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Andalas obstetrics and gynecology journal
Published by Universitas Andalas
ISSN : 25798324     EISSN : 25798413     DOI : https://doi.org/10.25077/aogj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health
Andalas Obstetrics And Gynecology Journal (AOJ) (e-ISSN: 2579-8324) is a peer-reviewed, open-access national journal published by Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of obstetrics, gynecology, and other related disciplines.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 18 Documents
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Search results for , issue "Vol. 10 No. 1 (2026)" : 18 Documents clear
Relationship Between Age And Menopausal Status With The Incident Of Epithelial Ovarian Carcinoma At RSUP Dr. M. Djamil Padang Harsby, Carmiyana Puja; Muhammad, Syamel; Yenita, Yenita
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.88-96.2026

Abstract

Introduction : High Grade Serous Ovarian Carcinoma (HGSOC) been the dominant subtype and accounted for the highest mortality rate of epithelial ovarian cancer. Therefore, knowledge of the risk factors for epithelial ovarian cancer was needed for early detection. Age and menopausal status were examples of risk factors. This study aimed to determine the relationship between age and menopausal status with the incidence of epithelial ovarian cancer subtype of HGSOC at M Djamil Central Hospital Padang. Method : This type of research is an observational analytic research design cross-sectional. The form sample is secondary data used in the total sampling method, which comes from 90 patients of ovarian cancer. Research in analysis univariate and bivariate presented in form table frequency. Result : In this study, it was found that epithelial ovarian cancers subtype HGSOC was found mostly in women aged > 50 years (68,9%) and who had experienced menopause (80%). In the analytic test, the p value for age and menopausal status was 0.382 and 0.104. Conclusion: Concluded there is no relationship between age and menopausal status with the incidence of epithelial ovarian cancer subtype HGSOC at M Djamil Central Hospital Padang
The Relationship of Age with TNF-α Levels in Pregnancy and Abortion Monika, Cici; Revilla, Gusti; Karmia, Hudila Rifa; Nurhajjah, Siti; Welan, Rahmani
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.97-107.2026

Abstract

Introduction: Tumor Necrosis Factor Alpha (TNF-α) plays a crucial role in the early control of abortion. This increase can be influenced by age. The purpose of this study was to analyze the relationship between age and TNF-α in both normal pregnancies and abortion. Method: The type of research is analytic with a cross sectional design, collecting samples using total sampling technique, resulting in 36 patients who were subsequently assessed for TNF-α levels at the Biomedical Laboratory of Andalas University. The source of research data is secondary data. Data analysis involved the Spearman correlation test, Independent T-test, and Mann-Whitney test. Result: The average gestational age was younger, the average maternal age was older, and the average TNF-α levels were higher in abortion compared to normal pregnancy. The BMI of all patients was normal. There is a significant difference between age in normal pregnancy and abortion (p = 0.001), there is no relationship between age and TNF-α levels in normal pregnancy (p = 0.429), there is no relationship between age and TNF-α levels in abortion (p = 0.862), and there is no difference in TNF-α levels between normal pregnancy and abortion (p = 0.248). Conclusion: there is a significant difference between age in normal pregnancy and abortion.
Obstructed Hemivagina and Ipsilateral Renal Agenesis (OHVIRA) Syndrome: A Rare Case Report Ega Atista; Yulia Margaretta Sari
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.163-169.2026

Abstract

Introduction: The Herlyn-Werner-Wunderlich (HWW) syndrome, also known as obstructed hemivagina and ipsilateral renal agenesis (OHVIRA), is a rare form of Mullerian Duct Anomalies (MDA). The patient with OHVIRA syndrome has dysmenorrhea, abdominal pain, and a lump in the belly. Although the exact cause and pathology of OHVIRA syndrome are unknown, early diagnosis and treatment can reduce acute symptoms and preserve normal fertility. Case Report: This article reports a case of 15 a 15-year-old woman who complained of foul mucopurulent discharge. Ultrasound finding uterus didelphys, right obstructed hemivagina with resultant pyocolpos, and suspected of right renal agenesis. The patient was diagnosed with OHVIRA syndrome. The patient underwent vaginal septal resection, and the pyocolpos was drained. Discussion: Intraoperatively, a completely obstructed longitudinal vaginal septum was identified on the right hemivagina, with purulent fluid consistent with pyocolpos. After septal resection, adequate drainage was achieved and communication between both hemivaginas was established. Postoperatively, the patient showed clinical improvement, with resolution of vaginal discharge and relief of vaginal obstruction. No intraoperative or immediate postoperative complications were observed. During short-term follow-up, the patient remained asymptomatic, with no evidence of recurrent obstruction or infection. Conclusion: This case highlights several important aspects of OHVIRA syndrome, including its atypical postpartum presentation, diagnostic challenges, and unpredictable reproductive outcomes. Ultrasonography plays a key role in early detection. Vaginal septal resection and drainage are effective in relieving symptoms and preventing complications. Reporting this rare presentation contributes to improved awareness and timely management of OHVIRA syndrome in adolescents.
Korelasi antara Kadar Asam Urat Tinggi dengan Tingkat Keparahan Preeklamsia: Menjelajahi Hubungan Antara Hiperurisemia dan Tingkat Keparahan Preeklamsia: Perspektif Klinis Putra, I Wayan Artana; Widiyanti, Endang Sri; Amanda Sherman
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.16-25.2026

Abstract

Introduction: Preeclampsia is a pregnancy complication marked by hypertension and multi-organ dysfunction, contributing to significant maternal and fetal morbidity and mortality, particularly in developing nations. Identifying severe cases early remains challenging due to limited biomarker specificity and predictive accuracy. Uric acid has been proposed as a potential marker, though its reliability in predicting severity remains debated. Methods: This cross-sectional study included 54 pregnant women diagnosed with preeclampsia at RSUP Prof. Dr. I.G.N.G Ngoerah, Denpasar, with a gestational age of over 20 weeks. Participants were selected through consecutive sampling. Data on serum uric acid, blood pressure, proteinuria, and creatinine levels were analyzed using parametric statistical tests to assess correlations with preeclampsia severity. Results: Elevated uric acid levels (>6 mg/dL) were significantly associated with severe preeclampsia (p=0.039), with a prevalence ratio of 2.96. Strong correlations were found between uric acid and blood pressure (r=0.71, p=0.012) and proteinuria (r=0.64, p=0.012), while a moderate correlation existed with serum creatinine (r=0.40, p=0.002). Conclusion: Serum uric acid levels can be a useful indicator for assessing preeclampsia severity. However, its predictive value should be combined with other clinical and biochemical markers to enhance early detection and management strategies
Comparative Sexual Outcomes of Laparoscopic Davydov and SIS Graft for Neovagina in MRKH Patients: Meta-Analysis Wael Oemar; Tyas Priyatini
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.26-40.2026

Abstract

Introduction: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital anomaly of the female reproductive system, characterized by the absence of the uterus and upper vagina. Neovaginal reconstruction is the primary treatment to enable normal sexual function. Two commonly used techniques are the laparoscopic Davydov procedure and the use of Small Intestine Submucosa (SIS) grafts. Methods: A systematic review and meta-analysis were conducted on studies comparing these two surgical techniques in MRKH patients. Literature searches were performed through multiple international databases. Inclusion criteria involved both observational and experimental studies reporting anatomical and sexual function outcomes postoperatively. Statistical analysis was performed to compare the outcomes of both techniques. Results: The review found that both techniques are effective in achieving satisfactory anatomical and functional neovagina creation. However, differences were observed in parameters such as duration of molding use, vaginal length, and FSFI domain scores. The laparoscopic Davydov procedure showed advantages in anatomical outcomes and shorter molding duration, while SIS grafts demonstrated better scores in some subjective aspects of sexual function. Conclusion: Both the laparoscopic Davydov procedure and SIS grafts are effective in neovagina creation for MRKH patients. The Davydov technique offers superior anatomical results and reduced postoperative dilation time, whereas SIS grafts may provide improved sexual desire, arousal, and satisfaction. Further studies with larger and more diverse populations are needed to validate these findings.
The Role of Transforming Growth Factor Beta (TGF-β) in Pelvic Organ Prolapse : A Systematic Review Yulia Margaretta Sari; Bobby Indra Utama; Zelly Dia Rofinda; Elliyanti, Aisyah
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.58-69.2026

Abstract

Introduction: Pelvic organ prolapse (POP) is a gynaecological disorder with a rising prevalence, significantly affecting quality of life. While the pathogenesis of POP is multifactorial, alterations in the extracellular matrix (ECM) have been implicated, particularly the role of transforming growth factor-beta (TGF-β) in ECM remodelling. However, the precise relationship between TGF-β and POP remains unclear. Methods: A systematic review was conducted following PRISMA guidelines. Relevant studies were identified from PubMed, Scopus, Web of Science, and the Cochrane Library. Inclusion criteria focused on studies investigating TGF-β expression in women with POP. Data extraction included study design, patient demographics, TGF-β detection methods, and key findings. Results: Analysis of nine studies revealed mixed findings. Four studies reported a significant reduction in TGF-β1 expression in POP patients, suggesting impaired ECM regulation via the TGF-β1/Smad3 pathway. Three studies found no significant differences in TGF-β levels between POP and control groups, while one study linked increased TGF-β1 levels to severe prolapse, possibly as a compensatory response. Variations in methodology, sample size, and patient characteristics contributed to inconsistencies across studies. Conclusion: Current evidence suggests that TGF-β1 plays a role in POP pathogenesis, with lower levels potentially weakening ECM integrity and higher levels in advanced cases reflecting a failed reparative response. Further research is needed to explore TGF-β interactions with other biomarkers and assess its potential as a therapeutic target.
Smartphone-Based Kegel Exercises for Stress Urinary Incontinence: A Systematic Review and Meta-Analysis of RCT Hakim, Surahman; Djusad, Suskhan; Kadarusman, Adib Kamil Putra; Hadinata, Valencia; Amelia, Safira; Suskhan, Rizki Fauzi; Adriansyah, Putri Nadhira
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.1-15.2026

Abstract

Introduction : To evaluate the effectiveness of smartphone-based applications in supervising Kegel exercises for women with Stress Urinary Incontinence (SUI), specifically in improving treatment adherence and reducing symptom severity as measured by the ICIQ-UI-SF score. Method : This study compares smartphone-based applications for supervising Kegel exercise in women with SUI. Article retrieved from 3 databases using specific keywords. ICIQ-UI-SF scores and adherence data is the main outcome in this article.  Results : Five RCTs with a total of 475 participants were included. Three studies demonstrated improved adherence among intervention groups using smartphone applications. Meta-analysis revealed that application based supervision resulted in significantly better post-treatment ICIQ-UI-SF Score (SMD: -0.46, CI [-0.65,-0.28], p < 0.00001)  Conclusion : Smartphone applications as a supervision tool for SUI patients who underwent Kegel exercise as a conservative treatment is proven to reduce severity and increasing adherence of the therapy.
Efficacy of Autologous Platelet-Rich Plasma (PRP) on Perineal Wound Healing: A Controlled Non-Randomized Clinical Trial. Fadli, Muhammad; Utama, Bobby Indra; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.153-162.2026

Abstract

Introduction: Perineal wounds are a very common complication of vaginal birth. Perineal trauma associated with childbirth is defined as damage to the skin, perineal muscles, as well as the sphincter and anal epithelium complex. This study aims to determine the effect of PRP use on perineal wounds.  Method: A single-center, controlled, non-randomized, non-blinded clinical trial was designed in patients with perineal wounds after vaginal delivery. PRP was taken from each patient's serum (autologous). Perineal wound healing after intervention was assessed using the Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale. Perineal wound pain was assessed using the Visual Analog Scale (VAS). Result: The current study involved 56 samples, 28 people per group. The average age of the patients was 28.38 ± 6.280 years. The highest education was high school, 42.9%, while the lowest was elementary school (21.4%). The highest VAS scale was 3 (42.9%) and the lowest was 1 (5.4%). The prevalence of the highest degree of perineal wounds in general was degree 2 (98.2%). The highest score was in the moderately healed group on PRP administration (92.9%). In contrast to the control group, the mildly healed category was 21.4% and not healed 14.4%.  Conclusion: There is a significant relationship between the PRP to healing perineal wounds in vaginal delivery patients at the Seberang Padang Health
Identification of Gender in Early Pregnancy Using Cell-Free Fetal Dna Hermawan, Budi Junio; Utama, Bobby Indra; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.135-144.2026

Abstract

Introduction: Traditionally, chorionic villus sampling and amniocentesis can be used to help identify fetal gender around 11 weeks of pregnancy. However, the risk of miscarriage with these procedures is approximately 1 to 3%. The discovery of cell-free fetal DNA (cffDNA) fragments in the plasma and serum of pregnant women carrying male fetuses has made reliable and accurate diagnosis using non-invasive procedures an option for determining fetal gender. To determine the success rate of fetal gender identification in early pregnancy using Cell Free Fetal DNA. Methods: An analytical observational research method to identify fetal gender in early pregnancy through Cell Free Fetal DNA examination in maternal blood. A total of 70 samples were collected using quota sampling technique. Data analysis was performed using sensitivity and specificity tests, as well as cross-sectional analysis to determine the relationship between PCR test results and gender at birth.      Results: The PCR test has low sensitivity (14.29%), meaning the test is less effective in correctly detecting male gender, resulting in many false negatives. However, it has high specificity (98.11%), indicating its excellent ability to detect female gender with very few false positives. Additionally, the Pearson Chi-Square statistical test resulted in a p-value of 0.033 (p < 0.05), indicating a statistically significant relationship between PCR test results and gender at birth.   Conclusion: Statistically, this test is better at identifying females than males, with a lower error rate for females.  
Treatment of Prepubertal Labial Adhesion: A Case Report Khalilullah, Ibnuzaer; Utama, Bobby Indra; Sari, Yulia Margaretta
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.179-186.2026

Abstract

Introduction : Labial adhesion is a condition in which the labia minora adhere to each other, either partially or completely, and is most commonly observed in prepubertal girls. The highest incidence typically occurs between the ages of 3 months and 6 years, a period during which lower estrogen levels make the vulvar mucosa more susceptible to irritation and adhesion. Objective : To report and discuss a rare case of labial adhesion on prepubertal. Methods : A prepubertal girl diagnose with labial adhesion at Dr. M. Djamil Central Hospital was reported and discuss the management. Result : A four-year-old girl was referred to the outpatient urogynecology clinic by a network hospital for labial adhesion. Upon general assessment, the child's development appeared appropriate for her age. Her medical history did not reveal any significant illnesses, surgical procedures, or history of sexual abuse, and her general physical examination was normal. Upon inspection, the labia majora were normal, but he labia minora appeared fused with a 0.2 cm gap at the proximal area of the adhesion. The adhesions appear thick and non-transparent For this patient, we decided to proceed with excision of the labial area without first attempting estrogen therapy. Seven days post-operation, the patient returned for a follow-up visit in good condition. The surgical wound was dry, urination was normal, and the examination showed a normal vaginal opening. Conclusion: From this case report, we conclude that for long-standing labial adhesion characterized by tissue thickening, labial excision is the appropriate and effective treatment option.

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