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Aji Winanta
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K.H. Sudja Building G3, 2nd Floor, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Jalan Brawijaya (Lingkar Selatan), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta
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INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol. 6 No. 1 (2025): August" : 8 Documents clear
Formulation and evaluation of lip balm preparations of ethanolic extract from beetroot (Beta vulgaris L.) Hadi, Ismanurrahman; Shinta, Tiara Aries; Putra, Teguh Adiyas
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.19331

Abstract

Beetroot (Beta vulgaris L.) is a source of betacyanin that could be used as a natural dye and is known as an antioxidant that can protect the skin from exposure to free radicals. Lip balm, one of the popular cosmetics, often uses natural ingredients as active compounds to enhance colour and promote healthy skin. This study aims to formulate beetroot ethanolic extract into a topical lip balm preparation. The beetroot was extracted using ethanol solvent. The phytochemical screening was carried out to identify phytochemicals of flavonoids, saponins, tannins, and alkaloids within the ethanolic extract. The extract was formulated into a lip balm preparation with extract concentrations of 0% (F1), 5% (F2), 10% (F3), and 15% (F4). After formulation, the lip balm was physically examined for organoleptic, homogeneity, acidity, spreadability, and adhesivity of the product. The phytochemical screening exhibited positive results in all phytochemical groups tested in the beetroot ethanolic extract. Meanwhile, physical evaluation of lip balm demonstrates that all formulations had a semi-solid texture, cacao scent, and red color that increased in intensity proportionate with the extracts used (F2, F3, F4). Other parameters indicate a homogeneous product with suitable acidity (pH valued at 9) and adhesivity (>4 seconds). However, the spreadability test displayed low dispersion capabilities of the lip balm. Even though the spreadability values increased with higher beetroot extract, this value remained lower than the standard minimum dispersion of lip balm, thus indicating poor spreadability of the formula. The hedonic evaluation indicates that respondents tended to like the third formulation (F3). Based on this, the best and most preferred formula is at a concentration of 10% active substance (F3).
Formulation and Organoleptic Evaluation of Roselle (Hibiscus sabdariffa) Jamu Godog with Stability and Microbial Quality Assessment Irianto, Iramie Duma Kencana; Purwanto; Nurhaeni, Farisya; Ana Mardiyaningsih; Bangkit Ary Pratama; Fiqoh, Latifah Nisa; Febriana Ardiyanti
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.22102

Abstract

Jamu is a traditional medicinal preparation proven to have many pharmacological properties and is widely used in Indonesian society. Unfortunately, many people do not like herbal medicine because of its unpleasant taste and odor. This phenomenon has driven much research in modifying the organoleptic parameters of jamu to make it more acceptable to the tongues and noses of consumers while still having a potent effect on health. This study, thus, aimed to formulate a roselle (Hibiscus sabdariffa)-enhanced jamu godog (traditional Indonesian herbal decoction) and evaluate its organoleptic properties, physical stability, and microbial quality. Jamu godog was prepared by sequentially boiling and mixing ground ginger, turmeric, lemongrass, roselle, rock sugar, and lime, with roselle concentrations set at 0%, 0.3%, and 0.6%. Organoleptic attributes and pH stability were assessed before and after storage at 4°C and 25°C for seven days. Microbial contamination was measured via total plate count (TPC) after storage at 4°C for three and seven days. A hedonic test with 40 participants across two age groups evaluated sensory acceptance. Results indicate that the addition of roselle at 0.3% concentration optimized taste and overall acceptability while maintaining pH stability and microbial safety within BPOM standards throughout the storage period. This formulation demonstrates potential as a palatable and microbiologically safe herbal preparation with enhanced consumer acceptance.  
TLC and UV-Visible Spectrophotometry Validation for Identification of Sildenafil Citrate in Aphrodisiac Herbal Medicine Azizi, Khodadad Trimawan; Haresmita, Perdana Priya; Permatasari, Desy Ayu Irma
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.23627

Abstract

Traditional medicines, also known as jamu, have sometimes been found to contain medicinal chemicals to enhance the effectiveness of these products. Sildenafil citrate, which is clinically effective in improving erectile function, can cause harmful side effects when included in herbal products. This study, therefore, aims to validate the identification of sildenafil citrate in aphrodisiac herbal medicine using Thin Layer Chromatography (TLC) and UV-visible spectrophotometry. The samples were prepared by macerating 100 mg of the jamu in 96% ethanol for 24 hours. The samples were then evaluated using TLC and a UV-visible spectrophotometer, with validation parameters including linearity, precision, limit of detection (LOD), and limit of quantitation (LOQ). This study uncovered that one of the three samples tested positive for sildenafil citrate, as evidenced by similar Retention factor (Rf) values in two TLC systems. Additionally, analysis using UV-visible spectrophotometry revealed that the average content of sildenafil citrate in the sample was 23.96%, with a relative standard deviation (RSD) of 0.74% and LOD and LOQ values of 10.28 and 34.27 µg/mL, respectively. The methods of analysis, including TLC and UV-visible spectrophotometry, for sildenafil citrate identification are expected to be valuable for regulatory and supervisory agencies in monitoring the distribution of such herbal medicines.  
Reworking Potential of Polyvinylpyrrolidone K-25 as a Binder in The Production of Paracetamol Tablets Agatha Budi Susiana Lestari; Okana, Lie Dofi Ananda Madelin
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.27034

Abstract

Binding agents play an important role in maintaining the bond between active and additional ingredients in tablets, especially when subjected to repeated compression. One commonly used binder is polyvinylpyrrolidone (PVP) K-25. However, issues often arise regarding the binder's potential when undergoing multiple compressions. This research, hence, aims to determine the reworking potential of PVP K-25 with different concentration levels as a binder, focusing on the physical properties of the mixtures and the resulting paracetamol tablets. The study follows a pure experimental design with a two-way completely randomized research design. Tablets were compressed and subsequently crashed again twice. Various tests, including flow properties and compressibility for the mixtures, as well as compatibility, hardness, friability, and disintegration time for the tablets, were conducted to assess their physical properties. The obtained data were subjected to statistical analysis, starting with the Shapiro-Wilk normality test, followed by Kruskal-Wallis and Post-Hoc Mann-Whitney tests. The research findings indicate that PVP K-25 can maintain its potential as a binder, as evidenced by the physical properties of both the mixtures and the resulting paracetamol tablets.
Analysis of the Entrapment Efficiency of Thymoquinone in Microcapsules of Black Cumin Seed Oil (Nigella sativa L.) Using High Performance Liquid Chromatography Ofa Suzanti Betha; Supandi, Supandi; Addina Syahida; Boy Reynaldi Noor; Nelly Suryani; Sabrina Dahlizar; Yuni Anggraeni; Barita J. Siregar; Zilhadia
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.27545

Abstract

Thymoquinone is the main active compound found in black cumin seed oil (Nigella sativa). This study intends to analyze the efficiency of its absorption in microcapsules by the ionic gelation of cross-linked alginate and the CaCl2 method, and loading with black cumin seed oil in a concentration of 20%. Thymoquinone was used as a marker to establish quality standards for this microcapsule preparation. Analysis of thymoquinone in microcapsules was performed using a pre-optimized, high-performance liquid chromatography method. Method optimization utilized an Acclaim® Polar Advantage II (C18) column with a flow speed of 1.5 mL/min, a UV detector wavelength of 252 nm, and an injection volume of 20 μL with an isocratic system on a methanol eluent composition: water (70:30). This method revealed a good linearity value (r = 0.9997) in the range of 0.5 – 500 μg/ml. The detection and quantitation limits were 8.67 μg/mL and 28.9 μg/mL, (%diff) was about -1.864 to 1.562, precision (% RSD) was 0.052 to 0.113%, and the recovery was 98.135 to 101.563%. The results of this method validation were then applied to determine thymoquinone loading in black cumin seed oil microcapsules. The results of the absorption efficiency value of black cumin seed oil microcapsules by the ionic gelation alginate and CaCl2 method, which contained 20% oil concentration in the formula, were 81.769%.
Antioxidant Activity from Glucomannan Degradation Product Using β- mannanase Enzyme with DPPH Method
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.23778

Abstract

Antioxidants are defined as chemical components or compounds that can inhibit damage due to the oxidation process. Glucomannan, which is formed from a polysaccharide called mannan, has various benefits, such as anti-inflammatory, hypoglycemic, hypolipidemic, and antioxidant properties. This research aims to determine the antioxidant activity of glucomannan degradation using the β-Mannanase enzyme and the effect of temperature and pH on its antioxidant activity. Researchers carried out three degradation variations in the form of pH variations (5.5, 7, and 9) and temperature variations (45℃, 55℃, and 65℃), which resulted in 9 samples. The method used for antioxidant testing is DPPH. The antioxidant activity parameters were assessed based on the IC50 value obtained from the antioxidant test results. The best degradation results of glucomannan were pH 5.5 and a temperature of 65℃ with an IC50 value of 39.603 µg/mL due to the influence of pH and temperature on antioxidant activity, where low pH will have high antioxidants and high temperatures will cause a considerable reduction, resulting in high antioxidants.
Optimization of Extraction Factors in Aerial Plantago major L. Based on RSM to TPC Levels
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.26735

Abstract

Plantago major L. is known as an old medicinal plant. Some studies report that P. major has significant benefits in the world of health because of its phenolic content. Ultrasonic-assisted extraction (UAE) was chosen because it can extract faster with better yields. The best extraction conditions need to be sought to obtain optimum phenolic levels. Optimization can be done with Response Surface Methodology (RSM). This study aimed to obtain the best extraction conditions that produce optimum total phenolic levels. This study used the RSM Box-Behnken Design method. The study was conducted using 3 factors, namely the material-solvent ratio (1:5; 1:10; 1:15), ethanol-aqueous ratio (100:0; 50:50; 0:100), and extraction time (20, 40, 60) minutes, which was formulated using Design Expert 13. Total phenolic content (TPC) was measured using a UV-Vis Spectrophotometer. The analysis revealed that the quadratic polynomial model can be used to improve the extraction of P. major aerials. The best extraction conditions for TPC were a material-solvent ratio of 1:5.09; ethanol-aqueous ratio 73.27:26.73; extraction time 29.01 min, yielding a TPC value of 29.730 mg GAE/g. The experimental data were consistent with the predicted results. It demonstrates the applicability of the model and the success of the response surface methodology in optimizing the projected extraction conditions.
Cytotoxic and In Silico Evaluation of Hyrtios erectus Extract Against T47D Breast Cancer Cells: A Potential Marine-Derived Anticancer Agent
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.26988

Abstract

Hyrtios erectus is a marine sponge species with promising potential as an anticancer agent. This study aimed to evaluate the cytotoxic activity of Hyrtios erectus extract against T47D breast cancer cells and assess the drug-likeness of its active compounds through in silico approaches. The investigation began with a phytochemical screening of the extract, followed by a cytotoxicity assay using the MTT method. The in silico analysis included PASS prediction, ADMET evaluation, and molecular docking. Phytochemical screening revealed the presence of flavonoids, alkaloids, terpenes, and saponins. The cytotoxicity test yielded an IC₅₀ value of 12.73 ± 1.05 µg/mL and a selectivity index (SI) of 18.16, indicating strong cytotoxic activity and high selectivity towards T47D breast cancer cells. PASS and ADMET analyses predicted that 20 identified compounds possess anticancer potential with low toxicity. Molecular docking results exhibited favorable binding energies for 2-chloro-6-phenyl-8H-quinazolino[4,3-b]-quinazolin-8-one, Echinoclerodane A, and 5-hydroxy-1H-indole-3-carboxylic-acid-methyl-ester, suggesting significant interaction with cancer-related protein targets. These findings support the potential of Hyrtios erectus extract and its bioactive compounds as promising candidates for anticancer drug development.

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