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JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Published by Universitas Airlangga
ISSN : 19073623     EISSN : 26849453     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Juxta (Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. Juxta provides a forum for original article to the editor and it will be published Two-times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in Juxta.
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Articles 191 Documents
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Decubitus Ulcer Patients Profile in Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018 Azmil Permatasari; Magda Rosalina Hutagalung; Nuniek Nugraheni Sulistiawaty; Agus Susanto Budi
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.46-50

Abstract

Highlights:1. Decubitus ulcers can be caused by prolonged immobilization and constant pressure on the body.2. Decubitus ulcer patients were dominated by females, aged 46-65 years old, and the most common comorbidity history was patients with limb weakness. AbstractIntroduction: Continuous pressure on the area of the skin, especially in areas with bone protrusion can cause decubitus ulcers. Decubitus ulcers can occur to anyone, both children and adults, male or female, especially in people who experience daily immobility in a bed or wheelchair. Many treatments are performed in order to prevent decubitus ulcers to not becoming a more dangerous condition. This study aimed to determine the profile of pressure ulcers in Dr. Soetomo General Hospital Surabaya.Methods: This was a cross-sectional descriptive retrospective study. Secondary data were collected from 25 medical records of pressure ulcer patients in the Outpatient Clinic Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018. The data such as age, gender, risk factors, comorbidities history, and management were taken. The calculation was performed using Microsoft Excel.Results: The majority of patients with pressure sores at the Outpatient Clinic Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018 were dominated by female patients aged 46-65 years old (24%), with the most common risk factor being immobilization (96%). Patients’ history showed that most patients with decubitus ulcers suffered from a weakness in the limbs (13%). The most common treatment was wound bed preparation (46%) and education (46%).Conclusion: Pressure ulcers most often occurred in women aged 41-65 years or the elderly. Most patients experienced immobilization as a risk factor for pressure ulcers. These patients were dominated by those who had a history of illness with limb weakness. The therapy applied to patients with pressure sores was the preparation of wound beds and education to the patient.
In Vitro Antimicrobial Activity Evaluation of Ginger (Zingiber officinale) Absolute Ethanol Extract against Uropathogenic Escherichia coli (UPEC) Angeline Felicia; Kartuti Debora; Ramadhani Ramadhani
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.51-56

Abstract

Highlights: 1. Ginger (Zingiber officinale) has an antimicrobial activity against Uropathogenic Escherichia coli (UPEC) which commonly causes urinary tract infection (UTI) in women.2. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ginger against UPEC in this study was 1000 mg/ml. AbstractIntroduction: Uropathogenic Escherichia coli (UPEC) is commonly found in the urine culture of women with urinary tract infections (UTIs) and is often resistant to several antimicrobials. Herbals, such as ginger (Zingiber officinale), are known to have antimicrobial activity against various microorganisms. This study was conducted to determine the antimicrobial activity of ginger against UPEC.Methods: This was a true experimental study to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) using agar dilution method. The McFarland 0.5 suspension of UPEC was inoculated on agar with 6 different ginger concentrations, i.e. 2,000 mg/ml, 1,000 mg/ml, 500 mg/ml, 250 mg/ml, 125 mg/ml, and 62.5 mg/ml. The MIC and MBC were read as the lowest concentration without visible growth.Results: No visible growth of bacteria on agar at a concentration of 2,000 mg/ml and 1,000 mg/ml. Thus, the value of MIC and MBC for UPEC was 1,000 mg/ml.Conclusion: Ethanol extract of ginger has antimicrobial activity against UPEC. In this study, the MIC and MBC for UPEC was 1,000 mg/ml.
Sedentary Lifestyle and Overweight in Relation to the Risk of Polycystic Ovary Syndrome in Senior High School Students in Surabaya Shafira Noorania Putri; Budi Santoso; Budiono Budiono
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.57-61

Abstract

Highlights:1. Most senior high school students live a sedentary lifestyle.2. Hyperinsulinemia and hyperandrogenism were related to an increased risk of PCOS in adolescents.3. Sedentary lifestyle and overweight were found to have a significant correlation with increased risk of PCOS in adolescents. AbstractIntroduction: Adolescent polycystic ovary syndrome (PCOS) is one of the endocrine and metabolic disorders characterized by oligomenorrhea and hyperandrogenism. A sedentary lifestyle in adolescence increases the risk of overweight and obesity. Being overweight may increase the risk of PCOS in adolescents by the mechanism of insulin resistance and hyperinsulinemia, which affects the function of adrenal and ovarium androgen production. The increase of androgen has an important effect on PCOS. This study aimed to examine the relationship between a sedentary lifestyle and being overweight as the risk of PCOS in adolescents.Methods: This was an observational analytic study with a cross-sectional design. This study was held at State Senior High School (SMAN) 5 Surabaya from February to April 2020. The sample of this research was chosen by random sampling of all female students in SMAN 5 Surabaya. The data were collected by direct measurement of student’s weight and height and a questionnaire consisting of Global Physical Activities Questionnaire, menstrual cycle, and Ferriman–Gallwey score. The students were stated at risk of PCOS if they had an abnormal uterine bleeding pattern and had Ferriman–Gallwey score ≥5. The data were analyzed using logistic regression analysis.Results: Of 82 students (100%), 32 students were overweight (39%), 5 students had obesity (6.1%), 44 students were performing a sedentary lifestyle (53.7%), 42 students had Ferriman–Gallwey score ≥5 (51.2%), 38 students had an abnormal uterine bleeding pattern (43.3%), and 35 students were at risk of PCOS (42.6%). Logistic regression analysis showed there was a significant relationship between a sedentary lifestyle and the risk of PCOS (p = 0.004) and a significant relationship between being overweight and the risk of PCOS (p < 0.001). People with a sedentary lifestyle have 6.3 folds higher risk of PCOS than normal people, and people with overweight have 16.2 folds higher risk of PCOS than normal people.Conclusion: Sedentary lifestyle and overweight have the role of increasing the risk of PCOS in adolescents.
Incidence of Respiratory Tract Infection in Children with Cyanotic and Acyanotic Congenital Heart Disease: A Comparative Study Syafira Yasmine; I Ketut Alit Utamayasa; Bambang Herwanto
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.62-66

Abstract

Highlights:1. The incidence of respiratory tract infection (RTI) showed no difference between patients with cyanotic and acyanotic congenital heart disease (CHD).2. RTI patients with acyanotic CHD experienced longer hospital lengths of stay. AbstractIntroduction: Respiratory tract infection (RTI) is the leading cause of children mortality rate in the world. Congenital heart disease (CHD) is a common congenital disease that plays a role in RTI incidents. However, between the 2 types of CHD, which type that is more potential to cause the RTI is not well identified. The aim of this study was to compare the incidence and hospitalization time of RTI between 2 types of CHD and describe the profile of the patients based on gender, age, nutrition, and immunization status.Methods: This retrospective study identified the medical records of children with RTI and all types of CHD aged 0-18 years old at Dr. Soetomo General Hospital Surabaya. The diagnosis of CHD was observed by echocardiography and RTI was observed by clinical symptoms.Results: Of 135 patients, the incidence of RTI showed no difference between a patient with cyanotic and acyanotic CHD. The majority of the patient was aged less than 3 years old (93.3%) and dominated by male patients (53.3%). The frequency of children with severe underweight and good nutritional status was equal. There were 85 patients who had incomplete immunization based on their age. The most common type of acyanotic CHD was an atrial septal defect (ASD). Cyanotic CHD was dominated by the tetralogy of Fallot (ToF). Pneumonia was the common type of RTI (108/135). RTI patients with acyanotic CHD had a longer time of hospitalization than cyanotic patients (11 days).Conclusion: This study found that RTI patients with acyanotic CHD experienced longer hospital lengths of stay.
Effectiveness of Medication, Surgery, and Combination Therapy to Decrease Intraocular Pressure on Glaucoma Outpatient at Outpatient Ophthalmic Clinic Dr. Soetomo General Hospital Surabaya in January – December 2017 Muhammad Bagas Pratista; Nurwasis Nurwasis; Kusuma Eko Purwantari; Indri Wahyuni
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.67-72

Abstract

Highlights:1. Combination of medication and surgery on glaucoma had the least post-therapy intraocular pressure.2. There was no significant difference in the efficacy of drugs, surgeries, and combination of both therapies for glaucoma intraocular pressure reduction. AbstractIntroduction: Glaucoma leads to blindness in its end stage. Quality of life drops as visual field loss as progressive optic nerve damage since high intraocular pressure elevation. Glaucoma treatment focused on aqueous humor regulation, thus the intraocular pressure is maintained at normal.Methods: This was a retrospective analytical study using secondary data gathered from medical records as total sampling data. The sample was determined by the purposive non-probability technique. The mean of intraocular pressure after therapies was defined as the dependent variable while the independent variable was the type of therapy.Results: Combined therapy (16.00 ± 6.77 mmHg) had the least post-therapy intraocular pressure. The statistical test indicated no significant difference in the effectiveness of medication, surgery, and combination therapy for glaucoma intraocular pressure reduction.Conclusion: There was no prominent difference in the efficacy of drugs, surgeries, and combined therapies for glaucoma intraocular pressure reduction.
Therapeutic Communications of Doctors and Hypertensive Patients’ Satisfaction Reka Elvia Dirda Prasasta; Linda Dewanti; Dominicus Husada; Lilik Djuari
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.73-78

Abstract

Highlights:1. Doctors who perform therapeutic communication make patients more satisfied with their services.2. Good therapeutic communication is the most effective way to establish relationships with patients with long-term treatment such as hypertension. AbstractIntroduction: Hypertension or high blood pressure is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg at two measurements at intervals of five minutes under adequate rest/calm conditions. Therapeutic communication is the most effective and important thing in establishing relationships between doctors and patients. Good communication based on trust will produce satisfaction from the patients, thus they can seek treatment again. This study aimed to analyze the relationship between therapeutic communication and hypertensive patients’ satisfaction measured among those who visited the Primary Health Center (PHC) of Surabaya to control their blood pressure.Methods: This was a cross-sectional quantitative study with all hypertensive patients who visited the PHC in November 2018-January 2019 as the subjects. Characteristics of the subjects, as well as the doctors and the therapeutic communication practices, were rated by the patients. Patients’ satisfaction was collected using validated questionnaires.Results: According to a relationship analysis between doctors’ therapeutic communication and patients’ satisfaction, it is found that there was a significant relationship. This was based on a significance value of 0.00 and smaller than 0.05. The better the communication applied by the doctor, the more satisfied the patient was. This study showed that service satisfaction was influenced by therapeutic communication where doctors at the PHC try to fulfill every indicator.Conclusion: There was a relationship between the therapeutic communication of doctors and the satisfaction of hypertensive patients at the PHC.
Bone Age Measurement in Pediatric Patients of Universitas Airlangga Hospital from January 2018 to December 2019 Dinda Chandra Yuliantari; Anggraini Dwi Sensusiati; Ahmad Suryawan; Muhammad Faizi
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.83-87

Abstract

Highlights:1. There was a significant relationship between bone age calculated by the Tanner Whitehouse II method (TW2-20) and chronological age.2. There was a slowdown in bone age in pediatric patients at Universitas Airlangga Hospital (RSUA). AbstractIntroduction: Bone age is an indicator of biological and skeletal maturity in individuals. It is different from chronological age which is calculated based on the time of birth. The differences in chronological age and bone age can indicate abnormalities in bone development. This study aimed to determine the profile of bone age in pediatric patients at Universitas Airlangga Hospital and the relationship between bone ages examined using the Tanner Whitehouse II (TW2-20) method and their chronological ages.Methods: This was a cross-sectional observational analytic study. Secondary data were collected from medical records and X-Ray examination results from Department of Radiology Universitas Airlangga Hospital (RSUA) Surabaya from January 2018 to December 2019. The data of age, gender, and history of illness were taken. From the collected X-ray results, bone age was examined using the TW2-20 method. Then, a normality test was performed using the Shapiro-Wilk for data less than 50 samples. The results showed that the data were normally distributed (p = 0.419). Data processing of the difference between bone age and chronological age was performed using the parametric paired T-test with a confidence level of 95%.Results: 32 samples were obtained from pediatric patients undergoing X-ray examinations from January 2018 to December 2019. The average bone age difference in male patients was 0.64 years old with the highest average difference found in the age range of 9-11.99 years old. The average bone age difference in female patients was 1.1 years old with the highest average difference found in the age range of 12-14.99 years old. There was a significant difference between bone age calculated using the TW2-20 method and chronological age (p < 0.001).Conclusion: Based on the comparison of the average bone age in pediatric patients and their chronological age, all samples showed deceleration of bone age in pediatric patients at RSUA. Based on the analytical study, the TW2-20 method was not suitable for the sample examined.
Effect of Carrots (Daucus carota L.) on Gastric Histopathology of Piroxicam-Induced Mice as a Peptic Ulcer Prevention Jennifer Susanto; Danti Nur Indiastuti; Gondo Mastutik
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.88-92

Abstract

Highlights:1. Carrots (Daucus carota L.) can reduce the side effects of non-steroidal anti-inflammatory drugs (NSAIDs) due to its gastroprotective components.2. Histopathological studies of the gastric inflammation signs showed that carrots can prevent NSAID-induced peptic ulcers. AbstractIntroduction: Non-steroidal anti-inflammatory drugs (NSAIDs) consumption contributes significantly to gastrointestinal morbidity, including peptic ulcers. NSAIDs cause gastric mucosal damage by inhibiting PGE2 and PGI2 secretion, increasing HCl secretion, and also causing local irritation and neutrophil adhesion. Flavonoids and chlorogenic acid are gastroprotective agents found in carrots (Daucus carota L.). Therefore, this study aimed to validate the effect of carrots on gastric histopathology of piroxicam-induced mice.Methods: This was an experimental study using a post-test-only control group design. 35 mice were divided into 5 groups and were allowed to adapt for 1 week. The negative control group received 0.25 mL aqua dest, while the positive control group received 0.104 mg famotidine. Group A, B, and C received carrot extract with each dosage was 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. The mice were induced 2 hours later with 0.052 mg piroxicam. The treatments lasted 14 days. Each stomach was taken and examined on the 15th day. Afterward, histopathological preparations were made.Results: The results of the histopathological signs of inflammation using the Kruskal-Wallis method showed p = 0.000, indicating that there was an effect of the carrot extract in preventing the inflammation on the gastric histopathology (p < 0.05).Conclusion: In conclusion, this study confirmed that carrot extract is more effective in avoiding peptic ulcers due to NSAID consumption.
In-Silico Study: Potential Inhibitor of Cyclin-Dependent Kinase 6 (CDK6) from Natural Plant Compounds for Melanoma Treatment Putri Aliya Ahadini; Adhyatma Ismu Reihan; Muhamad Bagus Wira Utama; Siti Khaerunnisa; Fadilah Fadilah
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V13I22022.93-99

Abstract

Highlights:1. Melanoma is the most aggressive and dangerous type of skin cancer. 2. Cyclin-dependent kinase 6 (CDK6) had a role in melanoma progression.3. Chlorogenic acid, guattegaumerine, luteolin, and acronycine were potential natural compounds in plants as CDK6 inhibitors. AbstractIntroduction: Melanoma is the most aggressive and dangerous type of skin cancer. It usually occurs in the skin because melanocytes originate from the neural crest cells that migrate. A previous study stated misregulation of cyclin-dependent kinase 6 (CDK6) had a role in melanoma progression. This study aimed to identify the potential natural compound targeting and modulating the CDK6.Methods: This was an investigative study using in-silico docking analysis to search for compatible ligands and potential inhibitors to CDK6 protein. This study screened 46 natural compounds based on the drug-likeliness based on Lipinski’s rules of five and used PyRx (AutoDock Vina) software for the initial screening. 10 compounds with the highest binding energy underwent docking simulation using Molecular Operating Environment (MOE) software.Results: Chlorogenic acid, guattegaumerine, luteolin, and acronycine were potential natural compounds in plants as CDK6 inhibitors.Conclusion: This study found that chlorogenic acid was the most potential to be an inhibitor of CDK6 compared to other compounds screened.
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JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 13 No. 2 (2022): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

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