cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rizky Ardian Hartanto Sawal
Contact Email
rizkyardianhartanto@gmail.com
Phone
+6282242543071
Journal Mail Official
lppm.stiferasemarang@gmail.com
Editorial Address
LPPM Sekolah Tinggi Ilmu Farmasi Semarang Jl. Medoho III No. 2, Semarang
Location
Kota semarang,
Jawa tengah
INDONESIA
Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 244 Documents
 8   9   10   11   12 
Identifikasi Interaksi Obat Pada Pasien Lansia Yang Berisiko Sindrom Metabolik Di Puskesmas Aikmel Sovia, Fitriwati; Hardiyanti, Novi; Rafsanjani, Arief; Oktresia, Erma Ewisa
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p39-46

Abstract

Metabolic syndrome is an increasingly prevalent health problem in both developed and developing countries, including Indonesia. The treatment of metabolic syndrome often involves polypharmacy, which increases the potential for drug interactions. Drug interactions are considered clinically important if they can cause increased toxicity or reduce the therapeutic effects of drugs, leading to a failure to achieve the desired therapeutic effect. Reported cases of drug interactions are more common in elderly patients. This study aims to determine the potential Drug-drug Interactions (DDIs) in elderly patients at risk of metabolic syndrome at Puskesmas Aikmel. The study uses a descriptive observational method with prospective data collection. The population in this study consists of outpatient patients at Puskesmas Aikmel from May to July 2021, meeting the inclusion criteria: patients diagnosed at risk of metabolic syndrome, elderly patients (age ? 60 years), and using a minimum of 2 drugs. Sampling was done using total sampling technique. The results of the study indicate 99 cases of potential drug interactions identified in the prescription of elderly patients. The drug classes with potential interactions include antihypertensive drugs in 51 (51.51%) cases, antihyperglycemic drugs in 42 (42.42%) cases, and dyslipidemia drugs in 6 (6.06%) cases. The types of drug interactions observed were pharmacokinetic interactions in 37 (37.37%) cases, pharmacodynamic interactions in 58 (58.58%) cases, and unknown interactions in 4 (4.04%) cases. The severity of these potential interactions was classified as minor in 5 (5.05%) cases, moderate in 86 (86.87%) cases, and major in 8 (8.08%) cases.
IDENTIFIKASI MANGIFERIN DAN UJI AKTIVITAS PENGKELAT BESI PADA EKSTRAK DAUN MANGGA (Mangifera indica L.) : IDENTIFIKASI MANGIFERIN KRISTYANTI, YULIA; Lutsina, Novi Winda; More, Evanisia
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p47-54

Abstract

Blood disorder caused by unbalanced globin synthesis resulting in damage to hemoglobin and recessive inheritance, handling do regular blood transfusions. Repeated blood transfusions in the long term lead to the accumulation of iron in the body. The purpose of this study was to determine the content and of mangiferin activity extract M. indica L leaf as an iron chelating in vitro. indica L leaf extract obtained by maceration method with 96% ethanol. Testing mangiferin content by TLC methods and iron chelating effectiveness in vitro using methods Ferrous ion chelating (FIC), the principle of the method is to measure the ability of a compound to compete with ferozine the metal chelate iron. Identification of TLC revealed that there is content mangiferin on leaf extract M indica L, by the similarity of color patches and Rf extracts and mangiferin, by using three types of the mobile phase is n-hexane: ethyl acetate: water (6: 3: 1) with Rf 0.1, ethyl acetate: formic acid: water (8: 2: 1) with Rf of 0.34 and methanol: chloroform: water (7: 2: 1) with Rf 0.8, Test result the ability of the metal chelate extract M. indica L leaf of ethanol has an iron chelating effect as in vitro methods FIC. Concentration higher of the iron chelating higher percentage. Extract at concentrations of 1, 10, 20, 30 and 40 ug / ml respectively have iron chelating percentage 6,44%, 29,87%, 58,85%, 75,74% and 92,99%, with values (IC50) it is 18,73 µg/ml.
ISOLASI DAN UJI AKTIVITAS ANTIFUNGI EKSTRAK ETANOL KULIT BUAH DELIMA MERAH (Punica granatum L.) TERHADAP Candida albicans More, Evanisia; Mbulang, Yohana; Krisyanti, Yulia
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p55-64

Abstract

The research about isolation and antifungal activity test of ethanol extract of Punica granatum L peel towards Candida albicans’ has been done. The objectives of this study are to determine any secondary metabolite compounds that can be isolated from Punica granatum L peel, to determine antifungal activity of Punica granatum L peel extract and to determine the most effective concentration to inhibit Candida albicans’ growth. Based on phytochemical test result, it can be concluded that secondary metabolite compounds contained in Punica granatum L peel extract are flavonoide and tannin. The process was continued by TLC and PTLC. Based on TLC process, eluent with best separation was methanol:ethyl acetate (3:1) with 0,44 and 0,51 as the Rf values. The eluent from the following TLC was used for PTLC process. PTLC results showed one round spots, the yellow one with Rf value = 0,77. The following process was antifungal activity test using agar diffusion method and Candida albicans was used for this purpose. The antifungal testing process was done by varying the concentration of Punica granatum L peel extract to 10%, 20%, 40% and 50%. The result showed that the four concentrations can inhibit the Candida albicans’ growth, indicated by transparent zone surrounding the concentration. One way Anova results Fcount> Ftable = 116,709727> 5,064, it indicates that there is significant influence of various concentration to resistivity zone diameter. The process continued by analyzing the most effective concentration using multiple Tukey comparative test with 1% significance level. The result showed that the most effective concentration to inhibit Candida albicans’ growth was 50% Punica granatum L peel extract with its resistivity capacity is 22,26 mm.
Kajian Hubungan Kuantitatif Struktur Dan Aktivitas (HKSA) Senyawa Kurkumin Dan Turunannya Sebagai Agen Anti Tumor Darah Terhadap Penghambatan Pertumbuhan Sel K562 Puspitasari, Ismi; Astuti, Sari; Harmastuti, Nuraini
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p65-75

Abstract

Curcumin was reported can suppress the growth of blood tumor cells. This study aims to determine the physical and chemical properties of curcumin derivatives that give affect to antitumor activity of blood cells which were expressed as the best HKSA equation model. This   study   used   curcumin   and   twelve   derivatives   which   have   antitumor   activity parameters of blood cells (K562) as IC50. Parameters of physicochemical properties of curcumin compounds series and their derivatives as descriptors include net charge of atoms in the curcumin framework structure, EHOMO, ELUMO, Log P, E Hid, a, MR, Volume, Surface area (SA), Total Energy, dipole moment (u), Hf, and Mass which are the results of geometric optimization calculations using the PM3 semiempirical method with hyperchem application. HKSA equation model was built using the BuilQSAR statistical calculation analysis. The best HKSA equation model is then validated internally and externally. Calculation of statistical analysis with BuldQSAR, the descriptor that has the most influence is  obtained, namely net  atomic charge, EHOMO,  surface area, dipole moment and  Hf with  linear regression equation: Log 1/IC50 : + 1.7622 (± 0.3655) qC4 - 0.9457 (± 0.1047) E Homo + 0.0013 (0.0002) SA + 0.0575 (± 0.0216) u - 0.0068 (± 0.0004) Hf - 11.4161 (± 1.0440) , n = 10; R = 0.999; R2= 0,9990; SPress = 0.0232. as well as non-linear regression equation : Log 1/IC50 = + 15.1400 (±4.9008) qC7 + 7.4959 (± 5.6081) qC8 - 0.5839 (± 0.1397) qC15 + 0.0005 (± 0.0003) SA - 0.0054 (±0.0008) Hf - 5.7246 (±3.2476), n = 10; R = 0,999, R2 = 0,9977; SPress = 0.0341.
Standardisasi dan Skrining Fitokimia Ekstrak Daun Singkil (Premna corymbose) Priamsari, Margareta Retno; Solichah, Ayu Ina; Aminah, Icha Yuliska
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p76-80

Abstract

Standardization is needed to obtain uniform raw materials that can guarantee the pharmacological effects of singkil plants. Phytochemical screening is the initial stage in a phytochemical research that aims to provide an overview of the class of compounds contained in the plant under study. The purpose of this study was to determine the standardization profile and class of chemical compounds in the ethanol extract of singkil leaves. This type of experimental research. Singkil leaf extraction was carried out by maceration method with 70% ethanol solvent, then followed by standardization test of singkil leaf ethanol extract. The next step is testing phytochemical compounds by identifying alkaloids, flavonoids, saponins, tannins, triterpenoids/steroids through phytochemical screening which are analyzed descriptively.The standardization results showed that the ethanol extract of singkil leaves had a dry shrinkage of 3.43%±1.28% (w/w), the extract content was soluble in water in singkil leaf powder was 20.01%±0.22% (v/w), the water soluble extract content of singkil leaf extract was 19.81 ± 0.22% (v/w), the ethanol soluble extract content of singkil leaf powder was 24.48 ± 0.24 %(v/w), ethanol soluble extract content of singkil leaf extract was 26.88 ± 1.16 %(v/w), specific gravity of singkil leaf extract was 0.91 ± 0.00 %(v/v), and ash content of singkil leaf extract. was 30.40 ± 0.00 %(w/w). The results of phytochemical screening showed that the ethanolic extract of singkil leaves contained flavonoids, tannins, saponins and triterpenoids
Pengaruh Pelarut N-Heksan, Etil Asetat, Dan Etanol 96% Terhadap Kadar Flavonoid dan Aktivitas Antioksidan Kulit Buah Lamtoro (Leucaena leucocephala) ina bulu, atalia tamo; Novembrina, Metrikana
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p81-86

Abstract

Lamtoro rind waste in Indonesia is produced in large quantities so it can become a problem for the environment if not managed properly. Lamtoro rind extract contains chemical compounds such as flavonoids, alkaloids, saponins, phenolics, and tannins. Flavonoid compounds, one of the phenolic groups widely found in plant tissues, can act as antioxidants. This study aims to examine the effect of N-hexane, ethyl acetate, and 96% ethanol on the levels of flavonoids and the antioxidant activity of lamtoro rind (Leucaena leucocephala). Lamtoro rind was made simplicial and extracted by maceration method using N-hexane, ethyl acetate, and 96% ethanol separately for 3x24 hours. Each extract was analyzed to determine the levels of flavonoids by UV-Vis spectrophotometry method and antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhidrazyl) method. The results of the analysis showed that 96% ethanol gave the extract with the highest levels of flavonoids, followed by ethyl acetate and N-hexane of 15.345 µg/g, 14.899 µg/g and 10.234 µg/g respectively. In addition, the antioxidant activity of lamtoro rind extract was also shown to be higher in 96% ethanol extract compared to ethyl acetate extract and n-hexane extract calculated with IC50 values of 39.914 ppm, 30.788 ppm, and 164.304 ppm respectively. Based on this study, it can be concluded that 96% ethanol resulted in lamtoro rind extract with higher levels of flavonoids and stronger antioxidant activity compared to using N-hexane or ethyl acetate as solvents. These results indicate that lamtoro rind has the potential as a useful source of flavonoids and antioxidants.
PENETAPAN KADAR FLAVONOID EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L.) Ayuningtyas, Nurista; Ayu Ina, Ayu Ina; Setyopuspito, Anastasia; Trisina, Jessica; Mardiyono, Amida Kesya
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p93-97

Abstract

Noni fruit has traditionally been used for treatment due to its secondary metabolite content, one of which is flavonoid. This research aims to determine the secondary metabolite content of 96% ethanol extract of noni fruit and total flavonoids in the extract. The research method was conducted experimentally. Noni fruit extract was obtained by maceration method, phytochemical screening was performed to determine the content of secondary metabolites in qualitatively. Total flavonoids were analyzed by colorimetric method with quercetin as standard. Quercetin levels were measured by Spectrophotometry Uv-Vis. The results obtained yield of noni fruit extract 3.60% + 0.31. Phytochemical screening of noni fruit extract contains flavonoids, alkaloids, tannins, steroids, and saponins. The quercetin standard curve equation obtained y = 0.0067 x - 0.0148 with r = 0.9959. The result of total flavonoids in ethanol extract of noni fruit was 0.166% + 0.004.
PROFIL PENGGUNAAN OBAT TRADISIONAL PADA MASYARAKAT DESA PEGANDON KENDAL Suwarni, Sri; Septiyana, Ria; Fajaryanti, Nita; Indrasari, Ferika
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p87-92

Abstract

This study discusses the profile of the use of traditional medicine in Pegandon Village, where this study aims to obtain an overview of traditional herbal medicine producers in the Pegandon village area and an overview of the use of traditional medicine in traditional herbal medicine businesses in the Pegandon village area. This research was conducted using a descriptive method with a questionnaire as a data collector. The respondents in this study were the Pegandon village community. The results of the study showed that the highest use of traditional medicine in Pegandon village was women (100%), aged 31-40 years (40%), housewife (92%), last high school education (47.7%). Most of the types of illness were diarrhea (30%) and menstrual pain (30%) with a duration of illness that was mostly experienced less than one week (96%), most of the actions taken when sick by respondents were to see a doctor, health center or hospital (68%), most of the purpose of using traditional medicine is to cure a sudden/mild illness (34%) by buying traditional medicine at a traditional herbal medicine seller (42%), the dosage form most respondents use is in the form of herbal medicine (46%) with the average duration of use is 1 day (46%), the most sources of information are obtained from family (30%) on the grounds that they are made from natural ingredients (90%), the amount of use is mostly one tablespoon (40%) , the traditional medicine that is used mostly does not cause side effects (92%), when side effects appear some respondents still continue traditional medicine (2%), but there are those who go to the doctor or switch to modern medicine (40%), and there are who stopped using traditional medicine (58%). Keywords: traditional medicine, pegandon village
Potensi Anti Bakteri Hard Candy Ekstrak Asam Jawa (Tamarindus indica L.) dengan Minyak Sereh Wangi (Oleum Citronellae) Saptawati, Tunik; Handayani, Dwi Nurul; Gloria, Fransisca; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p98-103

Abstract

Tamarind and Sereh wangi (Citronellae winterianus Jowitt) are widely planted in Indonesia. Citronella oil is widely used as an anti-bacterial because of its secondary metabolite content. This study aims to determine the anti-bacterial potential of hard candy with active ingredients of tamarind extract and citronella oil. Tamarind fruit extract was prepared by maceration method using 96% ethanol solvent. Hard candy is made in 3 formulas with tamarind extract and citronella oil 0,1% (F1), citronella oil 0,2% (F2), and citronella oil 0,2% (F3). Antibacterial activity of hard candy examined using the disc diffusion method by measuring the diameter of the inhibition zone for the growth of Staphylococcus aureus and Escherichia coli bacteria. The result of the diameter of the inhibition zones F1, F2, and F3 for Escherichia coli were 4.25, 4.38, and 5.35 mm, respectively. The the diameter of the inhibition zones F1, F2, and F3 for Staphylococcus aureus were 2.30, 2.67 and 2.90 mm, respectively . It was showed that hard candy with active ingredients of tamarind extract and citronella oil was able to inhibit the growth of bacteria. The difference in the diameter of the inhibition zone between the formulas was analyzed using One Way Anova. The significance value is <0.05, so there is a significant difference in anti-bacterial activity between formulas. The concentration of citronella oil influence on antibacterial activity where the greater the concentration of citronella oil, the antibacterial activity to Staphylococcus aureus and Escherichia coli will increase. Keywords: Citronella oil, Tamarind, Hard Candy, Antibacterial.
EFEKTIFITAS IMPLEMENTASI BUDAYA KAIZEN DALAM PENINGKATAN CUSTOMER SATISFACTION DI PUSKESMAS BANGETAYU KOTA SEMARANG Suwarni, Sri; Arfiyani, Aulia; Septiyana, Ria; Gloria, Fransisca
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p126-132

Abstract

Pemerintah telah mengawal mutu pelayanan kefarmasian dalam Standar Pelayanan Kefarmasian. Kualitas pelayanan meliputi teknis dan proses pelayanan dengan mengukur kepuasan pasien, yang dilakukan dengan angket secara periodik. Kaizen merupakan salah satu upaya perbaikansecara terus menerus untuk peningkatan kualitas mutu. Penelitian ini bertujuan mengetahui efektifitas implementasi budaya kaizen dalam peningkatan customer satisfaction di Puskesmas Bangetayu Kota Semarang. Penelitian eksperimental metode observasional kuantitatif menggunakan instrument kuesioner. Sampel diambil 350 responden pasien yang mendapatkan Pelayanan Kefarmasian dibagi sebelum dan sesudah Implementasi suatu budaya perbaikan kaizen dengan teknik purposive sampling. Tahapan analisis menggunakan DMAIC (Define, Measure, Analyze, dan Control). Perlakuan yang diterapkan adalah budaya kaizen (5S) yaitu seiri, seiton, seiso, shitsuke, seiketsu. Hasil improve penerapkan budaya kaizen berupa perbaikan sistem layanan dengan pembiasaan budaya resik, rajin, rapi, ringkes, rawat dalam teknis pelayanan kefarmasian menunjukkan bahwa terjadi peningkatan kepuasan pasien sebesar 1,67%. Hasil uji Wilcoxon p = , upaya perbaikan dengan adanya perbedaan signifikan antara sebelum dan sesudah penerapan budaya kaizen pada peningkatan costumer satisfaction dengan nilai keefektifan setiap indikator dengan uji N-Gain memiliki nilai keefektifan 52% yang berarti kurang efektif untuk pemilihan strategi budaya kaizen yang diterapkan di instalasi farmasi Puskesmas Bangetayu Kota Semarang sehingga dibutuhkan alternatif pembiasaan budaya kaizen lainnya.

Page 10 of 25 | Total Record : 244

 8   9   10   11   12 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue Vol 8 No 1 (2025) Vol 7 No 2 (2024) Vol 7 No 1 (2024) Vol 6 No 2 (2023) Vol 6 No 1 (2023) Vol 5 No 2 (2022) Vol 5 No 1 (2022) Vol 4 No 2 (2021) Vol 4 No 1 (2021) Vol 3 No 2 (2020) Vol 3 No 1 (2020) Vol 2 No 2 (2019) Vol 2 No 1 (2019) Vol 1 No 2 (2018) Vol 1 No 1 (2018) More Issue