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Maulana Yusuf Alkandahri
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Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Published by Universitas Buana Perjuangan Karawang
ISSN : 25275801     EISSN : 25809601     DOI : https://doi.org/10.36805/farmasi
Core Subject : Health,
Medicine & Pharmacology
Biologi Farmasi, Farmakoekonomi, Farmakologi dan Toksikologi, Farmasetika dan Teknologi Farmasi. Farmasi Klinik, Farmasi Sosial, Kimia Farmasi
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 7 Documents
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Search results for , issue "Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi" : 7 Documents clear
ETNOBOTANI TUMBUHAN OBAT OLEH WARGA DAYAK MERATUS DI DESA GUNUNG RIUT KABUPATEN BALANGAN KALSEL Nashrul Wathan; Rina Rina; Nadia Rahmah; Hilya Aulia; Nita Pujianti
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.2904

Abstract

Traditional knowledge about the use of medicinal plants owned by various indigenous Dayak tribes in Kalimantan reflects that people's lives cannot be separated from the surrounding natural resources, especially medicinal plants. The purpose of this study was to determine the types of medicinal plants, the percentage of medicinal plant parts used and to determine how to process and use medicinal plants by traditional healers of the Dayak Meratus tribe in Gunung Riut Village. Informants are determined by purposive sampling technique. The result of the interview showed 28 species and divided into 18 families of medical plants used to treat toothache, back pain, skin diseases, fever, influenza, syphilis, fractures, wounds, hypertention, jaundice, malaria, hemorrhoids, increase stamina, laxative, asthma and indigestion. The percentage of plant parts that are widely used are leaves (26.67%), roots (23.33%), and stems (13.33%). Processing methods by soaking, boiling, pounding, without processing, squeezing, heating, cutting and burning. How to use by applying, massaging, sticking, drinking, pinching, bathing, and eating.
FORMULASI SEDIAAN HAIR TONIC EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lamk.) DAN DAUN RAMBUTAN (Nephelium lappaceaum L.) TERHADAP PERTUMBUHAN RAMBUT Siti Hindun; Nopi Rantika; Aji Najihudin; Acep Indra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.3008

Abstract

Moringa olifera lamk and Nephelium lappaceaum L leaves are empirically widely used to stimulate hair growth. The purpose of this research is to combine the kelor leaf extract and rambutan leaf extract formulated in hair tonic. The hair tonic preparations made were evaluated by performing a physical test of the preparation and knowing the best concentration of kelor leaf extract and rambutan leaf extract on rabbit hair growth. The hair tonic were orepared in 3 formulations with the ratio of kelor leaf exract and rambutan leaf extract (1:3 , 1:1 and 3:1)% w/v. the positive control used is hair tonic Minoxidil 2%. Physical tests of the preparation include organoleptic test, pH test, homogeneity test and Viscosity test. Hair growth activity on the 3 rabbits shaved hair and hair growth measurements until the 28 st day. The data of growth measurements were tested statistically by ANOVA test metode. Based on the reseach result, in can be concluded that hair tonic combination of kelor leaf extract and rambutan leaf extract with ratio (1:1)%, has average hair length 3 cm and hair weight 0,236 g is the optimum concentration in stimulating hair growth aktivity with positive control has average hair length 2,025 cm and hair weigth 0,207 g. Test statistically there was no significant difference between extract and positif control (P < 0,05).
ANALISIS PERSEPSI PENYAKIT TERHADAP KUALITAS HIDUP PASIEN DIABETES MELITUS TIPE II DI RUMAH SAKIT UMUM DAERAH TORABELO Amelia Rumi; Adifa Salsabila
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.3847

Abstract

Diabetes mellitus is a disorder that occurs in heterogeneous metabolism due to chronic glycine. Diabetes mellitus also occurs due to disorders in insulin secretion or impaired insulin effect or both factors. Based on the results of the research of the Central Sulawesi Health Office, especially in Sigi Regency, the number of people with type II diabetes mellitus is 15,244 people suffering from type II diabetes mellitus. The purpose of this study was to determine the relationship of the perception of disease in the quality of life of patients with type II diabetes mellitus in the Torabelo regional hospitals. This study used a cross sectional method with the number of respondents, namely 100 respondents, data collection using disease perception questionnaires and live quality questionnaires provided to respondents directly. The results of the study that were obtained from disease perception questionnaires for positive categories, namely 70%, the neutral category of 20% and the negative category of 10%, while the result of life quality cakes are obtained by the category of good 12%, and 88% poor. The results of the chi square test received p = 0.028 or < a (0.05), Ha accepted was rejected meaning to having a relationship between illness perception of the disease of patients with the type II diabetes mellitus. The conclusion was obtained from this study, namely there is a relationship between the perception of disease with the quality of life. The occurrence of increased quality of life due to good disease perceptions.
UJI STABILITAS SEDIAAN AMPISILLIN SULBAKTAM SETELAH REKONSTITUSI I Gede Edy Sagitha; Suharjono Suharjono; Yulistiani Yulistiani; Isnaeni Isnaeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.4333

Abstract

Repeated use of antibiotic ampicillin sulbactam after reconstitution, therefore in storage various many factor can affect it stability such as type of solvent used, storage temperature and storage time. Objective of study is to analyze the chemical stability product of ampicillin sulbactam in repeated use with the parameters of the solvent and storage temperature Sample products were weighed and reconstituted using WFI and NS solvents, diluted ad 20 ppm and put into sterile vials. Then stored at room temperature (25-30 ° C) and refrigerator temperature (4-8 ° C). Storage is carried out for 24 hours which is divided into 4 -time series, namely 0, 1, 4 and 24 hours. Each time series is microbiological tested and after 18 hours incubation the inhibition zone is observed and its diameter measured using calipers. Result of study is at 0th hour showed a significant difference in different solvents. Samples dissolved with NS solvents have a greater inhibition zone than those dissolved using WFI. This happens because there is a primary salt effect that occurs with the influence of electrolytes (salt) or variations in the strength of ions can affect the coefficient of activity that affects the reaction rate. From the statistical analysis at the 1st and 4th hours, the storage temperature that provides significant result, storage in the refrigerator produces better results compared to storage at room temperature. At 24 hours the temperature and solvent did not give the significant result on the stability of the sulbactam ampicillin sample. Conclusion is NS solvents give better results than WFI solvents. Samples are more stable if stored in a refrigerator. After 4 hours based on the above study the sample no longer meets the requirements of Indonesian Pharmacopoeia 5th edition
IDENTIFIKASI SENYAWA AKTIF EKSTRAK DAUN JARAK KEPYAR (Ricinus communis) DENGAN ANALISIS FITOKIMIA DAN GC-MS SEBAGAI KANDIDAT SENYAWA OBAT Sulwiyatul K Sani; Baiq Erna; Atri Sri Ulandari
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.5115

Abstract

As a tropical country with biodiversity, Indonesia is rich with flora especially those with potential as medicinal plants such as Jarak Kepyar (Ricinus communis). Leaves of jarak kepyar (Ricinus communis) are used as a medicine for wounds, rash, abscess, and fever. Therefore, the purpose of this study was to determine the active compound in ethanol and n-hexane extract of jarak kepyar (Ricinus communis) leaves using phytochemical analysis and GC-MS. The research method used is the experimental method in the laboratory. The steps of the research were extraction of jarak kepyar (Ricinus communis) leaves using 96% ethanol and n-hexane with the maceration method. Furthermore, jarak kepyar (Ricinus communis) leaves extract was analyzed qualitative and quantitatively by phytochemical screening and GC-MS analysis. The results of the phytochemical screening showed that the chemical compounds contained in the ethanol extract of jarak kepyar (Ricinus communis) leaves were flavonoids, alkaloids, terpenoids, tannins and phenolics. While the chemical compounds contained in the n-hexane extract of jarak kepyar (Ricinus communis) leaves are alkaloids. GC-MS analysis of the ethanol and n-hexane extracts of jarak kepyar (Ricinus communis) leaves showed that several compounds that are found in the extract of jarak kepyar (Ricinus communis) leaves such as 2-ethoxycarbonyl-5-oxo-pyrolidine, delta-octalactone, trimethyl ester or trimethyl citrate, quinic acid, 2,3- Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and methyl oleate have potential as medicinal compounds.
ANALISIS POTENSI DAUN TORBANGUN (Plectranthus amboinicus) SEBAGAI ANTIBAKTERI TERHADAP Klebsiella pneumoniae SECARA IN SILICO Nabila Nur Nafiati; Rini Madyastuti Purwono; Nurhidayat Nurhidayat; Laksmi Ambarsari
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.5190

Abstract

Antibiotic-resistant is a global issue. Klebsiella pneumoniae has high priority to find its antibiotic because it has extended-spectrum beta-lactamase (ESBL) enzyme that makes the bacteria easy to resist the antibiotic. The study of phytochemicals in medicinal plants is one of the efforts to find antibiotics. Indrulizia is one of the empirical medicinal plants containing flavonoids used to treat disease. The aim of this study was to analyze the potential of borage as an antibacterial agent against Klebsiella pneumoniae in silico. Docking is the method for this study using AutoDock Vina. This is an application for docking the enzyme ESBL from K. pneumoniae, referred to as SHV (sulfhydryl variable), and the metabolite second from plants. The parameters analyzed were binding free energies, inhibition constants and visualization in 3D and 2D. The free energy of binding and the inhibition constant of the native ligand are -6.7 kcal/mol and 12.118 μM. The binding free energy values ​​of apigenin 7-glucuronide and rosmarinic acid show higher potencies than the native ligand of SHV-1 (1,4-thiazepine).
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN OBAT PADA PASIEN RAWAT INAP PENYAKIT COVID-19 KATEGORI SUSPEK NON-COMORBID DENGAN TERAPI OBAT KOMBINASI ANTIVIRUS DAN ANTIBIOTIK DI SALAH SATU RUMAH SAKIT KOTA BANDUNG PERIODE JULI – DESEMBER 2021 M. Hilmi Fathurrahman; Nela Simanjuntak; Neng Siti Sopiah
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.5251

Abstract

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The cost of his treatment requires a large amount of money. This study aims to analyze the cost-effectiveness of drug use in hospitalized patients with COVID-19 in the category of non-comorbid suspects with combination antiviral and antibiotic therapy at the Bandung Hospital Period July – December 2021. This study uses a non-analytic descriptive method. Data collection was carried out retrospectively by accessing medical record data. Samples that met the inclusion criteria in this study were 48 patients. Cost-effectiveness analysis was carried out by calculating the Average Cost Effectiveness Ratio (ACER) and Incremental Cost Effectiveness Ratio (ICER), then a sensitivity analysis was carried out to determine the parameters that affect cost-effectiveness by increasing drug costs to 2.5%, 5%, 7.5%. . The results of the analysis show the use of combinations of antivirals and antibiotics in COVID-19 patients, namely there are 16 variables and the most cost-effective (cost-effective) treatment is the combination of ceftriaxone inj with oseltamivir obtained at ACER = Rp. 1.005.724, the combination of azithromycin with ceftriaxone inj. is obtained at ICER = Rp.-2.113,412. The results of the sensitivity analysis showed that there was no change in ACER and ICER even though the drug price was increased up to 7.5% and the combination of inj ceftriaxone with oseltamivir remained the most cost-effective.

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