlated with the mother's caregiver burden (p<0.05, r=0.118). Maternal caregiver burden is not correlated with marital status, education level, occupation, and economic status. Conclusion: Mothers with ASD children experience a psychological burden while caring for ASD children. Psychosocial support and assistance from the environment are urgently needed to reduce the caregiver burden on mothers so that they can improve the outcomes of interventions and therapy for children with ASD.
Gram Negative Bacteria (Escherichia coli) Win Against Gram Positive Bacteria (Staphylococcus aureus) in The Same Media Neisya Intan Cahyaningtyas Agung Putri; Ramadhani Ramadhani; Eddy Bagus Wasito
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30177

Abstract

Introduction: Biodiversity of the microorganism in Indonesia lead to the large amount of patient with infection. Human can get infected in two different place, with different kind of bacteria that cause the infection. This may lead to bacteremia without knowing which bacteria type whose causing it, either the Gram positive or Gram negative bacteria, whereas the treatment of this two types of bacteria are different. The aim of this study is to determine the doubling time of the Gram positive and Gram negative bacteria when they are grown in the same lesion and the kinds of bacteria that we need to eliminate first.Methods: Staphylococcus aureus and Escherichia coli bacteria were used as samples in this study. Bacterial culture in nutrient broth with 0.5 OD turbidity were mixed then incubated in incubator with 35˚C. Every one hour within 24 hour, 0.01 ml of bacterial culture was taken in serial dilutionover time, varying between 106 – 1012, . It was then planted in nutrient agar plate with droplets technique. After it had been incubated for 24 hours, we counted the Colony Forming Unit per ml (CFU/ml) to time, then the doubling time of the bacteria. The result were then compared between the Staphylococcus aureus and Escherichia coli group.Results: Two tailed t-test result of the doubling time between Staphylococcus aureus dan Escherichia coli was < 0,05 (p=0,000) wich means that there is significant difference of the doubling time between Staphylococcus aureus (24,35 ± 2,23 munites), and Escherichia coli (18,37 ± 0,50 minutes). When grown in the same media, Gram positive bacteria (Staphylococcus aureus) had slower doubling time than Gram negative bacteria (Escherichia coli) as much as 1.32 times.Conclusion: In bacteremia with two possible kinds of bacterial suspect, we need to eliminate the Gram negative bacteria first.
Risk Factor Characteristics Of Patients With Uterine Prolapse In Gynecology Outpatient Clinic In Dr. Soetomo Hospital, Surabaya Vemaniarti Lian Pravitasari; Eighty Mardiyan Kurniawati; Pirlina Umiastuti
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30789

Abstract

Introduction: Uterine prolapse can occurs due to the failure of the ligamentous and fascial supports of the uterus. It causes inconvenience to the patients because of genital tract dysfunction and decrease quality of life. The risk factor are multifactorial. Advancing age, increasing parity, vaginal delivery, and menopause is associated with the uterine risk factors. The aim of this study is to describe the stage, treatment, age, parity, vaginal delivery, and menopause status of women with uterine prolapse in Dr. Soetomo General Academic Hospital, Surabaya. Methods: This research is a descriptive study. The sample is included all women with complaints of uterine prolapse diagnosed and treated at Dr. Soetomo General Academic Hospital, Surabaya from January – December 2017. Statistical was analysed descriptively.Results: From total 82 patients of uterine prolapse in Gynecology Outpatient Clinic Dr. Soetomo General Academic Hospital, Surabaya in 2017, most of the uterine prolapse patients were older than 65 years old (45.1%) and multiparous (62.2%). More than half of the patients (61%) have had more than three vaginal deliveries and have gone through menopause (91.5%). Stage IV prolapse, 33 cases (40.2%) has the highest percentage. Mostly, 47 cases (57.3%) received conservative treatment. Conclusion: Uterine prolapse is most likely to be found in women with older age, came from those in the age group of >65 years old. The incidence of uterine prolapse might increase in multiparous women, have more than three vaginal deliveries, and have gone through menopause. Most of them is on stage IV and received conservative treatment. It is important for women to be educated about uterine prolapse risk factor as an uterine prolapse prevention.
A Systematical Review of The Effect of Ketogenic Diet on Bcl-2 (B-cell lymphoma-2) Expression as An Apoptosis Marker in Cancer Treatment Vania Islamey Kusuma; Reny I’tishom; Ema Qurnianingsih; Purwo Sri Rejeki
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30173

Abstract

Introduction: Ketogenic diet seems to be in a great demand nowadays as a lot of people are interested in adopting it into their lifestyle. It is also found that the ketogenic diet shows several beneficial effects including cancer prevention. However, the detail mechanism still remains unknown. Therefore, this review was aimed to find out the effect of ketogenic diet on Bcl-2 (B-cell lymphoma-2) expression in cancer.Methods: We searched published literatures in PubMed through 2011-2020 using specific keywords. The literatures were filtered according to inclusion and exclusion criteria. Animal model, total sample size, underlying condition/inflammatory process occurs, details of the intervention/diet including diet contents in control group and high-fat group, and the duration of the intervention, Bcl-2 results, and p-value were extracted.Results: 7 studies were included in this review. Bcl-2 expression found decrease in 5 out of 6 studies. Similar result also obtained in Bcl-2 protein level, which measured by western blot. Bcl-2 protein level shows a decrease in 2 out of 3 studies.Conclusion: This review shows that high-fat diet that contained in ketogenic diet most likely lead to decrease in Bcl-2 expression. Therefore, indicating the ability of ketogenic diet to affect cancer progression by inducing apoptosis process.
Immunomodulator Effect of Lemongrass Extract (Cymbopogon nardus L.) to Increase Immune Cells as a Precaution Against SARS-CoV-2 Putri Ayu Ika Setiyowati; Rofiatun Solekha; Sri Bintang Sahara Mahaputra Kusuma Negara; Reny Rosalina
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.26619

Abstract

Introduction: In humans, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can damage some tissue when the immune systems was decrease. Natural product from the plant often used to improve immune response against microorganism including virus. This study aimed to determine the potential antioxidant of lemongrass extract (C . nardus) with various dosage that can provide immunomodulatory effects and find an optimal dosage to be used.  Methods: The method used observasional analytic, using animal model of 30 male mice strain BALB/C, weight 25-30 gram, divided into 5 groups; the positive control group was given 0.05 mL of  0.05% CMC within 14 days, negative control group was given IMBOOST® tablet 200 mg/kg body weight (bw) within 14 days, treatment groups  were given C. nardus extract with various doses 50 mg/kg bw, 150 mg/kg bw, and 300 mg/kg bw.  In day 21 all group were injected with 0,2 ml of  pathogen bacterial (S. aureus). Blood samples were taken three times: 7th day, 14th day, and 21th day. Results: The results showed that lemongrass extract (C. nardus) was able to influence the leukocyte and lymphocytes count with significant different (p<0.05). The optimal dose is 150 mg/kg body weight. Conclusion: The antioxidant compounds that contain in the C. nardus extract have an ability to increasing the immune system in the dose 150 mg/kg bw , but in the dose 300 mg/kg bw became toxic that can make a skin injury or death in animal test.
Association between Smoking Habit and Pulmonary Tuberculosis at Dr. Soetomo General Academic Hospita Balivia Andi Permata Hapsari; Prastuti Asta Wulaningrum; Rimbun Rimbun
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30641

Abstract

Introduction: Smoking has been reported as one of tuberculosis (TB) risk factor. The association between smoking and TB has been proven in multiple studies, but little known about the association between smoking degree and sputum smear positive. Methods: An analytic observational study using cross-sectional design. Data of patients with pulmonary TB conducted at DOTS (Directly Observed Treatment Short course)/MDR (Multi Drug Resistance) outpatient and inpatient ward in Dr Soetomo General Hospital Surabaya from January to October 2018. The degree of smoking was measured using Brinkman Index (BI). The odds ratio (OR) and 95% confidence intervals (CI) were also estimated.Results: There were 94 patients with pulmonary TB, 56 non-smoker and 38 smoker. Light smoking (P = 0,120, OR = 0.200, 95% CI: 0.022-1.823), moderate smoking (P=0.377, OR = 1.667, 95% CI: 0.533-5.209), heavy smoking (P=0.076, OR= 0.333, 95% CI: 0.96-1.160). Moderate smoking compared to heavy smoking as a control (P=0.33, OR = 5.000, 95% CI=1.096-22.820). Conclusion: There’s no significant correlation between smoking habits and sputum smear positive, but the present study evidenced the patients with smoking habits had greater chance to get sputum smear positive than non-smokers. Patient with moderate smoking compared to heavy smoking had greater chance to get sputum smear positive.
The Pathophysiology and Outcomes of Diabetic Patients with Coronavirus Disease 2019 (COVID-19) Victor Perdana Kusuma; Deasy Ardiany
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30030

Abstract

Introduction: Coronavirus Disease 2019 (COVID-19) is a respiratory tract infection caused by the SARS-CoV-2 virus, which was announced a pandemic by the World Health Organization (WHO) on March 11, 2020. On March 2, 2020, two confirmed cases of COVID-19 were initially reported in Indonesia. COVID-19 has been reported in 96.2 million people around the world. COVID-19 has already stolen the lives of almost 2 million individuals. Diabetes mellitus patients face an additional challenge with this disease (DM). Several studies have found a link between diabetes mellitus and COVID-19, as well as a bad prognosis for persons with DM and COVID-19. Aim of this study was to learn more about the link between diabetes and COVID-19, as well as the pathophysiology of diabetes.Methods: We searched for articles in PubMed and Google Scholar databases till February 2021, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “diabetes”Results: Diabetes Mellitus increased the severity and mortality of COVID-19 patients due to mechanisms involving inflammation and immune system activation, increased coagulation activity, oxidative stress, glucotoxicity, endoplasmic reticulum stress, renin-angiotensin-aldosterone system disorders, apoptotic mechanisms, mitochondrial dysfunction, and damage to pancreatic beta cells. COVID-19 infection can also lead to hyperglycemia and new-onset diabetes.Conlusion: Diabetes Mellitus is one of the comorbidities linked to a worse COVID-19 prognosis, according to the findings of this literature study. Furthermore, current research suggests that COVID-19 might cause hyperglycemia or new-onset diabetes, which has a poorer prognosis than COVID-19 patients with pre-existing diabetes.
Prenatal Risk Factors on Children’s Cerebral Palsy Case at RSIA Bunda Jakarta Banatul Banatul Lariza; Kurnia Dwi Artanti; Taufiq Taufiq Hidayat
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.27449

Abstract

Introduction: Cerebral Palsy is a disease that is less recognized by the public due to the lack of information related to CP in Indonesia. Aims to analyze prenatal risk factors that influence the evidence of CP RSIA Bunda Jakarta.Methods: This study was conducted in April 2021 at RSIA Bunda Jakarta, an analytical study with a case control design. The sample in this study were 124 respondents from mothers of children who underwent outpatient treatment at the RSIA Bunda Jakartaas cases and controls. each taken by simple random sampling technique. Data were analyzed using the test chi-square to analyze the relationship between variables.Results: The results of statistical analysis showed that the risk factors associated with the incidence of CP were maternal age (p= 0.00; OR= 13.25; 95% CI= 2.93-59.93), preeclampsia (p= 0.00; OR= 2,06; 95% CI= 1,71-2,48), TORCH (p= 0.00; OR= 2.40; 95% CI= 1.92-3.01), and antenatal care (p= 0.00; OR= 41.2; 95% CI= 5.45-317.0). Conclusion: Risk factors affecting the occurrence of CP in children include age <20 or ≥35 years, preeclampsia, TORCH infection and antenatal care visits <4 times. It is necessary to increase intervention programs at various levels of health services to diagnose and prevent the occurrence of cerebral palsy in children so that optimal maternal and child health is achieved. and further research is needed to determine other risk factors that can cause CP in children such as perinatal and postnatal risk factors.

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