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Jurnal Prima Medika Sains
Published by Universitas Prima Indonesia
ISSN : 26863502     EISSN : 27146707     DOI : https://doi.org/10.34012/jpms
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Prima Medika Sains adalah jurnal ilmiah di bidang kesehatan dan kedokteran yang terbit dua kali dalam setahun yaitu pada bulan Juni dan Desember. Diterbitkan oleh Universitas Prima Indonesia yang secara teknis dikelola Program Studi Magister Kesehatan Masyarakat Fakultas Kedokteran Universitas Prima Indonesia. Berisi tulisan hasil penelitian lapangan atau laboratorium maupun studi pustaka di bidang kesehatan dan kedokteran.
Arjuna Subject : Kedokteran - Kesehatan Masyarakat, Kesehatan Lingkungan dan Pekerjaan
Articles 18 Documents
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Search results for , issue "Vol. 7 No. 1 (2025): June" : 18 Documents clear
Recurrent flaccid paralysis due to hypokalemia as an unusual presentation of hypothyroidism Nainggolan, Prima Heptayana; Meliala, Terang
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.5741

Abstract

Background: Recurrent flaccid paralysis with low level of potassium can be found in hypokalemic periodic paralysis or thyrotoxic periodic paralysis. Hypokalemic Periodic paralysis associated with hypothyroidism is rare in the existing literature. Case illustration: A 41-year-old man had been admitted to the emergency ward due to weakness of his lower extremities for 3 days before the admission. He had the same symptoms one year ago. Based on the physical examination, decreases in both muscle strength and physiological reflexes in lower extremities had been found. From laboratory examination, the serum potassium level had reduced up to 1,7 mmol/l, with high TSHs and normal T3 and T4 level. The nerve conduction studies had revealed normal limits. Following a potassium correction, the patient had shown improvement. Discussion: In most cases, hypokalemic periodic paralysis is caused by pure hypokalemia or high thyroid hormone level in serum (as in thyrotoxic periodic paralysis). However, this patient was diagnosed as hypokalemic periodic paralysis with subclinical hypothyroidism. This case is therefore a very rare and unusual presentation of hypothyroidism. The relation between hypokalemic periodic paralysis and hypothyroidism remains unclear. Conclusion: Hypokalemic periodic paralysis associated with hypothyroidism is rare and understanding about this condition has not been established thus far in the literature. Thyroid examination is needed for patients with hypokalemic periodic paralysis.
The role of catechol-o-methyltransferase in postpartum depression Dewi, Indah Kusuma; Natasia, Caroline Putri; Gunadi, Julia Windi; Sanjaya, Ardo
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.5844

Abstract

The global prevalence of postpartum depression is increasing annually. This condition has been associated with polymorphisms in the catechol-O-methyltransferase (COMT) enzyme, which plays a critical role in the degradation of catecholamines. Therefore, a literature review was conducted to examine the influence of COMT enzyme variants on postpartum depression, with a focus on specific time periods and genetic variants implicated in the disorder. The review methodology involved a systematic search of articles on the PubMed database using the keywords "catechol-O-methyltransferase," "postpartum depression," and "role of COMT in postpartum depression." Inclusion criteria required full-text availability in either Indonesian or English. Four relevant studies were identified that investigated the relationship between COMT enzyme variants and postpartum depression. Evidence suggests that the COMT Val158Met polymorphism may affect the risk of postpartum depression in the context of elevated estrogen levels, as high estrogen concentrations are known to downregulate COMT expression. Additionally, certain single nucleotide polymorphisms (SNPs), including rs2020917 (TT genotype), rs737865 (GG genotype), and the COMT rs4680 Met variant allele, have been shown to modulate the influence of COMT on postpartum depression independently of estrogen levels, possibly through interactions with other enzymatic pathways.
Endobronchial hamartoma: Diagnostic challenges and clinical implications of a rare benign lung tumor Fazharyasti, Vininta; Wahyono, Djuwita Adi; Wardhana, Samuel Raymond Rumantir; Putranto, Terawan Agus
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6112

Abstract

Introduction: Endobronchial hamartomas are rare benign lung tumors, representing only 0.025%–0.032% of all lung tumors and 1.4% of hamartomas. Originating in the bronchial passages, these tumors comprise cartilage, fat, fibrous tissue, and epithelium. Despite their benign nature, they can cause bronchial obstruction, post-obstructive pneumonia, and atelectasis. Case Report: A 68-year-old male presented with chronic cough and hemoptysis. Imaging revealed a calcified mass in the right lower bronchus, causing partial obstruction. Bronchoscopy identified a smooth, obstructive mass without bleeding or necrosis. Histopathological examination confirmed an endobronchial hamartoma, showing benign bronchial mucosa, cartilage, adipose tissue, submucosal glands, and myxoid stroma. Discussion: Diagnosing endobronchial hamartomas is challenging due to their rarity, nonspecific symptoms, and nonspecific imaging findings. Advanced imaging techniques, such as computed tomography (CT) scans, can identify calcifications or fatty components, aiding diagnosis. However, histopathological confirmation is crucial to differentiate these lesions from malignant or other benign pulmonary tumors. Early recognition and treatment are essential to prevent complications like recurrent infections and irreversible airway damage. Conclusion: Although rare, endobronchial hamartoma is a clinically significant benign lung tumor due to its potential to cause notable complications. The diagnostic challenge lies in its often nonspecific initial imaging findings. However, combining advanced radiology modalities, such as computed tomography (CT) and histopathological evaluation. Early recognition of this tumor from other pulmonary lesions is crucial for treatment and better patient outcomes.
Optimizing nutritional status with nutritional therapy in malnourished patient post whipple’s procedure: A case report Stefani, Shiela; Sunardi, Diana; Sonia, Steffi
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6235

Abstract

The prevalence of malnutrition is considerably high among patients with pancreatic cancer and that Whipple procedure is associated with high morbidity and mortality rates. Post-Whipple procedure nutritional therapy can help to preserve nutritional status, accelerate recovery of functional capacity, and improve patient’s quality of life. A 65-year-old malnourished woman underwent Whipple procedure for adenocarcinoma of ampulla of Vater. Oral pre-operative nutrition was given in the form of normal food and oral nutritional supplement (ONS). Eight hours before surgery, the patient received ONS containing 30 g carbohydrate. The patient was given early enteral nutrition at <48 hours post-operatively and was given oral nutrition as soon as she regained consciousness. The patient experienced post-operative pancreatic fistula (POPF) grade A. Post-operative in-hospital and homecare nutritional therapy included supply of energy, macronutrients, micronutrients, and nutritional education adjusted to the patient’s clinical condition and intake tolerance. Energy intake during hospitalization attained 109% of the estimated total energy requirement that consisted of up to 1.9 g/kg/day protein. Homecare nutritional intake reached almost 2 times basal energy requirement with 2.2 g/kg/day protein intake. The patient experienced improvement of clinical symptoms, POPF, intake tolerance, glycemic control, and functional capacity. The patient was allowed to be discharged and treated in the outpatient clinic, without readmission in the next 2 months. Adequate hospital and homecare medical nutritional therapy in post-Whipple procedure may improve nutritional status and functional capacity, improve clinical outcome, and prevent readmission of patients.
Medicinal potential of gambier extract for recurrent aphthous stomatitis treatment Amaliah, Nurfitri; Saud, Muhammad Yamin
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6581

Abstract

Recurrent aphthous stomatitis (RAS) remains as one of the most common disorders in the oral cavity. Various treatment options for RAS conditions include topical, systemic, and the use of traditional ingredients that have pharmacological content. One of the plants known to have good pharmacological content for RAS treatment is gambier (Uncaria Gambier). Gambir plant extract is known to have various benefits for health, including in the management of RAS due to the active ingredient compounds in the form of anti-inflammatory, antioxidant and antibacterial properties. One of the active compounds possessed by gambier plant extract in the form of catechine is proven to have the ability to reduce inflammation and help to accelerate the healing process in RAS cases.
Effectiveness of platelet rich plasma injection for achilles tendon injury in wistar rats: An experimental study Nasution, Nino; Reza, Muhammad
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6612

Abstract

Tendon injuries, particularly Achilles tendon ruptures, significantly impact athletes and labourers, affecting daily activities and quality of life. The platelet plasma rich (PRP) injections have emerged as a treatment option due to their abilities in stimulating growth factors, essential for the healing processes. This study investigates the effectiveness of PRP injections in healing Achilles tendon injuries in Wistar rats. Thirty male Wistar rats were divided into three groups: Group 1 received a 100 µL PRP injection, Group 2 received a 50 µL PRP injection, and Group 3 received a 100 µL NaCl injection as a control. The Achilles tendons were surgically transacted and sutured using modified Kessler method, followed by PRP or NaCl injections. Rats were euthanized on days 15 and 30 for histological and biomechanical evaluations. This study found that PRP administration had a significant effect on histological tendon healing on the 15th and 30th, with the best improvement at a PRP dose of 100 µL, especially in the early phase of healing. PRP also had a significant effect on tendon healing in terms of biomechanical function on the 15th and 30th days, with the best improvement at a PRP dose of 100 µL, especially in the final phase of healing. This study provides detailed biomechanical and histological insights into the tendon healing process, which may be challenging to obtain in human studies due to ethical and logistical constraints. The PRP injection improves healing in the Achilles tendon rupture in Wistar rats.
Lived experience and impact of oral phosphodiesterase-5 inhibitors among patients with type 2 diabetes mellitus complicated by erectile dysfunction: A qualitative study Ramali, Khairul Nazli; Draman, Nani; Zainuddin, Aida Maziha; Muhamad, Rosediani; Ismail, Shaiful Bahari
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6616

Abstract

This study explored the experiences of men with Type 2 Diabetes Mellitus (T2DM) who also experienced erectile dysfunction (ED) and delayed seeking medical treatment. Using a phenomenological approach, in-depth interviews were conducted with 15 male patients, aged 18 and above, who had been using phosphodiesterase-5 (PDE5) inhibitors for at least three months. Thematic analysis of the interviews, framed by sexual script theory, identified three key themes. Patients reported feelings of sexual distress, a perceived loss of manhood, and inadequacy as husbands, which negatively affected their wives and relationships. Many initially believed that alternative therapies could cure ED, delaying their pursuit of conventional medical treatment. However, after complementary treatments failed, they recognized the benefits of PDE5 inhibitors. These medications significantly helped patients regain sexual strength, self-esteem, and satisfaction in their relationships. This study underscores the profound impact ED has on the sexual well-being of men with T2DM and highlights the importance of PDE5 inhibitors in improving sexual function and restoring intimacy within couples. It also emphasizes the need for early intervention and education on the effectiveness of medical treatments for ED.
Cytotoxicity evaluation of combined Piper betle-bioactive glass on dental pulp stem cells Allosias, Jacqueline Ann; Noor, Siti Noor Fazliah Mohd; Luddin, Norhayati; Ghani, Huwaina Abd
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6626

Abstract

Recent advances in dentistry emphasize the use of synthetic and natural bioactive materials for regenerating the dentine-pulp complex. This study assesses the cytotoxic effects of Piper betle-conditioned media, alone and combined with bioactive glass 45S5 Bioglass. Three test groups were used: Piper betle-only, Bioactive glass-only, and the combined Piper betle-Bioactive glass. Cytotoxicity was measured using the MTT assay on dental pulp stem cells on day one, two, four, seven, and fourteen. Cells exposed to 4.00 mg/ml Bioactive glass-only showed the highest cell viability, while Piper betle-only demonstrated the highest viability at a concentration of 31.25 µg/ml. The combined Piper betle-Bioactive glass showed the best results at 4 mg/ml and 30 µg/ml. Overall, the combination group had the highest cell viability, followed by the Bioactive glass-only and Piper betle-only groups. No significant differences were found between the combination and Bioactive glass-only groups, but significant differences existed between the combination and Piper betle-only groups. In conclusion, the combination of Piper betle and Bioactive glass enhances dental pulp stem cell proliferation, warranting further investigation into its regenerative potential.
The combined effect of neonatal hypothyroidism and low family income on intellectual disability: A review of mechanisms and interventions Sutanti, Sutanti; Suryawan, I Wayan Bikin
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6651

Abstract

This review investigates the combined effect of neonatal hypothyroidism and low family income on the prevalence of intellectual disability, drawing insights from existing literature, including specific findings from studies involving neonatal cases such as 15 cases at Wangaya Regional Hospital Denpasar. Neonatal hypothyroidism significantly impacts cognitive development due to the critical role of thyroid hormones in brain maturation. Concurrently, low family income acts as a risk factor for intellectual disability by limiting access to essential healthcare, education, and developmental resources. The review explores the epidemiology of neonatal hypothyroidism, highlighting global and regional variations influenced by genetic, environmental, and socioeconomic factors. It delves into the mechanisms by which neonatal hypothyroidism affects brain and cognitive function, leading to deficits in intelligence, memory, attention, and executive function. Furthermore, the review examines the relationship between socioeconomic status and intellectual disability, emphasizing the role of resource scarcity and environmental factors associated with poverty. Findings from the reviewed literature suggest a compounding effect of neonatal hypothyroidism and low family income on a child's cognitive development and intellectual disability risk. Addressing this complex interplay necessitates a multifaceted approach, including early detection, prompt treatment, and integrated interventions spanning healthcare, education, and social support services. The review underscores the importance of equitable access to newborn screening, comprehensive early intervention programs, and family-centered support for children from low-income households.
Association between cardiothoracic ratio and aortic arch calcification with estimated glomerular filtration rate in hypertensive patients Pratomo, Fransiskus Aryo; Icksan, Aziza Ghanie; Nasution, Ikhwanul Hakim
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6677

Abstract

Hypertension remains a leading cause of global cardiovascular mortality, including in Indonesia. Target organ damage, particularly renal impairment, underscores the need for easily obtainable biomarkers for early detection. Although not explicitly recommended in current guidelines, the cardiothoracic ratio (CTR) and aortic arch calcification (AAC), both assessable via chest radiography, represent readily available and cost-effective screening tools. This study aimed to evaluate the association between these radiographic markers and decreased estimated glomerular filtration rate (eGFR) in hypertensive patients at Royal Prima Hospital, thereby addressing a crucial knowledge gap in resource-limited settings with restricted access to advanced imaging modalities. A cross-sectional analysis was conducted involving 175 hypertensive participants, stratified according to their chronic kidney disease (CKD) stage. Baseline demographics, hypertension status, CTR, AAC, and eGFR were assessed. Bivariate correlation and multivariate regression analyses were performed to determine the relationships between CTR, AAC, and eGFR. The study population exhibited a high prevalence of cardiovascular comorbidities, with 82.3% demonstrating cardiomegaly (mild-to-severe CTR) and 61.7% presenting with AAC. Bivariate analysis revealed a strong inverse correlation between eGFR and both CTR (r = −0.418, p < 0.001) and AAC score (r = −0.457, p < 0.001). Multivariate regression confirmed that both CTR (B = -1.738, p < 0.001) and AAC (B = -16.127, p < 0.001) were significant predictors of eGFR decline. Progressive CKD stages were associated with increased CTR (52.3% in Stage 1 vs. 58.7% in Stage 5) and greater AAC severity (0% advanced calcification in Stage 1 vs. 34% in Stage 5). Age, sex, and blood pressure did not show significant correlations with eGFR (p > 0.05). CTR and AAC are strongly associated with renal dysfunction, reinforcing the evidence of an interaction between cardiovascular pathology and CKD progression. These markers have the potential to serve as accessible biomarkers for identifying high-risk patients, thereby facilitating early intervention in resource-limited settings.

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