cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rizky Ardian Hartanto Sawal
Contact Email
rizkyardianhartanto@gmail.com
Phone
+6282242543071
Journal Mail Official
lppm.stiferasemarang@gmail.com
Editorial Address
LPPM Sekolah Tinggi Ilmu Farmasi Semarang Jl. Medoho III No. 2, Semarang
Location
Kota semarang,
Jawa tengah
INDONESIA
Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 4 No 1 (2021)" : 8 Documents clear
ANALISA DRUG RELATED PROBLEMS (DRPs) PADA PASIEN CHRONIC KIDNEY DISEASE (CKD) DI INSTALASI RAWAT INAP KLINIK SARI MEDIKA KABUPATEN SEMARANG: Analisa DRP pada pasien CKD Poppy Diah Palupi; Veronika Jayaningsih
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.57

Abstract

Drug-Related Problems(DRPs) are unwanted events affecting patients related to treatment that can interfere with the success of therapy. This study aims to determine and analyze the DRPs that occur in Chronic Kidney Disease (CKD) patients in the Sari Medika Clinic, Semarang. This research is a descriptive study with retrospective design on CKD patients by taking samples using purposive sampling technique compared to the several Guidelines Pharmacotherapy Handbook 9th edition 2015, Kidney Disease Improving Global Outcomes (KDIGO), The Renal Drug Handbook Third Edition 2009, Clinical Practice Guide & Clinical Pathway for Heart Disease, Blood Vessels 2016, and Henry Ford Health System six edition 2011. The results of the study conducted on 84 CKD patients showed there were DRPs in 66 patients: Indication without therapy (30.86%), therapy without indication (6.17%), sub-therapeutic dose (1.23%), excessive drug doses (13.58%), improper drug selection (45.68%), and patients failing to receive drugs (2.47%).
Pengaruh Pemberian Ekstrak Etanol Daun Dandang Gendis (Clinacanthus nutans (Burm F) Lindau) Terhadap Daya Analgetik Dan Gambaran Makroskopis Lambung Mencit Maria Happy Christian Klau; Rosa Juwita Hesturini
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.59

Abstract

Dandang gendis (Clinacanthus nutans (Burm f.) Lindau) is one of the plants used for as medication for various type of illness. One of its uses is as an analgesic drug. This study aims to determine the effect of dandang gendis leaf extract on the analgesic activity and macroscopic image of the stomach of white rats. This research was conducted using a completely randomized unidirectional pattern. The creature used as treatment subjects were separated into five groups consists of five individual each: group I as negative control rats who were only given 1% Na-CMC equivalent, group II as positive control was given acetosal 500mg / KgBB, group III was given extract treatment with a dose of 450mg / KgBB, group IV was treated with the extract at a dose of 500mg / KgBB, group V was given an extract treatment at a dose of 550mg / KgBB. All groups were given acetic acid induction as a mediator of pain. The results showed that the ethanol extract of Dandang Gendis leaves had an analgesic effect and was safe to use as an analgesic at a dose of 500mg / KgBB.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN JOHAR (Cassia siamea Lamk.) TERHADAP Salmonella typhi ATCC 13311 Isna Jati Asiyah Asiyah; Taufik Turahman
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.62

Abstract

Salmonella typhi are pathogenic bacterium that are source main cause of typhoid fever. The effort for the treatment of Salmonella typhi bacterial infections is using of antibiotics. However, reports stated that this bacterium having resistance to the chloramphenicol, cotrimoxazole, and amoxicillin antibiotics. Also, the using of antibiotics in the long term have seriously bad effects for the human body that causes disfunction of the liver, kidneys, and heart. The solution can be done to reduce the use of antibiotics is using natural ingredients. Plants that have potential as an antibacterial are johar (Cassia siamea Lamk). This research aims to determine antibacterial activity of ethanol extract johar leaves (Cassia siamea Lamk) against Salmonella typhi along with the value of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The test using diffusion and dilution methods. Extracts are made in 4 variaties concentration: 100%, 75%, 50%, and 25%. Phytochemical tests in this research include test the content of flavonoids, alkaloids, saponins, and tannins. The test results showed that all of the compounds contained in extract johar leaves. The results showed that the ethanol extract of johar leaves have antibacterial activity against Salmonella typhi. The concentration of ethanol extract johar leaves (Cassia siamea Lamk) 100% has the biggest inhibition zone against the growth of Salmonella typhi bacteria with an inhibition zone of 9.9 mm, while the concentration of ethanol extract johar leaves 25% has the lowest inhibition zone diameter of 6 mm. The MIC value of extract johar leaves against Salmonella typhi can not be determined, but the MBC value is 12.5%.
Formulasi Orally Disintegration Tablet (ODT) Candesartan Cilexetil Dengan Croscarmellose Sodium dan Crospovidone Sebagai Superdisintegrant Nurista Dida Ayuningtyas; Yahya Febrianto; Tutut Lutfi
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.64

Abstract

Candesartan cilexetil is a group of selective AT1 hypertension drugs (angiotensin II receptor antagonist 1). The drawback of candesartan cilexetil in conventional tablets is that it cannot be used for geriatric patients who have difficulty swallowing tablets, patients with developmental disorders of the muscle and nervous system (tremors), and in schizophrenic patients that lead to poor patient compliance, so to overcome this problem alternative dosage forms are made new namely ODT candesartan cilexetil. This study aims to determine the effect of the combination of superdesintegrant croscarmellose sodium and crospovidone on the quality test of the physical properties of tablets. Candesartan cilexetil ODT tablets bolted by direct compression method with variations in levels of superdesintegrant croscarmellose sodium and crospovidone 2: 3,5%, 2,75: 2,75%, 5: 0,5%, 4,25: 1,25 %, 3,5: 2%. Tests conducted to determine the physical quality of candesartan cilexetil ODT, namely organoleptic, weight uniformity, size uniformity, hardness, brittleness, disintegration time, wetting time and water absorption ratio. Showed an increase in the use of crospovidone (5%) and a decrease in croscarmellose sodium (0.5%) had a greater effect on the disintegration time because it could make the tablet porous when in contact with water so that it would accelerate the disintegration time of 29.167 seconds and increase the speed of wetting the tablets 25.33 seconds. The combination of superdisintegrant croscarmellose sodium and crospovidone (0.5: 5%) in formula 3 can provide physical properties that meet the best quality ODT requirements for candesartan cilexetil.
Aktivitas Antihiperkolesterolemia Ekstrak Batang Dan Akar Kemangi Hutan (Ocimum sanctum) Pada Tikus Putih Magi Melia; Maria Astriyani Adeodatus; Yohana Krisostoma Anduk Mbulang
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.70

Abstract

Hypercholesterolemic is a condition characterized by an increase in fasting Low Density Lipoprotein (LDL) levels without an increase in triglyceride levels and a decrease in HDL (High Density Lipoprotein) levels. Ocimum Sanctum is a plant that can be used as an alternative anti-hypercholesterolemic treatment because it contains alkaloids, flavonoids, tannins, saponins, triterpenoids, and eugenol. The objective of this study is to determine the anti-hypercholesterolemic activity and to determine the most effective dose of extracts of stems and roots of Ocimum sanctum, which can show anti- hypercholesterolemic effects in white rats. A total of 25 male white rats were divided into 5 groups. Group I (simvastatin 0.18 mg / 200gr BW), group II (0.5% Na CMC), groups III, IV and V (extracts of stems and roots of Ocimum sanctum with their respective doses of 50 mg / kgBW, 75 mg / kgBW and 100 mg / kgBW) and measured LDL and HDL cholesterol levels using the Direct and Indirect methods. The data obtained were analyzed using ANOVA. The results of statistical analysis showed that there was an anti-hypercholesterolemic effect at the three doses of extracts of stems and roots of Holy Basil (Ocimum Sanctum). The best dose in reducing LDL and increasing HDL compared to simvastatin is 100 mg / KgBW.
FORMULASI DAN EVALUASI HANDBODY LOTION EKSTRAK DAUN BAYAM MERAH (Amaranthus tricolor L.) DENGAN VARIASI KONSENTRASI TRIETANOLAMIN DAN ASAM STEARAT SEBAGAI EMULGATOR Yahya Febrianto; Novia Putri Santari; Wahyu Setiyaningsih
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.71

Abstract

Red spinach leaves contain flavonoids, saponins and tannins which have antioxidant potential which can be formulated into Handbody lotion. Handbody lotion is a cosmetic preparation used on the hands and body, formed from a liquid emulsion consisting of an oil phase and a water phase which is stabilized by the emulgator. The purpose of this study was to determine the effect of triethanolamine and stearic acid concentrations as emulsifiers and to determine the comparison of variations in the concentrations of triethanolamine and stearic acid which meet the physical evaluation requirements of handbody lotion preparations. The research method used is experimental research with data analysis using one way ANOVA. The results showed that the red spinach leaf extract handbody lotion was homogeneous and had a pink color, semi-solid shape and a distinctive smell of strawberry. It has a pH range of 7.30-7.42, a range of values for the spreadability of 5.20-6.17 cm, a range of values for adhesion from 4.42-6.27 seconds. The concentrations of triethanolamine and stearic acid as emulgators had a significant effect on the physical evaluation of the red spinach leaf extract handbody lotion including the pH test, spreadability and adhesion with a significance of p> 0.05. The comparison of the formula variation triethanolamine emulgator: stearic acid that meets the test requirements is formula 1 (2%: 7%), formula 2 (2.5%: 6.5%), formula 3 (3%: 6%), formula 4 ( 3.5%: 5.5%), formula 5 (4%: 5%).
PENGARUH PERBEDAAN SUHU PENGERINGAN GRANUL (40°C,50°C,60°C) TERHADAP SIFAT FISIK TABLET PARACETAMOL Agustina Putri Pitarisa Sudarsono; Masithoh Nur; Yahya Febrianto
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.72

Abstract

The most widely consumed analgesic and antipyretic drug by the community is paracetamol. One of the dosage forms is tablets. The manufacture of tablet preparations must go through various processes, one of which is drying. Things that need to be considered in the drying process include the temperature used for drying. This study aims to determine the difference in drying temperature of the granules on the physical properties of paracetamol tablets. This research uses a comparative type of research, which is to see the effect of differences in granule drying temperature on the physical properties of paracetamol tablets. Tablets were made by wet granulation method which consisted of 3 formulas. The formula used is the same, the only difference is the temperature. The drying temperatures used were 40°C, 50°C, 60°C. Parameters tested for paracetamol tablets include: organoleptic (shape, color, odor), weight uniformity, hardness, friability and disintegration time. The average weight uniformity test results are between 508.65-517 ± 0.48-1.88 mg . The results of the tablet hardness test were between 5.04-7.3 ± 0.29–0.43 kg. The results of the tablet friability test were between 0.48-0.68 ± 0.042-0.13%. The results of the test the time between tablet disintegration was between 4.17-7.07 ± 5.03-12.01 minutes. The results of the statistical test of the granules and the physical properties of the tablets showed that the data were normally distributed with a sign value. > 0.05, in the homogeneity test the data is homogeneous with the sign value. > 0.05. The results of the ANOVA One-Way test obtained sign results. <0.05, which means that there is a significant difference between the formulas.
PENETAPAN KADAR VITAMIN C PADA BUAH NANAS KALENG (Ananas comocus L.) DENGAN METODE SPEKTROFOTOMETRI UV-Vis DAN TITRASI IODIMETRI Ruwista, Anista; Sugiyo, Warlan; Mahesa, Sandi
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitamin C has an important role in the human body, namely carrying out its functions such as in the synthesis of collagen, the formation of carnitine, is involved in cholesterol metabolism, become bile acids, and plays an important role in the formation of the neurotransmitter norepinephrine. Vitamin C intake must be obtained from outside the body because this vitamin cannot be synthesized in the body through the biosynthetic pathway. Pineapple fruit is one of the fruits that contain vitamin C. The purpose of this study was to analyze the levels of vitamin C in canned pineapples for which the result of vitamin C on the AKB value on the packaging label were not known using UV-Vis spectrophotometry and iodimetric titration. The method used in the qualitative analysis of vitamin C is identification by color raction using Fehling A and B reagents and KMnO4 reagent. Quantitative analysis of vitamin C using the UV-Vis spectrophotometry method with a wavelength of 0,0031 % while the results from the iodimetric titration methode obtained an average % of vitamin C levels from canned pineapple samples of 0,050 % w/w.

Page 1 of 1 | Total Record : 8

 1 

Filter by Year

2021 2021


Reset
Filter By Issues
All Issue Vol 8 No 1 (2025) Vol 7 No 2 (2024) Vol 7 No 1 (2024) Vol 6 No 2 (2023) Vol 6 No 1 (2023) Vol 5 No 2 (2022) Vol 5 No 1 (2022) Vol 4 No 2 (2021) Vol 4 No 1 (2021) Vol 3 No 2 (2020) Vol 3 No 1 (2020) Vol 2 No 2 (2019) Vol 2 No 1 (2019) Vol 1 No 2 (2018) Vol 1 No 1 (2018) More Issue