cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Machrozi Alfian
Contact Email
machrozialfian@student.ub.ac.id
Phone
+6282280000315
Journal Mail Official
machrozialfian@student.ub.ac.id
Editorial Address
Tata Surya Malang
Location
Unknown,
Unknown
INDONESIA
Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Published by Pharmaceutical Journal of Indonesia
ISSN : -     EISSN : 2461114X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan petugas pengelola obat dengan tingkat ketersediaan obat di beberapa Puskesmas Kota Malang. Penelitian yang dilakukan merupakan observasional analitik cross sectional. Teknik pengambilan sampel responden adalah dengan total sampling. Instrumen yang digunakan adalah kuesioner pengetahuan petugas pengelola obat dan lembar pengumpul data tingkat ketersediaan yang dilihat dari data LPLPO
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 155 Documents
 4   5   6   7   8 
Pengaruh Konseling Apoteker terhadap Tingkat Pengetahuan Pasien dalam Penggunaan Allopurinol dan Analgesik di Apotek Wilayah Kota Malang Muthiah, Dewi -
Pharmaceutical Journal of Indonesia Vol 5, No 2 (2020)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2020.005.02.9

Abstract

Gout merupakan suatu proses inflamasi yang terjadi karena deposisi kristal asam urat pada jaringan sekitar sendi. Insiden dan prevalensi gout terus meningkat setiap tahunnya. Allopurinol merupakan obat gout yang tergolong sebagai Obat Wajib Apotek (OWA). Syarat pemberian OWA yaitu memenuhi ketentuan dan batasan tiap jenis obat per pasien serta memberikan informasi meliputi dosis, aturan pakai, kontraindikasi, dan efek samping. Allopurinol biasa diresepkan dengan analgesik untuk terapi gout. Keberhasilan terapi dalam penggunaan allopurinol dan analgesik dapat dipengaruhi oleh tingkat pengetahuan pasien, sehingga perlu diimbangi dengan pemberian informasi yang benar oleh apoteker. Penelitian ini bertujuan untuk mengetahui pengaruh konseling apoteker terhadap tingkat pengetahuan pasien dalam penggunaan allopurinol dan analgesik di apotek wilayah Kota Malang. Metode penelitian yang digunakan adalah experimental dan jenis penelitian one group pretest – posttest. Pemilihan sampel apotek dilakukan dengan teknik cluster sampling, sedangkan sampel responden menggunakan teknik purposive sampling sesuai kriteria inklusi dan eksklusi. Jumlah responden yang diperoleh sebanyak 87 responden dari 15 apotek yang berada di wilayah Kota Malang. Analisis statistik yang digunakan adalah uji Wilcoxon, untuk mengetahui pengaruh konseling apoteker terhadap tingkat pengetahuan pasien dalam penggunaan allopurinol dan analgesik. Prosedur penelitian ini juga telah mendapatkan persetujuan laik etik dengan No. 85/ EC/ KEPK-S1-FARM/ 03/ 2019. Berdasarkan hasil penelitian, menunjukkan adanya peningkatan pengetahuan secara signifikan (p=0,000) setelah diberikan konseling oleh apoteker terkait penggunaan allopurinol dan analgesik. Sehingga dapat disimpulkan bahwa, konseling apoteker berpengaruh positif terhadap tingkat pengetahuan pasien dalam penggunaan allopurinol dan analgesik.Kata kunci : Gout, Konseling, Pengetahuan, Allopurinol, Analgesik
Literatur Review Trastuzumab Induced Cardiotoxicity (TIC) In Patient With Breast Cancer : Pharmacology Aspect, Mechanism of Cardiotoxicity, Risk Factor and Treatment Strategies Jaya, Nur
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Breast cancer (BCA) is the most common cancer in women. Since the last 2 decades, early diagnosis and specific molecular targeted neoadjuvant and adjuvant therapy had been reducing breast cancer mortalities. Unfortunately, the improvement of the survival rate is followed by the emergence of cardiotoxicity effect from cancer therapy that had seen in several cases. This showed that trastuzumab treatment significantly affects the functional and structural characteristics of the heart. The mechanism of trastuzumab-related cardiotoxicity is not fully understood. This review will summarize the pharmacology and mechanism of trastuzumab-induced cardiotoxicity, investigate its risk factors, and consider the appropriate management for the patients.Discussion: Trastuzumab is a monoclonal antibody, that acts as human epidermal growth factor tyrosine kinase HER2 (Erb B2) antagonist, frequently given for breast cancer patients. Trastuzumab is not only expressed through the excessive HER2 in positive breast cancer but can also disrupt the cardiomyocytes growth and selectively inhibit the structure and function of the heart causing dilated cardiomyopathy. Some studies recommended angiotensin-converting enzyme inhibitor (ACEI), enalapril, to prevent the late cardiotoxicity and angiotensin receptors blocker (ARB) and also beta-blocker (BB), candesartan and bisoprolol, to significantly reduce LV dysfunction event, as the management of trastuzumab-induced cardiotoxicity.Conclusion: Delaying trastuzumab administration after previous anthracycline treatment can prevent or reduce the risk/synergy effect of cardiotoxicity. The temporal withdrawal and reinitiation after LV systolic function stabilization, both spontaneously or using heart failure therapy, partially succeed in preventing cardiotoxicity. And, monitoring the troponin release was found as the first and the most sensitive test to detect cardiotoxicity early signs, with a proven impact on cardiac prognosis, particularly for trastuzumab (after the previous anthracycline).Keywords: Trastuzumab-Induced Cardiotoxicity; Pharmacology Aspect, Mechanism of Cardiotoxicity, Risk Factor and Treatment Strategies.
ZODIA SOAP AS REPELLENT AGAINST AEDES AEGYPTI MOSQUITOES Simaremare, Eva Susanty
Pharmaceutical Journal of Indonesia Vol 3, No 1 (2017)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Zodia is known as a native plant from Papua which is traditionally  used as a mosquitoes repellent. The contents of zodia leaves are linalool and a-pinene which have been scientifically tested as a  mosquitoes Aedes aegypti L repellent caused Dengue hemorrhagic fever (DHF). Essential oil of zodia has got by vapor distillation  will be made as repellen in soap. The purpose of this research is to create a solid soap and    mosquito repellent of zodia leaf (Evodia suaveolens Scheff) and to know the efficacy of the repellent against Aedes aegypti L. The results of this study indicated that the steam distilation process on this study produced 48,33 ml of the essential oils. The blue spot appeared on Thin Layer Chromatography (TLC) and the value of Rf  is 0,3 indicated a linalool. All formulations  produce good solid  soap  in terms of organoleptic, pH, ability to form foam and skin irritation tests. Solid soap with 1,5 ml zodia essensial oil was the most effective formula as Aedestaegypti L repellentfor two hours. The protection efficacy was reduced because the oil is  volatile. Zodia soap was made successfully with white cream , aromatic smell, and solid phase. Soap has great foam, pH 8-9, homogeny, and non-irriating. The addition of concentration essential oils increase protection power as reppelent.  With The addition of essential oils 1,5%, the protection power soap was 81% to mosquito Aedes aegypti L.
Literatur Review Idarucizumab Pharmacology as Dabigatran Antidotes : Mechanism of action, pharmacokinetics, efficacy and safety Tanti, Yunita Dwi
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A B S T R A C TBackground: Atrial Fibrillation (AF) is a common abnormal heart rhythm , responsible for high rate of cardiovascular and cerebrovascular morbidity and mortality. The prevalence of AF in the general population is about 3%. Stroke patients with AF have a high mortality rate up to 50% in one year, compared to stroke patients without AF which is 27%. Dabigatran etexilate is an oral thrombin inhibitor that had been approved for stroke prevention in nonvalvular atrial fibrillation patients and also has a role in venous thromboembolism (VTE) prevention and treatment. Since dabigatran usage result in hemorrhage and might lead to immediate intervention or surgery, a specific reversal agent (antidote) is highly needed during this emergency situation. A specific reversal agent for dabigatran is Idarucizumab.Discussion:Idarucizumab has a high affinity to both free and thrombin-bound dabigatran, and also its metabolite, acylglucoronide. Idarucizumab can neutralize the anticoagulant effect from dabigatran by binding them to form a stoichiometric complex with 1:1 molar ratio. Idarucizumab and dabigatran interaction have a very fast on-rate and a slow off-rate resulting in a stable Idarucizumab-dabigatran complex which elicits its effect in a few minutes.Conclusion: Idarucizumab can reverse the effects of dabigatran anticoagulants in a few minutes by forming a stable complex. Some study concerning Idarucizumab efficacy and safety on healthy patients and patients with renal disorder, showed that Idarucizumab can be well tolerated. There was no severe adverse event, dose-dependent event, drop-out due to an adverse event, and no relevant clinical findings were reported for vital sign, physical examination, electrocardiogram, cardiac telemetry, or laboratory parameters.Keywords:Idarucizumab, Dabigatran, stroke, Nonvalvular Atrial Fibrillation
The Effect of PLGA Nanoparticles of Nigella sativa Seed Extract on Catalase Level in The Liver Tissues of Type 2 Diabetes Mellitus Rats oktaviana, pratiwi
Pharmaceutical Journal of Indonesia Vol 2, No 1 (2016)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background:Nigella sativa (NS), a medicinal plant, has antidiabetic and antioxidant effects via regulating blood glucose and antioxidant defence level. One of the antioxidant defence capacity is catalase (CAT) which prevents oxidative stress in the DM progression via balancing redox state. This enzyme could be increased by Nigella sativa seeds extract (NSE). However, plant-derived product has limited efficacy in clinical trial. Thus one of drug delivery system, PLGA encapsulated nanoparticle, may improve this efficacy. Objectives: The aims of this study were to evaluate CAT level in the liver tissues of male DM Sprague dawley rats after oral administration of NSE 48 mg/kgBW/day (P1), PLGA nanoparticle of NSE 48 mg/kgBW/day (P2), glibenklamide 0,45 mg/kgBW/day (PP), and normal diet without therapy (DN). Methodology: True experimental design post test controlled group, 24 rats were fed by high-fat diet for 40 days and followed by intraperitoneal injection of 35 mg/kgBW STZ. These rats were divided into 4 groups: DN, PP, P1, and P2 respectively. Results: Thymoquinone which possesses antioxidant effect was identified by qualitative phytochemical evaluation. PLGA nanoparticle was prepared from nanoprecipitation. The oral administration of PLGA nanoparticle NSE for 26 days to DM rats lowered fasting blood glucose (FPG) (66,67%) better than P1, PP, and DN. The PLGA nanoparticle of NSE did not significantly increased the CAT level in the liver tissues of DM rats (analyzes Oneway-ANOVA p = 0.872). However, the mean of CAT level in the liver tissues of DM rats was higher in group P2 compared to those in the other group. Conclusion: These results exhibited antidiabetic and antioxidant effects of PLGA nanoparticle NSE in term of  fasting blood glucose level  and CAT level in liver tissues. Key words:Nigella sativa,PLGA Nanoparticle, Catalase
STRATEGI PENINGKATAN PRODUKSI SENYAWA ARTEMISININ DAN TURUNANNYA DENGAN KONSEP BIOTEKNOLOGI khasanah, uswatun -
Pharmaceutical Journal of Indonesia Vol 4, No 2 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Artemisinin is a sesquiterpen lactone that was isolated from the Artemisia annua. Artemisinin was used as antimalarial since 1980, when chloroquine resistance case occurred. The demand of artemisinin as antiamalarial was not accompanied by an increase in artemisinin production. Until now, artemisinin production is obtained through isolation process of genus Artemisia. Various studies have been carried out to meet the needs of artemisinin as antimalarial drug. Some studies used biotechnology technic for example plant tissue culture, genetic engineering to modulate artemisinin biosynthetic pathway, and the addition of organic fertilizer in A.annua agriculture. Some researches added compounds which play a role  in the biosynthesis of artemisinin in A.annua cell culture, e.g mevalonic acid, sodium acetate and casein. In addition, the production of artemisinin derivatives is also carried out through biotechnology techniques using hair root culture from certain plants. Production of artemisinin is also increased by adding organic fertilizers, such as NaCl, potassium phosphate, and ammonium nitrate. Several studies also produce transgenic plants by inserting genes that encode terpenoid precursor compounds, farnesil pyrophosphate.
Pengaruh Perbedaan Konsentrasi Surfaktan Non Ionik terhadap Karaktersitik Niosom Pterostilben Kartika Zulfa; Ferri Widodo; Oktavia Eka Puspita
Pharmaceutical Journal of Indonesia Vol. 6 No. 1 (2020)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2020.006.01.4

Abstract

Radiasin sinar UV yang berlebih dapat menyebabkan kerusakan kulit hingga melanoma, khususnya sinar UVB. Efek kronis dari paparan sinar UVB yang berlebih dapat menginduksi mutasi gen, karena langsung menyebabkan kerusakan pada DNA seluler dengan memproduksi ROS di epidermis, dermis dan sel epitelium kulit. Penggunaan tabir surya sangat diperlukan untuk mencegah terjadinya hal tersebut. Tabir surya yang mengandung antioksidan sangat direkomendasikan untuk menangkal radikal bebas dari sinar UVB. Pterostilben merupakan salah satu senyawa fenolik, yang memiliki aktivitas farmokologi antioksidan dan UV filter menjadi salah satu senyawa yang direkomendasikan untuk komponen tabir surya. Untuk meningkatkan efek farmakologi pterostilben pada penggunaan topikal, pterostilben perlu diformulasikan sistem penghantaran. Niosom merupakan vesikel surfaktan non ionik menjadi salah satu sistem pembawa amfifilik yang dapat  membawa bahan aktif bersifat hidrofobik seperti pterostilben, diharapkan mampu meningkatkan efek farmakologi dengan meningkatkan penetrasi pterostilben ke kulit. Pembuatan niosom pterostilben menggunakan surfakan non ionik (span 80 dan span 60) dengan metode hidrasi lapis tipis. Tujuan dari pengembangan formulasi niosom pterostilben adalah untuk melihat pengaruh konsentrasi surfaktan non ionik (span 80 dan span 60), yaitu 2, 4, dan 6 g terhadap ukuran partikel yang dihasilkan dan menentukan formulasi optimum. Hasil uji karakteristik ukuran partikel niosom pterostilben dianalisis statistik menggunakan One-Way ANOVA dengan p<0,05. Hasil dari penelitian ini menunjukkan bahwa ukuran niosom pterostilben semakin kecil dengan peningkatan konsentrasi span 60. Berdasarkan hasil tersebut, didapatkan formulasi optimum niosom pterostilben yaitu pada penggunaan span 60 dengan konsentrasi 6 g.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kacapiring (Gardenia augusta Merr.) dan Fraksinya Terhadap Salmonella typhi Kherid, Mohammad Thahir
Pharmaceutical Journal of Indonesia Vol 5, No 2 (2020)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2020.005.02.5

Abstract

Infeksi tifoid disebabkan oleh bakteri Salmonella typhi. Infeksi dapat diobati dengan antibiotik. Namun, penggunaan antibiotik sering terjadi resistensi bakteri. Sehingga dibutuhkan alternatif pengobatan lain yang lebih efektif dalam pengobatan. Tumbuhan memiliki fungsi sebagai agen antibakteri. Gardenia merupakan salah satu tumbuhan yang diduga memiliki aktivitas antibakteri. Penelitian ini melakukan pengujian antibakteri pada ekstrak etanol daun kacapiring dan fraksinya terhadap S. typhi. Fraksinasi menggunakan metode partisi cair-cair dan uji antibakteri menggunakan metode difusi cakram dengan konsentrasi uji 20%, 25%, 30%, dan 40%. Hasil pengujian menunjukkan ekstrak, fraksi n-heksana, fraksi etil asetat semua konsentrasi dan fraksi etanol-air 20% dan 25% memiliki diameter zona hambat 0,000 mm. Pada fraksi etanol-air 30%, dan 40% memiliki diameter hambat masing-masing 7.564 ±0,081 mm dan 8.529 ±0,081 mm. Hasil statistik menunjukkan bahwa dari semua sampel uji, hanya fraksi etanol-air konsentrasi 30% dan 40% yang memiliki aktivitas antibakteri karena memiliki perbedaan yang signifikan terhadap kelompok kontrol negatif. Namun, konsentrasi 30% terhadap 40% tidak menunjukkan adanya perbedaan signifikan sehingga hasil tersebut memiliki aktivitas yang sama terhadap pertumbuhan S.typhi
The Perceived Waiting Time versus the Actual Drug Waiting Time in the Outpatient Pharmacy at Persada Hospital Setiawati, Lisa
Pharmaceutical Journal of Indonesia Vol 3, No 2 (2018)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The target of quality service for Persada Hospital outpatient pharmacy has been achieved in which the average time spent on waiting for the non-compounded drug is 11 minutes and for the compounded drug is 25 minutes. That achievement has not been able to alter the perceived length of the drug waiting time at the outpatient pharmacy evidenced by the number of losses resulting from unattended prescriptions due to the long wait. This study is aimed to find out and analyze the main factors leading to the perceived length of drug waiting time at the outpatient pharmacy and come up with alternative solutions thereto. The employed method in this study is descriptive qualitative research comprising the observation, interview and the collection of secondary data. The researchers conducted an observation on the process and flow of the prescription service of the outpatient pharmacy and proceeded to the focus group discussion to discover the main problems using Fish Bone Diagram.  The uncertain length of the wait time was found to be the major cause. To resolve the issue of the uncertainty of the waiting time, the Time Motion Study was conducted on the service response time as a follow up by providing the estimated waiting duration guide (information)  for the outpatient pharmacy. This guide comprises 3 categories of the service waiting time of 10-15 minutes, 25-45 minutes, and 25-60 minutes. 
ALIROCUMAB : MECHANISM OF ACTION, PHARMACOKINETICS, SAFETY, AND CLINICAL OUTCOMES Medina, Farah; -, Sumarno
Pharmaceutical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperlipidemia is an established risk factor for developing cardiovascular disease (CVD). The latest guideline on lipid management emphasize treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) at doses proven to reduce CVD events.  However, some of statin-treated patients have persistently elevated cardiovascular risk due to inadequate lowering of low density lipoprotein cholesterol (LDL-C) levels. In addition, adverse effects of statins may limit their tolerability and therefore the ability to attain effective doses in some patients. A new class of drugs that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) has been developed to treat hyperlipidemia.  PCSK9 inhibitors are monoclonal antibodies for proprotein convertase-subtilicin/kexin type 9 which significantly reduces the concentration of LDL-C in vivo by inhibiting the degradation of LDL receptors in hepatocytes. The introduction of the PCSK9 inhibitor was heralded a new era of intensive LDL-C reductions with LDL-C concentrations lowered below the rate that once thought possible with conventional treatments such as statins. On July 24, 2015, the United States Food and Drug Administration (FDA) approved Alirocumab, the first converged proprotein of the Subtilisin Kexin 9 (PCSK9) inhibitor. This review discusses the mechanisms of action, pharmacokinetics, safety and clinical outcomes of the Alirocumab.

Page 6 of 16 | Total Record : 155

 4   5   6   7   8 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol. 10 No. 2 (2025) Vol. 10 No. 1 (2024) Vol. 9 No. 2 (2024) Vol. 9 No. 1 (2023) Vol. 8 No. 2 (2023) Vol. 8 No. 1 (2022) Vol. 7 No. 2 (2022) Vol. 7 No. 1 (2021) Vol. 6 No. 2 (2021) Vol 6, No 1 (2020) Vol. 6 No. 1 (2020) Vol 5, No 2 (2020) Vol 5, No 1 (2019) Vol. 5 No. 1 (2019) Vol 4, No 2 (2019) Vol 4, No 1 (2018) Vol 3, No 2 (2018) Vol 3, No 1 (2017) Vol 2, No 2 (2017) Vol 2, No 1 (2016) More Issue