cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Supomo
Contact Email
jurnal.apdfi@gmail.com
Phone
+6281347065975
Journal Mail Official
jurnal.apdfi@gmail.com
Editorial Address
APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Jl. Buaran II No. 30 A, I Gusti Ngurah Rai, Klender Jakarta Timur, Indonesia Telp. 021 - 86615593, 4244486. Email : apdfi.2013@gmail.com
Location
Kota adm. jakarta timur,
Dki jakarta
INDONESIA
Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
 19   20   21   22   23 
Comparison of Ethyl Acetate and Ethanol Solvents on Total Flavonoid Content from (Gnetum gnemon L.) Using UV-Vis Spectrophotometry Panji Ratih Suci; Valiandri Puspadina; Andri Priyoherianto Andri Priyoherianto; Nurfitriawatie Nurfitriawatie; Fahmi Ardianti Purnawiranita; Achmad Misbakhul Maulana; Ach Zakyah Al Fauzi
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.951

Abstract

Melinjo peel (Gnetum gnemon L.) is an agricultural by-product that is generally underutilized, despite its high content of flavonoid compounds with potential antioxidant activity. This study aimed to compare the effectiveness of ethanol and ethyl acetate as extraction solvents for flavonoids from melinjo peel based on differences in solvent polarity. Extraction was carried out using the maceration method, followed by quantitative analysis using spectrophotometry. Sample preparation involved drying and pulverizing the melinjo peel, extraction with ethanol and ethyl acetate at a material-to-solvent ratio of 1:10, phytochemical screening, thin-layer chromatography analysis, preparation of a quercetin calibration curve, and determination of total flavonoid content. Total flavonoid content was determined through the formation of a complex with aluminum chloride, and absorbance was measured at a wavelength of approximately 430 nm. Statistical analysis was conducted to evaluate differences between the two solvents. The results demonstrated that the ethanol extract produced a higher total flavonoid content (51.86 mg quercetin equivalent per gram of extract) compared to the ethyl acetate extract (46.05 mg quercetin equivalent per gram). The higher extraction efficiency of ethanol is attributed to its greater polarity, which enhances the solubilization of polar flavonoid compounds. In conclusion, ethanol is a more effective solvent than ethyl acetate for extracting flavonoids from melinjo peel, and these findings support the potential utilization of melinjo peel as a natural source of bioactive compounds for applications in the food, pharmaceutical, and cosmetic industries.
Analysis of Antioxidants and Flavonoid Compounds of Ethanol Extract of Starfruit Leaves (Averrhoa Bilimbi L) Using the DPPH Method Ersalina Nidianti; Widi Agustin Wulandari; Dina Kamelia
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.952

Abstract

Starfruit (Averrhoa bilimbi L.) is not only a commonly consumed fruit but also widely used in traditional medicine. The plant has long been utilized by the community to help treat various ailments, including coughs and rectal inflammation. This study aimed to determine the total flavonoid content and antioxidant activity of ethanol extracts of starfruit leaves that had been fractionated using n-hexane.The extraction process was carried out using the maceration method with 70% ethanol, followed by fractionation with 95% n-hexane to separate active compounds from the crude extract. The total flavonoid content in the n-hexane fraction of the ethanol extract was measured using a UV-Vis spectrophotometer at a wavelength of 229-230 nm, while antioxidant activity was evaluated using the DPPH method, also measured at 515 nm. The results showed that the total flavonoid content of the n-hexane fraction of the ethanol extract was 37,3 mgQE/g extract. The antioxidant activity test yielded an IC50 value of 6.58 μg/mL, compared to a standard IC50 value of 2.45 μg/mL for vitamin C. These findings indicate that the n-hexane fraction of starfruit leaf ethanol extract possesses very strong antioxidant properties.
In Silico Evaluation of Ciplukan (Physalis angulata Linn.) Compounds as Potential Serotonin Reuptake Inhibitors for Antidepressant Development Azki Alfazahrah; Alifda Nurhayati; Bianti Meylia Wijaya; Larasati Arum Sari; Nabila Dinar Wulan; Luthfi Ahmad Muchlashi
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.953

Abstract

Starfruit (Averrhoa bilimbi L.) is not only a commonly consumed as a fruit but is also widely used in traditional medicine. The plant has long been utilized by the communities to help treat various ailments, including coughs and rectal inflammation. This study aimed to determine the total flavonoid content and antioxidant activity of the ethanol extracts of Averrhoa bilimbi leaves fractionated using n-hexane. The extraction process was carried out using the maceration method with 70% ethanol, followed by fractionation with 95% n-hexane to separate active compounds from the crude extract. The total flavonoid content in the n-hexane fraction of the ethanol extract was measured using a UV-Vis spectrophotometer at a wavelength of 229-230 nm, while antioxidant activity was evaluated using the DPPH method at 515 nm. The results showed that the total flavonoid content of the n-hexane fraction of the ethanol extract was 37.3 mgQE/g extract. The antioxidant activity test produced an IC50 value of 6.58 μg/mL, compared to a standard IC50 value of 2.45 μg/mL for Askorbat acid. These findings indicate that the n-hexane fraction of Averrhoa bilimbi leaves ethanol extract possesses very strong antioxidant properties.
Phytochemical Screening and Total Flavonoid Content of Annona squamosa and Centella asiatica Ethanolic Extracts for Diabetic Wound Patch Junaedi Junaedi; Yetri Elisya; Ulya Syafrina
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.967

Abstract

Diabetic wounds are one of the chronic complications of diabetes mellitus, characterized by delayed healing and a high risk of bacterial infection. The development of natural product-based pharmaceutical preparations is considered a promising alternative approach due to their relative safety and wide availability. Soursop leaves (Annona squamosa L.) and gotu kola leaves (Centella asiatica L.) are known to contain various secondary metabolites that contribute to antibacterial activity and wound healing. This study aimed to perform phytochemical screening and determine the total flavonoid content of ethanolic extracts of soursop leaves and gotu kola leaves as a scientific basis for the development of an antibacterial patch for diabetic wound management. Extraction was conducted using maceration with 96% ethanol. Qualitative phytochemical screening was performed to identify flavonoids, phenolics, tannins, saponins, steroids, and alkaloids. Total flavonoid content was determined using UV–Vis spectrophotometry with quercetin as the reference standard at a maximum wavelength of 427 nm. The results showed that the extraction yields of soursop leaf and gotu kola leaf ethanolic extracts were 14.64% and 14.72%, respectively. Both extracts contained flavonoids, phenolics, tannins, steroids, and alkaloids, while saponins were detected only in the gotu kola leaf extract. The total flavonoid contents of soursop leaf and gotu kola leaf extracts were 1.5% and 1.12%, respectively. In conclusion, ethanolic extracts of soursop leaves and gotu kola leaves possess phytochemical profiles that support antibacterial and wound-healing activities, indicating their potential as active ingredients in antibacterial patch formulations for diabetic wounds.
The Effect Of Drying Method On The Yield Of Kecombrang Leaves (Etilngera Elatoir) Using The Maceration Method With 70% Ethanol Solvent Tuti Alawiyah; Dwi Yuliani
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.974

Abstract

Kecombrang leaves (Etlingera elatior) have potential as traditional medicinal materials due to their secondary metabolite content, which exhibits antioxidant and antibacterial activities. Drying is an important step in the processing of plant simplicia. This study aimed to determine the effect of different drying methods (sun drying, drying cabinet, and shade drying/room temperature) on moisture loss and extract yield of kecombrang leaves using the maceration method with 70% ethanol as the solvent. This study employed a completely randomized design with 18 samples. The simplicia were dried according to each method, macerated for 3 days, filtered, and concentrated using a water bath. Data were analyzed using normality and homogeneity tests, followed by One-Way ANOVA and Post Hoc Tukey HSD. The results showed that all methods met the acceptable moisture loss requirement (<10%), with the lowest values obtained from the drying cabinet method (6.53–8.02%) and the highest from shade drying (9.67–9.99%). The highest extract yield was obtained from the drying cabinet method (12–18%), followed by sun drying (8–16%), while shade drying produced the lowest yield (4–12%). One-Way ANOVA indicated a significant difference among the drying methods (p = 0.001). Post Hoc Tukey HSD showed that the drying cabinet method was significantly different from sun drying (p = 0.031) and shade drying (p = 0.002), while no significant difference was found between sun drying and shade drying (p = 0.411). In conclusion, the drying cabinet method is the most effective method for producing higher extract yield of kecombrang leaves. 
Adverse Drug Reactions to Antituberculosis Drugs in Tuberculosis Patients Using the Naranjo Algorithm at a Regional Hospital in Mataram Recta Olivia Umboro; Fitri Apriliany; Pande Made Desy Ratnasari; Anita Mursiany
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.975

Abstract

Tuberculosis (TB) remains one of the major health problems in Indonesia. As of October 2023, 67,770 TB cases were reported in West Nusa Tenggara Province (NTB). TB treatment requires long-term therapy using combinations of antituberculosis drugs (ATBD), which have the potential to cause Adverse Drug Reactions (ADRs). ADRs that are not properly identified and managed can increase morbidity and mortality in TB patients and negatively affect treatment outcomes.This study aimed to determine the incidence of ADRs related to the use of ATBD in TB patients at Mataram City Regional General Hospital, NTB, from February to June 2023. This observational study employed a cross-sectional design. Data were collected through structured interviews, and the Naranjo Algorithm was used to assess the causality between reported symptoms and drug use. A total of 66 patients were included in the study. The most common definite ADRs was associated with rifampicin, characterized by reddish discoloration of urine (45.70%), followed by isoniazid-induced fatigue (34%). Probable ADRs were observed with streptomycin, isoniazid, rifampicin, and pyrazinamide, mainly presenting as itching or skin rash (11.10%). Possible ADRs included headache (4.90%) and pain (4.30%), predominantly related to rifampicin use. In conclusion, ADRs among TB patients receiving ATBD at Mataram City Regional General Hospital were diverse, with rifampicin-related urine discoloration being the most prevalent. Identification of ADRs using the Naranjo Algorithm is important for early intervention, improving treatment success, and preventing drug resistance.
Antibacterial Activity Test of Combined Extracts of Guava Leaves (Psidium guajava L.) and Celery Stalks (Apium graveolens L. var. dulce) Against Staphylococcus aureus and Escherichia coli Dhiyanti Ika Salamah; Putri Eka Sari; Indri Astuti Handayani
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i2.995

Abstract

Antibiotic resistance in pathogenic bacteria such as Staphylococcus aureus and Escherichia coli has become a critical global health concern. Flavonoids, tannins, and saponins in guava leaves (Psidium guajava L.) and celery stalks (Apium graveolens L. var. dulce) suggest their potential as natural antibacterial agents, but studies on their combined effectiveness remain limited. This study aimed to evaluate the synergistic effect, optimal concentration, and antibacterial activity of combined guava leaf and celery stalk extracts against gram-positive and gram-negative bacteria. This laboratory-based experimental study used the maceration method with 96% ethanol as the solvent. Antibacterial activity was assessed through the disc diffusion method against S. aureus and E. coli. The study tested 40% single extracts and combinations in ratios of 1:1, 1:2, and 2:1. The findings showed that the combination did not produce a synergistic effect. The highest antibacterial activity against S. aureus was observed in the 2:1 combination, producing an inhibition zone of 11.06 mm, although still lower than the 40% guava leaf extract (11.75 mm). In E. coli, all treatments demonstrated weak activity, with the 1:1 combination yielding the highest inhibition zone of 3.74 mm. Statistical analysis using ANOVA and Games-Howell indicated a significant difference for S. aureus, while the Kruskal-Wallis test showed no significant difference for E. coli (p > 0.05). The combination of guava leaf and celery stalk extracts did not exhibit a synergistic effect. The 2:1 combination was the most effective against S. aureus, while the 1:1 combination showed limited activity against E. coli.
Formulation and Physicochemical Characterization of Guava (Psidiumguajava L.) Leaf Extract-Loaded Chitosan Nanoparticles Winda Prasetya Rini; Yunahara Farida; Deni Rahmat
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/nq2rzz42

Abstract

Guava (Psidium guajava L.) leaf extract is rich in secondary metabolites; however, its utilization as a therapeutic agent is frequently hindered by poor solubility and low bioavailability. The development of submicron-scale drug delivery systems, specifically chitosan nanoparticles, presents an approach to overcome these limitations. This study aimed to formulate and characterize chitosan nanoparticles loaded with guava leaf extract to fulfill the physicochemical stability parameters of a nanosuspension preparation. The extraction process was conducted using the maceration method with 96% ethanol. The nanoparticles were synthesized via the ionic gelation method using a 1% chitosan polymer and sodium tripolyphosphate (NaTPP) as the cross-linking agent. The characterization of the nanoparticle system included physical stability, particle size, polydispersity index (PdI), zeta potential, and morphological observation using a Transmission Electron Microscope (TEM). The freeze-dried powder was subsequently formulated into a nanosuspension, and its physical quality was evaluated. The results indicated a corrected extract yield of 26.65%. The selected nanoparticle formula (F4) exhibited an average particle size of 923.6 nm, a PdI of 0.606, and a zeta potential of +21.6 mV, demonstrating a spherical morphology but with a relatively broad particle size distribution. The evaluation of the nanosuspension over four weeks demonstrated a physically stable preparation with a pH range of 4.18–4.21, a specific gravity up to 1.0795 g/mL, and a 100% redispersion capability. In conclusion, the guava leaf extract was successfully prepared as a preliminary submicron particle formulation, demonstrating its potential to be further optimized and developed into a physicochemically stable nanosuspension.

Page 23 of 23 | Total Record : 228

 19   20   21   22   23 

Filter by Year

2019 2026


Reset
Filter By Issues
All Issue Vol. 8 No. 2 (2026): Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 1 (2022): Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 3 (2021): Jurnal Riset Kefarmasin Indonesia Vol. 3 No. 2 (2021): Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 1 (2021): Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 3 (2020): Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 1 (2020): Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 3 (2019): Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia More Issue