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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 253 Documents
 22   23   24   25   26 
FORMULASI SEDIAAN MASKER GEL PEEL OFF EKSTRAK DAUN SIRIH CINA (PEPEROMIA PELLUCIDA) Nasution, Nurul Mawaddah; Br Ginting, Astriani Natalia; Yunus, Muhammad
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1622

Abstract

Acne vulgaris is a common skin disorder often associated with increased sebum production and colonization of Cutibacterium acnes on the skin. Peperomia pellucida L. is a medicinal plant known to contain secondary metabolites such as flavonoids, alkaloids, saponins, and tannins, which have potential for use in the development of natural cosmetic formulations. This study aimed to formulate Peperomia pellucida leaf extract into a peel-off gel mask preparation and evaluate its physical characteristics. The extraction of the leaves was carried out using a maceration method with 96% ethanol as the solvent. The obtained extract was then formulated into four different concentrations (0%, 2%, 4%, and 6%) using a gel base consisting of polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), triethanolamine (TEA), glycerin, nipagin, nipasol, and distilled water. The evaluation of the formulations included organoleptic observation, homogeneity test, pH measurement, drying time, and spreadability test. The results showed that all formulations produced homogeneous preparations with pH values ranging from 5.75 to 6.20, drying time between 15–25 minutes, and spreadability ranging from 6.3 to 6.8 cm. Increasing extract concentration affected the organoleptic characteristics and drying time of the preparations. Based on the physical evaluation results, the formulation containing 4% extract demonstrated the most optimal physical characteristics compared with the other formulations.
TINJAUAN LITERATUR: POTENSI TANAMAN OBAT SEBAGAI SUMBER ANTIOKSIDAN ALAMI Faramayuda, Fahrauk; Safrudin, Nurul Safirah; Windyaswari , Ari Sri
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1623

Abstract

Oxidative stress is a major driver of degenerative diseases, while synthetic antioxidants may pose long-term safety risks. The need for safer natural antioxidants has accelerated the exploration of medicinal plants, which are rich in bioactive compounds with antioxidant potential, particularly flavonoids and polyphenols. This systematic review aimed to classify antioxidant compounds from medicinal plants according to their phytochemical groups and to appraise their therapeutic potential based on recent pharmacological evidence. Articles published between 2015 and 2025 were retrieved from PubMed, Google Scholar, Garuda. Fifteen studies met the inclusion criteria for antioxidant activity testing. The review identified dominant antioxidant constituents, classified by chemical structure, including phenols, polyphenols, flavonoids, quercetin, and flavonoid–hydroquinone derivatives, reported across multiple plant species (Table 1). Plants consistently described as antioxidant sources were reundeu (Straurogyne elongata), moringa (Moringa oleifera), Indonesian bay leaf (Eugenia polyantha), water clover (Marsilea crenata), mango leaves (Mangifera indica), raru wood (Cotylelobium lanceolatum), and Jamaican cherry (Muntingia calabura), exhibiting moderate to strong antioxidant activity mainly in DPPH and FRAP assays. Overall, the findings indicate that antioxidant activity correlates with structural features such as the number and position of hydroxyl (–OH) groups, conjugated systems, and metal-chelating capacity. However, these compounds still face challenges related to poor stability and low bioavailability, suggesting that nanotechnology-based delivery systems may enhance formulation effectiveness. In conclusion, the plants reviewed contain promising antioxidant constituents, with quercetin and flavonoids emerging as the most active compounds, supporting their development as candidates for natural antioxidant-based phytopharmaceutical raw materials in Indonesia.
UJI AKTIVITAS ANTIOKSIDAN TERHADAP EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. var. arum manis) MENGGUNAKAN METODE DPPH Mahzura, Siti; Br Ginting, Astriani Natalia; Harahap, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1624

Abstract

Radikal bebas dapat memicu stres oksidatif yang berperan dalam berbagai penyakit degeneratif, sehingga diperlukan sumber antioksidan alami yang aman dan efektif. Daun mangga arum manis mengandung berbagai senyawa bioaktif seperti flavonoid, alkaloid, tanin, saponin, dan triterpenoid yang berpotensi sebagai antioksidan. Tujuan penelitian ini adalah mengetahui aktivitas antioksidan ekstrak etanol daun mangga arum manis (Mangifera indica L. var. arum manis) menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Metode penelitian yang digunakan adalah eksperimen laboratorium. Daun mangga dikumpulkan dari Kecamatan Secanggang, Kabupaten Langkat, kemudian dideterminasi di Herbarium Medanense. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%. Skrining fitokimia dilakukan untuk mengidentifikasi kandungan metabolit sekunder. Uji aktivitas antioksidan dilakukan menggunakan variasi konsentrasi ekstrak 20, 40, 60, 80, dan 100 ppm serta vitamin C sebagai kontrol positif. Sampel direaksikan dengan larutan DPPH 50 ppm dan absorbansi diukur pada panjang gelombang 517 nm setelah inkubasi 30 menit. Hasil penelitian menunjukkan bahwa persentase inhibisi meningkat seiring peningkatan konsentrasi ekstrak, dengan nilai inhibisi tertinggi sebesar 50,2% pada konsentrasi 100 ppm. Analisis regresi linear menghasilkan nilai IC₅₀ sebesar 98,73 ppm yang termasuk kategori aktivitas antioksidan kuat. Sebagai pembanding, vitamin C menunjukkan nilai IC₅₀ sebesar 6,07 ppm yang mengindikasikan aktivitas antioksidan sangat kuat. Kesimpulan penelitian ini adalah bahwa ekstrak etanol daun mangga arum manis memiliki aktivitas antioksidan kuat berdasarkan nilai IC₅₀. Meskipun potensinya lebih rendah dibandingkan vitamin C, ekstrak ini tetap menunjukkan kemampuan signifikan sebagai sumber antioksidan alami. Penelitian lanjutan disarankan menggunakan metode FRAP atau ABTS untuk memperkuat hasil.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. ‘Arumanis’) TERHADAP Staphylococcus aureus Alya, Cinta; Br Ginting, Astriani Natalia; Harahap, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1625

Abstract

The increasing prevalence of bacterial resistance to antibiotics has encouraged the exploration of natural products as alternative antimicrobial agents. This study aimed to evaluate the inhibitory potential of the ethanolic extract of ‘Arumanis’ mango leaves (Mangifera indica L. ‘Arumanis’) against Staphylococcus aureus ATCC 25923. The research was conducted using a laboratory experimental design including plant identification, preparation of simplicia, extraction by maceration with 96% ethanol, phytochemical screening, and antibacterial activity testing using the disk diffusion method. The extract was tested at concentrations of 5%, 10%, and 15% (50–150 mg/mL), with three replications (n=3) for each treatment and control group. The inhibition zones were measured including the 6 mm disk diameter and analyzed descriptively as mean ± standard deviation. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. The antibacterial assay showed inhibition zone diameters of 3.00 ± 2.12 mm (5%), 4.38 ± 2.51 mm (10%), and 6.13 ± 2.63 mm (15%), while the positive control chloramphenicol (30 µg/disk) produced a 21.43 ± 0.06 mm inhibition zone and the negative control (10% DMSO) showed no inhibitory effect. Although inhibition zones were observed at all concentrations, the diameters were relatively small compared to the standard antibiotic. Therefore, the ethanolic extract of M. indica ‘Arumanis’ leaves demonstrates concentration-dependent inhibitory potential against S. aureus, but with limited antibacterial activity, indicating the need for further evaluation using dilution methods to determine the Minimum Inhibitory Concentration (MIC).
FORMULASI MASKER GEL DENGAN EKSTRAK DAUN MANGGA ARUMANIS (Mangifera Indica L.) SEBAGAI BAHAN AKTIF Helgiera, Tasyah; Br Ginting, Astriani Natalia; Bangar, Roy Indrianto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1626

Abstract

Exposure to ultraviolet (UV) radiation and environmental pollution can generate free radicals that contribute to skin damage and accelerate premature aging. One approach to protect the skin from these effects is the use of antioxidants derived from natural sources. Arumanis mango leaves (Mangifera indica L.) contain secondary metabolites such as flavonoids, tannins, and saponins which have potential antioxidant activity and can be utilized as active ingredients in cosmetic formulations. This study aimed to formulate a gel mask containing ethanol extract of arumanis mango leaves and to evaluate the physical quality of the preparation. The extract was obtained using the maceration method with 96% ethanol as the solvent. The gel mask was formulated into three different extract concentrations, namely 0%, 4%, and 6%. The physical evaluation included organoleptic test, homogeneity, pH, spreadability, and drying time tests. The results showed that the gel mask preparations exhibited good physical characteristics, with homogeneous appearance, pH values ranging from 5.16–6.26, spreadability of 5.5–6.8 cm, and drying time of 17–20 minutes. The variation in extract concentration affected the color of the preparation but did not significantly influence the overall physical stability of the gel. Therefore, ethanol extract of arumanis mango leaves can be formulated into a gel mask preparation that meets the physical quality requirements for skincare products.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL PADA BUAH BIT (Beta vulgaris L.) MENGGUNAKAN METODE DPPH (2,2-DIPHENYL-1-PICRYLHYDRAZIL) Nadeak , Dian Sry Rejeki; br ginting, Astriani Natalia; Harahan, Daimah Wirdatus Sanaun
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1637

Abstract

Oxidative stress due to the accumulation of free radicals plays a role in the development of various degenerative diseases, so that natural antioxidant sources that can be scientifically evaluated are needed. Beetroot (Beta vulgaris L.) is known to contain bioactive compounds such as betalains, flavonoids, and polyphenols that have the potential as antioxidants. This study aims to evaluate the antioxidant activity of beetroot (Beta vulgaris L.) ethanol extract in vitro using the DPPH method. Extraction was carried out by maceration method using 96% ethanol. The antioxidant activity test was carried out using DPPH solution with absorbance measurement at a wavelength of 517 nm. The extract was tested at a concentration range of 10–100 µg/mL with three replications, while quercetin was used as a positive control. Antioxidant activity was expressed as the percentage of DPPH radical inhibition and the IC₅₀ value calculated using linear regression analysis. The results showed that the beetroot ethanol extract had an IC₅₀ value of 3.35 µg/mL, while quercetin had an IC₅₀ value of 2.76 µg/mL. The yield of the extract obtained was 20.29%. These results indicate that the beetroot ethanol extract has DPPH radical scavenging activity in the in vitro test system used.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ASPIRIN DAN CLOPIDOGREL PADA PASIEN STROKE ISKEMIK RAWAT INAP DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022–2025 Nasution, Nursaima Putri; Harahap, Daimah Wirdatus Sanaun; Br Ginting, Astriani Natalia
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1647

Abstract

Ischemic stroke is one of the leading causes of mortality and long-term disability, imposing a substantial economic burden due to high treatment and rehabilitation costs. Antiplatelet therapies such as aspirin and clopidogrel are commonly used for secondary prevention to reduce the risk of recurrent stroke; however, differences in treatment costs require evaluation to support efficient use of healthcare resources. This study aimed to analyze and compare the total cost and cost-effectiveness of aspirin and clopidogrel therapy in patients with ischemic stroke at Royal Prima General Hospital during the period 2022-2025. This study was an observational analytic study with a retrospective design using patients’ medical record data. The analysis was conducted from the hospital perspective by calculating direct medical costs, including drug costs, hospitalization, diagnostic examinations, and medical procedures. Pharmacoeconomic evaluation was performed using the Cost-Effectiveness Analysis (CEA) approach, with cost-effectiveness assessed through the calculation of the Cost-Effectiveness Ratio (CER) based on patients’ clinical outcomes. The results demonstrated differences in total treatment costs between aspirin and clopidogrel therapy, influenced by variations in cost components and patients’ clinical characteristics. In conclusion, cost-effectiveness analysis using CEA and CER can provide a scientific basis for selecting antiplatelet therapy that is rational and cost-efficient in the management of patients with ischemic stroke.
TINJAUAN LITERATUR: ETNOFARMASI DAN AKTIVITAS FARMAKOLOGI KULIT PISANG KEPOK (Musa paradisiaca formatypica) Sadino, Asman; Fadhlillah, Faizah Min; Hajar, Dhea Siti; Apriani, Riza
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1649

Abstract

Ethnopharmaceutical study is an approach to explore the local knowledge of people from certain tribes and ethnicities regarding the utilization of plants as traditional medicines. This review aims to examine the ethnopharmaceutical utilization and pharmacological activity of kepok banana peel waste (Musa paradisiaca formatypica) based on current scientific evidence. The method used was narrative review through literature searches on Google Scholar and PubMed databases of full-text articles published in the period 2011-2026. The keywords used included “ethnopharmaceutical,” “Musa paradisiaca,” “kepok banana peel”, and “pharmacological activity of Musa paradisiaca.” Included articles were national and international accredited/ISSN publications that addressed the ethnopharmaceutical aspects and pharmacological activity of kepok banana peel, while irrelevant articles and publications below 2011 were excluded. The results showed that kepok banana peel has been utilized as a traditional medicine by several ethnic groups in Indonesia, including Dondo, Kaili, Mori, Sasak, and Banggai. Pharmacologically, kepok banana peel is reported to have several main activities including antidiarrheal, anti-inflammatory, wound healing (cuts and burns), and anti-acne activity. Based on these findings, kepok banana peel waste has the potential to be developed as an ethnopharmaceutical-based traditional medicine ingredient and candidate raw material for pharmaceutical preparations supporting therapy.
TINJAUAN LITERATUR: AKTIVITAS ANTIDIABETES MELLITUS BEBERAPA TANAMAN FAMILI MALVACEAE Sadino, Asman; Nuari, Doni Anshar; Apriani, Riza; Muharam, Ceceng Fajar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1650

Abstract

The Malvaceae family is a group of plants widely used empirically as traditional medicine to help control diabetes mellitus (DM) and has been supported by various experimental studies. This review aims to assess the types of Malvaceae family plants that have potential as antidiabetics and to summarize scientific evidence related to their pharmacological activity and the active compounds involved. The method used was a narrative review through a literature search in Google Scholar and PubMed for full-text articles published during 2011–2026. The included articles consisted of in vitro and in vivo studies discussing the antidiabetic or antihyperglycemic activity of Malvaceae family plants, while duplicate articles, review articles, proceedings, and irrelevant publications were excluded. Based on the selection process, several articles met the criteria for descriptive analysis. The results showed that several Malvaceae family plants have antidiabetic potential, including hibiscus (Hibiscus rosa-sinensis), roselle (Hibiscus sabdariffa), okra (Abelmoschus esculentus), durian (Durio zibethinus), sidaguri (Sida cordifolia), kapas hantu (Abroma augusta), biruan (Grewia asiatica), kapuk (Ceiba pentandra), kembang sore (Abutilon indicum), and pulutan (Urena lobata), all reported to have blood glucose-lowering effects. This activity is related to secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and phenolic compounds, which act through antioxidant mechanisms, increased insulin sensitivity, inhibition of α-amylase and α-glucosidase enzymes, and protection of pancreatic β cells. Based on these findings, Malvaceae family plants have the potential to be developed as sources of natural medicine candidates and supportive therapies in the management of diabetes mellitus.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL SIRIH CINA (PEPEROMIA PELLUCIDA) DENGAN MENGGUNAKAN METODE DPPH Aini, Nurul; Ginting, Astriani Natalia Br.; Kaban, Vera Estefani
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1664

Abstract

Chinese betel (Peperomia pellucida L.) is a plant known to contain various secondary metabolites with potential antioxidant activity. This study aimed to identify the bioactive compounds present in the ethanol extract of Chinese betel and to evaluate its antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was performed using 96% ethanol and yielded an extract recovery of 8.75% from 400 grams of simplicia. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and triterpenoids/steroids, while saponins were not detected. Antioxidant activity was evaluated at five concentrations (20–100 ppm) with vitamin C used as a reference standard. The IC₅₀ value of the Chinese betel ethanol extract was 63.49 ppm, indicating strong antioxidant activity, whereas vitamin C showed an IC₅₀ value of 6.06 ppm, classified as very strong antioxidant activity. Based on these findings, the ethanol extract of Chinese betel shows potential as a natural antioxidant source and warrants further investigation for the development of natural product-based formulations.

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