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Essential: Essence of Scientific Medical Journal
Published by Universitas Udayana
ISSN : 19790147     EISSN : 26556472     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Essence of Scientific Medical Journal (ESSENTIAL) merupakan salah satu media publikasi ilmiah yang dimiliki oleh Kelompok Ilmiah Hippocrates FK Unud. Jurnal Essential menerima karya ilmiah berupa penelitian dan tinjauan pustaka dari seluruh mahasiswa kesehatan di Indonesia. Essential (Essence scientific Medical Journal) menerima dan mempublikasikan artikel penelitian dan tinjauan pustaka dalam ruang lingkup ilmu kesehatan atau bidang kedokteran meliputi ilmu dasar kedokteran, ilmu klinis dan kesehatan komunitas, ataupun penelitian eksperimental hewan atau manusia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 103 Documents
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Cerek Elektrik Berbasis Flash Heat Treatment: Penerapan Teknologi Praktis Dalam Mencegah Transmisi HIV Dari Ibu Ke Bayi Di Masa Menyusui Eddy Zulfikar
Essence of Scientific Medical Journal Vol 17 No 1 (2019): Volume 17 No. 1 (Januari-Juni 2019) ESSENTIAL: Essence Of Scientific Medical Jou
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2019.v17.i01.p05

Abstract

Introduction: HIV/AIDS is still become a major problem in global health, especially for the women population. HIV-infected women have a greater risk of transmitting HIV to their babies through the Mother to Child Transmission (MTCT) which mostly occurs during breastfeeding. Prevention of MTCT of HIV by replacing exclusive breastfeeding with formula milk is still controversial, considering that breast milk contains antibodies and other protective nutrients that can protect the babies from various infectious diseases. Therefore, the latest effective method is needed to prevent transmission of HIV from mother to child during breastfeeding, namely Flash Heat Treatment (FHT). Discussion: See above the total 30 breast milk samples tested, it was found that the average HIV concentration in breast milk without heating was 8,266 copies/ml with a mean log of 3.45 copies/ml, compared to flash heated milk which shows an almost undetectable level of HIV, which is under 400 copies/ml. This proves that breast milk with a flash heated method can inactivate HIV in breast milk and prevent the transmission of HIV from mother to child during breastfeeding. In addition, the application of FHT in the form of electric kettles can be promising to achieve stabilization and standardization of the use of FHT that is appropriate at the level of housewives. Conclusion: The use of FHT-based electric kettles in breast milk could become an effective and affordable method in preventing HIV transmission from mother to child during breastfeeding, especially in low to middle income countries. Keywords: electric kettles, FHT, HIV, MTCT
POTENSI CURCUMIN DALAM EKSTRAK RIMPANG KUNYIT (CURCUMMA DOMESTICA L.) SEBAGAI MODALITAS PENCEGAHAN PREEKLAMSIA PADA IBU HAMIL DENGAN RESISTANSI INSULIN I Made Bagus Cahya Wibawa; Agus Indra Yudhistira Diva Putra; Erick Kusuma Tandiono
Essence of Scientific Medical Journal Vol 16 No 2 (2018): Volume 16 No. 2 (Juli-Desember) : Essence Of Scientific Medical Journal
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2018.v16.i02.p07

Abstract

Introduction: Preeclampsia is a pregnancy disorder characterized by significantly increased blood pressure (systolic pressure ?140 mmHg, diastolic pressure ?90 mmHg) induced by pregnancy and proteinuria. Preeclampsia is often associated with hyperglycemic state, and studies found that hyperglicemia increases the risk of preeclampsia up to three times higher.Discussion: There are correlations between insulin resistance and glucose intolerance with preeclampsia, shown by the statistics that 20% and 15% of pregnant women with DM Type 1 and Type 2 respectively will develop preeclampsia. Excessive glucose level could induce intracellular changes in cytotrophoblasts that causes placental abnormalities and leads to preclampsia. Recent studies found that hyperglicemia treatment could reduce the risk of preeclampsia up to 54% (RR:0,46;95% CI:0,22-0,97). Turmeric extract contains curcumin that is known for its antidiabetic activity. Curcumin can reduce the insulin resistance and glucose intolerance by inhibition of ROS production to maintain the viability of islet cells, suppression of inflamatory cytokines (TNF-?, IL-6, NFkB) production, stimulation of glucose transporter (GLUT-4) expression and glucose clearance, and suppression of FFA level.Conclusion: Curcumin is potential to be used as a new modality to prevent preeclampsia on women with insulin resistance and glucose intolerance, but the exact amount of turmeric extract or curcumin concentration needed to achieve the desired effect is still unknown.
Analisis Faktor Risiko Pasien Gagal Jantung dengan Reduced Ejection Fraction di RSUD Dr. H. Abdul Moeloek Provinsi Lampung Rama Agung Prakasa; Debby Cinthya D. Valentina; Riestya Abdiana; Riana Handayani; Nurulando Imansyah BP
Essence of Scientific Medical Journal Vol 18 No 1 (2020): Volume 18 No. 1 (Januari - Juni 2020) Essential: Essence of Scientific Medical J
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2020.v18.i01.p07

Abstract

ABSTRAK Pendahuluan : Penyebab kematian akibat penyakit tidak menular nomor satu ditempati oleh penyakit kardiovaskular. Congestive heart failure (CHF) merupakan salah satu masalah kesehatan dalam sistem kardiovaskular yang angka kejadiannya terus meningkat tiap tahunnya. Metode: Penelitian ini menggunakandesain analitik retrospektif. Sumber data penelitian menggunakan data sekunder berupa rekam medik pasien untuk melihat variabel-variabel penelitian berupa karakteristik dan faktor-faktor risiko yang berhubungan dengan pasien CHF di RSUD Abdul Moeloek Lampung periode Januari-Juni 2018. Data diolah dengan menggunakan IBM SPSS Statistic 24. Hasil : Hasil analisis statistik dengan chi squareterhadap faktor risiko pada pasien dengan HFERF didapatkan hasil usia memiliki p-value0,85; jenis kelamin memiliki 0,611; dan faktor risiko lain seperti hipertensi, diabetes melitus (DM),penyakit jantung koroner(PJK) dan merokok memiliki p-value berturut-turut yaitu 0,113; 0,044; 0,057 dan 0,083. Secara statistik, faktor risiko yang berpengaruh dengan kejadian HFERF adalah DM. Pembahasan : Pasien dengan DM memiliki risiko untuk menderita penyakit gagal jantung dua kali lebih besar. Pada studi Framingham dikatakan bahwa DM secara independen meningkatkan risiko penyakit gagal jantung 2 kali pada laki-laki dan 5 kali pada perempuan. Peningkatan insiden gagal jantung pada DM juga menetap meskipun memperhatikan faktor lain seperti usia, hipertensi, hiperkolesterolemia dan PJK. Simpulan: Faktor risiko DM berpengaruh secara signifikan terhadap tingginya kasus HFrEF. Jenis kelamin, usia, hipertensi, PJKdan merokok tidak berpengaruh secara signifikan terhadap tingginya kasus HFrEF di Rumah Sakit Umum Daerah Abdul Moeloek. Hal ini menunjukkan bahwa faktor yang diteliti tidak berbeda secara signifikan antara HFrEF dengan gagal jantung tipe lain. Kata kunci: ejection fraction, faktor risiko, gagal jantung
POTENSI MICRORNA10-B DAN MICRORNA-155 SEBAGAI MODALITAS MUTAKHIR DALAM DETEKSI MIKROMETASTASIS/ISOLATED TUMOR CELLS (ITC) PADA KANKER PAYUDARA STADIUM DINI Feliani Sanjaya; Ivana Beatrice Paulus; Felicia Puspita Sari
Essence of Scientific Medical Journal Vol 16 No 1 (2018): Volume 16 No. 1 (Januari-Juni) : Essence Of Scientific Medical Journal
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2018.v16.i01.p04

Abstract

Pendahuluan: Metastasis merupakan penyebab kematian utama pada kasus kanker payudara. Metastasis diawali dengan mikrometastasis/isolated tumor cells (ITC) yang dapat terekspresi pada sirkulasi darah tepi (Circulating Tumor Cells/CTC) atau sumsum tulang (Disseminated Tumor Cells/DTC). Identifikasi mikrometastasis penting dilakukan sebagai upaya mendeteksi distant metastasis pada masa mendatang. Sampai saat ini belum ada pemeriksaan mikrometastasis yang efektif. Untuk itu, perlu adanya modalitas screening metastasis kanker payudara dengan biomarker miR-10b dan miR-155. Metode: Tinjauan pustaka disusun berdasarkan literatur seperti jurnal dan website. Kata kunci yang digunakan yaitu “EMT”, “kanker payudara”, “mikrometastasis”, “miR-10b” dan “miR-155” pada search engine scholar.google.com ,www.nature.com dan Pubmed. Dari 80 jurnal yang ditelaah, 70 jurnal ditemukan sesuai dengan topik bahasan dan digunakan sebagai referensi karya ini. Pembahasan: Proses metastasis kanker payudara didahului oleh mikrometastasis yang berkaitan dengan epithelial-mesenchymal transition (EMT). Proses EMT mengekspresikan beberapa faktor yakni SNAI1 , SNAI2 dan Twist yang berkorelasi dengan peningkatan ekspresi miR-10b secara signifikan. MiR-155 sebagai biomarker yang memilliki peran penting dalam regulasi transforming growth factor ? (TGF-?). TGF-? merupakan regulator dari EMT, sehingga miR-155 berkorelasi dengan proses EMT. MiR-155 dan miR-10b memiliki keunggulan baik sensitivitas maupun spesifisitas serta dengan prosedur invasif minimal sehingga jika dikombinasikan dapat menjadi agen potensial biomarker metastasis kanker payudara. Simpulan: MiR-10b dan miR-155 merupakan agen potensial dalam deteksi metastasis kanker payudara. Penelitian lebih lanjut diperlukan untuk mengetahui efektivitas kombinasi miR-10b dan miR-155 dalam mendeteksi metastasis kanker payudara untuk menambah bukti ilmiah.
HUBUNGAN PENGETAHUAN DIET PASIEN DIABETES MELLITUS TIPE II TERHADAP KONTROL GULA DARAH SEWAKTU DI PUSKESMAS RAJEG Moch. Rizki Ramadhan; Alvin Zulmaeta; Frizky Ramadhan; Nida Raniah; Putri Rahmah Ajizah; St. Rafidah Ali; Tri Yudha Nugraha
Essence of Scientific Medical Journal Vol 17 No 2 (2020): Volume 17 No. 2 (Juli-Desember 2019) Essential: Essence of Scientific Medical Jo
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2020.v17.i02.p07

Abstract

Pendahuluan: Prevalensi diabetes mellitus (DM) tipe II di Indonesia khususnya di Puskesmas Rajeg pada tahun 2019, menunjukkan adanya peningkatan cakupan penderita DM. Pengetahuan dan manajemen diet yang baik dapat memberikan kontrol DM yang lebih baik dan mencegah terjadinya komplikasi. Metode: Penelitian ini menggunakan metode deskriptif analitik dengan desain cross sectional. Data yang diambil meliputi kuesioner, pemeriksaan gula darah sewaktu (GDS), dan rekam medis pasien. Sampel penelitian ini berjumlah 30 pasien DM tipe II yang berobat di Puskesmas Rajeg. Sampel diambil dengan teknik simple random sampling lalu data dianalisis dengan uji chi-square. Hasil: Secara keseluruhan sampel, kriteria tingkat pengetahuan kurang sebanyak 18 orang (60%) dan tingkat pengetahuan baik 12 orang (40%). GDS <200 mg/dl sebanyak 14 orang (47%) dan GDS ?200 mg/dl sebanyak 16 orang (53%). Hasil analisis chi-square menunjukkan adanya perbedaan bermakna antara pengetahuan diet DM terhadap kontrol GDS (p-value= 0.002). Analisis chi-square antara tingkat pendidikan terhadap pengetahuan diet DM menunjukkan perbedaan bermakna (p-value= 0.008). Simpulan: Terdapat perbedaan bermakna antara pengetahuan diet DM terhadap kontrol GDS. Faktor yang teridentifikasi memiliki hubungan bermakna terhadap rendahnya pengetahuan adalah tingkat pendidikan.
Potensi Antibodi Anti-PfRH5 Terkonjugasi Nanopartikel Poly(lactide-co-glycolide) acid (PLGA) sebagai Inovasi Vaksin Malaria Falciparum Gde Adit Putra Deva; Agung Bagus Sista Satyarsa; Sang Ayu Arta Suryantari; I Made Susila Utama
Essence of Scientific Medical Journal Vol 17 No 1 (2019): Volume 17 No. 1 (Januari-Juni 2019) ESSENTIAL: Essence Of Scientific Medical Jou
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2019.v17.i01.p01

Abstract

Malaria Falciparum adalah salah satu penyakit infeksi disebabkan oleh parasit protozoa Plasmodium falciparum yang memiliki morbiditas dan mortalitas terbesar kasus malaria pada manusia. Upaya pencegahan dan penanganan malaria falciparum saat ini masih mendapat hambatan dari resistensi terhadap insektisida dan obat anti-malaria. Untuk itu, perlu adanya metode pencegahan parasit yang bersifat lebih spesifik yakni berupa vaksin dengan target protein parasit. Tinjauan pustaka dilakukan berdasarkan literatur seperti jurnal dan website. Dari 60 jurnal yang ditelaah, 46 jurnal ditemukan sesuai dengan topik bahasan dan digunakan sebagai referensi karya ini. Dalam siklus hidup P.falciparum terjadi fase invasi terhadap eritrosit. Plasmodium falciparum Reticulocyte-binding Protein Homologue 5 (PfRH5) dan basigin (BSG) dari eritrosit adalah pasangan ligan-reseptor esensial dalam invasi eritrosit. Tambahan nanopartikel poly(lactide-co-glycolide) acid (PLGA) sangat penting untuk melindungi komponen vaksin antibodi anti-PfRH5 agar tidak mudah mengalami degradasi yang membantu untuk meningkatkan efikasi kerja vaksin dalam menginhibisi proses invasi oleh merozoit. Karena berperan sebagai target yang penting dalam menginhibisi invasi merozoit, potensi PfRH5 sebagai vaksin malaria sangat signifikan dan spesifik. Potensi PfRH5 juga didukung dengan munculnya respon imun alami yang dapat menghambat pertumbuhan parasit. Respon imun tersebut melibatkan IgG spesifik terhadap PfRH5 yang dapat memberikan efek protektif dengan menghambat terjadinya ikatan antara PfRH5-BSG sehingga proses invasi tidak terjadi. Vaksin malaria (antibody anti-PfRH5 terkonjugasi nanopartikel PLGA) yang spesifik pada merozoit merupakan modalitas pencegahan potensial dalam perkembangan vaksin malaria falciparum. Penelitian lebih lanjut diperlukan untuk mengetahui efikasi dan induksi antibodi pada tubuh oleh anti-PfRH5 masih diperlukan untuk menambah bukti ilmiah.
PERAN SOLUBLE GROWTH STIMULATION GENE-2 (sST2) PLASMA DARAH SEBAGAI FAKTOR PROGNOSTIK PREEKLAMSIA BERAT Yonathan Siswo Pratama; Laksmi Maharani
Essence of Scientific Medical Journal Vol 16 No 2 (2018): Volume 16 No. 2 (Juli-Desember) : Essence Of Scientific Medical Journal
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2018.v16.i02.p02

Abstract

This article is aimed to know the role of soluble growth stimulation gene-2 (sST2) as a prognostic factor in patients with severe preeclamsia. A search was conducted on Pubmed, GoogleScholar and ScienceDirect based on selected clinical question. The articles selection was based on inclution and exclution criteria. Three articles were critically appraised for its validity, importance and applicability. All three choosen articles state that higher sST2 plasma is correlated with overall survival patients with severe preeclamsia. SST2 level may serve as a prognostic factor regarding overall survival in patients with severe preeclamsia.
Prevalensi dan Luaran Gangguan Hemodinamik Dengue Shock Syndroma pada Anak Di Departemen Anak RSUD Dr SOetomo Fenska Seipalla; Ira Dharmawati; Sundari Indah Wiyasihati
Essence of Scientific Medical Journal Vol 18 No 1 (2020): Volume 18 No. 1 (Januari - Juni 2020) Essential: Essence of Scientific Medical J
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2020.v18.i01.p06

Abstract

Abstract The prevalence of Dengue infection has increased markedly worldwide. Dengue shock syndrome (DSS) is a severe manifestation of dengue virus infection. Higher mortality of DSS was found in children. This study’s aim was to portray prevalence and hemodynamic outcome in children attending the department of pediatric in Dr. Soetomo General Hospital. A Descriptive Retrospective study of children aged <15 years old with DSS was performed and evaluated from 2013-2016. The samples were divided into 5 groups, aged <1 years old, 1-2 years old, 3-5 years old 6-11 years old and 12-15 years old. Data were taken secondarily and calculated with Microsoft Excel 2010. The most common findings were prevalence of DSS in 6-11 years old group and mortality rate in <1 years old group. This can be seen as in the hemodynamic outcome; the average HR was higher in aged group 1-2 years old while RR was higher in group under 1-year-old. Meanwhile, the average blood pressure, PP, and MAP were lower in children under 2 years old. The hemodynamic outcome varies on each group based on age. Incidence of DSS remained high in older children but mortality rates were high in younger children.
CORONARY STENT COATED WITH MESENCHYMAL STEM CELLS-ANGIOGENIC GROWTH FACTOR SEBAGAI AGEN REENDOTELIALISASI DAN PENCEGAHAN RESTENOSIS I Nyoman Tri Pramartha; Gede Setula Narayana; Ni Putu Elsinthia Suryaningsih
Essence of Scientific Medical Journal Vol 17 No 2 (2020): Volume 17 No. 2 (Juli-Desember 2019) Essential: Essence of Scientific Medical Jo
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2020.v17.i02.p01

Abstract

ABSTRACT Introduction: acute myocardial infarction (IMA) is the caused of medical emergencies with around 17.9 million global deaths. There are various factors associated such as unhealthy food dietary like high fat diet, sedentary lifestyle, smoking and alcohol. The pathogenesis of IMA begins with the formation of lesions atherosclerotic plaque that caused in decreased O2 perfusion (ischemia) and nutrition resulting in cardiomyocyte necrosis (infarction). The main treatment for overcoming IMA nowdays is percutaneous coronary intervention (PCI) using bare metal stents (BMS) with the disadvantage of achieving up to 50% restenosis. Innovations using drug eluting stent (DES) have not been efficient and led to restenosis and low reendothelization processes. New modalities that tends to have a better effect needed to increase reendothelization and prevent restenosis. Discussion: the construction of coronary stents coated with mesenchymal stem cells (MSC) angiogenic growth factors begins with the formation of MSC culture and then using the TALEN system inserted plasmids containing HGF-VEGF gene. Then implanted in the CoCr stent and ready to be administrated. The resulting work effect is accelerating reendothelization through the proliferation and differentiation of MSC and strengthening the intima tunica by increasing the formation of tight junctions between epithelium. In addition, the effects taken in restenosis. This prevention is caused by immunomodulators and anti-inflammatory effects provided by angiogenic growth factors and induction of autophagi, thus recycling cell nutrients in atherosclerotic lesions. Conclusion: the use of coronary stents coated with mesenchymal stem cell (MSC) angiogenic growth factors is needed as the latest IMA therapy with endothelial acceleration through the proliferation and differentiation of MSC and ancestral cells and the use of restenosis replacement through the use of antibacterial and nutrient recycling.
POTENSI KOEKSPRESI CHIMERIC ANTIGEN RECEPTOR (CAR) DAN GEN FOXP3 PADA SEL T REGULATORS SEBAGAI MODALITAS TERAPI PENATALAKSANAAN AUTOIMUN Yulia Cahya Khasanah
Essence of Scientific Medical Journal Vol 16 No 2 (2018): Volume 16 No. 2 (Juli-Desember) : Essence Of Scientific Medical Journal
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2018.v16.i02.p05

Abstract

Introduction: Autoimmune disease is immune response that damages self-tissues and disrupts physiologicalfunctions of the body. The prevalence of autoimmune diseases has continued to increase globally since World WarII. In US, this disease is the leading cause of death and commonly seen in women. Conventional autoimmunemedicine suppresses most of immune system and causes patients to be more susceptible to opportunistic infectionsand cancer. Based on these facts, therapeutic innovations that are specific to pathological immune cells are needed.Molecular therapy using stable, target-specific Tregs engineered is potential as the latest modality for autoimmunetherapy.Discussion: Autoimmune occurs when adaptive immune response attacks self-antigens. The autoimmunemechanism is then followed by activation of a large number of T cells. All activated T cells are controlled by Tregulators or Tregs. Tregs have weaknesses which are low selectivity and stability. For this reason, Tregengineering with selective receptor expression and Treg stabilizer is needed. The selective receptors that can bemodified with T cells are Chimeric Antigen Receptor (CAR). CAR is known to selectively inhibits pathologicalimmune responses and stops inflammation. CAR is combined with Treg stabilizer which gives the effect ofamplification and stabilization, that is Forkhead box P3 (FoxP3). FoxP3 is core protein that functions as the mainregulator of Tregs development and self-tolerance.Conclusion:CAR/FoxP3-Engineered Tregs express FoxP3 that have strong affinity for self-antigens through CARreceptors. The application of CAR/FoxP3-Engineered Tregs increases the selectivity and stability of Treg cells tosupress autoimmune.

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