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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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EVALUASI FORMULASI MASKER CLAY DARI EKSTRAK ETANOl DAUN PEPAYA (CARICA PAPAYA L.) SEBAGAI ANTI JERAWAT Fauziah, Fauziah; Alvanny, Nurliza; Andalia, Kiki
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.283

Abstract

Papaya Leaf Extract is known to contain alkaloid and flavonoid compounds that can inhibit the preparation of peptidoglycan in bacterial cells and reduce immunity in target organisms. For ease of use of papaya leaf extract, it is formulated in the form of a mask. This study aims to formulate a clay mask from papaya leaf ethanol extract and the effectiveness of anti-acne use of clay mask preparation of papaya leaf ethanol extract for 4 weeks. The method used in this study is an experimental method carried out at the AKAFARMA laboratory in Banda Aceh. The samples used were Formula 0, Formula 1, Formula 2 and Formula 3 masks of papaya leaf ethanol extract with concentrations for Formula 1 (2.5 %), Formula 2 (5%) and Formula 3 (7%). The results of the research on the physical properties and stability of the clay mask preparation on organoleptic testing showed that all formulas did not change color and odor for 4 weeks, but there was a change in shape at F0, FI, and FII on the 28th day. The homogeneity test of all preparations showed a homogeneous arrangement. The resulting pH test is 5.7-6.5, the resulting dispersion test is 5-5.5. The dried preparation test resulted in 25-30 minutes. and the anti-acne effectiveness test of each mask preparation F0, FI, FII, and FIII the average percentage reduction in the number of acne was 20.83%, 22.63%, 28.75%, and 50%. Papaya leaf ethanol extract clay mask FIII (7.5%) was the maximum in reducing the number of pimples on the volunteers' faces. The conclusion in this study is that papaya leaves can be formulated as a clay mask.
FORMULASI DAN EVALUASI FISIK MASKER GEL PEEL OFF DARI SERBUK SISIK IKAN MUJAIR (Oreochromis mossambicus) Mutmainnah, Mutmainnah; Abdullah, Abulkhair; Syawie, Muvida
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.290

Abstract

Masker gel peel off merupakan salah satu kosmetik yang digunakan untuk perawatan kulit yang dapat memutihkan, mengecilkan pori-pori, melembabkan dan menutrisi kulit. Salah satu bahan yang dapat dijadikan bahan utama masker gel peel off adalah sisik ikan mujair (Oreochromis mossambicus). Sisik ikan mujair mengandung kolagen yang bermanfaat sebagai antiaging. Penelitian ini bertujuan untuk mendapatkan formula masker gel peel off dari sisik ikan yang terbaik dengan memvariasikan konsentrasi PVA (5% dan 10%) dan HPMC (2% dan 4%). Dalam penelitian ini dibuat 4 formula yang berbeda. Pada sediaan dilakukan pengujian karakteristik yang meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji waktu mengering, dan uji hedonik. Hasil penelitian menunjukkan sediaan yang dibuat sudah memenuhi kriteria. Semua formula memiliki tekstur semi padat, beraroma jeruk, dan berwarna abu-abu dan semua formula menunjukkan homogenitas yang baik. Hasil uji pH diperoleh: F1 (5,0), F2 (5,6), F3 (5,5), dan F4 (5,4). Hasil uji daya lekat diperoleh: F1 (400 g : 5,2 cm), F2 (600 g : 5,2 cm), F3 (600 g : 5,4 cm), dan F4 (600 g : 5,4 cm). hasil uji waktu mengering: F1 (55 menit), F2 (33 menit), F3 (33,3 menit), F4 (56,3 menit). Dapat disimpulkan bahwa serbuk sisik ikan mujair dapat dijadikan sediaan masker gel peel off. Formula 2 menjadi formula terbaik dengan konsentrasi PVA 10% dan HPMC 2%.
FORMULASI LULUR BODY SCRUB BERAS KETAN HITAM (ORYZA SATIVA VAR. GLUTINOSA) DENGAN PERPADUAN YOGURT SEBAGAI ZAT AKTIF Agata, Shelly Dwi; Jayadi, Lukky
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.293

Abstract

Scrub is a cosmetic preparation for skin care that functions as an abrasive in the form of scurb granules that can remove dead skin cells from the epidermis. The scrub used in this study was derived from black glutinous rice (Oryza Sativa Var. Glutinosa) which contains antioxidant components and can help activate vitamin B1 which helps maintain healthy skin and helps skin look brighter. In addition, the components of the active substance are also needed. Yogurt was chosen as the active ingredient of the preparation because it has Alpha Hydroxy Acid (AHA) which can help the exfoliation process and help remove dead skin cells and increase the skin's natural moisture factor. The purpose of making body scrub preparations using yogurt as an active substance with varying concentrations of 0%, 5%, 10% and 15%. This research was conducted experimentally. The physical quality test of the preparation includes organoleptic test, homogeneity test, pH test, adhesion test, dispersibility test, stability test, and emulsion type test. The results show that the preparations made meet the physical evaluation of the scrub preparations meet the quality requirements, meet the organoleptic quality evaluation, namely the formulation of the scrub preparations F0, F1, F2, and F3 with semi-solid texture, purplish gray color with a mixture of black glutinous rice and yogurt. Each preparation is homogeneous. Emulsion type o/w. pH ranged from 7, 45 - 6, 74. It complies with the quality requirements of the spreadability test and has good emulsion stability. The conclusion of this study is that the F3 formulation with the addition of 15% yogurt has the best physical quality in the organoleptic test, homogeneity test, pH test, dispersibility test, stability test, and emulsion type test.
STUDI TINGKAT PENGETAHUAN DAN PERILAKU SWAMEDIKASI OBAT ANALGESIK PADA PASIEN DI APOTEK KOTA SAMARINDA Susanti, Aprilia Diah; Dewi, Sinta Ratna
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.298

Abstract

Self-medication is a behavior of the community to perform health treatment for themselves without having to consult with health workers. Analgesic is a non-steroidal anti-inflammatory drug (NSAID) group that is used to relieve pain, so it is often used by people to treat pain without losing awareness. This study aimed to describe the study of the level of knowledge and behavior of self-medication of analgesic drugs at the Samarinda City Pharmacy. This research is a type of quantitative research with the cross-sectional method. Sampling using non-probability sampling by purposive sampling. The sample used in this study was 147 respondents. The results showed that the majority of respondents on drug selection indicators (89.1%), drug class (83.65%), how to use (92.5%), and drug storage (75.96%) with behavioral levels on the selection indicator. drug (89.8%), drug class (87.1%), method of use (83.7%), and drug storage (77.5%). The patient's level of knowledge and the behavior of self-medication of analgesic drugs is included in the good category.
PENGARUH KOMBINASI SODIUM LAURIL SULFAT DAN NATRIUM KLORIDA TERHADAP KARAKTERISTIK SAMPO EKSTRAK LIDAH BUAYA Andriani, Luh Nela; Putra, I Gusti NAWW; Tunas, I Ketut
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.304

Abstract

The shampoo industry in Indonesia is growing. The shampoo formulation contains 2 main ingredients, namely sodium lauryl sulfate (SLS) and sodium chloride (NaCl). One example of natural ingredients in the manufacture of shampoo is Aloe Vera (Aloe vera L.). This study aims to determine the effect of variations in the concentration of SLS and NaCl on the physical and chemical properties of shampoo. This research is an experimental study with 8 formulas. Includes organoleptic test, homogeneity test, viscosity test, foam height test, specific gravity test, and pH test. Making shampoo preparations by weighing all ingredients according to each formulation, leaving the shampoo for 1 day before testing for 4 weeks of storage.The results showed that the organoleptic test and the homogeneity test of NaCl and SLS had no effect on shampoo. In the specific gravity test and the pH test of NaCl and SLS there was no dominant influence on the specific gravity of shampoo. In the foam height test, the SLS coefficient value is higher than NaCl so that SLS dominantly affects the height of the shampoo foam. In the viscosity test the coefficient value of NaCl is higher than SLS so that NaCl dominantly affects the viscosity of the shampoo. The conclusion from this research is that NaCl has a dominant influence on the physical properties, namely viscosity, while SLS has a dominant influence on the physical properties, namely the height of the shampoo foam.
Molecular Docking Investigation of Caffeic Acid Phenethyl Ester (CAPE) Interaction with IL-6 and TNF-α for Anti-Inflammatory Potential Aisyah Nabila; Khalish Arsy Al Khairy Siregar; Paula Mariana Kustiawan
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.719

Abstract

Inflammation is a physiological response to tissue injury mediated by pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Although conventional anti-inflammatory drugs are effective, their long-term use is associated with adverse effects, prompting interest in safer natural alternatives. Caffeic acid phenethyl ester (CAPE), a major bioactive constituent of propolis, has been reported to exhibit anti-inflammatory properties. This study aimed to investigate the interaction of CAPE with IL-6 and TNF-α using molecular docking to evaluate binding affinity and molecular interactions. Docking simulations were performed to predict the binding behavior of CAPE and compare it with diclofenac sodium as a reference compound. CAPE exhibited binding affinities of −5.1 kcal/mol against TNF-α and −5.0 kcal/mol against IL-6, whereas diclofenac sodium showed slightly stronger binding affinities of −5.5 kcal/mol and −5.2 kcal/mol, respectively. In addition, CAPE shared several interacting residues with the reference compound, suggesting a similar binding orientation within the active sites of both proteins. These findings indicate that CAPE possesses favorable binding characteristics toward TNF-α and IL-6. However, the obtained binding affinities represent preliminary predictions of ligand–protein interactions and require further validation through molecular dynamics simulations and experimental studies. This study provides molecular insights into the anti-inflammatory potential of propolis-derived compounds and supports their further exploration as natural lead compounds for anti-inflammatory drug development.
Activity Test Of Papaya Fruit Extract And Curcuma Mangga As An Appetite Enhancer With Anorexia Test Model On Marshmallow Preparation Innovation Ridwan Mu'zizat; Rival Rizki Hadiansyah Saputra; Rizqi Indra Hartanto; Rifki Budiansyah; Zulkaida; Fauzia Ningrum Syaputri
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/85gyvt83

Abstract

Feeding difficulties in children are becoming an increasing global problem. Natural alternatives such as Carica papaya and Curcuma mangga are believed to increase appetite. This study tested the combination of the two as an anorexia agent in the form of marshmallows, as an attractive, nutritious, and attractive delivery innovation for active substances that children like. The study used a combination of Carica papaya and Curcuma mangga extracts in marshmallow form to treat anorexia. The process includes extraction, phytochemical testing, rat testing, marshmallow formulation, and organoleptic evaluation, weight uniformity, and hedonic test for children and adults to assess its effectiveness and acceptability. Phytochemical screening showed Carica papaya and Curcuma mangga extracts contained alkaloids, steroids, polyphenols, and vitamin C. The anorexia test had a p-value of 0.05. The anorexia test has a p value (>0.05) so it has an insignificant value, but the extract still increases appetite. The formulated marshmallow has a chewy texture, a favorable aroma, but the taste and texture are less attractive to panelists. Carica papaya and Curcuma mangga extracts contain active compounds and showed appetite- enhancing effects although not statistically significant. Marshmallow has a vanilla aroma that is preferred, but the taste and shape are less than optimal. The study is limited in number of samples, further quantitative analysis and formulation evaluation are recommended.
Overview Of Toddlers Diarrhea Self-Medication At Pharmacy “X”, Sidoarjo, January-March 2025 Ach Zakyah Al Fauzi; Andri Priyoherianto; Lailatus Sholihah
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.899

Abstract

Diarrhea is one of the common health problems in toddlers and is often treated through self-medication by the community. Choosing the right medicine is very important to avoid complications, considering the low immune system of toddlers and the potential risks of using drugs without a doctor's prescription. This study used a qualitative descriptive design, the study was conducted at the "X" Pharmacy, Sidoarjo District, Sidoarjo Regency from January to March 2025. The sample consisted of 90 parents/caregivers of toddlers who bought diarrhea medicine for their children and met the inclusion criteria. The results showed that the types of drugs most often chosen for self-medication for diarrhea in toddlers were probiotics (46%), zinc supplements (41%), oralit (11%), and a combination of kaolin-pectin (2%). The characteristics of the respondents were mostly aged 20-25 years and had a high school or diploma education level. The choice of diarrhea medicine in self-medication in toddlers was dominated by the use of probiotics and zinc, in accordance with the recommendations of the Indonesian Ministry of Health in handling diarrhea. However, there is still a need to improve education to the public regarding the rational use of drugs and clinical indications for giving antibiotics. An active role is needed for health workers, especially pharmacists, in providing accurate information to the public to prevent the negative impacts of inappropriate self-medication.
Development Of Papaya Leaf Extract/Pva-Based Nanofibers Using Electrospinning Method For Medical Appliaction as A Wound Dressing Brahma Jesayas Bua; Melvia Natalia Aponno; Marissa Gloryanti Soplanit; Ervina Rumpakwakra
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.933

Abstract

The nanofiber manufacturing process is carried out using the electrospinning method, which produces nanometer-sized fibers. This study used a mouse test animal model, where wounds in mice were treated with papaya leaf extract/PVA nanofibers, then compared with a control group using commercial wound dressings. Evaluation was carried out based on wound healing parameters, such as the speed of wound closure and the ability to form an inhibition zone on E. Coli bacteria. Based on the results of SEM testing, it was seen that the morphology of papaya leaf extract/PVA nanofibers had been successfully synthesized with the formation of fibers. The results of observations for the inhibition of E. Coli bacteria for extract concentrations of 5% and 10% for 7 and 24 hours were 13.33 and 12.43 mm. The application of 10% papaya leaf extract/PVA nanofibers was then tested as a wound dressing on test animals (mice). The results showed that after 9 days, 10% papaya leaf extract/PVA was able to accelerate wound healing in mice. Overall, this research can contribute to the development of nanotechnology-based wound dressing materials that utilize natural resources for medical applications. 
Determination of Caffeine Content in Ethanolic Extract of Robusta Coffee Beans (Coffea canephora) Using UV-Vis Spectrophotometry Vina Purnamasari; Ririn; A Hasrawati
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.936

Abstract

Caffeine is one of the main bioactive compounds in robusta coffee beans (Coffea canephora) that has potential applications in pharmaceutical and cosmetic formulations, particularly for hair growth stimulation. This study aimed to determine the caffeine content in ethanolic extract of robusta coffee beans using UV-Visible spectrophotometry. The research was conducted using an experimental laboratory design. Robusta coffee bean extract was obtained by maceration using ethanol as the solvent. Qualitative identification of caffeine was followed by quantitative analysis using UV-Vis spectrophotometry at a maximum wavelength of 273 nm. A calibration curve was constructed using standard caffeine solutions, and the caffeine content of the extract was calculated based on the linear regression equation. The results showed that the calibration curve exhibited good linearity within the tested concentration range. Quantitative analysis revealed that the caffeine content of the ethanolic extract of robusta coffee beans was 221.58 mg/g extract, which is consistent with previously reported caffeine levels in Coffea canephora. These findings confirm that robusta coffee beans are a significant natural source of caffeine and support their potential utilization as raw material for pharmaceutical and cosmetic products. This study provides quantitative data that may serve as a scientific basis for further formulation development and quality control of caffeine-containing herbal products.

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