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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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INDONESIA
Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 233 Documents
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Formulasi Dan eval_uasi Sediaan Handbody Lotion Ekstrak Pegagan (Centella Asiatica L.) Kombinasi Niacinimade M. Ali, Nur Faizah
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2464

Abstract

Pegagan extract comes from the pegagan plant (Centela Asiatica L.) containing saponins, asiticosides, asiatic acid, and madecasate which can stimulate the production of collagen I, a protein that stimulates the wound healing process. This plant can be used as a raw material for skin care. Pegagan in the form of hand body lotion is used for skin care and other body parts. This study aims to determine the effect of differences in the concentration of Stearic Acid and cetyl alcohol in the Handbody Lotion formulation on the results of the preparation eval_uation test. Physical eval_uation tests of the preparation include organoleptic tests, homogeneity tests, pH tests, viscosity tests, and stability tests. The test results obtained the optimum formula, namely formula 1 with a ratio of cetyl alcohol and stearic acid with a desirability value of 1. The results of the stability test showed that the handbody lotion preparation was stable from the organoleptic parameters, homogeneity, pH, viscosity
THE eval_UATION OF PRESCRIPTION SCREENING PHASE PRESCRIBING ERROR IN PEDIATRIC PRESCRIPTIONS AT MITRAKITA CLINIC SEMARANG PERIOD JANUARY 2024 Damayanti, Widiya Widiya
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2471

Abstract

The issue of Medication Error in prescriptions can cause harm to patients that may result in a mistake in the use of drugs. Incomplete prescriptions, whether administratively, pharmaceutically, or clinically, can lead to medication errors. This study was conducted to eval_uate the completeness of prescriptions in the administrative, pharmaceutical, and clinical aspects of pediatric prescriptions at the Mitrakita Clinic and to ascertain compliance with Minister of Health Regulation No. 34 of 2021. This research is an observational study that is descriptive in nature, using a retrospective data collection method on pediatric prescriptions at the Mitrakita Clinic for the month of January 2024. Data collection in this research employed random sampling with a sample size of 160 prescriptions. Prescriptions were eval_uated for their compliance administratively, pharmaceutically, and clinically based on Minister of Health Regulation No. 34 of 2021. The data obtained was processed using SPSS with univariate analysis methods (descriptive analysis) and presented in the form of tables and percentages. This study aims to reduce the risk of medication errors in prescriptions at Mitrakita Clinic Semarang. Data from 160 prescriptions, after being tested and analyzed using SPSS, showed that the data were normally distributed and homogeneous. The results of the prescription screening eval_uation for prescribing errors in pediatric prescriptions at Mitrakita Clinic Semarang showed that the percentage of errors in the administrative review was 29.922%, in the pharmaceutical review was 5.104%, and in the clinical review was 14.018%. Thus, the average medication error occurring in pediatric prescriptions at Mitrakita Clinic during January 2024 was 16.348%, leading to the conclusion that prescriptions made at Mitrakita Clinic Semarang are in accordance with Minister of Health Regulation No. 34 of 2021.
eval_UASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN PNEUMONIA DI BALAI BESAR KESEHATAN PARU MASYARAKAT (BBKPM) MAKASSAR Arifin, Erlin Putri Hendrawati
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2486

Abstract

Pneumonia is one of the leading causes of death in children under five, particularly in developing countries such as Indonesia. Antibiotics are the mainstay of therapy for bacterial pneumonia; however, inappropriate use can lead to resistance and treatment failure. This study aims to eval_uate the rationality of antibiotic use in pediatric pneumonia patients at the Public Lung Health Center (BBKPM) Makassar using the Gyssens method. This was a descriptive study conducted from April to June 2025 using retrospective medical record data from 33 pediatric inpatients aged 1–5 years diagnosed with pneumonia and receiving antibiotic therapy from January to December 2024. Antibiotic rationality was assessed using the Gyssens algorithm, which classifies antibiotic use into category 0 (rational) and categories I–VI (irrational). The results showed that out of 64 antibiotic prescriptions, 20 (31%) were categorized as rational (category 0), while 44 (69%) were irrational. The highest proportion of irrational use was category III B (34%) for too-short duration, followed by category IV A (31%) for suboptimal effectiveness, and IV B (3%) for safety concerns. No cases were found in categories I, II, III A, IV C, IV D, V, or VI. These findings indicate that while some antibiotic use was appropriate, a significant portion was not, highlighting the need for regular eval_uation and better adherence to clinical guidelines to optimize antibiotic therapy and reduce resistance risks in pediatric pneumonia treatment.
Interaksi Obat dan Makanan Pada Pasien Diabetes Melitus Asiyah, Siti Nur
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2495

Abstract

Diabetes mellitus merupakan penyakit metabolik yang disebabkan oleh gangguan metabolisme pada organ pankreas ditandai dengan terjadinya peningkatan gula darah atau hiperglikemia. Pengelolaan diabetes umumnya melibatkan terapi farmakologis dengan berbagai jenis obat antidiabetik dalam mengontrol kadar gula darah serta mencegah terjadinya komplikasi jangka panjang. Tujuan penelitian ini adalah menganalisis interaksi obat Glibenklamid dan Metformin yang dikonsumsi pasien diabetes mellitus dengan minuman herbal. Metode penelitian yang digunakan adalah penelitian deskriptif kualitatif dengan memperoleh data primer dan data sekunder. Hasil penelitian menunjukkan bahwa mengonsumsi obat-obatan, Glibenklamid dan Metformin bersamaan dengan minuman herbal akan menimbulkan efek sinergis. Dengan penggunaan tanaman herbal, seperti daun keres, bunga telang, dan daun kelor bersamaan dengan obat - obatan yang dapat menurunkan kadar gula darah. Kesimpulan dari penelitian adalah didapatkan jika interaksi obat-makanan, yakni minuman herbal dan interaksi obat-obat dapat berpengaruh terhadap penurunan kadar gula darah meski tidak secara efektif.
The PHARMACY AND ARCHIPELAGO CON PHARMACY AND ARCHIPELAGO CONSTITUTIONAL THEORY: PHARMACY AS GUARDIAN OF ETHICAL AND LOCAL LEGAL BALANCE: FARMASI DAN TEORI KONSTITUSI NUSANTARA: APOTEKER SEBAGAI PENJAGA KESEIMBANGAN ETIS DAN HUKUM LOKAL Dita, Rahma Dita; Sudrajat, Hendra
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2512

Abstract

This article explores the role of pharmacists as ethical and legal mediators within pluralistic legal systems in Indonesia. Informed by the theory of Konstitusi Nusantara (Nusantara Constitution), this study frames the pharmacist not merely as a medical professional but as a guardian of balance between local customs and national regulations. Using a qualitative normative-juridical method and interdisciplinary analysis across pharmaceutical sciences, constitutional law, and health anthropology, this research draws from literature and regional practices in Papua, Kalimantan, and Nusa Tenggara. Findings show that pharmacists often navigate overlapping norms professional codes, state law, and local customary systems especially when working within indigenous communities. Their unique position enables them to build culturally respectful communication, advocate for the safe use of traditional remedies, and promote ethical healthcare grounded in local wisdom. The study calls for curricular reform in pharmacy education that integrates local legal-cultural knowledge and for policies that institutionalize collaboration between pharmacists and customary authorities. This research provides conceptual and practical insights for building inclusive, locally rooted healthcare governance in Indonesia. Keywords: Pharmacist, Local wisdom, Legal pluralism, Indigenous health
The Antibacterial Activity of Ethanol Extract, n-Hexane Fraction, and Ethyl Acetate Fraction of Water Hyacinth Leaves (Eichhornia crassipes) Growing on the Banks of the Mahakam River Against Propionibacterium acnes: Aktivitas Antibakteri Ekstrak Etanol, Fraksi n-Heksana dan Fraksi Etil Asetat Daun Eceng Gondok (Eichhornia crassipes) yang Tumbuh di Tepi Sungai Mahakam Terhadap Propionibacterium acnes dewi, herlina ekapratama; Cahya, Muhammad Dwi Cahya; Pratiwi, Putri Rinda
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2595

Abstract

Propionibacterium acnes is a gram-positive bacterium that causes acne. Water hyacinth (Eichhornia crassipes) is a plant commonly found along the banks of the Mahakam River that has antibacterial properties. The purpose of this study was to perform a phytochemical screening and determine the antibacterial activity of the ethanol extract, n-hexane fraction, and ethyl acetate fraction of water hyacinth (Eichhornia crassipes) leaves against Propionibacterium acnes bacteria. Antibacterial activity was measured by the diameter of the inhibition zone using the agar diffusion method. Phytochemical screening results showed that the ethanol extract and ethyl acetate fraction of water hyacinth leaves were positive for flavonoids, alkaloids, and tannins, while these metabolites were not found in the n-hexane fraction. Each test solution was prepared at concentrations of 5%, 7.5%, 15%, and 30%. The antibacterial activity test yielded average inhibition zone diameters for the ethanol extract, n-hexane fraction, and ethyl acetate fraction of 12.70 mm, 12.85 mm, and 13.17 mm, respectively.
FORMULASI DAN UJI STABILITAS FISIK SERTA PENENTUAN NILAI SPF (Sun Protecting Factor) GEL MOISTURIZER EKSTRAK ETANOL DAUN KELAKAI (Stenochlaena Palustris (BURM. F.) Bedd.) Sembiring, Pintata
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2605

Abstract

Flavonoids in kelakai (Stenochlaena palustris) leaves function as powerful antioxidants that increase skin protection against UV radiation through absorption and scattering of ultraviolet rays. The presence of chromophore groups in the form of conjugated double bonds in flavonoids is able to absorb UVB rays so as to reduce their intensity on the skin and contribute to increasing the Sun Protection Factor (SPF) value of the moisturizer gel. This allows the product to function as a moisturizer as well as a natural plant-based sunscreen. This research aims to formulate kelakai leaf extract moisturizer gel, eval_uate its physical stability, and measure the SPF value. The extract was obtained through maceration, then made into moisturizer gel with concentrations of 3% (F1), 5% (F2), and 7% (F3). For four weeks, organoleptic, homogeneity, spreadability, pH, stability, viscosity, and centrifugation tests were conducted. The results showed that all formulas were homogeneous, brownish yellow (F1), light brown (F2), and dark brown (F3) in color; spreadability 5.39-6.20 cm; pH 5.07-5.96; stable at room temperature and cold; viscosity 6192-7108 cPs; and no phase separation. In vitro SPF measurements using a UV-Vis spectrophotometer at a wavelength of 290-320 nm showed the highest SPF value in F3 (7% extract) of 27.51, while F1 and F2 were 18.49 and 21.94 respectively, so that the three formulas can provide optimal protection from UV rays.
eval_uasi Penggunaan Antibiotik Profilaksis pada Pasien Bedah Caesar dengan Menggunakan Metode Gyssens di Rumah Sakit X Mojokerto Amanda, Cantika Putri
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2608

Abstract

Introduction: Delivery is a physiological process of expelling the fetus and placenta from the uterus, either spontaneously through the vagina or through operative procedures such as cesarean section. Cesarean section has become one of the commonly performed methods of delivery, but it carries a higher risk of surgical wound infections compared to normal delivery. The use of prophylactic antibiotics is important to prevent such complications; however, in practice, it often does not conform to guidelines, which can reduce the effectiveness of infection prevention and trigger antibiotic resistance. Objective: To assess the rationality of prophylactic antibiotic use in cesarean section patients at Hospital X in Mojokerto. Method: This study employs a descriptive observational method with a retrospective approach. Data was collected from 87 medical records of cesarean section patients during the period of 2024–2025. The eval_uation of prophylactic antibiotic use was conducted based on the Gyssens method to assess the accuracy of diagnosis, indications, drug selection, dosage, route and interval of administration, as well as the duration of therapy. Results: The majority of patients (92%) received prophylactic antibiotics rationally (Gyssens category 0). A small number of patients fall into category IIa (5%) due to dose inaccuracies, and category IVd (3%) with the use of broad-spectrum antibiotics. Conclusion: The use of prophylactic antibiotics in cesarean section patients at Hospital X Mojokerto is mostly rational (92%), while (8%) is irrational.
PENETAPAN KADAR DIETILEN GLIKOL (DEG) PADA SIRUP ANAK YANG BEREDAR DI APOTEK DENGAN METODE SPEKTROFOTOMETRI UV-VIS sulasmi, sulasmi
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2703

Abstract

Penelitian ini bertujuan untuk menetapkan kadar dietilen glikol (DEG) pada sirup anak yang beredar di apotek menggunakan metode spektrofotometri UV-Vis, sekaligus memvalidasi metode tersebut. DEG dikategorikan sebagai zat berbahaya yang dapat menyebabkan gagal ginjal akut, dengan batas aman tidak boleh melebihi 0,1%. Sampel diambil secara purposive sampling dari tiga merek sirup yang paling banyak dibeli di Apotek Deli Tua. Hasil penelitian menunjukkan panjang gelombang maksimum DEG adalah 625 nm , dengan operating time optimal 15 menit. Kurva kalibrasi menunjukkan linearitas tinggi (R2=0,999). Kadar rata-rata DEG pada sampel A, B, dan C berturut-turut adalah 0,08756%, 0,16138%, dan 0,1334%. Dua dari tiga sampel tersebut melebihi ambang batas aman 0,1% yang ditetapkan BPOM, mengindikasikan potensi risiko kesehatan. Validasi metode menunjukkan akurasi (80-120% recovery) dan presisi (%RSD < 2%) yang baik. Oleh karena itu, penelitian lanjutan dengan metode analisis lain dan analisis toksikologis direkomendasikan.
FORMULASI DAN UJI KETAHANAN SEDIAAN PARFUM SPRAY BUNGA LILI ( Lilium longiflorum) Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2704

Abstract

This study aimed to formulate and evaluate the fragrance longevity of lily flower (Lilium longiflorum) spray perfume. Lily essential oil was extracted using steam distillation and formulated at concentrations of 5%, 10%, and 15% with additional fixatives, solvents, solubilizers, and preservatives. Evaluations included organoleptic tests, density, pH, fragrance longevity, stability, and aroma preference. Results showed that all formulations had good clarity, homogeneity, and skin-safe pH values (5.29–5.55). Formula 2 (10%) provided the best balanced fragrance intensity and received the highest preference score from panelists. The longest fragrance retention was achieved by Formula 3 (15%), though its intensity was considered too strong. In conclusion, lily essential oil spray perfume can be formulated stably with adequate fragrance longevity, showing potential as a competitive natural perfume product.

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