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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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FORMULASI SEDIAAN GEL SCRUB WAJAH SERBUK BIJI KOPI ARABIKA (Coffee arabica) DENGAN KONSENTRASI KARBOPOL 940 SEBAGAI GELLING AGENT Natasha Faruqi Andrian Putri; Desy Nawangsari; Sunarti Sunarti
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p68-73

Abstract

ABSTRACT Coffee is a plant that is rich in benefits. Arabica coffee beans contain antioxidants that can provide benefits, one of which is preventing cell damage due to exposure to free radicals. Arabica coffee is formulated in the form of a gel scrub with the gelling agent carbopol 940. This study aims to determine the best concentration of gelling agent on the physical properties and stability of the Arabica coffee bean gel scrub and when used it causes irritation or not. Pure experimental research method to determine the effect of certain treatments by comparing with the control group that was not given treatment. Evaluation of gel scrub preparations included evaluation of the physical quality of the preparation and irritation test on 3 rabbits. The results of the evaluation of the preparations showed that all gel scrub preparations were in the form of a gel with black granules, distinctive smell, homogeneous, stable during 6 cycles of storage, pH value (4.5-7.8), adhesion (2-300 seconds), spreadability (5-7 cm) and viscosity (2000-4000 cp), irritation test in rabbits caused a slight irritating skin reaction. The results of the statistical test with the one way anova test showed that there was a significant difference between the formulas with a significance value (p < 0.05). However, the stock can still be said to be stable because it is still in the range of requirements. In conclusion, the gel scrub produced has good physical characteristics and causes a slight irritation of the skin reaction. Arabica coffee bean powder can be formulated as a gel scrub preparation which has good physical characteristics in formula IV with a concentration of carbopol 940 2%. and stable at 6 cycles of storage.
HUBUNGAN KADAR GULA DARAH DENGAN TEKANAN DARAH PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS SOKARAJA 1 Habib Fatah Roniawan; Peppy Octaviani DM; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p74-78

Abstract

Type 2 Diabetes Mellitus is a condition when blood glucose in the body is not controlled due to impaired sensitivity of pancreatic cells to produce the hormone insulin. The World Health Organization (WHO) states that there are 422 million people in the world who suffer from diabetes mellitus, an increase of about 8.5% in the adult population and an estimated 2.2 million deaths. The purpose of this study was to determine the characteristics of patients with type 2 diabetes at the Sokaraja 1 Health Center and to find out how the relationship between blood sugar levels and blood pressure of type 2 diabetes mellitus patients at the Sokaraja 1 Health Center. The method used is observational analysis in perspective with a cross sectional approach. The results of this study using the Pearson correlation test showed that 46 patients were majority aged 51 to 60 (39.1%), male 13 patients (28.3%) female 33 patients (711.7%), long time to diagnose diabetes mellitus greater than 1-4 years (73.9%) and there is a relationship between blood sugar levels and blood pressure with a significance value of 0.375.
UJI ANALGESIK KOMBINASI EKSTRAK ETANOL DAUN BLIMBING WULUH (Averrhoa bilimbi L.) DAN DAUN KELOR (Moringae Oliferae L.) PADA MENCIT JANTAN GALUR Swiss Webster Devi Amalila; Galih Samodra; Adita Silvia Febriana
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p91-97

Abstract

Analgesic drugs are used to reduce and relieve pain without loss of consciousness. The plants used as analgesics were Moringa leaves (Moringae Oliferae L.) and starfruit leaves (Averrhoa Bilimbi L.), because these two plants showed the presence of compounds such as flavonoids, alkaloids, saponins, and tannins. The aim of the study was to determine the analgesic effect. In Moringa leaf and star fruit leaf male Swiss Webster mice, the combined dose of 2:2 and 800 mg of Moringa oleifera extract and 1000 mg of star fruit extract were reduced in each rat. The method used to test the analgesic activity is the hot plate method. The responses of mice before administration and 0, 15, 30, 45, and 60 minutes after administration were observed, and the data were analyzed by ANOVA and LSD tests. Moringa leaf extract and belimbing wuluh leaf extract at a combined dose of 1:1, 2:2, 2:1 had analgesic effect on male Swiss Webster strain male mice. The three best combinations that gave analgesic effect were at a combination of 2:2 doses and 800mg and 1000mg doses, the average tensile protection results obtained were 0%, 65; 06%, 13; 65%, -15.29%, 18; 33%.
FAKTOR RESIKO KEJADIAN DIABETES MELITUS TIPE 2 DI PUSKESMAS PURWOKERTO SELATAN KABUPATEN BANYUMAS Fasikhatul Qomariyah; Peppy Octaviani DM; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p79-84

Abstract

Diabetes Mellitus (DM) type 2 is a metabolic disease characterized by an increase in blood sugar levels caused by a decrease in insulin secretion or insulin function disorders.. The purpose of this study was to determine the risk factors for type 2 diabetes melitus based on age, gender, obesity, physical activity, smoking habits in the South Purwokerto Public Health Center, Banyumas Regency. The method used is quqntitative prospectively using a correlation description design or design with a cross sectional approach. The results of this study using the charactristics of the respondents showed that of the 64 patients the majority of the respondents were aged in the adult category (20-60 years) as many as 34 people (53,1%) and the again in the elderly category (> 60 years) as many as 30 people (46,9%) and none of the respondents wre in the adolescent category (11-19 yeras). Most of the respondents were female as many as 48 people (75,0%) while 26 while the male sex was 16 people (25,0%) 38 respondents (59,6%) were not obese, while 26 respondents were obese (40,6%). Physical activity of category as many as 26 people (40,6%) modrate physical activity as many 20 people (68,8%). Most of the respondents who smoked wre 23 people (35,9%) and there was a relationship between the risk factors of age, gender, obesity, physical activity, smoking habit with type 2 diabetes melitus.
Tingkat Pengetahuan Dan Sikap Pelajar Di Smk Kerabat Kita Bumiayu Mengenai Kasus Penyalahgunaan Obat Dengan Metode Peer Education Sebagai Upaya Apoteker Dalam Promosi Kesehatan Radesty Citra Agmalia; Peppy Octaviani DM; Sunarti Sunarti
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p85-90

Abstract

Drug abuse is estimated to affect 35 million people globally and requires treatment. Seeing the magnitude of the influence of group membership for adolescents, a health promotion strategy with the right method is needed, so that the information received can increase students' knowledge and attitudes regarding drug abuse cases. The purpose of this study was to determine the effect of the peer education method on the level of knowledge and attitudes of students regarding drug abuse cases. This type of research is descriptive with a cross sectional approach. The population in this study are students SMK Kerabat Kita Bumiayu. The research sample was 94 respondents. The research instrument used was a questionnaire. Conclusions based on univariate analysis, the majority of students there are 68 male (72.3%), female students 26 (27.7%) and students living with parents 54 (57.4%) the status of living in boarding houses is 37 (39.4%) and the status of living with parents is 3 (3.2%). The results showed that the peer education method had an effect on students' knowledge and attitudes regarding drug abuse cases (P = 0.0000). In conclusion, there is an influence of the peer education method on the knowledge and attitudes of students at SMK Kerabat Kita Bumiayu.
Formulasi Sediaan Pasta Gigi Gel Minyak Atsiri Daun Jeruk Nipis (Citrus Aurantifolia) Dengan Variasi Konsentrasi Carbomer 940 Sebagai Basis Gelling Agent Nurista Dida Ayuningtyas; Agustina Putri Pitarisa Sudarsono; Anastasiya Sisca Yuswanti
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p98-103

Abstract

Background : Lime leaves contain flavonoids, tannins, and saponins. This content is known to have activity as an antibacterial and protective of gums and teeth. Based on these activities, lime leaves can be developed as an active ingredient in gel toothpaste preparations. In the manufacture of gel toothpaste, the component that plays an important role is the gelling agent. Purpose: In this study, a variation of the gelling agent Carbomer 940 will be used to make a gel toothpaste with lime leaf extract. Methods: The independent variable used is Carbomer 940 with a variation of 3 formulas, namely 0.6%; 1.2%; and 1.8%. The evaluations carried out on gel toothpaste were organoleptic, homogeneity, pH, adhesion, spreadability and pH. Data analysis was carried out with SPSS software to see the differences between each formula. Results: The results showed that the formula 1-3 was homogeneous with a clear, homogeneous color, and a characteristic smell of menthol with a pH range of 5.85-7.49; spreading area 20.60-29.91 cm2, adhesion 6.01-35.1 seconds. The results of statistical tests with one-way ANOVA obtained a significant difference between each formula.
Profil Pengelolaan dan Biaya Obat Tidak Digunakan pada Mahasiswa Farmasi Universitas Sari Mulia Banjarmasin Juliana Safitri Kamah; Melviani Melviani; Eirene E.M Gaghauna
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p1-7

Abstract

Introduction: Health care as a whole is based on spending on drugs. Use of drugs that are not optimal also arise which will cause losses or cost losses due to drugs that are unusedObjective: Find the management of drugs and cost of unused drugs for Pharmacy students at Sari Mulia University, Banjarmasin. Methods: Research method used a survey type. Sampling technique used purposive sampling method with a total sample of 81 respondents. Data were analyzed using Microsoft Excel program. Results: Drug management for pharmacy students, most students get drugs at pharmacies, have paid attention to drug labels or brochures when using drugs, store drugs in place protected from sunlight, and dispose of drugs when drugs have expired. Drug costs based on the highest therapeutic class, namely analgesic, antipyretic, and anti-inflammatory therapy classes, namely Rp. 182,501. Reason the drug was unused was because it was cured at a cost of Rp. 289,038,-. The method or plan managing unused drugs is plan dispose of them in the trash a cost of Rp. 302,843 of the total cost obtained is Rp. 646,695,-. Conclusion: Conclusion of study is most of the students get their drugs at pharmacies, have paid attention to drug labels or brochures when using drugs, store drugs in a place protected from sunlight, and dispose of drugs when the drug has expired. Cost of drugs that are unused in this study is Rp. 646,695,- . Keywords: Drug Management, Cost, and Drug Unused
OPTIMASI FORMULASI FAST DISINTEGRATING TABLET (FDT) DIFENHIDRAMIN HCL DENGAN AC-DI-SOL SEBAGAI SUPERDISINTEGRANT DAN MANITOL SEBAGAI BAHAN PENGISI Raihanah Raihanah; Noval Noval; Agustina Hotma Uli Tumanggor
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p8-19

Abstract

Diphenhydramine HCl is a drug that is used to reduce and block the effects of histamine in the body, to speed up the action of the drug and increase its effect, especially for pediatric and elderly patients. FDT is made with the active ingredient Diphenhydramine HCl combined with superdisintegrant Ac-Di-Sol and Mannitol as filler. To determine the effect of the optimal combination of Ac-Di-Sol and Mannitol in the FDT Diphenhydramine HCl formulation. This study uses a Quasi Experiment Design method with a Non Equivalent Control Group design. FDT was made with 5 different Ac-Di-sol and Mannitol formulations by direct compression method and then evaluated for moisture content, flow rate, angle of repose, compressibility, uniformity of size, uniformity of weight, friability, hardness, disintegration time, disintegration time and wetting time. The results of the research are descriptive analysis and Simplex Lattice Design using Software Design Expert Version 10.0. Evaluation of the physical properties of the powders showed that all formulations met the requirements of moisture content, angle of repose and compressibility, while the flow properties of all formulations did not meet the requirements. The results of the evaluation of the physical properties of FDT produced a clean white color, odorless, with a slightly bitter taste. All FDT formulations met the requirements for uniformity of weight, friability, hardness, disintegration time, and disintegration time, while the results of the uniformity of size and wetting time of all formulations did not meet the requirements. The combination of the concentration ratio of Ac-Di-Sol and Mannitol affects the aspects of brittleness, hardness, disintegration time and wetting time. Formulation 4 is the optimal formulation with the composition of Ac-Di-Sol 12.5 mg and Mannitol 7.5 mg with a desirability value of 0.953.
Floating System Tablet Ekstrak Daun Pepaya (Carica papaya L.) Kombinasi Matriks HPMC K4M dan Na CMC Martinah Martinah; Noval Noval
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p20-29

Abstract

Floating system tablets combination of HPMC K4M and Na matrix. CMC and the active substance of papaya leaf extract (Carica papaya L.), by floating in the stomach for a long time and can release the active substance from papaya leaf extract to treat ulcers in the stomach for a certain time to improve its working mechanism. This study used an experimental method with bivariate analysis. Tablet Floating system was made by direct compression method and evaluation includes evaluation of powder, evaluation of physical properties of tablets and evaluation of floating system made in five formulations with different concentrations of HPMC K4M and Na matrix. CMC. The evaluation results of powder, LOD, flow properties, and quiet angle in all formulations met the requirements, while the compressibility test at F4 did not meet the requirements. The resulting tablet has a brown color, is bitter, has a characteristic smell of extract, and is elongated in shape. Tablets in all formulations have uniformity of weight according to the requirements. The results of the hardness test showed that none of the formulations met the requirements, while the friability test of all formulations met the requirements. In the lag time test, all formulations meet the requirements of 1 second, while the floating time results show that all formulations do not meet the requirements. The evaluation results show that the optimal formulation is F5. Combination of HPMC K4M and Na matrix. CMC affects the evaluation of LOD, quiet angle, compressibility, friability, hardness, and floating time. Keywords : Papaya leaf extract (Carica papaya L.), floating system tablets, HPMC K4M and Na.CMC
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PENGELOLAAN OBAT MANDIRI DI MASYARAKAT KELURAHAN BELIMBING RT.12 KABUPATEN TABALONG Fatimatuzahra Fatimatuzahra; Melviani Melviani
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p30-36

Abstract

Introduction: Efficient drug management greatly determines the success of the overall management, to avoid inaccurate and irrational calculation of drug requirements so that appropriate drug management is necessary. Drug management aims to ensure the availability of good quality drugs, Purpose : The general purpose of this study was to determine the factors associated with self-administration of drugs in the community in Belimbing Village, rt 12, Murung Pudak District, Tabalong Regency.Method : The method used in this research is using the Cross Sectional method. The sampling technique used in this research is purposive sampling. Data analysis using Spearman Rho test..Results : The results obtained from 70 respondents to self-administration of drugs have a sufficient value (91.4%). There is no relationship between drug management and 3 factors, namely education, income, and information that have a value (p-value > 0.05)Conclusion :Based on the research that has been done, the results show that there is no significant relationship between factors and self-medication management

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