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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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THE ROLE OF CARCINOEMBRYONIC ANTIGEN IN ASSESSING THE SUCCESS OF SURGICAL TREATMENT IN COLORECTAL CANCER BASED ON STAGING Anindya Widyasari; Betty Agustina Tambunanan; Vicky S. Budipramana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1333

Abstract

Colorectal cancer is the third most common cancer in Indonesia. Determination of staging is needed to determine the treatment of colorectal cancer which has four stages. Carcinoembryonic Antigen (CEA) is a serological marker for monitoring colorectal cancer status, prognostic determination, monitoring of treatment success, detecting early recurrence and spreading. The purpose of this study was to determine the evaluation of successful surgical therapy in colorectal cancer by CEA examination at each stage. Descriptive observational studies were conducted using secondary data of pre and post-surgical colorectal cancer patients examined for CEA and treated at the Dr. Soetomo Hospital from January 2015 to December 2016. The samples obtained from this study were 48 patients, with the most of them at the age of 41-60 years as much as 70.83%. Females were more than males (66.67% vs. 37.33%). The most staging stage, stage 4 was as much as 43,75% followed by stage 3 as much 41.67%, the rest were stage 1 as much as 10.42%, and stage 2 as much as 4,17%. The highest decrease in CEA levels was found in stage 4 by 85%, followed by stage 2 of 53.5%, stage 1 of 43.4% and stage 3 of 33.1% but statistically only the decrease in stage 3 was significant. In stage 1, there was a difference in pre-operative CEA with a mean of 3.09 ng/mL (0.17-5.83 ng/mL) vs. post-operative with a mean of 1.75 ng/mL (0.84-3.14 ng/mL), stage 2 levels of pre-operative CEA with a mean of 3.82 ng/mL (0.15-7.48 ng/mL) vs. post-operative with a mean 1.77 ng/mL (1.46-2.08 ng/mL), stage 3 levels of pre-surgical CEA with a median of 13.85 ng/mL (1.09-71.21 ng/mL) vs. post-operative with a median 9.26 ng/mL (<0.5-68.23 ng/mL), stage 4 pre-surgical CEA levels with a median 183.77 ng/mL (0.54-2861 ng/mL) vs. post-operative with a median 27.28 ng/mL (0.51-155.10 ng/mL). There was a decrease in CEA levels from the total number of patients by 67%, whose CEA levels remained at 12% and as much as 21% of their CEA levels increased. Successful evaluation of surgical therapy in the colon and rectal cancer by CEA examination was still varied at each stage where CEA levels decreased significantly in stage 3.
PEMBERIAN PROTEIN ADHESIN 38-KILODALTON MYCOBACTERIUM TUBERCULOSIS PERORAL MENINGKATKAN JUMLAH MAKROFAG DAN LIMFOSIT USUS MENCIT BALB/c Rahma Triliana; Ade A Kartosen; Dianika P Puspitasari; Sri Murwani; Sanarto Santoso; Maimun Z Arthamin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1015

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is one of the world health problems. Oral vaccination of M.tb hasa potential to reduce the risk and complication of TB. The 38-kDa adhesin protein as one of oral TB vaccine candidates has not beenproven. This study is aimed to determine M.tb 38-kDa adhesin protein effect on macrophage and lymphocyte numbers in mice intestineafter an oral administration. BALB/c mice (n=20), age 6–8 weeks, and were divided into 4 groups: control (K), adjuvant (A), 38-kDa100μg adhesin protein (P), and combination of 100μg 38-kDa adhesin protein with adjuvant (PA). An oral administration was givenat the beginning with 2 boosters every 4 weeks. After 3 days of the second booster, the mice were killed and the intestine was taken andstained with haematoxylin eosin (HE) to measure its macrophages and lymphocytes number. The mean ±2SD were 18.4 (3.71) and6.09 (0.34), 23.0 (7.78) and 8.86 (1.19), 42.2 (13.63) and 23.49 (3.91), 95.4 (30.11), and 53.57 (13.79) respectively for K, A, Pand PA group. The statistical test showed a significant difference among each group revealing the role of M.tb 38-kDa adhesin proteinas immunogenic inducing cellular immunity in intestine. In this study, so far it was found that the oral administration of M. tb 38-kDaadhesin protein has an ability to increase macrophage and lymphocyte numbers in the mice intestinal BALB/c.
CORRELATION BETWEEN ADENOSINE DEAMINASE ACTIVITY IN PLEURAL FLUID AND SERUM OF PATIENTS WITH PLEURAL EFFUSION Pande Putu Ayu Patria Dewi; Aryati Aryati; Leonita Anniwati; Isnin Anang Marhana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i2.1321

Abstract

Pleural effusion is an abnormal accumulation of fluid in the pleural space resulting from increased production of fluid or decreased resorption of fluid in the pleural space. Pleural effusion can be caused by infectious diseases, malignancies, collagen disease, gastrointestinal disease, heart disease and other causes such as medication. Adenosine Deaminase (ADA) is an enzyme involved in the catabolism of purines. This enzyme can be measured in pleural fluid, serum and other body fluids such as cerebrospinal and ascites fluid. The aim of this study was to analyze the correlation between adenosine deaminase activity in pleural fluid and serum in patients with pleural effusion. This research was an observational study with a cross-sectional design. Examination of ADA activity was performed in pleural fluid and serum. Adenosine deaminase activity was examined using photometric methods (Non-Giusti), using Diazyme reagent by TMS 24i Premium. Subjects were 46 patients with pleural effusion caused by malignancies, tuberculosis and systemic diseases. Mean±SD ADA activity for all pleural effusion samples in serum was 13.037± 8.365 (0.5-34.1) U//L and pleural fluid 30.843± 28.860 U//L (1.3-140.8). No correlation between ADA activity in serum and pleural fluid (r=0.173, p= 0.252) was found in all samples. No correlation between ADA activity in serum and pleural fluis was found in malignancies (r=0.109, p=0.630), tuberculosis (r= 0.366, p=0.123), systemic diseases (r =0.466, p=0.429) and non-tuberculosis group (r=0.126, p=0.532). There was no correlation between pleural fluid ADA activity and serum. 
NILAI RUJUKAN FREE LIGHT CHAIN SERUM DENGAN IMUNOTURBIDIMETRI Lidya Utami; Riadi Wirawan; Alida R Harahap; Abdul Muthalib; Harny Edward
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1006

Abstract

The light chains of immunoglobulin are produced in larger quantity rather than heavy chains, therefore small amount of free lightchains (FLC) can be found in the blood of healthy individuals. Free light chain production is increased in the clone’s proliferation ofmalignant B cells, i.e. in myeloma. Therefore the FLC level measurement can be used for diagnosis aid of myeloma and related B cellsdisorders. The aim of this study is to establish reference range of serum FLC κ, FLC λ, and κ/λ ratio in population ≥40 year’s old usingimmunoturbidimetry assay. Serum FLC κ, FLC λ and κ/λ ratio were measured in 240 healthy male and female attending medical checkup in MMC hospital. Healthy subjects were determined by anamnesis and physical examination, with routine haematology, ESR, andserum creatinine level within normal ranges. The serum FLC assays were performed in the Clinical Pathology Laboratory, RSCM, usingHitachi 912 with immunoturbidimetry method. The results were analyzed by SPSS 11.5 program. Serum FLC normal reference valuein 40-84 years old healthy subjects are: FLC κ 11.7–30.6 mg/L, FLC λ 9.7–25.0 mg/L, and κ/λ ratio 0.79–1.75. This research is thefirst study for finding serum FLC values in the Indonesian population. The normal reference value found is similar with another studyusing the same platform analyzer.
ANEMIA KEKURANGAN (DEFISIENSI) ZAT BESI BAYI Aida Amelda; Hanifah Maani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 3 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i3.961

Abstract

Anemia usually happened in childhood. Babies 6–12 years old as are those group that are sensitive to iron deficiency anemia (IDA)Hemoglobin is a mean corpuscular volume (MCV), red-cell distribution width (RDW) examination with blood film evaluation that canbe used to screen IDA, especially in high risk babies. This study was carried out by the cross sectional method in healthy babies 6-12years old in Padang city, on November 2006 until January 2007. They were examined in the Clinical Pathology Laboratory of Dr. MDjamil hospital Padang. The samples consisted of 2 ml venous blood EDTA and laboratory examinations. The results were Hb, MCV,and RDW with ABX micros 60. Also blood film evaluation if Hb were 11g/dL. The means of Hb, MCV and RDW were 11.1 ± 1.07 g/dL,71.7 ± 4.70 fl and 14. 2 ± 1.37%. In 62 (45.9%) babies were anemic as a result of IDA examination and the rest of 33 babies (532%) the blood film were normocytic normochromic 49% and normocytic hypochromic (+), mild anisocytosis 51%. In Padang city theIDA examination in 6-12 years old babies were high frequencies in grade I and II by blood film method
CORRELATION OF AA INDEX WITH DEGREE OF LIVER FIBROSIS IN CHRONIC HEPATITIS B PATIENTS Rika Andriany; Ibrahim Abdul Samad; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1362

Abstract

A liver biopsy is the gold standard for diagnosing and staging liver fibrosis in chronic hepatitis B patient but with many disadvantages so it is difficult to use as a routine examination. Research on index based on serum marker is helpful in predicting liver fibrosis. We conducted a study of the alpha-fetoprotein (AFP) and partial activated thromboplastin time (APTT) index or AA index in relation to the degree of liver fibrosis in chronic hepatitis B patients. This study was a retrospective cross-sectional study in dr.Wahidin Sudirohusodo Hospital Makassar by taking the data from medical records of chronic hepatitis B patients from January 2015 to December 2016. Samples were chronic hepatitis B patients who were tested for AFP, APTT and Fibroscan. The result showed the total of 79 chronic hepatitis B patients, 23 with severe fibrosis, 9 with moderate fibrosis, 26 with mild fibrosis, and 21 with no fibrosis. Spearman correlation test showed a significant correlation between the AA index and the degree of fibrosis (p <0.001) and showed a positive correlation between both of them with a very strong correlation (r = 0.830). Oneway Anova test showed a significant difference between the AA index and the  degree of fibrosis (p<0.001). The results of this study indicate that the AA index can be used as a predictor of fibrosis in chronic hepatitis B patients. It is suggested to do another study with larger sample based on the degree of fibrosis.
TROMBOSIT ABNORMAL PASCAPERSALINAN Prihatini .; S. Hadi; Wijanda H T Sylvaranto; Maksum .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1029

Abstract

Pregnant women with cardio vascular failure caused by hypertension may show pre-eclampsia or eclampsia syndrome. The syndromewas confirmed by the hypertension family history when she was pregnant or during labour formerly. The influence was shown in thehaematological examination, besides inducing hypertension during pregnancy. The examination must be an accurate laboratory procedureto avoid complication. The routine obstetric examination should be a physical, laboratory as well as USG one. Exspecially laboratoryexamination for pre-eclampsic and eclampsic patients like clinical chemistry, blood examination, urinalysis and special examinationas ANA, ACA and TAT The result of laboratoric examination showed anemic,trombosits was normal and TAT abnormal. The baby wasborn normal. After 3 months post labour the result of TAT still hyper-reactive especially for ADP agonist and hypo-reactive for collagenagonist. This patient have a trombosit function failure based on TAT and must be care to cardiovascular disease. Pregnant women withpre-eclamptic or eclamptic risk must be monitored the trombosit function beside clinical laboratoric and obstetric examinations
ANALISIS KADAR ASAM URAT PADA PASIEN KARSINOMA MAMMA Susi Sevianty; Uleng Bahrun; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.992

Abstract

In malignancy cases, an increase of uric acid level is often observed after therapy (Tumor Lysis Syndrome), but some studies also indicated an increase before therapy which is related to a refusal reaction against tumor, and specific only for certain malignancy cases.Carsinoma mammae is the second most common malignancy among women in Indonesia, so that studying the phenomenon occurredin carcinoma mammae including uric acid level are expected to provide insight in management of carcinoma mammae. A longitudinalstudy was conducted by collecting secondary data from medical record of carcinoma mammae patients in Wahidin SudirohusodoHospital for period of July 2007–June 2008. Data were analyzed by using Wilcoxon Signed Rank Test with alpha 0.05. 12 of subjectsare considered eligible for study criteria, with the age ranging from 28–60 years old. In generally, uric acid level determined beforeand after chemotherapy showed a level in normal range, except for 3 samples before therapy and 3 different samples after therapyshowed a level more than 5.7 mg/dL. Statistic result showed mean uric acid level before chemotherapy was 4.508 ± 1.2566 mg/dL andafter chemotherapy was 5.025 ± 1.3240 mg/dL (p = 0.16). Increased of uric acid level is not significant level was found in serum ofcarcinoma mammae before and after chemotherapy.
CORRELATION OF FREE HEMOGLOBIN LEVEL AND PLASMA NITRIC OXIDE IN PACKED RED CELL DURING BLOOD BANK STORAGE PERIOD Ricca Fitria; Zelly Dia Rofinda; Desywar Desywar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1485

Abstract

Stored red blood cells undergo morphological and biochemical changes with increased storage time, commonly refferred as the storage lesion, reduced integrity of erythrocyte membrane, causing hemolysis and increased free plasma hemoglobin level. Nitric Oxide (NO) is an endogenous vasodilator with the major role in vascular and blood flow regulation. Accumulation of free hemoglobin (fHb) during storage RBC hemolysis is thought to be correlated with elevated NO consuming causes low NO level that significantly impair endothelial function. This study aim to was to analyze the correlation of free Hb and plasma nitric oxide level during PRC storage period in the blood bank. This research was an analytic study with a cross-sectional design to 14 unit PRC those were stored in Dr. M. Djamil Padang Hospital Blood Bank. The study was conducted from May 2016 to August 2017. The assay was performed for 28 days of storage with one week intervals. Free plasma hemoglobin and NO level were analyzed by cyanmethemoglobin and colorimetry method respectively. Spearman test was used to access the correlation between free Hb level and nitric oxide plasma with p<0.05 means significant.  Most donors were male (85.7%) with age range were 33(9) years. Free Hb and nitric oxide level were significantly differenced in each week storage periods (p<0.05). Two parameters was significantly had moderate negative correlation during storage periods (r=-0.56; p=0.01).
GAMBARAN FUNGSI HATI DAN GINJAL PADA PENDERITA MALARIA Darmawaty .; Fitriani M; Ruland DN Pakasi; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.950

Abstract

the prevalence of malaria disease is still high in Indonesia. It requires to be diagnosed and handled quickly to decrease themorbidity and the mortality. the purpose of this study was to evaluate the results liver and kidney function tests of malaria patients forcomplications and to know the etiology. A cross sectional method was used for this study by using medical record of malaria patientsthat at Wahidin Sudirohusodo hospital in Makassar during January to December 2006. Malaria was diagnosed based on pheripheralblood while the examination of Sgot, SgPt (DgKC method), ureum (Barthelots method) and creatinine (Jaffe's method) were doneby chemistry autoanalizer. the increasing concentration of Sgot was found on 14 patients (42.4%) which was consisted of high at 12patients, SgPt on 13 patients (39.4%), ureum on 2 patients (6.1%) and creatinine on 11 patients (33.3%). Plasmodium falciparum wasfound on 18 patients (54.5%) and Plasmodium vivax on 15 patients (45.5%). the Sgot, SgPt, ureum, and creatinine concentrationsmostly exist in normal range, this indicated that liver and kidney damage was still mild. the etiology of malaria disease was Plasmodiumfalciparum and Plasmodium vivax, it was found from examination of pheripheral blood. there was no significant different in this studyfor the increasing of Sgot, SgPt, ureum and creatinine concentrations based on plasmodium etiology.

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