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Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS)
Published by Universitas Muhammadiyah Gresik
ISSN : -     EISSN : 27150518     DOI : http://dx.doi.org/10.30587/herclips.v1i02
Core Subject : Health, Science, Social,
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Medicine & Pharmacology Physics Public Health
The purpose of this journal is to facilitate Pharmacist, Scientist, and Researcher to publish research articles or articles reviews. This journal basically contains of topics on Herbal, Pharmaceutical, Clinical, and Sciences. This journal is managing by health faculty Pharmaceutical diploma study program University of Muhammadiyah Gresik
Arjuna Subject : Kedokteran - Biokimia, Kedokteran
Articles 88 Documents
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Uji Efektivitas Ekstrak Kunyit Putih (Curcuma Zedoaria Rosc.) dalam Menghambat Bakteri Staphylococcus epidermidis: Uji Efektivitas Ekstrak Kunyit Putih (Curcuma Zedoaria Rosc.) dalam Menghambat Bakteri Staphylococcus epidermidis Budianto, Nugroho Eko Wirawan; Bawahab, Alivia Putri
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.8044

Abstract

Masalah kesehatan di negara tropis salah satunya indonesia yang tidak pernah dapat diobati secara tuntas adalah penyakit infeksi. Penyakit infeksi akibat bakteri yang paling sering dijumpai di lingkungan sekitar adalah jerawat. Staphylococcus epidermidis adalah salah satu bakteri paling banyak menyebabkan penyebab jerawat setelah Propionibacterium acne. Kunyit putih (Curcuma Zedoaria Rosc.) merupakan tanaman yang berkhasiat untuk penyembuhan infeksi. Sebagai obat alami, kunyit putih memiliki kandungan senyawa aktif seperti kurkumin, flavonoid, minyak atsiri, fenolik, dan alkaloid menurut fitokimia. Penelitian ini mencoba untuk mengetahui apakah ekstrak etanol dari kunyit putih mampu mencegah pertumbuhan bakteri Staphylococcus epidermidis. Metode penelitian eksperimental dengan desain post test only control group design menggunakan Metode sumuran. Hasil penelitian menunjukkan bahwa zona hambat sebesar 30,78 mm pada kontrol positif, 0 mm pada kontrol negatif, 34,18 mm pada konsentrasi 20%, 35,38 mm pada konsentrasi 40%, 37,95 mm pada konsentrasi 60%, 41,27 mm pada konsentrasi 80%, dan 36,87 mm pada konsentrasi 100%. Konsentrasi tertinggi yaitu 80% dengan diameter hambat 41,27 mm. Ekstrak kunyit putih (Curcuma Zedoaria Rosc.) dengan konsentrasi (20%, 40%, 60%, 80%, dan 100%) memiliki efektivitas antibakteri terhadap pertumbuhan Staphylococcus epidermidis
FORMULASI DAN KARAKTERISASI NANOEMULSI EKSTRAK ETANOL 96% CUMI-CUMI (Loligo Sp) DAN VIRGIN COCONUT OIL Najih, Yuli Ainun; Halim, Wenny Carmen Isoka; Mazidah, Ellen Nadhira; Ghaliyah, Talitha Sahda Rahmah; Kartosinggih, Michelle Eloy Fariyanto; Rofiq, Aichi Ainur
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.8335

Abstract

Cumi-cumi (Loligo Sp) salah satu biota laut yang mengandung lecithin, kolagen, dan memiliki aktivitas antioksidan tinggi yang efektif untuk mencegah scavenger dan menurunkan stress oksidatif radikal bebas. Permasalahan yang timbul dari penggunaan bahan laut adalah kelarutan, ukuran partikel yang besar sehingga sukar menembus lapisan kulit dan tidak stabil saat formulasikan dalam bentuk sediaan. Tujuan Penelitian ini adalah membuat formula cumi-cumi (Loligo Sp) dalam sistem nanooemulsi dan karakterisasinya. Penelitian diawali dengan optimasi sistem nanoemulsi dengan sonikator ekstrak cumi-cumi (loligo Sp), VCO (fase minyak), dan PEG-7 (surfaktan). Hasil yang diperoleh terdapat 3 formula dengan perbandingan ekstrak:minyak:surfaktan F5 (0,4:15:70), F6 (0,4:20:60), dan F11 (0,4:2:85) yaitu uji organoleptik ekstrak cumi-cumi dan sediaan nanoemulsi tidak menunjukkan perbedaan tiap formula. Hasil ukuran partikel diperoleh berturut-turut 14,97nm , 24,70nm , 45 nm ; uji turbidimetri 3,37 NTU, 3,09 NTU, 4,77 NTU; Uji pH 6,44; 6,46; 6,45 ; uji antioksidan (DPPH) ekstrak diperoleh 1,5948 dan nanoemulsi 0,0480; uji viskositas 129,1 cp; 143,30 cp; 159,63 cp. Hasil uji stabilitas fisik metode cycling test pH dan viskositas menunjukkan tidak terdapat perbedaan bermakna antara pH dan viskositas sebelum dan sesudah cycling test. Uji stabilitas fisik metode sentrifugasi didapatkan hasil sediaan stabil tidak terjadi pemisahan fase minyak dan air. Formulasi ekstrak etanol 96% cumi-cumi (loligo Sp) dan Virgin Coconut Oil yang optimal berdasarkan hasil evaluasi karakteristik fisik dan uji stabilitas adalah formula 5.
Formulasi Dan Aktivitas Antibakteri Paper Soap Minyak Biji Kurma (Phoenix dactylifera L.) Ardelia, Annora Putri; Syarifah, Anisa lailatusy
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.8373

Abstract

Pengolahan limbah biji kurma sangat penting untuk meningkatkan nilai jual biji kurma sebelum dibuang sebagai limbah. Biji kurma mengandung senyawa asam oleat dan steroid yang diketahui mempunyai aktivitas antibakteri. Penelitian ini bertujuan untuk mengetahui formulasi, mutu fisik dan kimia, serta aktivitas antibakteri sabun kertas (paper soap) minyak biji kurma. Metode penelitian ini meliputi pembuatan serbuk simplisia, ekstraksi minyak biji kurma dengan metode soxhletasi, skrining fitokimia, dan formulasi paper soap dengan kandungan minyak biji kurma yang berbeda, yaitu F1 (3,75%); F2 (7,5%); dan F3 (15%). Selanjutnya, dilakukan evaluasi mutu fisik dan kimia serta uji aktivitas antibakteri dengan metode sumuran. Hasil penelitian menunjukkan bahwa mutu fisik paper soap minyak biji kurma adalah berwarna kuning muda, berukuran 4x4 cm, berbau lemon, homogen, dan keseragaman bobot F1, F2, dan F3 secara berurutan adalah 0,321 g; 0,338 g; 0,362 g. Nilai pH F1, F2, dan F3 adalah 9,83–10,03. Ketiga formula mempunyai asam lemak bebas <1%, kadar air <10%, dan rata-rata zona hambat formula 1, 2, dan 3 secara berurutan adalah 8,66±1,90 mm; 9,33±1,01 mm; 8,75±2,25 mm. Kesimpulan penelitian ini adalah mutu kimia ketiga formula sesuai SNI 2588-2017 dan SNI 3532-2016, serta aktivitas antibakterinya termasuk dalam kategori sedang.
A Bibliometric Study of 3D Printing In Pharmaceutical Technology For Tablet Dosage Form Annisa, Viviane
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.9608

Abstract

Three-dimensional printing (3DP) is the process of producing 3D items layer by layer using computer-generated designs. 3DP has been utilized to manufacture numerous drug dosage forms. The goal of 3D printing products is to create personalized medicine so it can enhance medication compliance and obtain better treatment outcomes. There are a lot of publications about fabricated tablets using 3DP. However, the results of analyses based on previous research in this field are lower. We conducted a bibliometric study using RStudio and VOSviewer software to summarize tabletting using 3DP research from 2014-2024. This study was based on the Scopus Database, and 405 suitable publications were evaluated. The most productive authors are Basit, A.W, Goyanes, A., and Gaisford, S., from the Department of Pharmaceutics, UCL School of Pharmacy, University College London, United Kingdom. Its affiliations and its country are also ranked the highest in producing articles in this field. In the future, 3DP will be an attractive alternative for tablet printing. Pharmacists in hospitals and drugstores can produce personalized tablets to improve treatment outcomes.
INNOVATION OF DEODORANT STICKS AND LOTIONS BASED ON BETEL NUT EXTRACT AS AN ANTIBACTERIAL PROBLEM OF BODY ODOR AGAINST STAPHYLOCOCCUS AUREUS BACTERIA Tari, Yusnia; Sihombing, Elsa Anggriani; Maimum, Maimum; Efendi, M Rifqi; Pratiwi, Pupa Dwi; Yuliawati, Yuliawati; Haryani, Yeni
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.9625

Abstract

Body odor is a common problem caused by the interaction between sweat and Staphylococcus aureus bacteria. Areca nut has potential as a pharmaceutical preparation because it contains secondary metabolite compounds such as alkaloids, flavonoids, tannins, saponins and polyphenols which have antibacterial properties. This research aims to extract areca nut seeds using the maceration method with 96% ethanol and formulate them into stick deodorant and lotion with a concentration of 5%. Physical properties tests were carried out to evaluate pH, homogeneity, spreadability, melting point and antibacterial activity. The research results showed that stick deodorant had a pH of 4.5, while lotion deodorant had a pH of 5.5. Both preparations showed good homogeneity without the presence of coarse particles. The spreadability of the lotion was recorded at 5.3 cm, increasing to 5.5 cm with the addition of a 50 gram load. The melting point of bar deodoran is around 80°C, and bar deodorant melts completely within 60 minutes at 100°C. Both types of deodorant showed a significant inhibition zone diameter against bacteria, namely 18.16 mm for lotion and 16.77 mm for stiks. Areca nut extract showed very strong antibacterial activity with an inhibition zone diameter of 20.14 mm.
IDENTIFIKASI RHODAMIN-B DALAM LIPTINT YANG BEREDAR DI MAHASISWI FARMASI UNIVERSITAS MUHAMMADIYAH GRESIK Purwanto, Hepfriya Nur Rachma; Harahap, Hotma Wardhani
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.9645

Abstract

Good cosmetics are cosmetics that do not contain ingredients harmful to the skin or other body health, such as rhodamin-B dye. Lipstick is the most widely used decorative cosmetic product, one type of lipstick is lip tint.According to the Regulation of the Head of the POM RI Agency No.18 of 2015 concerning Technical Requirements for Cosmetic Materials, prohibited dyes include Red K3 and K10 dyes (Rhodamin-B) but are widely misused in lipsticks. Rhodamin-B is a synthetic dye used in the textile and paper industry.Rhodamin-B is harmful to the body due to its chemical properties and contains heavy metals, for example such as chlorine and alkylating compounds. Based on preliminary studies that have been carried out, as many as 33.33% of Pharmacy Students of the University of Muhammadiyah Gresik used lip tint and there were four lip tint samples that were tested. Based on the results of three types of qualitative tests, namely Rhodamin-B kits, thin layer chromatography and lip tint sample staining tests, it was concluded that there was no rhodamin-B hazardous material content in the four circulating samples.
Formulasi dan Uji Stabilitas Fisik Sediaan Gel Antiseptik Ekstrak Daun Sirih (Piper betle Linn.) dan Jeruk Nipis (Citrus aurantifolia Swingle) Menggunakan Gelling Agent Hydroxypropyl Methylcellulose (HPMC) Bachtiar, Muhammad Rifky
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.9646

Abstract

In the era of the Covid-19 pandemic, hands are one of the main media for the spread of viruses or bacteria, so antiseptic preparations are needed as one of the preventive measures or prevention efforts. Many plants from natural ingredients that can be used to make antiseptics include betel leaf extract and lime juice. The selection of betel leaf and lime as ingredients for the manufacture of this hand sanitizer gel is due to the presence of flavonoids which have antioxidant and antibacterial functions. This study aims to determine the physical stability of hand antiseptic gel from betel leaf extract (Piper betle L.) and lime juice (Citrus aurantifolia Swingle) using HPMC base and to determine HPMC base at what concentration can produce antiseptic gel preparations. Betel leaf extract (Piper betle L.) and lime juice (Citrus aurantifolia Swingle) with good physical characteristics. This research is experimental using a qualitative descriptive method. The results of this study indicate that from the three formulas that have been made, the preparation is stable for 7 days and there is no change in smell, color, and shape. Based on the test results, it can be seen that the best formula is the HPMC concentration of 0.6 grams in terms of organoleptic, homogeneous, pH, adhesion and hedonism tests which also show the best with the highest total average value, which is equal to 3.3.
PERBANDINGAN NILAI Q GERD PASIEN BPJS RAWAT JALAN YANG MENDAPAT TERAPI ANTASIDA DAN OMEPRAZOL DENGAN ANTASIDA DAN LANZOPRAZOL DI KLINIK PRATAMA X SIDOARJO Purwati, Ely; Priyoherianto, Andri; Safitri, Rifdah Atikah
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.9647

Abstract

Introduction: Gastroesophageal Reflux Disease (GERD) is a digestive tract disorder characterized by repeated reflux of stomach contents into the esophagus, causing various symptoms such as heartburn, regurgitation, heartburn, and sleep disorders. The prevalence of GERD throughout the world ranges from 15%-25%, with an increasing trend in several countries including Indonesia. Objective: This study aims to compare the Q value of GERD for outpatient BPJS patients who received combination therapy with antacid + PPI drugs [Omeprazole or lanzoprazole]. Method: This research uses a descriptive research type using a cross sectional research design, evaluated with the GERD-Q Questionnaire. Results: The results in this research are that the drugs used for GERD therapy are PPI and antacids based on research results showing that this therapy can effective in reducing the symptoms of gerd experienced by patients, the combination of antacid + lansoprazole/omeprazole + antacid is very effective in reducing the Q value of gerd from statistical data showing that the reduction between the 2 combinations is not significantly different P<0. Conclusion: The average decrease in the Q value of GERD for outpatient BPJS patients who received antacid + omeprazole, and antacid +lansoprazole therapy at the Pratama X Sidoarjo clinic was 7.25, and 9.875.

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