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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Apotek Kimia Farma X Kecamatan Banjarmasin Timur Nor Ellisa; Mustaqimah Mustaqimah
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p37-40

Abstract

Background : The quality of service in the health sector is health service that lead to patient satisfaction. Satisfaction is very important in healt service because it can measure the quality of health services. Objective : The purpose of this study was to observe and identify the level of patient satisfaction with pharmaceutical service at Kimia Farma X Pharmacy, East Banjarmasin District. Methods : This type of research is observational research with descriptive research methods. Descriptive research is research carried out with the aim of making a description or description of a situation objectively with a cross sectional study with a total of 32 respondents. Result : Based on the results of the study, it was found that 11 of the 20 statements submitted to respondents were at the level of satisfaction "Quite Satisfied" with a percentage of 55%. Conclusion : Based on the results of the research that has been done, it can be concluded that the level of patient satisfaction with the quality of pharmaceutical service at Kimia Farma Pharmacy, East Banjarmasin District is Quite Satisfied.
Pengembangan Formula Spray Gel Ekstrak Etanol Daun Komba- Komba (Eupatorim Odoratum) Sebagai Kandidat Repellent Michrun Nisa; Irmayani Irmayani; Sweety Dwy Sarty
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p41-45

Abstract

Repellent is an insecticide that is used to protect the skin from mosquito bites. Spray gel is a form of developing gel preparations applied through a pump spray. Ethanol extract of komba – komba (Eupatorium odoratum) leaves with a concentration of 7% has mosquito repellent activity because it contains compounds that are toxic to mosquitoes. 100% protection at the 1st hour followed by 73% at the 6th hour. This study aims to formulate the ethanolic extract of komba-komba leaves in the form of a spray gel with a variation of the gelling agent carbopol 940: HPMC, namely, 0.5%: 0.25%; 1% : 0.5% ; and 1.5% : 0.75%. Physical evaluation of the preparation includes organoleptic test, pH test, viscosity test, spray pattern test and dry time. The evaluation results show that formula 2 meets the param eters of the physical properties of the spray gel preparation
Evaluasi Sifat Fisik Dan Uji Iritasi Sediaan Sabun Wajah Ekstrak Etanol Biji Salak Pondoh (Salacca zalacca (Gaert.) Voss) Rafi Firman Khaqiqi; Desy Nawangsari; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p46-52

Abstract

One of the beneficial parts in salak pondoh is the seeds. Salak pondoh seeds have antioxidant activity that can counteract free radicals. This potential can be utilized in the formulation of facial cleansing cosmetics. The purpose of this study was to formulate the ethanolic extract of salak pondoh seeds into a facial soap, then tested the physical properties and tested for acute irritation. The ethanol extract of salak pondoh seeds was formulated in several concentrations, namely 1%, 3% and 5%. Evaluation of the physical properties includes organoleptic tests, pH tests, foaming tests, viscosity tests and spreadability tests. The acute dermal irritation test used a rabbit. The data obtained were statistically tested using the one-way ANOVA method to determine the difference between each formula. The results is a brown liquid facial soap (with extract) and white (without extract). Evaluation of the physical properties resulted pH and foaming tests according to standards but viscosity and spreadability did not match. The non-fulfillment of the viscosity standards and the spreadability caused by the Viscosity Modifier (NaCl) in the formula needs to be adjusted further. This facial soap is moderately irritant to animal skin. The irritation is thought to occur because Sodium Lauryl Sulfate (SLS) in the formula can affect erythema and edema in the test animals. Keywords: salak pondoh seeds, facial soap, physical properties, irritation test
Formulasi dan Uji Sifat Fisik Sediaan Masker Wajah Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L.)) Yeni Pratiwi; Desy Nawangsari; Dina Febrina
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p53-59

Abstract

Mangga merupakan tanaman yang memiliki banyak manfaat. Daun mangga arumanis memiliki aktivitas antibakteri yang mampu menghambat pertumbuhan sel bakteri. Mangiverin yang terkandung dalam daun mangga arumanis (Mangivera indica L.) mempunyai efek sebagai antimikroba. Ekstrak daun mangga arumanis diformulasikan dalam bentuk masker bubuk dengan kombinasi tepung beras untuk menghasilkan efek yang sinergis. Penelitian ini bertujuan untuk mengetahui pengaruh sifat fisik dan stabilitas sediaan setelah dan sebelum dilakukan uji cycling test. Masker bubuk dibuat dalam tiga formula dengan memvariasikan konsentrasi tepung beras dan ekstrak daun mangga arumanis yaitu dengan perbandingan F(1) 2:8, F(2) 4:6 dan F(3) 6:4. Secara organoleptic masker yang dihasilkan pada F(1) berwarna putih kecoklatan, bau khas, tekstur setengah padat, untuk F(2) dan F(3) berwarna kuning kecoklatan, bau khas dan tekstur setengah padat. Hasil uji homogenitas semua formula homogen,uji pH F(1) 6,3, F(2) 6,0 F(3) 5,8, uji daya lekat F(1) 33,90 detik, F(2) 33,56 detik, F(3) 30,37 detik, waktu mengering F(1) 33,90, F(2) 33,56, F(3) 30,37 menit dan uji daya sebar baik. Dapat disimpulkan bahwa masker yang dihasilkan memiliki karakteristik yang baik.
UJI AKTIVITAS ANTI INFLAMASI EKSTRAK ETANOL BAWANG MERAH (Allium Cepa L.) VARIETAS BIMA BREBES PADA TIKUS PUTIH JANTAN GALUR WISTAR Abidia Kamil; Adita Silvia; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p60-64

Abstract

Shallots are one of the leading vegetable commodities in Indonesia. The center for shallot production is Central Java Province, especially in the Brebes Regency area. Shallots (Allium cepa L) can be used as medicine, one of which is as an anti-inflammatory. The purpose of this study was to determine the anti-inflammatory activity and to determine the best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain. The method used is the experimental method. Shallot extract (Allium cepa L.) was extracted using 70% ethanol by maceration method. The test animals used were white male rats wistar strain as many as 25 rats weighing 200-250 grams. The test animals were divided into 5 groups, namely the negative control group (Na CMC 0.5%), the positive group (Na Diclofenac), the onion extract dose variation group (25 mg/KgBW, 50 mg/KgBW, and 100 mg/KgBW). . Treatment 1 hour afterthe hind legs of rats was induced by subplantar carrageenin. The measurement of the volume of edema on the soles of the rats' feet was observed once every 1 hour for 6 hours. The results of the study showed that there was antiinflammatory activity at the three doses (25 mg/KgBW, 50 mg/KgBW and 100 mg/KgBW) ethanol extract of shallot (Allium cepa L) Bima Brebes in male white rats of the Wistar strain. The best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain is 50 mg/KgBW.
Kejadian Nyaris Cidera (KNC) Pada Pelayanan Resep Pasien Poli Penyakit Dalam di Instalasi Farmasi Rawat Jalan RS Roemani Muhammadiyah Semarang Octasari, Paulina Maya; Yulia, Rika; Rukminingsih, Fef
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p1-6

Abstract

The paradigm changing in health care form “quality” to “quality and safety” aims to improve the quality of life of patient. One of the efforts is to minimize the occurrence of incidents. The largest number of the patient safety incidence is Nearly Injury Incidence, which is 18.53%. The increased risk of NPC can be caused by their presence of polypharmacy. Polypharmacy is often experienced in patients at the Internal Medicine Polyclinic at Roemani Muhammadiyah Semarang Hospital. Therefore, it is necessary to conduct research to determine the number of KNCs in the prescription service of poly internal medicine patients in the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang. The study was a descriptive observational study with prospective data from prescription services for patients with internal medicine at the Outpatient Pharmacy Installation of Roemani Muhammadiyah Hospital Semarang in March 2020. Evaluations were carried out at each stage of prescription service. Stages consist of prescribing, taking drugs, and preparing medicines etiquette, checking. Data were analyzed and grouped according to the type of KNC at each stage of prescription service for patients with internal medicine, the number and percentage of KNC on each prescription sheet. The results showed that there were 25 KNCs on 375 sheets of prescribed poly patients in internal medicine at Roemani Muhammadiyah Hospital Semarang. The percentage of KNC is the drug entry stage of 9 KNC (2.4%), the taking stage of 15 KNC (4%), the preparation stage of 1 KNC (0.27%).
ANALISIS BAHAN KIMIA OBAT ASAM MEFENAMAT DALAM JAMU PEREDA NYERI YANG BEREDAR DI NGAWI DAN ONLINE SHOP SECARA KLT DAN SPEKTROFOTOMETRI UV-VIS Harjanti, Reslely; Pratiwi, Intan; Sarimanah, Jamilah
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p7-16

Abstract

One of the medicinal chemicals (BKO) that is abused in herbs preparations for pain reliever is mefenamic acid. Mefenamic acid is a class of non-steroidal anti-inflammatory drug (NSAID). The addition of mefenamic acid in herbs medicine aims to increase the effect of pain relief, but can caused harmful effects, including digestive tract disorders, hemolytic anemia, and seizures. The purpose of this study is to determine the presence of mefenamic acid in pain reliever herbs circulating in Ngawi and online shop.The samples in this study were several brands of pain reliever herbs from 4 herbal medicine shops (A,B,C, and D). This research is using purposive sampling method based on inclusion criteria. Samples was analyzed qualitatively by thin layer chromatography (TLC) method using cyclohexane:chloroform: methanol:glacial acetic acid (60:30:5:5) as mobile phase and silica GF254 as stationary phase. Quantitive analysis using spectrophotometry UV-Vis method. The results showed that 10 of 16 samples of herbal pain reliever were positive for mefenamic acid with levels ranging from 1.28% -7.30%. The UV-Vis spectrophotometric analysis method suitable for the analysis of mefenamic acid in herbal medicine for pain reliever based on validation results that meet the requirements includes linearity with r value 0.99956, accuracy 8 ppm was 100.32%, 10 ppm was 100.84%, 12 ppm was 100.61%, precision 1.33%, LOD 0.8914299023 ppm, and LOQ 2.701302734 ppm.
Hubungan Frekuensi Pemberian ERYTHROPOIETIN STIMULATING AGENT (ESA) Dengan Peningkatan Hemoglobin Pasien Hemodialisa Di RSUD Ciawi Nurafni, Silvi; Desminingrum, Tri; Samsiah, Siti
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p17-24

Abstract

Anemia complicated by CKD occurs 80-90% due to deficiency of erythropoietin. Erythropoietin Stimulating Agent (ESA) therapy is the main choice at Ciawi Hospital. Chronic Kidney Failure (CKD) is the 7th 10th biggest disease in Ciawi Hospital. The aim of the study was to evaluate the success of Erythropoietin Stimulating Agent (ESA) treatment in Hemodialysis (HD) patients at Ciawi General Hospital. This research is descriptive in nature, collecting retrospective data from secondary data from medical records, laboratory data from Hb patients. Sampling was taken using the total sampling method, namely all outpatient Hemodialysis (HD) patients at the Ciawi Hospital for the period October-December 2021 who met the inclusion and exclusion criteria totaling 47 patients. The results of this study show the sociodemographic picture of patients with Chronic Kidney Failure (CKD) with anemia complications, the most age range being 46-55 years, 18 patients (38.30%), the most sex being male, 25 patients (53.19%). The description of the duration of Hemodialysis (HD) therapy is that the most ? 12 months 27 patients (57.45%). The description of the highest frequency of ESA administration was at a frequency of 2 times a month with the Hb category increasing by 21 patients (63.6%) and the Hb category decreasing by 12 patients (36.4%). There is no relationship between the frequency of Erythropoietin Stimulating Agent (ESA) therapy with an increase in hemoglobin values in patients with chronic kidney failure undergoing hemodialysis and suffering from anemia as indicated by a significance value (P-value) of 0.659 > 0.05.
FORMULATION A NATURAL COSMETIC SCRUB OF DURIAN HUSK (DURIO ZIBETHINUS MURR.) AND THE CHARACTERISTIC TESTS) Febriani, Yuyun; Yuliana, Tri Puspita; Hariadi, Puspawan; Gemantari, Baiq Maylinda; Minawati, Minawati
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p25-32

Abstract

The high production of durian fruit gives an environmental problem if it is not used properly. Durian fruit skin contains flavonoids, phenolic compounds, saponins, and tannins which have antioxidant activity. Its antioxidant activity makes durian husk a candidate as a basic ingredient for natural cosmetics. Producing a formulation of scrub preparations as natural cosmetics based on the results of the characteristic test was the purpose in this research. Experimental research with a post-test design technique was carried out by making the changes of the concentration of durian husk as an active ingredient in the scrub preparations used in this study. The form of an oil-in-water cream scrub was used as the formulation in a change of concentration range of 1% (F1), 1.5% (F2), and 3% (F3) for each formula. Furthermore, the characteristic test was carried out which included organoleptic test, homogeneity test. pH test, viscosity test, spreadability test, and adhesion test. In this research also used statistica tests. The results showed that the best formulation is obtained from formulation 3 (F3) with a concentration of 3% durian rind. The characteristic test results include: stable organoleptic test for storage in terms of shape, color and odor; homogeneity test formed granules and there was no separation between the oil and water phases; Stable pH test according to skin pH at 5.05; spreadability test 7.3 cm; viscosity test 64 dPa.s; and 2.41 minutes of adhesion test. It pointed that all formulations fulfilled the requirements for topical scrubs in each characteristic test.
Therapeutic Drug Monitoring (TDM) Teofilin sebagai Antiasma di Indonesia Elizabeth, Maria; Rusdiana, Taofik
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p33-38

Abstract

Therapeutic Drug Monitoring (TDM) is a clinical pharmacy service aimed at increasing the effectiveness of therapy and improving patient safety. TDM is widely used in the use of drugs with a narrow therapeutic index or can cause toxic effects in small dose changes, such as theophylline. Theophylline is a xanthine class of drugs which is still often used in Indonesia and has a bronchodilatory effect so that it can be used in the treatment of asthma or chronic obstructive pulmonary disease (COPD). This drug has a narrow therapeutic index with a therapeutic dose of between 10-20 mg/L, concentrations above 20 mg/L can cause dangerous side effects such as nausea, vomiting, metabolic acidosis, gastrointestinal bleeding, and even death. Theophylline is one of the drugs that needs to be monitored related to the improvement of symptoms and drug levels in plasma. Therefore, the purpose of writing this article is to look at theophylline monitoring that has been carried out in Indonesia with a literature study approach using inclusion and exclusion criteria. The results obtained are that there are still a few hospitals that carry out therapy drug monitoring related to theophylline levels in the blood.

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