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Ripai Siregar
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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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INDONESIA
Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 231 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAN FRAKSI N-HEKSAN, ETIL ASETAT DAN AIR KULIT BAWANG MERAH (Allium cepa L.)TERHADAP BAKTERI Escherichia coli Lidia Klorida Br Barus
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2941

Abstract

Shallot peel (Allium cepa L.) is an agricultural waste that is known to contain secondary metabolite compounds such as flavonoids, alkaloids, tannins, and saponins that have the potential to have antibacterial activity. This study aims to determine the antibacterial activity of ethanol extract and the fraction of n-hexane, ethyl acetate, and water from onion peel against Escherichia coli bacteria. Extraction was carried out using the maceration method with 96% ethanol, then continued with liquid-liquid fractionation using n-hexane, ethyl acetate, and water. The antibacterial activity test was carried out using the disc diffusion method with concentrations of 40%, 60%, and 80%. The results showed that ethanol extract and shallot peel fractions had an inhibition against Escherichia coli, with the ethyl acetate fraction at a concentration of 80% indicating the largest inhibition zone. Thus, shallot peel has the potential to be developed as a natural antibacterial agent against Escherichia coli.
PENETAPAN KADAR AKRILAMIDA PADA MAKANAN HEWANI DAN NABATI PANGGANG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Sofia Eliasari Br Bangun; Sulasmi Sulasmi; Masria Phetheresia Sianipar
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2943

Abstract

This study aimed to determine the acrylamide levels in animal-based (grilled chicken and grilled fish) and plant-based (grilled Cilembu sweet potato) foods using the UV-Vis spectrophotometry method. Acrylamide is a carcinogenic compound formed in foods heated to high temperatures. The samples were tested qualitatively and quantitatively. Qualitative tests confirmed the presence of acrylamide in all three samples. Quantitative measurement was performed at a maximum wavelength of 267 nm and showed the average acrylamide levels in grilled Cilembu sweet potato, grilled chicken, and grilled fish were 51.3964 mcg/g, 38.1875 mcg/g, and 32.1383 mcg/g, respectively. The highest level was found in the grilled Cilembu sweet potato due to its higher carbohydrate content. Although the detected levels are below the daily toxic limit set by BPOM, excessive long-term consumption is not recommended. The method validation test showed results that met the requirements for linearity (r = 0.995) , accuracy (recovery range 101.58% - 106.33%) , and precision (RSD < 2%) , with LOD and LOQ values of 0.4111 and 1.3703, respectively. It was concluded that the UV-Vis spectrophotometry method is effective for the analysis of acrylamide in grilled food samples.
FORMULASI SEDIAAN LILIN EKSTRAK MINYAK ATSIRI BUNGA SEDAP MALAM (Polianthes tuberosa ) SEBAGAI AROMATERAPI Nova Rianti Marbun; Tio Ranti Sari Br Sembiring
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2944

Abstract

This study aims to formulate and evaluate aromatherapy wax preparations from nightshade flower essential oil extract (Polianthes tuberosa) as an effort to handle non-pharmacological stress. The essential oil of the nightshade flower is obtained through the method of steam distillation from 10 kg of fresh flowers, resulting in 30 ml of essential oil. The characterization of simplicia showed a moisture content of 5.71%, a water soluble cider content of 17.13%, an ethanol soluble cider content of 18.01%, a total ash content of 10.82%, and an acid-insoluble ash content of 1.49%, meeting the requirements of the Indonesian Herbal Pharmacopoeia. Phytochemical screening identifies alkaloids, flavonoids, tannins, saponins, triterpenoids, and glycosides. Aromatherapy candles are formulated in four variations of essential oil concentrations (Polianthes tuberosa): 0% (F0), 5% (F1), 10% (F2), and 15% (F3), as well as one positive control (F4). Physical evaluation shows all formulas have a good, dense, and air bubble-free appearance. The hedonic test showed that the F3 formula (15% essential oil) was preferred by the panelists in terms of aroma, shape, and color, and provided a significant relaxation and refreshment effect, close to the quality of commercial products. The F3's burn time reaches 10 hours, showing good durability.
FORMULASI UJI AKTIVITAS SEDIAAN GEL FACIAL WASH EKSTRAK DAUN PEDADA (Sonneratia alba Sm.) MENGGUNAKAN METODE DPPH sulasmi sulasmi
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2945

Abstract

This study evaluated the potential of pedada leaf extract (Sonneratia alba Sm.) as an active ingredient in a facial cleansing gel preparation. Antioxidant activity was tested using the DPPH method and the gel's physical characteristics were assessed. The results indicate that pedada leaves have potential as a natural antioxidant in gel-based facial cleansing cosmetic formulations. This study used an experimental method with a laboratory approach. Ethanol extract of pedada leaves was obtained through maceration and then formulated into facial wash gels at various concentrations. Evaluations were conducted on the physical properties of the preparation, such as pH, homogeneity, adhesion, spreadability, and viscosity. Antioxidant activity was tested using the DPPH method to determine the IC₅₀ value. The results showed that the facial wash gel preparation with pedada leaf extract met good physical standards, such as pH, viscosity, and homogeneity. The best antioxidant activity was obtained at a specific concentration with an IC₅₀ value of 50 ppm, indicating very strong antioxidant activity and potential for use in natural skin care products. The conclusion of this study indicates that pedada leaf extract can be formulated into a facial wash gel that meets physical standards and has very strong antioxidant activity. This study recommends the use of pedada leaves as a natural active ingredient in cosmetic products, and the need for further research to test long-term stability and safety of use.
PENETAPAN KADAR VITAMIN C PADA BROKOLI PUTIH (Brassica oleracea L.) YANG BEREDAR DI KECAMATAN DELI TUA DENGAN METODE SPEKTROFOTOMETRI UV-VIS Jhan Saberlan Purba; Tio Ranti Sari Br Sembiring
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2946

Abstract

White broccoli (Brassica oleracea L.) is a vegetable rich in vitamin C and has potential as a functional food source beneficial to health. This study aimed to determine the vitamin C content in white broccoli available in Deli Tua District using the UV-Vis spectrophotometric method and to evaluate the validity of the applied analytical method. The broccoli sample was extracted, analyzed qualitatively using iodine reagent, and quantitatively at a maximum wavelength of 265 nm. The calibration curve was constructed using five standard concentrations of vitamin C with a regression equation of y = 0.0495x + 0.0019 and a correlation coefficient r = 0.9996, indicating excellent linearity. The analysis showed that the vitamin C content was 1,8098 mg/g. The method validation met the required criteria: accuracy % recovery of 108.36%, precision RSD 0.47739%, limit of detection LOD of 0.18375, and limit of quantification LOQ of 0.61325. Therefore, the UV-Vis spectrophotometric method is proven valid and accurate for determining the vitamin C content in white broccoli.
UJI AKTIVITAS MOISTURIZER PROBIOTIK PRODUK KECANTIKAN TERHADAP BAKTERI Propionibacterium acnes dan Staphylococcus epidermidis Nina Irmayanti Harahap; elysa elysa; nurul dahlia harahap
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2948

Abstract

Acne is one of the most common skin disorders affecting adolescents and young adults, with severity ranging from mild to severe. The pathogenesis of acne is influenced by multiple factors, including the presence of skin microbiota, particularly Propionibacterium acnes and Staphylococcus epidermidis. Objective: This study aims to evaluate the effectiveness of probiotics formulated in a moisturizer gel in inhibiting bacterial activity without compromising their moisturizing function. Methods: This study employed an experimental design to evaluate the antibacterial activity of moisturizer gel formulations using the well diffusion method, with inhibition zone diameter as the measured parameter. Additionally, a moisturizing test was conducted on 18 volunteers with dry skin conditions. Results: The results demonstrated that all moisturizer gel formulations exhibited moderate antibacterial activity, with inhibition zone diameters ranging from 5 to 10 mm. The moisturizing test conducted on 18 volunteers indicated that all formulations maintained skin moisture within the normal range, with values between 30% and 50%. Conclusion: Based on the antibacterial activity test, it can be concluded that probiotic-containing moisturizer gels exhibit antibacterial properties. However, their effectiveness remains moderate, as indicated by the inhibition zone diameters within the range of 5–10 mm.
FORMULASI EKSTRAK ETANOL BUAH PARE DAN DAUN PEPAYA SEBAGAI LOSION REPELAN Aedes aegypti Gratia Apulina Cindylawsa Purba; Delisma Marsauli Simorangkir; Tio Ranti Sari Br Sembiring; Putri Anggita
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2949

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus from the genus Flavivirus and the family Flaviviridae, transmitted through the bites of Aedes aegypti and Aedes albopictus. One preventive measure can be achieved by using mosquito repellent lotion as a protective topical preparation. Bitter melon and papaya leaves contain flavonoids and antioxidants that have potential as natural repellent agents. This study aimed to evaluate the effectiveness of lotion formulations containing bitter melon and papaya leaf extracts at concentrations of 0%, 2%, 4%, and 6%. The research method included preparing lotion formulations based on an oil-in-water emulsion, followed by physical quality testing according to SNI 16-4399-1996, including assessments of homogeneity, emulsion type, two-week stability, and skin irritation. Repellent effectiveness was tested by observing the number of mosquitoes that died after contacting skin treated with the lotion. The results show that all formulations meet the physical quality requirements, are homogeneous, stable, possess an oil-in-water emulsion type, and do not cause skin irritation. The extracts increase mosquito repellency, as indicated by the greater number of dead mosquitoes with higher extract concentrations. The 6% formulation is the most effective concentration as a repellent or insecticidal agent against Aedes aegypti.
FORMULASI DAN UJI EFEKTIVITAS ANTIBAKTERI TERHADAP SEDIAAN Deodorant Spray EKSTRAK ETANOL BATANG SERAI WANGI (Cymbopogon nardus L.) TERHADAP BAKTERI Staphylococcus aureus Evi Deviana Gultom
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2951

Abstract

Abstract Body odor is one of the personal hygiene problems caused by bacterial activity such as Staphylococcus aureus on sweat. Continuous use of chemical-based deodorants may cause skin irritation; therefore, natural alternatives are needed. This study aims to formulate and evaluate the antibacterial effectiveness of a deodorant spray preparation made from citronella (Cymbopogon nardus L.) stem ethanol extract. The extract was obtained using the maceration method with 96% ethanol, followed by phytochemical screening to identify active compounds. The deodorant spray was formulated in three extract concentrations—5%, 10%, and 15%—and evaluated for organoleptic properties, pH, drying time, spray power, and homogeneity. The antibacterial effectiveness test against Staphylococcus aureus was carried out using the disc diffusion method. The results showed that all formulas met the physical evaluation requirements of deodorant preparations. The largest inhibition zone was observed in the formula containing 15% extract, with a diameter of 16.33 mm, categorized as strong inhibitory activity. Therefore, the ethanol extract of Cymbopogon nardus stem has the potential to be used as an active ingredient in natural antibacterial deodorant spray formulations against Staphylococcus aureus.
UJI AKTIVITAS DEODORANT SPRAY EKSTRAK ETANOL DAUN KITOLOD (Isotoma longiflora (L.) C. Presl) TERHADAP BAKTERI Staphylococcus aureus Delisma Marsauli Simorangkir; Gratia Apulia CP Purba; Tio Ranti Sari Br Sembiring; Sardamai Laia Laia
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.2953

Abstract

This study aims to determine the effectiveness of ethanol extract of cytolod leaves (Isotoma longiflora (L.) C. Presl) formulated in spray deodorant preparations as an antibacterial against Staphylococcus aureus. The extraction of cytolod leaves is carried out by the maceration method using 96% ethanol solvent. Spray deodorant preparations are made in three different extract concentrations, namely 3% (F1), 5% (F2), and 8% (F3), with positive control using commercial deodorant (AXE) and negative control in the form of a base preparation without extract. Antibacterial effectiveness testing was carried out using the suction diffusion method. The results of the physical evaluation showed that all formulas met the requirements of organoleptic, pH, clarity, viscosity, drying time, sprayability, and did not cause irritation to the skin. The results of the antibacterial activity test showed that the higher the concentration of the extract, the larger the barrier zone formed. Formulas with a concentration of 8% (F3) show the most effective inhibition activity with an average inhibition zone diameter of 15.73 mm, which belongs to the strong category.
PENGARUH EDUKASI RASIONALISASI ANTIBIOTIK TERHADAP PENGETAHUAN MASYARAKAT DI DESA SUNGAI LANANG dini armayanti; Chindiana Khutami; Septa Pratama
Jurnal Penelitian Farmasi & Herbal Vol. 8 No. 2 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i2.3036

Abstract

Irrational use of antibiotics contributes to the increasing incidence of antimicrobial resistance (AMR). Limited public knowledge regarding the indications and proper use of antibiotics leads to inappropriate usage. This study aimed to determine the level of community knowledge before and after educational intervention and to analyze the effect of education on improving knowledge among residents of Dusun III, Sungai Lanang Village. This study employed a pre-experimental one group pretest–posttest design involving 71 respondents selected through purposive sampling from a population of 245 individuals. Data were collected using a questionnaire that had been tested for validity and reliability. Statistical analysis was performed using the Wilcoxon Signed Ranks Test because the data were not normally distributed (p < 0.05). The results showed that prior to the educational intervention, the majority of respondents had poor knowledge (59%), whereas after the intervention, most respondents were categorized as having good knowledge (70%). The Wilcoxon test result showed p = 0.000 (p < 0.05), indicating a significant effect of education on improving knowledge. In conclusion, antibiotic rationalization education is effective in increasing community knowledge and should be implemented continuously to prevent antibiotic misuse.

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