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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 215 Documents
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PENGARUH PERBEDAAN METODE EKSTRAKSI DAUN JATI (Tectona grandis L.f) TERHADAP AKTIVITAS ANTIBAKTERI PADA Escherichia coli Sambodo, Dwi Kurniawati; Marsel, Fransiska; Sambodo, Herlina Prasetyowati; Arlesia, Nandia
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.259

Abstract

The use of teak is limited to wood and stems with high economic value. The part of the teak that has not been utilized optimally is the teak leaf. Teak leaves are only used traditionally as food wrappers and traditional medicines. According to several studies, Sumthong (2007) in Setyawan (2012) stated that teak leaves contain several bioactive compounds, namely tektoquinone, tannic acid, gallic acid and several other organic acids. The presence of bioactive compounds in teak leaves can also be used as an antibacterial agent. This study was conducted to determine the effect of different extraction methods maceration, percolation and microwave Microwave Assisted Extraction on the antibacterial activity of teak leaves against Escherichia coli bacteria. From the research, it can be concluded that the different extraction methods of teak (Tectona grandis L.f) leaves have a significant effect on the antibacterial activity of Escherichia coli and the microwave extraction method is effective as an antibacterial against Escherichia coli as seen from the clear zone produced which is greater than the maceration and percolation extraction methods.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BATANG SEKILANG (Embelia borneensis Scheff) TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus MENGGUNAKAN METODE DISC DIFFUSION Goetie, Inayah Herman; Sundu, Reksi; Supriningrum, Risa
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.260

Abstract

Sekilang is one of the plants in North Kalimantan and is found in the Ampan Ibau Forest. This plant is empirically used by the people of Long Temuyat Village as a poison from natural ingredients to catch fish and as a leech repellent. The content of active compounds in sekilang bark extract include alkaloids, tannins, saponins, flavonoids. These compounds have the potential as antibacterial, so it is necessary to test the antibacterial activity. The purpose of this study was to determine the antibacterial activity of the sekilang bark extract against Escherichia coli and Staphylococcus aureus bacteria. The research phase included plant determination, sample collection, maceration extraction, and antibacterial activity test using the disc diffusion method with extract concentrations of 20%, 30%, and 40%. The results showed that the ethanol extract of the bark of sekilang has the potential to inhibit bacterial growth. The antibacterial activity of the bark extract of the cruciferous plant against Escherichia coli bacteria at concentrations of 20%, 30% and 40%, respectively, was 5.9 mm, 6.7 mm and 5.9 mm. Meanwhile, the activity of the bark extract against Staphylococcus aureus at concentrations of 20%, 30% and 40%, respectively, was 7.6 mm, 6.8 mm and 8.0 mm. The antibacterial activity of the bark extract against both bacteria was included in the moderate criteria.
GAMBARAN FUNGSI HATI PASIEN DIABETES MELITUS TIPE II DI SALAH SATU RUMAH SAKIT SWASTA DI KABUPATEN DEMAK PERIODE OKTOBER-DESEMBER 2020 Pangestuningsih, Megi; Rukminingsih, Fef
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.262

Abstract

Type II DM patients use Oral Antidiabetic Agent (OAA) continuously for a long time. OAA metabolism occurs in the liver. The use of OAA continuously in the long term can cause liver function disorders. The purpose of this study was to describe the liver function of type II DM patients who were treated with OAA in a private hospital in Demak District. This study is an observational descriptive study using retrospective data obtained from medical record documents of outpatients with type II DM for the period October – December 2020. Sampling using purposive sampling technique. The inclusion criteria were outpatients with type II DM, JKN participants who received OAA therapy for at least one year, aged 36 – 65 years old, have AST and ALT laboratory examinations. Patients who received combination therapy with insulin, had a history of impaired liver function were excluded. The results showed that from 62 patients there were 39 female patients (62.9%), the most patients aged 56-65 years were 32 patients (51.61%). The longest duration of use of OAA was 1 year, namely 29 patients (46.77%). The most widely used OAA was a combination of biguanides and sulfonylureas in 36 patients (58.07%). A total of 51 patients (82.25%) did not experience liver function damage and as many as 11 patients (17.75%) showed mild liver function damage with the duration of using OHO for more than 1 year and using OHO combination.
PERILAKU PENGGUNAAN ANTIBIOTIK TANPA RESEP DI APOTEK X DI KOTA PAYAKUMBUH SUMATERA BARAT Yulia, Mega; Parsono, Ruddy; Armal, Khairil
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.264

Abstract

Antibiotic are organic compounds produced by various species of microorganisms and are toxic to other species of microorganisms. Irrational use of antibiotic can lead to resistance. The problem of resistance in addition to having an impact on morbidity and morality also has a very high economic and social impact. Research has been done on the behavior of using antibiotic without a prescription at pharmacy x in Payakumbuh City. The purpose of this study was to determine the use of antibiotic without a doctor's prescription at pharmacy X in Payakumbuh City. This research is non-experimental with data analyzed included the level of awareness of the use of antibiotic. The study used a descriptive method with random or accidental sampling with data collection using a questionnaire with 100 samples from 5296 populations. The results showed that the most widely used antibiotics were amoxicillin (46%); the type of disease that most patients treated with antibiotics was toothache (33%); the most sources of information about antibiotics came from friends or family (35%); the reason most people use antibiotics without a doctor's prescription is that previous treatment has a satisfactory effect (36%) and the level of patient awareness of the use of antibiotics is still in the sufficient category (42%).
PENETAPAN KADAR ALKALOID TOTAL PADA EKSTRAK N-HEKSAN DAN ETANOL BIJI KETUMBAR (Coriandrum sativum) MENGGUNAKAN SPEKTROFOTOMETER UV-Vis setyaningrum, lindawati; Susanti, Dhina Ayu
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.268

Abstract

Coriander (Coriandrum sativum) is one of the medicinal plants which is known to contain secondary metabolites such as flavonoids, tannins, terpenoids, saponins, steroids, and alkaloids. Alkaloids have therapeutic effects as antimalarials and cancer. Research in determining the alkaloids in coriander was carried out by separating the alkaloids from other substances using the soxhlet method extraction with two solvents ethanol and n-hexane. The total alkaloid content is determined using a UV-VIS spectrophotometer at wavelength 351,5 nm. The reaction of alkaloids with Bromocresol green (BCG) is obtained to form a yellow product. The use of berberine standard was obtained the total alkaloid content of ethanol and n-hexane extract in coriander seed (Coriandrum sativum) were 0.524% and 0.583% respectively, and the ratio of total alkaloid content of ethanol extract was smaller than that of n-hexane extract.
GAMBARAN PENGGUNAAN OBAT PADA PASIEN PENYAKIT GINJAL KRONIK (PGK) YANG MENJALANI HEMODIALISIS DI RS X BEKASI PERIODE JANUARI – MARET 2020 Prasetya, Niko; Tanty, Herty Nur; Iskandar, Honey; Pranacistri, Retnayu
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.269

Abstract

Chronic Kidney Disease (CKD) is a condition of kidney damage that occurs for 3 months or more in the form of structural or functional abnormalities of the kidneys with or without a decrease in the Glomerular Filtration Rate. So far, treatment for CKD can be done by hemodialysis, Continuous Ambulatory Peritoneal Dialysis (CAPD) and kidney transplantation. This study aims to determine the description of the use of drugs in CKD patients undergoing hemodialysis at Hospital X Bekasi from January to March 2020. This study was conducted using a descriptive method. Sampling in January - March 2020 was carried out with the total sampling method, namely all electronic prescription sheets of CKD patients undergoing hemodialysis at Hospital X Bekasi. Data were collected by calculating the amount and percentage based on the active substance and class of drugs used by CKD patients undergoing hemodialysis. Based on the results of observations of electronic prescriptions of drugs used by CKD patients undergoing hemodialysis at Hospital X Bekasi during January - March 2020, it can be concluded that the use of drugs based on the active substance is Calcium carbonate 500 mg capsules as many as 10580 capsules (59.07%), Sodium bicarbonate 500 mg tablets 1725 tablets (9.63%), Gentamicin sulfate 80 mg/2 ml inj 868 ampoules (4.85%), Vitamin C (ascorbic acid) 200 mg/2 ml inj 753 ampoules (4.21% ), Recombinant human erythropoietin 3000 IU 678 injection (3.78%).
GAMBARAN PENGETAHUAN MASYARAKAT TENTANG SWAMEDIKASI SAKIT GIGI DI RW 044 KELURAHAN BAHAGIA, BEKASI UTARA Iskandar, Honey; Sukowati, Yudha; Meryta, Aries; Setyaningrum, Noor Affni
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.270

Abstract

The practice of self-medication is a lot of medication errors. Medication errors due to a lack of drug information. Self-medication is defined as the selection and use of medicines both herbal and synthetic drugs by a person to treat a disease or symptom that is self-recognized. In self-medication, it is best to follow the rational drug use requirements. The use of a drug is said to be irrational if the possibility of negative impacts received by the patient is greater than the benefits. The purpose of this study was to find out the description of knowledge about dental pain self-medication in RW 044 Bahagia, North Bekasi in April 2020, regarding the understanding of dental pain self-medication, the use of chemical drugs in dental pain self-medication, the use of traditional medicines in self-medication dental pain, where to get medicine for self-medication of dental pain, the reasons for self-medication of dental pain, and a source of drug information in self-medication for dental pain. The research method used is a descriptive research method to the community at RW 044 with the provision that 1 KK completes 1 questionnaire, with an age range of 25-64 years. The results of this study have a sufficient level of knowledge of 70 respondents (53.03%), So it can be concluded that the picture of community knowledge in RW 044 Bahagia, North Bekasi is sufficient.
GAMBARAN TINGKAT PERSEDIAAN OBAT ANTI HIPERTENSI DI APOTEK IMPHI PERIODE JANUARI – MARET 2020 Meryta, Aries; Subagya, Guruh; Prasetya, Niko; Maulana, M Arman
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.271

Abstract

Hypertension or high blood pressure is the condition when blood pressure is at the value of 130/80 mmHg or more. This condition can be dangerous, if the patient's treatment is constrained by the quality management of a poor pharmaceutical installation (pharmacy). Efficient drug management is one of the most important factors in the success of overall management so that patients can obtain maximum treatment, and aim to avoid excess (stagnant) and deficiency (stockout) drug availability in pharmacies. The study aims to determine the degree of antihypertensive drug supply at Imphi Pharmacy from January to March 2020. This type of research uses non-experimental methods, which are types of research using quantitative descriptive methods. The sampling method uses a total sampling. The result is that all groups of antihypertensive drugs meet the average supply level of three months with a supply rate of ≥ 1.00 months, and there are two categories of drug stocks are ideal stock (supply levels ≥ 1.00 to ≤ 3.00) and stock is not ideal (inventory levels ≥ 3.00) and the most widely used antihypertensive drugs amlodipine 5 mg with an average use of 3 months as many as 1880 tablets with a stock rate of 1.22 months. All classes of antihypertensive drugs at Imphi Pharmacy each have a slowmoving drug resulting in a high level of drug supply. High levels of drug supply are influenced by several factors such as the number of declining drug requests, excess stock in the warehouse, and the transfer of the drug from generic to patent or otherwise by a physician.
EVALUASI MUTU FISIKA DAN KIMIA SEDIAAN KRIM LIP AND CHEEK DENGAN PEWARNA ALAMI EKSTRAK BUAH NAGA SUPER MERAH (Hylocereus Costaricensis) Efrilia, Mega; Agustina, Ika; Lestari, Tri
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.272

Abstract

Lip and cheek adalah kosmetik dwifungsi yang dapat digunakan sebagai pewarna bibir sekaligus perona pipi. Berdasarkan hasil pengawasan BPOM diketahui banyak pewarna sintetis berbahaya yang disalahgunakan sebagai pewarna kosmetik. Buah naga super merah diketahui dapat digunakan sebagai pewarna alami karena memiliki kandungan zat warna antosianin. Antosianin adalah zat warna yang berperan memberikan warna merah berpotensi menjadi pewarna alami untuk pangan ataupun untuk kosmetik, sebagai pengganti pewarna sintetis yang lebih aman bagi kesehatan. Oleh karena itu, pada penelitian ini dilakukan evaluasi mutu fisik sediaan lip and cheek dengan pewarna alami ekstrak buah naga super merah. Sediaan dibuat menggunakan dua variasi formula, yaitu F0 dengan konsentrasi ekstrak 0% sebagai kontrol dan F30 dengan konsentrasi ekstrak 30%. Ekstrak buah naga super merah dibuat menggunakan metode maserasi daging buah naga selama tiga hari dengan pelarut etanol 96% yang kemudian dipekatkan dengan rotary evaporator hingga menjadi ekstrak kental. Daging buah naga dipilih karena kadar antosianin yang terkandung lebih tinggi dibandingkan antosianin yang terdapat pada kulit buah naga. Sediaan dibuat dengan mencampur Fasa I yang sudah mencair dengan Fasa II menggunakkan homogenizer. Krim Lip & Cheek secara organoleptik merupakan sediaan semi padat dengan warna merah muda, memiliki bau khas, dan homogen. Serta memiliki pH 5,01 dengan nilai viskositas 209.200 cps.
UJI RESISTENSI BAKTERI Escherichia coli DARI SUMBER AIR BAKU DI KARAWANG TERHADAP ANTIBIOTIK SIPROFLOKSASIN Diniarti, Fuji Ayu; Kasasiah, Ahsanal; Hilmi, Indah Laily
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.281

Abstract

Infectious diseases are included in the ten most common diseases in Indonesia. The disease can be overcome by the use of antimicrobials, one of which is antibiotics. Antibiotics are drugs used to treat infections caused by bacteria. Excessive use of antibiotics without clear indications can have an impact on the occurrence of bacterial resistance to these antibiotics. One of the bacteria that is resistant to antibiotics is Escherichia coli. This study aims to determine the sensitivity of Escherichia coli isolated from raw water sources in Karawang to the antibiotic ciprofloxacin. Samples were obtained from irrigation water which is the source of raw water for one branch of Perumdam in Karawang. The samples were tested using Lactose Broth (LB) media, then confirmed using Eosin Methylene Blue (EMBA) media to confirm the presence of Escherichia coli bacteria equipped with Gram stain. Bacterial resistance test was carried out using Mueller Hinton Agar (MHA) media with disc diffusion method. The results showed that the average diameter of the clear zone formed around the paper disc was 30.16 mm. The isolates showed intermediate results against the antibiotic ciprofloxacin.

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