Article Per Year (5 Year)
p-Index From 2020 - 2025
2.133
P-Index
This Author published in this journals
All Journal Majalah Farmaseutik Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian Masyarakat (ABDIRA) Duta Pharma Journal Jurnal Ilmiah Kesehatan Journal of Biotropical Research and Nature Technology
Sandi Mahesa Yudhantara
Unknown Affiliation
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
FORMULASI KRIM EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana Linn.) SEBAGAI ANTIOKSIDAN MENGGUNAKAN VARIASI ASAM STEARAT DAN TRIETANOLAMIN Aditya Nuryanto Saputra; Sandi Mahesa Yudhantara
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kulit buah manggis merupakan suatu bagian tanaman yang terbukti memiliki aktivitas antioksidan karena memiliki senyawa kandungan flavonoid di dalamnya. Tujuan dari penelitian ini untuk mengetahui pengaruh variasi emulgator (asam stearat dan TEA) dalam sediaan krim ektrak kulit buah manggis terhadap sifat fisik dan aktivitas antioksidanya, serta mengetahui perbandingan emulgator yang paling baik. Ekstrak etanolik kulit buah manggis diperoleh menggunakan metode maserasi dengan etanol 70%. Krim dibuat menggunakan 5 formula dimana formula 1, 2, dan 3 masing-masing mengandung perbandingan asam stearat dan trietanolami sebanyak 10:2, 15:3, dan 20:4 dan formula 4 sebagaI kontrol negatif serta formula 5 sebagai kontrol positif dengan penambahan 1% rutin. Evaluasi sediaan dilakukan dengan mengamati sifat fisik yaitu : Homogenitas, viskositas, daya lekat,daya sebar, dan uji pH. Uji aktivitas antioksidan dilakukan dengan metode DPPH. Hasil penelitian menunjukan bahwa emulgator (asam stearat dan trietanolamin) mempengaruhi sifat fisik dari krim, semakin tinggi konsentrasi perbandingan, viskositas dan daya lekat semakin besar dan daya sebar semakin kecil, akan tetapi tidak mempengaruhi Aktivitas antioksidannya. Dalam formula 1 dengan perbandingan emulgator asam stearat dan trietanolamine 10:2 merupakan formula yang terbaik.
FORMULASI PATCH BUCCAL MUCOADHESIVE NIFEDIPIN MENGGUNAKAN KOMBINASI MATRIKS CARBOPOL® 940P DAN HIDROKSI PROPIL METIL SELULOSA (HPMC) K15M Sandi Mahesa Yudhantara; Yahya Febrianto
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Nifedipin merupakan kelompok dari antagonis kalsium (Calcium Entry Blockers) yang digunakan untuk terapi hipertensi yang mempunyai t½ 2-6 jam. Nifedipin mengalami first pass metabolism pada pemakaian oral, oleh karena itu dibuat penghantaran obat buccal dengan menggunakan sistem mucoadhesive yang dapat meningkatkan bioavailabilitas dan efektifitas nifedipin. Penelitian ini bertujuan mengetahui pengaruh konsentrasi Carbopol® 940P dan HPMC K15M terhadap sifat fisik patch, daya lekat dan pelepasan patch buccal mucoadhesive nifedipin. Penelitian dilakukan menggunakan lima formula dengan variasi konsentrasi Carbopol® 940P dan HPMC K15M. Pengujian dilakukan terhadap sifat fisik patch, kekuatan mucoadhesive dan pelepasan obat. Analisis terhadap pelepasan obat ditetapkan dengan apparatus II USP model padlle dengan menggunakan 500 mL medium buffer fosfat pH 6,8 pada kecepatan pengadukan 50 rpm, suhu 37±0,5° C selama 6 jam. Hasil dari penelitian menunjukan bahwa variasi konsentrasi Carbopol® 940P dan HPMC K15M berpengaruh terhadap swelling index, kekuatan daya lekat dan profil pelepasan patch buccal mucoadhesive nifedipin. Peningkatan proporsi HPMC K15M akan meningkatkan presentase swelling index, tetapi menurunkan jumlah obat yang dilepaskan. Peningkatan proporsi Carbopol® 940P akan meningkatkan durasi daya lekat patch. Proporsi kombinasi Carbopol® 940P 30 mg dan HPMC K15M 40 mg menghasilkan durasi daya lekat patch terlama.
Workshop Pembuatan Minyak Telon margareta retno; Kamilla Sekar; Sandy Mahesa Yudhantara
Jurnal Pengabdian Masyarakat (abdira) Vol 2, No 2 (2022): Abdira, April
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i2.147

Abstract

Telon oil is a product from Indonesia that has been known for a long time which can be developed to be made independently by the community. Objective provide an introduction to herbal plants that can be applied in the community. The approach method used is to provide an explanation of the scientific name or Latin name for herbal plants in Indonesia to class XII students of SMK Bhakti Kencana Kendal. Furthermore, an introduction to the types of herbal plants and herbal chemicals that will be used in the manufacture of telon oil is carried out, followed by formulating the composition of telon oil which will be made with fennel oil, eucalyptus oil and coconut oil. The result of the activity is that students are interested and able to apply pharmacognosy science and herbal chemicals into dosage forms that are beneficial to health, namely the manufacture of telon oil
Penyuluhan Ibu-Ibu PKK/Dawis Dan Guru SMA/SMK “The Miracle Of Antioxidant Therapy For The Degenerative Disease Prevention” Metrikana Novembrina; Nurista Dida Ayuningtyas; Ferika Indrasari; Sandy Mahesa
Jurnal Pengabdian Masyarakat (abdira) Vol 2, No 2 (2022): Abdira, April
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i2.148

Abstract

Oxidative stress plays an important role in the pathophysiology of the aging process and various degenerative diseases. Antioxidants are needed by the body to overcome and prevent oxidative stress. Plants native to Indonesia contain lots of antioxidants. The purpose of providing information or knowledge to PKK/Dawis mothers and SMA/SMK teachers about the efficacy of antioxidant therapy in preventing degenerative diseases. The method used is interactive online discussion. The 25 participants were first given a questionnaire to measure the level of participants' knowledge about the efficacy of antioxidants in the prevention of degenerative diseases. After that, the participants were given material about the efficacy of antioxidants in preventing degenerative diseases. After the activity of delivering the material, the participants were again given a questionnaire to measure the level of understanding related to the material that had been delivered. The results of the implementation of the activities and the results of the questionnaire based on the test. The results of the Mann-Whitney test showed that there was an average difference before and after participating in the training.
Peningkatan Mutu Tanaman Obat Keluarga (TOGA) untuk Meningkatkan Imunitasi pada Masa Pandemi Covid-19 di Desa Kalisegoro Kecamatan Gunungpati Kota Semarang Atalia Tamo Ina Bulu; Ayu Ina Solichah; Wahyu Setiyaningsih; Sandi Mahesa
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 2, No 3 (2022): Abdira, Juli
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i3.188

Abstract

TOGA is a restorative plant that can be used locally. This plant, if used and applied appropriately and accurately, will have an impact on the surrounding environment, especially during the COVID-19 pandemic. A good use of TOGA can directly affect a person's endurance. The aim is to provide an understanding to the public about TOGA (Family Medicinal Plants) which can improve health in the community. The implementation of community service activities is carried out using counseling and demonstration methods. The place used is a resident's house in the village of RW 2, Kalisegoro Village, Gunungpati District, Semarang City. The activity was held on May 15, 2022 with 50 female participants. Results Community service activities went well and smoothly starting from licensing to the implementation process of counseling and closing. Conclusion Participants get direct benefits on how to apply TOGA (Family Medicinal Plants) to increase immunity.
Optimisation and Formulation of Serum Gel Base with Variation of Gelling Agent I Nyoman Sudyana; Shesanti Citra Riana; Rokiy Alfanaar; Sudarman Rahman; Awalul Fatiqin; Mu’afa Purwa Arsana; Thathit Suprayogi; Yohanes Edi Gunawan; Sandi Mahesa Yudhantara; Yahya Febrianto
Jurnal Ilmiah Kesehatan Vol. 17 No. 1 (2024): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/jiks.v17i1.1774

Abstract

The skin is the largest organ on the human body that plays a vital role in protecting the body from environmental aggressions and maintaining internal balance, however, the natural aging process and exposure to external factors can cause various skin problems, including loss of elasticity, fine lines, and hyperpigmentation. To address these issues, the development of skincare products such as anti-aging gels is important. The aim of this study was to optimise the base of the anti-aging gel formulation by considering the selection of gelling agents with appropriate variations.The research method was conducted by obtaining five different formulas using a combination of gelling agents Carbopol and CMC Na with variations of Formula 1 which is 1% b/v carbopol with 2% b/v CMC Na, Formula 2 which is 1.25% b/v carbopol with 1.75% b/v CMC Na, Formula 3 which is 1.5% b/v carbopol with 1.5% b/v CMC Na, Formula 4 which is 1.75% b/v carbopol with 1.25% b/v CMC Na and Formula 5 which is 2% b/v carbopol with 1% b/v CMC Na . Physical testing was conducted to evaluate the formulation characteristics, including colourimetry, pH, viscosity, adhesion, and spreadability, comparisons between different formulas were conducted to determine the best base formula. The results showed that formula 5 with the ratio of gelling agent carbomer 2% b/v and CMC Na 1% b/v, is the optimal formula supported by physical testing, namely the metric choleretic test is good, homogeneous, pH 6.237 in accordance with the pH range of the skin, the Viscosity test has the highest viscosity of 148.34 d.Pas, the longest adhesion test with an adhesion time of 9.535 seconds, allowing the active substance to more easily penetrate the skin and be absorbed.
Pengaruh Penambahan Konsentrasi Ekstrak Perasan Lemon (Citrus limon (L.) Terhadap Aktivitas Antioksidan Pada Minuman Teh Bunga Telang (Clitoria ternatea L.) Priamsari, Margareta Retno; Subarjo, Nonik Triliana Warianti; Yudhantara, Sandi Mahesa
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p56-66

Abstract

Herbal tea is a drink made from leaves or flowers that are processed or processed as is done when making tea. A plant that is useful as herbal tea is the butterfly pea flowers (Clitoria ternatea L). Butterfly pea flowers are a safe and natural source of antioxidants. Lemon fruit (Citrus limon (L.) is another plant that is useful as an antioxidant besides butterfly pea flowers. The high nutritional content of lemon fruit, including vitamin C as an antioxidant. Antioxidants are important substances for  the body to maintain human health. This study aims to determine the effect of adding lemon juice extract concentration on antioxidant activity in butterfly pea flower tea drinks. Butterfly pea flower tea is made by brewing at a temperature of 70⁰C for 5 minutes. Lemon juice is made by squeezing using a lemon squeezer. The concentrations used in lemon juice are 25, 50, 100, 200, and 400 ppm. Testing was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method and the antioxidant potential was seen from the percentage inhibition value and IC50 using UV-Vis spectrophotometric absorbance measurements. The results in this study were obtained using a linear regression equation. Lemon juice extract on butterfly pea flower tea has an IC50 value of 60.792 ppm, while the value IC50 vitamin C is 3,160 ppm. Lemon juice extract on butterfly pea flower tea is classified as a strong antioxidant. This shows that the addition of lemon juice extract to butterfly pea flower tea has an effect on antioxidant activity. The SPSS results of antioxidant activity in butterfly pea flower tea with the addition of lemon juice extract showed a significant difference with the antioxidant activity of vitamin C namely 0,001 (p<0,05).
PERBANDINGAN KUALITAS KITOSAN PADA LIMBAH CANGKANG RAJUNGAN (Portunus pelagicus) REBUS DAN MENTAH DITINJAU DARI % N-DEASETILASI Yudhantara, Sandi Mahesa; Sugiyo, Warlan; Buanasari, Buanasari
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p200-204

Abstract

Chitosan is chitin that is deacetylated as much as possible whose quality can be measured by the value of % N-Deacetylated. Chitosan has the potential to be used in various industrial and health fields, so its needs are influenced by its quality standards. Crab shells, which are one of the sources of chitosan-making materials, have not yet been fully utilized, especially shells from consumption waste (restaurants). Researchers intend to test Chitosan derived from raw and cooked crab shells to compare their quality. The process of making chitosan goes through three main stages, namely deproteination, demineralization and deacetylation, while at the analysis stage using the base line method using an FT-IR spectrophotometer. As a result, the %N-Deacetylated price was obtained at 74.8640% in the raw crab shell sample (A), while in the cooked crab shell sample (B), the %N-deacetylation price was 68.9313 %. The difference between sample A and sample B is only 5.9327%.
DETERMINATION OF PIPERINE ISOLATE FROM JAVA CHILLI (Piper Retroofactum Vahl.) Using the High Performance Liquid Chromatography (HPLC) method Christina, Odilia Dea; Mahesa, Sandi; Elsa, Limpat
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p104-108

Abstract

Java chili fruit (Piper Retroofactum Vahl.) can be used in concoctions to treat fever, flatulence, heartburn, vomiting, overcome digestive disorders, stimulate appetite. In the traditional medicine industry in Indonesia, Java chili is one of the most needed raw materials, 9.5% of the total simplicia. Javanese chilies are round and dark green to brown in color. The content of the main secondary metabolites in chili plants is piperine, pipernaline, guineensine and essential oils. The purpose of this study was to determine the piperine content isolated from Java chili using the HPLC method. The column used is a C-18 type column, 2489 UV/Visible detector light. The mobile phase used was Acetonitrile : Methanol : Aquabidest (65:5:30) v/v. The isolation results obtained yield of 0.20% piperine isolate has a spicy taste, needle-shaped blackish brown color, difficult to dissolve in water and easily soluble in ethanol.From the results of the assay, the piperine content data was obtained at 37.48%
Penetapan Kadar Boraks Pada Makanan Yang Beredar Di Pasar Semarang Timur Menggunakan Metode Spektrofotometri UV-Vis Christina, Odilia Dea; Mahesa, Sandi; Wirawati, Ninik
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p168-173

Abstract

Borax (Sodium tetraborate) is a dangerous preservative that is not permitted to be used as a food ingredient. Borax is often misused to preserve various foods such as meatballs, wet noodles, banana molen, dumplings, lontong, ketupat, dumplings. In large quantities borax causes fever, anuria, coma, central nervous system damage, cyanosis, kidney damage, anemia, vomiting, diarrhea. The aim of this research is to determine borax levels in frequently consumed foods circulating in the East Semarang market. The food samples studied were meatballs, wet noodles and crackers sold at the East Semarang Market. Qualitative sample testing is organoleptic testing and TLC. In quantitative testing by determining levels using UV-Vis spectrophotometry using ethanol solvent. A total of 3 meatball samples, 1 noodle sample contained Borax. The borax levels in the meatball samples were B1 0.0052%, B2 0.0045%, B3 0.0046%. And the borax content in the wet noodle sample was M3 0.0045%.
Co-Authors Aditya Nuryanto Saputra Alfanaar, Rokiy Atalia Tamo Ina Bulu Ayu Ina Solichah Ayuningtyas, Nurista Dida Buanasari, Buanasari Christina , Odilea Dea Elsa, Limpat Fatiqin, Awalul Ferika Indrasari Fitri Hastuti I Nyoman, Sudyana, Kamilla Sekar margareta retno Margareta Retno Priamsari Metrikana Novembrina Muadifah, Afidatul Mu’afa Purwa Arsana Odilia Dea Christina Putri, Amalia Eka Rahman, Sudarman Rahmawati, Desti Linda Dwi Rohmawati, Lili Ruwista, Anista Shesanti Citra Riana Subarjo, Nonik Triliana Warianti Thathit Suprayogi Wahyu Setiyaningsih Warlan Sugiyo Wirawati, Ninik Yahya Febrianto Yohanes Edi Gunawan