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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
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FORMULASI DAN EVALUASI HANDBODY LOTION EKSTRAK DAUN BAYAM MERAH (Amaranthus tricolor L.) DENGAN VARIASI KONSENTRASI TRIETANOLAMIN DAN ASAM STEARAT SEBAGAI EMULGATOR Yahya Febrianto; Novia Putri Santari; Wahyu Setiyaningsih
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.71

Abstract

Red spinach leaves contain flavonoids, saponins and tannins which have antioxidant potential which can be formulated into Handbody lotion. Handbody lotion is a cosmetic preparation used on the hands and body, formed from a liquid emulsion consisting of an oil phase and a water phase which is stabilized by the emulgator. The purpose of this study was to determine the effect of triethanolamine and stearic acid concentrations as emulsifiers and to determine the comparison of variations in the concentrations of triethanolamine and stearic acid which meet the physical evaluation requirements of handbody lotion preparations. The research method used is experimental research with data analysis using one way ANOVA. The results showed that the red spinach leaf extract handbody lotion was homogeneous and had a pink color, semi-solid shape and a distinctive smell of strawberry. It has a pH range of 7.30-7.42, a range of values for the spreadability of 5.20-6.17 cm, a range of values for adhesion from 4.42-6.27 seconds. The concentrations of triethanolamine and stearic acid as emulgators had a significant effect on the physical evaluation of the red spinach leaf extract handbody lotion including the pH test, spreadability and adhesion with a significance of p> 0.05. The comparison of the formula variation triethanolamine emulgator: stearic acid that meets the test requirements is formula 1 (2%: 7%), formula 2 (2.5%: 6.5%), formula 3 (3%: 6%), formula 4 ( 3.5%: 5.5%), formula 5 (4%: 5%).
PENGARUH PERBEDAAN SUHU PENGERINGAN GRANUL (40°C,50°C,60°C) TERHADAP SIFAT FISIK TABLET PARACETAMOL Agustina Putri Pitarisa Sudarsono; Masithoh Nur; Yahya Febrianto
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.72

Abstract

The most widely consumed analgesic and antipyretic drug by the community is paracetamol. One of the dosage forms is tablets. The manufacture of tablet preparations must go through various processes, one of which is drying. Things that need to be considered in the drying process include the temperature used for drying. This study aims to determine the difference in drying temperature of the granules on the physical properties of paracetamol tablets. This research uses a comparative type of research, which is to see the effect of differences in granule drying temperature on the physical properties of paracetamol tablets. Tablets were made by wet granulation method which consisted of 3 formulas. The formula used is the same, the only difference is the temperature. The drying temperatures used were 40°C, 50°C, 60°C. Parameters tested for paracetamol tablets include: organoleptic (shape, color, odor), weight uniformity, hardness, friability and disintegration time. The average weight uniformity test results are between 508.65-517 ± 0.48-1.88 mg . The results of the tablet hardness test were between 5.04-7.3 ± 0.29–0.43 kg. The results of the tablet friability test were between 0.48-0.68 ± 0.042-0.13%. The results of the test the time between tablet disintegration was between 4.17-7.07 ± 5.03-12.01 minutes. The results of the statistical test of the granules and the physical properties of the tablets showed that the data were normally distributed with a sign value. > 0.05, in the homogeneity test the data is homogeneous with the sign value. > 0.05. The results of the ANOVA One-Way test obtained sign results. <0.05, which means that there is a significant difference between the formulas.
Potensi Antibakteri Sediaan Sabun Cair Ekstrak Kulit Nanas (Ananas comosus L. Merr.) Terhadap Bakteri Staphylococcus aureus ATCC 25923 Ismi Rahmawati; Riesky Maulida; Siti Aisyah
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p1-11

Abstract

Pineapple peels extract (Ananas comosus (L.) Merr.) has antibacterial activity against Staphylococcus aureus bacteria which causes skin infections. One of the infection prevention is by using antibacterial hand soap. This study aims to determine the physical quality, stability and antibacterial activity of the pineapple peels extract soap against S. aureus ATCC 25923. Pineapple peels extract obtained from maceration with 70% ethanol solvent was formulated into liquid hand washing soap. Soap formulations were made with the respective concentrations of 3%, 6%, and 9%. Each formula was tested for physical quality with parameters: organoleptic, homogeneity, pH, specific gravity, viscosity, and foaming capacity. Stability test using the freeze thaw method with organoleptic , pH, and viscosity. The formulation results were tested for antibacterial activity against S. aureus ATCC 25923 by the well diffusion method. Panelists testing was done with several respondents. Data analysis of physical quality, stability and activity was tested by SPSS statistics with a confidence level of 95%. Pineapple peel extract contains flavonoids, alkaloids, tannins, saponins and phenols. All three soap formulas have physical quality in accordance with SNI 2588: 2017. The three formulas are stable until the fifth cycle (one cycle of 48 hours). The three liquid soap formulas had antibacterial activity against S. aureus ATCC 25923. The formula with a concentration of 9% was not significantly different from the positive control and had the highest inhibitory diameter of 21.78 ± 0.84mm. The formula with a concentration of 9% were most preferred by the panelists.
Kajian Etnomedicine Tumbuhan Obat Antiinflamasi Pada Masyarakat Samin Kecamatan Margomulyo Bojonegoro Yaya Sulthon Aziz; Nadia Hasna
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p12-18

Abstract

The use of medicinal plants is mostly done by tribes in Indonesia, one of them is the Samin tribe. Information on the use of medicinal plants can be done using ethnopharmaceutical methods. This research was conducted to determine the use of plants as anti-inflammatory drugs, how to manufacture, how to use plants as anti-inflammatory drug ingredients in the tribe of Samin, and to obtain UV and ICF values based on bioprospective analysis. Determination of the informants in the Samin tribe with the Snowball sampling method, followed by semi-structured interviews. Bioprospective analysis of plants that have the potential to be anti-inflammatory. Bioprospective parameters tested were UV, ICF. ICF values are used to identify the most important disease categories and are used as parameters in plant species for further research. UV value which is the most widely used plant and high level of confidence for treatment. Obtained 11 types of anti-inflammatory diseases, 28 anti-inflammatory plants. There were 6 anti-inflammatory diseases including broken bones with a value of 1, stung by bees 1, mumps 0.75, scratch wounds 0.75, uric acid 0.33, and toothache 0.33. The results of the ICF values above, then obtained plants used for anti-inflammatory treatment with the highest UV values are betel 0.91, bitter 0.83, black taro 0.83, breadfruit 0.5, and greetings 0.5. The five plants that need further research are the black taro plant, for which there is no research that discusses more deeply, so the black taro plant is a potential source of new anti-inflammatory.,
Faktor Penyebab Perilaku Penjualan dan Pembelian Antibiotik Tanpa Resep Dokter Novita Dewi; Debby Juliadi
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p19-25

Abstract

Pharmacies are the main source of getting antibiotics. Access to antibiotics without a prescription at pharmacies is common in many countries, including Indonesia. The sale of antibiotics without a prescription in pharmacies has become a global problem, especially in developing countries. However, the dominant factor that causes the behavior of selling antibiotics without a prescription in Indonesian pharmacies is not known with certainty. The purpose of this article is to find out the dominant factors that influence the behavior of selling and using antibiotics without a doctor's prescription in pharmacies. The method used is by conducting library searches on search sites such as Google Schler with the keywords "antibiotics without a prescription, patient behavior, pharmacists, pharmacies". Where the results are factors that influence sales behavior and use of antibiotics without a doctor's prescription, namely the ease of access to antibiotics and cost savings factors, patient attitudes and recommendations from friends/relatives.
Investigasi Kandungan Parasetamol Pada Jamu Pegal Linu di Kawasan Pasar Malam Kota Banjarmasin Kalimantan Selatan Rahmadani Rahmadani; Tuti Alawiyah
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p26-30

Abstract

Herbal products are very well known by the people of Indonesian since ancient times in an effort to prevent disease, treat and restore fitness. Medicinal Chemicals (MCs) are often added to herbal preparations to increase the efficacy of herbal medicine and provide a more instant herbal effect. With an uncertain dose will cause very serious side effects for health. This research was conducted with 5 samples of herbal aches and pains in the night market area of Banjarmasin. The test was carried out by qualitative analysis using Thin Layer Chromatography (TLC) and quantitative analysis using UV-Vis Spectrophotometer. The results of the qualitative test showed the presence of paracetamol BKO in sample C and sample D and the results of the quantitative test resulted in sample C of 8.13 mg/Kg and sample D of 6.28 mg/Kg
Gambaran Penggunaan Vitamin C Sebagai Imunomodulator Pada Pasien Dewasa Dengan Covid-19: Studi Literatur Luh Tuti Suryati; Debby Juliadi
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p31-40

Abstract

Corona virus or COVID 19 is a virus that causes disease in animals or humans. COVID-19 more often attacks the respiratory tract. Improving the immunity of COVID-19 patients is very much needed because the treatment for COVID-19 has not been found. Vitamin C is a vitamin that can prevent and treat respiratory infections by enhancing various immune cell functions. Vitamin C acts as a powerful antioxidant and helps replace damaged cells so it can help with COVID-19. This literature study aims to determine the use of vitamin C as an immunomodulator in adult COVID-19 patients. The data collection method was obtained by reviewing 10 journals using Google Scholar and Pubmed using English-language journals. The keywords used are vitamin C, COVID-19, treatment. The results obtained in the form of intravenous vitamin C with a dose of can improve the lives of COVID-19 patients by increasing the immunity of infected patients. This can be seen from the inhibition of the development of cytokines and an increase in lymphocytes and CD4+ T cells. In addition, it improves the patient's respiratory function with an increase in PiO2/FiO2.
KEJADIAN STAGNANT DAN STOCKOUT OBAT KARDIOVASKULER DI INSTALASI FARMASI RUMAH SAKIT Eleonora Maryeta Toyo; Sri Suwarni; Yolanda Ernidiasanti
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p41-49

Abstract

Drug management is carried out as an effort to control drug inventory in hospital pharmacy installations to know the incidence of stagnant and stockout of cardiovascular drugs from the internal medicine specialist poly. This research was conducted in March-April 2021, with a cross-sectional study design with retrospective data search. The data instrument used is an electronic stock card specifically for the use of cardiovascular drugs in hospital outpatient installations, including; antianginal, antidyslipidemic, antihypertensive, and antiplatelet drugs. The number of samples used was 50 items of cardiovascular drugs. Data processing is carried out qualitatively and quantitatively. The results showed that the highest number was found in the antihypertensive therapy class as many as 32 items with an amount of stagnant 12% and a total stockout of 31.3%. Keywords: Cardiovascular Medicine, Stagnant, Stockout, Hospital
FORMULASI SEDIAAN PASTA GIGI DENGAN ARANG AKTIF TEMPURUNG KELAPA (Cocos nucifera L) SEBAGAI PEMUTIH GIGI Liana Febrianti; Desy Nawangsari; Adita Silvia F
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p50-57

Abstract

Teeth are one of the important aesthetic factors for a person, including tooth color. The effect of tooth discoloration can cause a person's lack of self-confidence. The use of teeth whitening materials can cause side effects in the oral cavity so that the use of natural ingredients is chosen as a tooth whitener, one of which is activated charcoal. Activated charcoal has an absorption capacity of 25-100%. The purpose of this study was to determine the activity of coconut shell-activated charcoal toothpaste as a teeth whitener. This study used 20 dentures and then soaked them in coffee solution for 17 days to change the color of the teeth. Tooth color was measured using a classical Vitapan shade guide. Teeth whitening activity test was carried out for 14 days. Toothpaste was made in 4 formulas with different concentrations of coconut shell-activated charcoal in formula 1 (0%), formula 2 (6%), formula 3 (10%), and formula 4 (12%). The results of the observation showed that the preparation of coconut shell-activated charcoal toothpaste can give tooth discoloration. A statistical tests showed that coconut shell-activated charcoal toothpaste had a significant difference in activity as a natural ingredient for whitening teeth.
FORMULASI, SIFAT FISIK DAN UJI AKTIVITAS ANTIOKSIDAN MASKER GEL PEEL OFF TEPUNG BERAS HITAM (Oriza sativa L. var Indica) Mely Nastiti; Desy Nawangsari; Dina Febrina
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p58-67

Abstract

Black rice (Oriza sativa L. var Indica) is a local variety that contains anthocyanin pigments. Anthocyanins are antioxidants that have a positive effect on health. Peel off face mask is a face mask that has the advantage that it is easy to remove like an elastic membrane. This study aims to determine the physical evaluation of the peel off gel mask preparation, antioxidant activity and stability of the peel off gel mask. This research method was carried out experimentally, the data were analyzed using the One Way ANOVA method with sig > 0.05. The conclusion of this study was that the black rice flour peel off mask preparation had a significant significant difference to the f1 dispersion test, but there was no significant difference between f2 and 3. There was no significant difference in the antioxidant test. Based on data analysis using one way ANOVA after the cycling test, the formulation was good for 6 cycles, namely formulations 2 and 3. Keywords: Antioxidant, Black rice, dan Peel off mask.

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