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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 253 Documents
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UJI POTENSI ANTIBAKTERI KOMBINASI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) DAN DAUN SESEWANUA (Cleodendron squamatum vahl.) TERHADAP BAKTERI Staphylococcus aureus Rintjap, Djois Sugiaty; Rindengan , Elvie Rifke; Pobela, Nadila Aurelia Putri; Ulaen, Selfie Petronella Joice; Barung , Elisabeth Natalia
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1567

Abstract

Cherry leaves (Muntingia calabura L.) and sesewanua leaves (Clerodendron squamatum Vahl) can be used as an alternative antibacterial treatment. Antibacterial testing of single compositions has been widely carried out but not yet on a combination of these two plants. The study aims to determine the antibacterial potential of a combination of ethanol extracts of cherry leaves and sesewanua leaves against Staphylococcus aureus. Cherry leaves and sesewanua leaves were extracted using the maceration method, 96% ethanol solvent. The test solution was made at concentrations of 5%, 10%, and 15%. The combination was made by mixing each concentration with a ratio of 1:1. Testing using the disc diffusion method, positive control Ciprofloxacin, negative control Sodium CMC 1%, observed 1x24 hours. The inhibition zone was measured using a caliper. The average results of the inhibition zone diameter of the ethanol extract of cherry leaves were 8.74±0.25 mm, 9.27±0.15 mm, 10.21±0.30 mm, the ethanol extract of sesewanua leaves was 6.96±0.83 mm, 7.46±0.56 mm, 7.17±0.13 mm. The combination of ethanol extract of cherry leaves and sesewanua leaves was 7.51±0.49 mm, 8.30±0.61 mm, 9.70±0.20 mm, Ciprofloxacin was 26.52±3.44 mm. The best results were at a concentration of 15% but not optimal. In conclusion, single extract of cherry leaves, single extract of sesewanua leaves, combination of ethanol extract of cherry leaves and sesewanua leaves (1:1) at concentrations of 5%, 10%, and 15% have moderate antibacterial activity against Staphylococcus aureus. The inhibitory power is greater in the single extract of cherry leaves compared to the combination of extracts.
ANALISIS EFEK SAMPING JANGKA PANJANG PENGGUNAAN ANTASIDA KALSIUM KARBONAT: NARRATIVE REVIEW Ridwan, Heri; Aliviani, Arvi; Febriyanti, Ine; Nathania, Levina Nabila; Ramadhan, Muhammad Gilang; Ramadani, Nur Oktavia; Maharani, Syifa Anisa
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1568

Abstract

The widespread use of calcium carbonate antacids in self-medication is often considered safe, but excessive consumption and long-term use can cause serious side effects that affect various body systems. This study aims to analyze the long-term side effects of calcium carbonate based on the latest scientific evidence. The method used was a narrative review by selecting relevant articles from PubMed, ScienceDirect, and Google Scholar through inclusion and exclusion criteria, resulting in six main articles for analysis. The results showed that prolonged use of CaCO₃ can cause progressive hypercalcemia, which has the potential to develop into Milk-Alkali Syndrome, characterized by hypercalcemia, metabolic alkalosis, and impaired kidney function. Further complications reported include nephrolithiasis, acute pancreatitis, metabolic disorders, and progressive renal dysfunction. In addition, CaCO₃ is known to interfere with the absorption of various drugs through chelation and changes in gastric pH, thereby potentially reducing the effectiveness of therapy. In conclusion, long-term use of calcium carbonate antacids without adequate monitoring can pose significant health risks, making education and supervision of antacid use essential to prevent toxicity and harmful drug interactions.
TINJAUAN LITERATUR: AKTIVITAS FARMAKOLOGI DAN KANDUNGAN SENYAWA DARI KACANG KEDELAI (Glycine max L.) Sadino, Asman; Apriani, Riza; Solihah, Puspa Sari Dewi; Rachmawati, Siti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1569

Abstract

Soybean (Glycine max L.) is a functional food from the legume group that is rich in bioactive compounds and has the potential to prevent degenerative diseases. This review aims to assess the content of the main active compounds and pharmacological activities of soybeans based on current scientific evidence. The method used is narrative review through literature searches on Google Scholar and PubMed databases of full-text articles published in the period 2010-2025. Articles included were in vitro and in vivo experimental studies that addressed the compound content and pharmacological activity of soybeans, while review articles, proceedings, and irrelevant publications were excluded. From the selection process, 12 articles were obtained that met the criteria for analysis. The results showed that isoflavones are the dominant compounds in soybeans that play a role in various pharmacological activities that can be grouped into several main categories, namely antioxidant and anti-inflammatory activities, metabolic activities (antidiabetes, antiobesity, and antihyperuricemia), and cardiovascular activities (antihypertension and anticholesterol). In addition, soy also shows potential as a supportive agent in the prevention of cancer and osteoporosis. Based on these findings, soy has great potential to be developed as a functional food and therapeutic support material in the prevention of degenerative diseases.
ANTIHIPERPIGMENTASI Hylocereus costaricensis MELALUI INHIBISI TIROSINASE: STUDI NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING Prasetyo, Bayu Febram; Alauddin, Daffa Rizal Dzulfaqaar; Purwono, Rini Madyastuti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1570

Abstract

Hyperpigmentation was driven by increased melanogenesis and oxidative stress, creating a need for effective and safe depigmenting candidates. This study aimed to identify bioactive compounds from Hylocereus costaricensis, to map hyperpigmentation-related targets and pathways using network pharmacology, and to evaluate the binding potential of selected compounds to a melanogenesis target using molecular docking. The workflow included compound screening and drug-likeness/ADMET evaluation, prediction of compound targets and hyperpigmentation-associated genes, construction of compound–target–disease and protein–protein interaction networks, topological and GO/KEGG enrichment analyses, and docking to TYRP1 (PDB: 5M8O). Five main candidates, namely 2,2-dimethyl-3-phenylpropanoic acid, ferulic acid, o-coumaric acid, p-coumaric acid, and vanillic acid, have met the initial criteria. Network pharmacology highlighted a multi-target mechanism by prioritizing key nodes including AKT1, EGFR, PIK3CA, TYR, and CDK4 and by indicating enriched signaling pathways relevant to pigmentation regulation and oxidative-stress responses. Docking results showed moderate affinities, with binding energies of approximately −6.551 to −6.184 kcal/mol and estimated inhibition constants of 15.779 to 29.315 µM, and 2,2-dimethyl-3-phenylpropanoic acid yielded the best score among the tested ligands. Overall, the integrated network pharmacology–docking strategy provided a rational prioritization of compounds and targets for developing anti-hyperpigmentation agents derived from H. costaricensis; however, the evidence remained preliminary and required further experimental validation and mechanistic confirmation.
KUALITAS MIKROBIOLOGIS ES BATU BALOK BERDASARKAN CEMARAN BAKTERI Coliform DAN Salmonella sp DI WILAYAH KARANGPAWITAN, KARAWANG Agustina, Putri; Risna, Kamelia; Wahyuningsih, Eko Sri; Gunarti, Neni Sri; Fikayuniar, Lia
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1571

Abstract

The cold temperature of ice cubes leads people to assume that ice cubes are safe for consumption without having to consider their type and quality. In reality, the cold temperature only weakens the bacteria in the ice cubes. Ice cube samples in this study were taken from the Karangpawitan area, because this area is one of the areas with many ice cube distributors, is busy, and is one of the culinary destinations for Karawang residents. The purpose of this study was to determine the quality of block ice cubes based on contamination by Coliform and Salmonella This research method includes qualitative research with an experimental approach, using the MPN test for Coliform and SSA media and gram staining for Salmonella Results from the Pondok Bogor and Kepuh locations showed positive block ice cube samples for Coliform bacteria. The Nagasari location for block ice cubes and plastic packaging tested positive for Coliform bacteria and negative for Salmonella The conclusion of this study is that the block ice cubes in the Karangpawitan area have quite high bacterial contamination. Positive results indicate that they do not meet the quality requirements based on Permenkes No. 492/Menkes/Per/IV/2010, which is >0/100 mL
UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL KULIT BUAH SUKUN (Artocarpus altilis (Parkinson) Fosberg) PADA MENCIT PUTIH JANTAN GALUR SWISS WEBSTER Renggana, Hesti; Sujana, Dani; Martiani, Isye; Amalia, Nur; Rantika, Nopi; Hindun, Siti; Rachyani, Evitri Risa
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1576

Abstract

Hyperuricemia is defined as an elevated serum uric acid level beyond the normal physiological range, which may result from increased purine metabolism or impaired renal excretion of uric acid. Long-term pharmacological management of hyperuricemia can lead to adverse effects, highlighting the need for alternative treatments derived from natural sources. One such alternative is the skin of Artocarpus altilis, which is rich in flavonoids. The objective of this study was to evaluate the antihyperuricemic activity of ethanol extract from Artocarpus altilis fruit skin in male mice induced with potassium oxonate and chicken liver extract. Serum uric acid levels were quantified using the Point of Care Testing (POCT) method with an Easy Touch® digital device. The doses administered were 100, 200, and 400 mg/kgBW, with 13 mg/BW of Allopurinol as a positive control. Statistical analysis was conducted using ANOVA followed by post-hoc LSD tests. The results indicated that the ethanol extract of breadfruit skin exhibited significant antihyperuricemic activity at all tested doses. A dose of 100 mg/kgBW resulted in a 40.72% reduction in serum uric acid levels, with an efficacy of 68.33%. The observed effect is likely attributed to the flavonoid content, which inhibits xanthine oxidase, thereby making the 100 mg/kgBW dose the most effective in reducing uric acid levels.
ANALISIS EFEKTIVITAS BIAYA OMEPRAZOLE DAN RANITIDIN PADA PASIEN DISPEPSIA DI INSTALASI RAWAT INAP RSUD UNDATA PALU Hardani, Ririen; Ambianti, Nurul; Safarudin, Rudi; Syafaah , Tri Atainah
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1582

Abstract

The prevalence rate of dyspepsia continues to increase, with cases of recurrence occurring in patients not only adding to the physical and psychological burden of patients, but can also pose an economic burden on both patients and the health system. This study aims to determine the cost of therapy in dyspepsia patients based on the ACER value. This study is a descriptive study, data obtained from medical records and financial data of dyspepsia patients at Undata Hospital, Palu. Data analysis was done descriptively using Microsoft excel and statistically using Kruskal wallis test, Chi-square and independent T-test. The results of the study based on the Kruskal wallis test obtained a p-value of 0.002 which indicates that there is a significant effect of secondary diagnosis on direct medical costs of dyspepsia patients, and the cost effectiveness of therapy based on the ACER value of omeprazole of Rp 35,965 and the ACER value of ranitidine of Rp 28,965. The conclusion of this study is that ranitidine is more cost effective than omeprazole in dyspeptic patients at the inpatient installation of RSUD Undata Palu.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL JAHE MERAH (ZINGIBER OFFICINALE VAR. RUBRUM) MENGGUNAKAN METODE DPPH Raja, Hera Derliana Lumban; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1610

Abstract

Antioxidants play an important role in warding off free radicals that can cause oxidative stress and various degenerative diseases. One potential source of natural antioxidants is red ginger leaves ( Zingiber officinale var. rubrum ). This study aims to determine the antioxidant activity of ethanol extract of red ginger leaves using the DPPH method. Extraction was carried out using ethanol solvent, then the antioxidant activity was tested at various concentrations of 20, 30, 40, and 50 ppm. The parameters observed included absorbance value, inhibition percentage, and IC ₅₀ value . The results showed that the inhibition percentage increased with increasing extract concentration. The IC₅₀ value obtained was 45.50 ppm , indicating that the ethanol extract of red ginger leaves has very strong antioxidant activity. Based on these results, it can be concluded that red ginger leaves have the potential as a source of natural antioxidants that can be developed in the fields of health and functional foods.
EFEKTIVITAS GEL DAUN KIPAHIT (Tithonia diversifolia) TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS Khadijah, Siti; Br Ginting, Astriani Natalia; Simanjuntak, Nerly Juli Pranita
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1614

Abstract

Diabetes mellitus is a chronic disease commonly associated with complications such as diabetic wounds, which are characterized by impaired tissue perfusion, prolonged inflammation, and increased susceptibility to infection, resulting in delayed wound healing. Although various topical therapies have been developed, the use of herbal-based formulations for diabetic wound management remains an area of ongoing research. Leaves of Tithonia diversifolia are known to contain secondary metabolites such as flavonoids, tannins, alkaloids, and saponins, which may support the wound healing process. This study aimed to evaluate the effectiveness of Tithonia diversifolia leaf extract gel on wound healing in streptozotocin (STZ)-induced diabetic rats. This experimental study used 30 male white rats divided into six groups: normal control, negative control (gel base), positive control (octeniline gel), and treatment groups receiving Tithonia diversifolia extract gel at concentrations of 5%, 10%, and 15%. The extract was obtained by maceration using 70% ethanol and formulated into a topical gel. Wound length was observed on days 0, 3, 7, and 14, and the data were analyzed using One-Way ANOVA followed by Tukey HSD test. The results showed that Tithonia diversifolia extract gel significantly affected wound healing from day 3 to day 14 (p < 0.05). The 10% and 15% formulations demonstrated better wound healing than the negative control, while the 15% formulation showed the most optimal result, with a mean wound length of 0.40 mm on day 14. Therefore, Tithonia diversifolia extract gel has potential to be developed as a topical preparation supporting wound healing under diabetic conditions.
UJI EFEKTIVITAS ANTIDIABETIK DAUN KIPAHIT (Tithonia diversifolia) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS MODEL DIABETES TERINDUKSI STREPTOZOTOCIN Hasanah, Nurul; Br Ginting, Astriani Natalia; Yunus, Muhammad
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1615

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Tithonia diversifolia (Kipahit) leaves are traditionally used for diabetes. This study aims to determine the antidiabetic effectiveness of Kipahit leaf ethanol extract on blood glucose levels in streptozotocin (STZ)-induced diabetic rats. The research was an experimental laboratory study using a post-test only control group design. Thirty male rats were divided into six groups: normal control, negative control (STZ), positive control (STZ + metformin), and three treatment groups receiving the extract at doses of 250, 350, and 450 mg/kg BW. The extract yield was 29.67%. Phytochemical screening showed positive results for flavonoids, alkaloids, saponins, tannins, and steroids. Blood glucose levels were measured on days 0, 3, 6, 9, 12, and 15. Data were analyzed using One-Way ANOVA and Duncan's post hoc test. The results showed that the extract significantly reduced blood glucose levels. The dose of 450 mg/kg BW was the most effective, with an effect comparable to metformin.

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