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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 226 Documents
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UJI POTENSI ANTIBAKTERI KOMBINASI EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) DAN DAUN SESEWANUA (Cleodendron squamatum vahl.) TERHADAP BAKTERI Staphylococcus aureus Rintjap, Djois Sugiaty; Rindengan , Elvie Rifke; Pobela, Nadila Aurelia Putri; Ulaen, Selfie Petronella Joice; Barung , Elisabeth Natalia
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1567

Abstract

Cherry leaves (Muntingia calabura L.) and sesewanua leaves (Clerodendron squamatum Vahl) can be used as an alternative antibacterial treatment. Antibacterial testing of single compositions has been widely carried out but not yet on a combination of these two plants. The study aims to determine the antibacterial potential of a combination of ethanol extracts of cherry leaves and sesewanua leaves against Staphylococcus aureus. Cherry leaves and sesewanua leaves were extracted using the maceration method, 96% ethanol solvent. The test solution was made at concentrations of 5%, 10%, and 15%. The combination was made by mixing each concentration with a ratio of 1:1. Testing using the disc diffusion method, positive control Ciprofloxacin, negative control Sodium CMC 1%, observed 1x24 hours. The inhibition zone was measured using a caliper. The average results of the inhibition zone diameter of the ethanol extract of cherry leaves were 8.74±0.25 mm, 9.27±0.15 mm, 10.21±0.30 mm, the ethanol extract of sesewanua leaves was 6.96±0.83 mm, 7.46±0.56 mm, 7.17±0.13 mm. The combination of ethanol extract of cherry leaves and sesewanua leaves was 7.51±0.49 mm, 8.30±0.61 mm, 9.70±0.20 mm, Ciprofloxacin was 26.52±3.44 mm. The best results were at a concentration of 15% but not optimal. In conclusion, single extract of cherry leaves, single extract of sesewanua leaves, combination of ethanol extract of cherry leaves and sesewanua leaves (1:1) at concentrations of 5%, 10%, and 15% have moderate antibacterial activity against Staphylococcus aureus. The inhibitory power is greater in the single extract of cherry leaves compared to the combination of extracts.
ANALISIS EFEK SAMPING JANGKA PANJANG PENGGUNAAN ANTASIDA KALSIUM KARBONAT: NARRATIVE REVIEW Ridwan, Heri; Aliviani, Arvi; Febriyanti, Ine; Nathania, Levina Nabila; Ramadhan, Muhammad Gilang; Ramadani, Nur Oktavia; Maharani, Syifa Anisa
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1568

Abstract

The widespread use of calcium carbonate antacids in self-medication is often considered safe, but excessive consumption and long-term use can cause serious side effects that affect various body systems. This study aims to analyze the long-term side effects of calcium carbonate based on the latest scientific evidence. The method used was a narrative review by selecting relevant articles from PubMed, ScienceDirect, and Google Scholar through inclusion and exclusion criteria, resulting in six main articles for analysis. The results showed that prolonged use of CaCO₃ can cause progressive hypercalcemia, which has the potential to develop into Milk-Alkali Syndrome, characterized by hypercalcemia, metabolic alkalosis, and impaired kidney function. Further complications reported include nephrolithiasis, acute pancreatitis, metabolic disorders, and progressive renal dysfunction. In addition, CaCO₃ is known to interfere with the absorption of various drugs through chelation and changes in gastric pH, thereby potentially reducing the effectiveness of therapy. In conclusion, long-term use of calcium carbonate antacids without adequate monitoring can pose significant health risks, making education and supervision of antacid use essential to prevent toxicity and harmful drug interactions.
TINJAUAN LITERATUR: AKTIVITAS FARMAKOLOGI DAN KANDUNGAN SENYAWA DARI KACANG KEDELAI (Glycine max L.) Sadino, Asman; Apriani, Riza; Solihah, Puspa Sari Dewi; Rachmawati, Siti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1569

Abstract

Soybean (Glycine max L.) is a functional food from the legume group that is rich in bioactive compounds and has the potential to prevent degenerative diseases. This review aims to assess the content of the main active compounds and pharmacological activities of soybeans based on current scientific evidence. The method used is narrative review through literature searches on Google Scholar and PubMed databases of full-text articles published in the period 2010-2025. Articles included were in vitro and in vivo experimental studies that addressed the compound content and pharmacological activity of soybeans, while review articles, proceedings, and irrelevant publications were excluded. From the selection process, 12 articles were obtained that met the criteria for analysis. The results showed that isoflavones are the dominant compounds in soybeans that play a role in various pharmacological activities that can be grouped into several main categories, namely antioxidant and anti-inflammatory activities, metabolic activities (antidiabetes, antiobesity, and antihyperuricemia), and cardiovascular activities (antihypertension and anticholesterol). In addition, soy also shows potential as a supportive agent in the prevention of cancer and osteoporosis. Based on these findings, soy has great potential to be developed as a functional food and therapeutic support material in the prevention of degenerative diseases.
ANTIHIPERPIGMENTASI Hylocereus costaricensis MELALUI INHIBISI TIROSINASE: STUDI NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING Prasetyo, Bayu Febram; Alauddin, Daffa Rizal Dzulfaqaar; Purwono, Rini Madyastuti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1570

Abstract

Hyperpigmentation was driven by increased melanogenesis and oxidative stress, creating a need for effective and safe depigmenting candidates. This study aimed to identify bioactive compounds from Hylocereus costaricensis, to map hyperpigmentation-related targets and pathways using network pharmacology, and to evaluate the binding potential of selected compounds to a melanogenesis target using molecular docking. The workflow included compound screening and drug-likeness/ADMET evaluation, prediction of compound targets and hyperpigmentation-associated genes, construction of compound–target–disease and protein–protein interaction networks, topological and GO/KEGG enrichment analyses, and docking to TYRP1 (PDB: 5M8O). Five main candidates, namely 2,2-dimethyl-3-phenylpropanoic acid, ferulic acid, o-coumaric acid, p-coumaric acid, and vanillic acid, have met the initial criteria. Network pharmacology highlighted a multi-target mechanism by prioritizing key nodes including AKT1, EGFR, PIK3CA, TYR, and CDK4 and by indicating enriched signaling pathways relevant to pigmentation regulation and oxidative-stress responses. Docking results showed moderate affinities, with binding energies of approximately −6.551 to −6.184 kcal/mol and estimated inhibition constants of 15.779 to 29.315 µM, and 2,2-dimethyl-3-phenylpropanoic acid yielded the best score among the tested ligands. Overall, the integrated network pharmacology–docking strategy provided a rational prioritization of compounds and targets for developing anti-hyperpigmentation agents derived from H. costaricensis; however, the evidence remained preliminary and required further experimental validation and mechanistic confirmation.
KUALITAS MIKROBIOLOGIS ES BATU BALOK BERDASARKAN CEMARAN BAKTERI Coliform DAN Salmonella sp DI WILAYAH KARANGPAWITAN, KARAWANG Agustina, Putri; Risna, Kamelia; Wahyuningsih, Eko Sri; Gunarti, Neni Sri; Fikayuniar, Lia
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1571

Abstract

The cold temperature of ice cubes leads people to assume that ice cubes are safe for consumption without having to consider their type and quality. In reality, the cold temperature only weakens the bacteria in the ice cubes. Ice cube samples in this study were taken from the Karangpawitan area, because this area is one of the areas with many ice cube distributors, is busy, and is one of the culinary destinations for Karawang residents. The purpose of this study was to determine the quality of block ice cubes based on contamination by Coliform and Salmonella This research method includes qualitative research with an experimental approach, using the MPN test for Coliform and SSA media and gram staining for Salmonella Results from the Pondok Bogor and Kepuh locations showed positive block ice cube samples for Coliform bacteria. The Nagasari location for block ice cubes and plastic packaging tested positive for Coliform bacteria and negative for Salmonella The conclusion of this study is that the block ice cubes in the Karangpawitan area have quite high bacterial contamination. Positive results indicate that they do not meet the quality requirements based on Permenkes No. 492/Menkes/Per/IV/2010, which is >0/100 mL
UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL KULIT BUAH SUKUN (Artocarpus altilis (Parkinson) Fosberg) PADA MENCIT PUTIH JANTAN GALUR SWISS WEBSTER Renggana, Hesti; Sujana, Dani; Martiani, Isye; Amalia, Nur; Rantika, Nopi; Hindun, Siti; Rachyani, Evitri Risa
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1576

Abstract

Hyperuricemia is defined as an elevated serum uric acid level beyond the normal physiological range, which may result from increased purine metabolism or impaired renal excretion of uric acid. Long-term pharmacological management of hyperuricemia can lead to adverse effects, highlighting the need for alternative treatments derived from natural sources. One such alternative is the skin of Artocarpus altilis, which is rich in flavonoids. The objective of this study was to evaluate the antihyperuricemic activity of ethanol extract from Artocarpus altilis fruit skin in male mice induced with potassium oxonate and chicken liver extract. Serum uric acid levels were quantified using the Point of Care Testing (POCT) method with an Easy Touch® digital device. The doses administered were 100, 200, and 400 mg/kgBW, with 13 mg/BW of Allopurinol as a positive control. Statistical analysis was conducted using ANOVA followed by post-hoc LSD tests. The results indicated that the ethanol extract of breadfruit skin exhibited significant antihyperuricemic activity at all tested doses. A dose of 100 mg/kgBW resulted in a 40.72% reduction in serum uric acid levels, with an efficacy of 68.33%. The observed effect is likely attributed to the flavonoid content, which inhibits xanthine oxidase, thereby making the 100 mg/kgBW dose the most effective in reducing uric acid levels.

Page 23 of 23 | Total Record : 226

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