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Narra J
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 28072618     DOI : https://doi.org/10.52225/narraj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Narra J is a multidisciplinary journal and it is published three times (April, August, December) a year. The objective is to promote articles on infection, public health, global health, tropical infection, one health and diseases in tropics. Narra J publishes original research work across all disciplines of medicine and allied sciences, related to infection, public health, global health, tropical infection, one health and diseases in tropics. The journal publishes Original articles, Short Report, Review articles, and Letters to the Editor. All articles published in Narra J are peer-reviewed and published online for immediate access and citation. Narra J publishes the primary research papers, review articles, short communications and letters on topics but not limited to: Public health Global health Infection Tropical diseases One health Biomedical sciences Epidemiology and clinical epidemiology Molecular biology Environmental health Microbiology Pharmacological sciences Diseases in tropics
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 565 Documents
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Sleep quality and cognitive function on self-rated health status among the elderly: Findings from the Indonesian family life survey (IFLS-5) Asri, Yuni; Zakaria, Amin; Yunita, Heny N.; Azizah, Fidrotin; Sasmiyanto, Sasmiyanto; Murtiyani, Ninik; B. Manga , Yankuba
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1103

Abstract

Cognitive decline poses a significant challenge for the elderly population globally. The aim of this study was to determine the prevalence of cognitive function and its associated factors among the elderly in the Indonesian family life survey’s fifth wave (IFLS-5) conducted from 2014 to 2015. The study included elderly individuals aged 60 and above, excluding proxy respondents and those with missing data. Various socio-demographic, cognitive function and health-related variables were analyzed, including age, sex, education level, marital status, residence, region, economic status, current employment, self-rated health status, happiness, sleep quality, depression, loneliness, and chronic conditions. Multivariate logistic regression analysis was used to identify the factors associated with cognitive functions among the 2,929 elderly respondents. The results revealed that 44.6% of the respondents reported poor cognitive function. In the unadjusted model, residence (OR: 0.81; 95%CI: 0.70–0.94), region of other islands (OR: 0.66; 95%CI: 0.54–0.81), sleep quality (OR: 0.53; 95%CI: 0.42–0.68), self-rated health status (OR: 1.38; 95%CI: 1.19–1.61), happiness (OR: 1.48; 95%CI: 1.22–1.79), and depression (OR: 1.22; 95%CI: 1.04–1.44) showed significant associations with cognitive function. After adjusting for confounding factors, the association remained significant for residence (OR: 0.77; 95%CI: 0.66–0.89), regions other than Java, Bali, and Sumatra (OR: 0.61; 95%CI: 0.50–0.76), self-rated health  (OR: 1.28; 95%CI: 1.09–1.51), happiness (OR: 1.30; 95%CI: 1.06–1.59), and sleep quality (OR: 0.60; 95%CI: 0.47–0.78). These findings emphasize the necessity of interventions aimed at enhancing sleep quality and overall health in order to preserve cognitive function among the elderly, thus potentially improving their quality of life. Implementing comprehensive health programs could significantly enhance the overall quality of life for the aging population, especially the elderly population.
A psychometric evaluation of the Indonesian version of the collaborative practice assessment tool (CPAT) for assessing interprofessional education and collaborative practice among health practitioners and students Ardyansyah, Bau D.; Cordier, Reinie; Brewer, Margo; Parsons, Dave
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1106

Abstract

Research focus has transitioned from interprofessional collaborative practice among qualified health practitioners to the involvement of pre-qualifying students in practicing interprofessional education. It is essential to establish outcome measures to enhance the seamless integration of interprofessional education and collaborative practice. The aim of this study was to develop a culturally appropriate quality measure for assessing interprofessional education and collaborative practice for health practitioners and students in Indonesia by performing cross-cultural validation of the collaborative practice assessment tool (CPAT). The consensus-based standards for the selection of health measurement instruments (COSMIN) standards of psychometric properties were used to guide the study. The evaluation of the psychometric properties was conducted, involving meticulous structural validity evaluation based on a three-step factorial analysis (exploratory factor analysis, confirmatory factor analysis, and multi-group confirmatory factor analysis) and measurement invariance. The parameters analyzed were related to the design requirements of a measure (i.e., targeted population, study sample, and size), the internal structure (structural validity, internal consistency, and measurement invariances), and hypotheses testing for construct validity based on a validated conceptual framework. This study involved 266 practitioners and 232 students. The COSMIN standards for general design requirements were fulfilled. Structural validity confirmed the 7-factor of 48-item structure; measurement invariances indicated configural, metric, and scalar invariants in both practitioner and student cohorts. Construct validity was confirmed by meeting the COSMIN requirement, with over 75% of the tested hypotheses accepted. In conclusion, the findings suggest the newly validated Indonesian CPAT has good psychometric properties concerning internal structure (i.e., structural validity, internal consistency, and measurement invariance) and hypotheses testing, and is therefore a quality measure for assessing interprofessional education and collaborative practice with health practitioners and students in Indonesia.
Preferences for a new vaccine against an emerging infectious disease: A discrete choice experiment among Millennials and Generation Z in Vietnam Pham, Gam H.; Tran, Quang V.; Bui, Hiep T.; Nguyen, Thoai D.; Vo, Trung Q.; Jedsadayanmata, Arom; Huynh, Bon H.; Sholihat, Nia K.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1107

Abstract

The rising threat of emerging infectious diseases (EIDs) highlights the need to understand factors influencing vaccine adoption. The aim of this study was to explore the willingness to vaccinate and vaccine acceptance preferences among Millennials and Generation Z in Vietnam. Convenience sampling was conducted, after which a traditional discrete choice experiment was performed. Participants were tasked with selecting their preferred options from a set of eight vaccination choice tasks, each consisting of two alternatives distinguished by varying degrees of vaccine efficacy, side effects, influential endorsements, trusted sources, and disease susceptibility through literature reviews, expert interviews, and pilot tests. A minimum sample size of 375 participants was recruited via Internet-based and paper-based surveys.  A latent class model was used to explore the heterogeneity in participant preferences, while a mixed logit model was employed to facilitate the computation of the predicted probabilities of vaccine acceptance. Among the 818 included participants, 494 (60.4%) were Millennials generation. The predicted probability of vaccine acceptance was 61.8%, with slight differences between Millennials (62.4%) and Generation Z (61.0%). Four latent classes with significant preference variations were identified. Class 1 (38%) was influenced by vaccine effectiveness, side effects, and health authority recommendations, showing lower opt-out rates. Class 2 (28%) prioritized vaccine effectiveness and authority recommendations but had higher opt-out rates and a stronger religious influence. Class 3 (23%) focused on vaccine effectiveness and side effects, with a tendency to opt-out. Class 4 (11%) valued high vaccine effectiveness and advice from family, with infection risks to family or local areas being significant motivators. Influential voices were more important in Classes 1 and 2, while side effects and effectiveness were prioritized in Classes 3 and 4. In conclusion, Vietnamese Millennials and Generation Z preferred vaccination when the vaccine had 90% efficacy, mild to moderate side effects, endorsements from the Ministry of Health, positive recommendations from family and social networks, and high exposure risks from family members.
Effect of moderate-intensity aerobic exercise on bladder TGF-β1 and type I collagen expressions in diabetic rat model Fatahajjad, Haykal H.; Soebadi, Mohammad A.; Putra, Rheza M.; Sulastri, Nur; Rahaju, Anny S.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1110

Abstract

Transforming growth factor-beta 1 (TGF-β1) and type I collagen play crucial roles in the pathogenesis of diabetic bladder disease (DBD). Moderate-intensity aerobic exercise increases antioxidant activity to help manage DBD. The aim of this study was to evaluate the effect of moderate-intensity aerobic exercise on the expression of TGF-β1 and type I collagen in the detrusor and lamina propria of the bladder in a type 2 diabetes mellitus (T2DM) rat model. A true experimental design with a post-test-only control group design was conducted with white rats (Rattus norvegicus), divided into three groups: a T2DM model group sacrificed after T2DM induction and diagnosed with T2D from a fasting blood glucose (FBC) test (Group C), a T2DM model group that did not receive exercise (Group NE), and a T2DM model group that received moderate-intensity aerobic exercise (Group E). Moderate-intensity aerobic exercise was conducted over six weeks, with a frequency of five days per week for 60 minutes per session. The findings revealed a significant reduction in TGF-β1 expression in the lamina propria in Group E compared to Group C (p=0.004) Additionally, both Group E (p=0.002) and Group NE (p=0.028) showed a significant reduction in type I collagen expression in the lamina propria compared to Group C. These findings provide a basis for further investigation regarding the mechanism of non-pharmacologic DBD management by employing moderate-intensity exercise.
Comparative analysis of synovectomy and total knee replacement in knee joint synovial chondromatosis: A case series Primaputra, Muhammad RA.; Malau, Vino D.; Budhy, Filberto; Yudhistira, Pramudito
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1115

Abstract

Synovial chondromatosis is a rare disorder characterized by cartilaginous growths within the joint lining, often confused with conditions like pigmented villonodular synovitis and rheumatoid arthritis. Primary treatment typically involves surgical synovectomy to remove the affected tissue and loose bodies. Documented cases are limited globally. The aim of this study was to present a case series of synovial chondromatosis and evaluate the functional outcomes by assessing the post-surgical Musculoskeletal Tumor Society (MSTS) score following different surgical interventions (synovectomy alone versus synovectomy with total knee replacement) in a resource-limited setting. Four cases of synovial chondromatosis were reported. A 61-year-old woman with a soft tissue tumor underwent synovectomy and total knee replacement on the right knee, then experienced a periprosthetic infection requiring revision arthroplasty, resulting in an MSTS score of 24. Another case was a 48-year-old woman who had a synovectomy for a lump on the right knee, also achieving an MSTS score of 24. Two additional cases involved women in their mid-to-late 60s who underwent synovectomy for knee lumps, with post-operative MSTS scores of 21 and 19, respectively. This case series underscores the diagnostic and management challenges of synovial chondromatosis in the knee joint, demonstrating various surgical interventions. This case series also suggested that the post-operative MSTS scores were slightly higher (indicating better outcomes) for synovectomy alone compared to synovectomy with total knee replacement, highlighting the need for further research to determine the most effective treatment approach.
Computational drug repurposing for tuberculosis by inhibiting Ag85 complex proteins Iskandar, Israini W.; Nurhasanah, Astutiati; Hatta, Mohammad; Hamid, Firdaus; Handayani, Irda; Chaera, Ummi; Yusriyyah, Andi A.; Jamaluddin, Balqis D.; Zaenab, St; Hidayah, Najdah; Karimah, Nihayatul; Permana, Andi D.; Massi, Muhammad N.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1130

Abstract

Tuberculosis (TB) remains a significant and deadly infection among pulmonary diseases caused by Mycobacterium tuberculosis, a highly adaptive bacterium. The ability of M. tuberculosis to evade certain drugs has been linked to its unique structure, particularly in the cell envelope, where the Ag85 complex proteins play an essential role in this part.  The aim of this study was to utilize a drug repurposing strategy targeting the Ag85 complex proteins. This study utilized a computational approach with 120 selected drugs experimentally identified to inhibit Tuberculosis. A virtual screening molecular docking with Autodock Vina was used to filter the compounds and identify the strong binders to the Ag85 Complex. Molecular dynamics simulations employed the Gromacs Packages to evaluate the stability of each complex, including root mean square deviation (RMSD), root mean square fluctuation (RMSF), and radius of gyration (RoG). Additionally, absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessments were conducted to gather more information about the drug-likeness of each hit compound. Three compounds, selamectin, imatinib, and eltrombopag were selected as potential drugs repurposed to inhibit the activity of the Ag85 complex enzyme, with binding affinities ranging between -10.560 kcal/mol and -11.422 kcal/mol. The MD simulation within 100 ns (3 replicas) showed that the average RMSD of each Ag85A complex was 0.15 nm–0.16 nm, RMSF was 0.09 nm–0.10 nm, and RoG was 1.80 nm–1.81 nm. For Ag85B, the average RMSD was 1.79 nm–1.80 nm, RMSF was 0.08 nm–0.09 nm, and RoG was 1.79 nm – 1.80 nm. Then, for Ag85C, the mean RMSD was 0.16 nm–0.18 nm, RMSF was 0.09, and RoG was 1.77 nm. The study highlights that these promising results demonstrate the potential of some repurposed drugs in combating the Ag85 complex.
Feasibility and pilot study of Indonesia’s first telehealth support program for gynecological cancer survivors undergoing chemotherapy Afiyanti, Yati; Juliastuti, Dyah; So, Winnie KW.; Setiowati, Retno; Nasution, Lina A.; Prawesti, Aprilia D.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1131

Abstract

Most Indonesian gynecological cancer survivors experience chemotherapy side effects on their physical and mental health as they face unmet needs of supportive care, which increases the likelihood of discontinuing treatment. Interventions in telehealth assist survivors in resolving these issues. The aim of this pilot study was to determine the feasibility of fighting distress, self-efficacy, health effects, and sexual (FoRSHE-X) interventions and evaluate their potential impact on distress level, side effects knowledge and management, self-efficacy, and sexual quality of life. The study involved gynecological cancer survivors who underwent chemotherapy and participated in ten weeks of individual social media-based education, tele-coaching, and teleconsultations, from September 2023 to June 2024. The study feasibility and pilot outcomes were evaluated using descriptive statistics and qualitative thematic analysis. Of the twelve women recruited, six (50%) completed the study, filled out pre- and post-intervention questionnaires, and participated in interviews. Fifty-four virtual education, coaching, and consultation sessions were performed individually. The statistical results indicated that participants were highly satisfied with the telehealth program, which significantly increased their knowledge (p=0.02), health practices (p=0.04), and self-efficacy (p=0.01). The qualitative analysis highlighted participants' and coaches' perspectives on the study’s acceptance, barriers, and recommendations. In conclusion, this pilot study suggests that a definitive trial to assess the FoRSHE-X interventions is feasible, acceptable, and can be applied not only to gynecological cancer survivors but also to other types of cancer, thereby broadening the potential impact of the study.
Diagnostic accuracy of urinary cytokeratin fragment-19 (CYFRA21-1) for bladder cancer Setianingsih, Yennie A.; Djatisoesanto, Wahjoe; Laksita, Tetuka B.; Aryati, Aryati
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1142

Abstract

Bladder cancer is known for its high recurrence rate and requires constant patient monitoring. To confirm the diagnosis, a tissue sample from a cystoscopy is required, which the patient often avoids. Urine has the potential to be utilized as a diagnostic fluid because of its non-invasive nature and various biomarker contents. The aim of this study was to determine the diagnostic value of cytokeratin fragment-19 (CYFRA21-1) level in urine for diagnosing bladder cancer. This single-center cross-sectional study was performed with eligible inclusion were adults aged ≥18 years who presented with hematuria and suspected bladder cancer from imaging. Patients with a history of intravesical chemotherapy, radiotherapy and immunotherapy were excluded. Urine samples were collected prior to the cystoscopy. Detection of urinary CYFRA21-1 was carried out using the ELISA method. Of 154 patients included in the study, the diagnosis of bladder cancer was confirmed in 92 patients. Patients with bladder cancer had significantly higher urinary CYFRA21-1 levels compared to the non-bladder cancer group. The sensitivity, specificity, positive and negative predictive value, and positive likelihood ratio of the CYFRA21-1 were 80.4%, 43.5%, 67.9%, 60% and 1.425, respectively. The area under the curve for CYFRA21-1 was 0.608, computed from a receiver operating curve with a cut-off value of 13.3 ng/mL. In conclusion, urinary CYFRA21-1 levels have moderate diagnostic accuracy in determining bladder cancer among suspected individuals. Due to its high sensitivity, this biomarker could potentially be used alongside other screening tools for bladder cancer detection.
GSTA1 gene polymorphisms are associated with cyclophosphamide effectiveness in lupus nephritis patients: A case-control study in Indonesia Indrawijaya, Yen YA.; Artarini, Aluicia A.; Hamijoyo, Laniyati; Iwo, Maria I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1144

Abstract

Glutathione-S-transferase alpha-1 (GSTA1) is an enzyme with high conjugation activity against aldophosphamide, a metabolite of cyclophosphamide and promoter polymorphisms in GSTA1 may influence the cyclophosphamide effectiveness. The aim of this study was to evaluate the effectiveness and side effects of cyclophosphamide in lupus nephritis patients, using GSTA1 variants as predictors. A case-control study was conducted at Hasan Sadikin Hospital, Bandung, Indonesia, involving 100 lupus nephritis patients from February 2023 to January 2024. The PCR-Sanger sequencing was used to genotype five selected single nucleotide polymorphisms (SNPs) in the GSTA1 promoter: -52 A>G, -69 T>C, -513 A>G, -567 G>T, and -631 G>T. The endpoint was assessed after six doses of cyclophosphamide by evaluating renal function, disease activity and side effects. Results indicated that six doses of intravenous cyclophosphamide treatment improved renal function and disease activity in the patients, as evidenced by significant changes in serum creatinine (0.79 vs 0.69 mg/dL), dipstick proteinuria (3.00 vs 1.50), creatinine clearance (98.50 vs 109.50 mL/min), and Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (M-SLEDAI-2K) score (8.61 vs 6.95). The AG genotype at -513 A>G was associated with reduced cyclophosphamide effectiveness (odds ratio (OR): 0.19; 95%CI: 0.19–0.60; p=0.019). The GT genotype at -631 G>T independently increased the progression of anemia (OR: 2.41; 95%CI: 0.26–22.12; p=0.040). This study highlights that the presence of GSTA1 variants affected cyclophosphamide effectiveness in lupus nephritis patients, with heterozygous polymorphisms at -513 (AA to AG) and -631 (TT to GT) predicting reduced effectiveness of cyclophosphamide by enhancing GSTA1 promoter activity, while anemia further exacerbated lupus nephritis disease severity. GSTA1 polymorphism was not associated with the presence of alopecia, amenorrhea, gastrointestinal disorders, and leukopenia during cyclophosphamide therapy.
Mothers’ perception of husband support during breastfeeding: A qualitative study in Indonesia Mardiyaningsih, Eko; Widyawati, Widyawati; Hapsari, Elsi D.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1149

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted maternal and perinatal healthcare worldwide, including in Indonesia. Restrictions on access to health services have forced mothers to adapt to new challenges in breastfeeding during the pandemic. The aim of this study was to evaluate mothers’ breastfeeding experiences and the role of husbands in providing support during this period. This qualitative research used a phenomenological approach. Data were collected from August to October 2022 through a focus group discussion (FGD). Participants were selected using maximum variation sampling, with eight mothers participating in the FGD. Data were analyzed using qualitative content analysis, revealing four main themes: (1) not all husbands fully supported mothers’ efforts to provide exclusive breastfeeding; (2) supportive and inhibiting factors help to provide exclusive breastfeeding; (3) mothers understood the benefits and identified the causes of failure in providing exclusive breastfeeding and complementary food for breast milk; and (4) various stressors experienced by mothers did not impede breastfeeding efforts. In conclusion, the findings highlight the need for healthcare workers, especially maternity nurses, to encourage continued breastfeeding and emphasize the importance of husbands’ support in providing exclusive breastfeeding initiatives. Interventions should be designed to actively involve husbands in supporting exclusive breastfeeding practices.

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