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INDONESIA
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Published by Universitas 17 Agustus 1945 Jakarta
ISSN : -     EISSN : 25028413     DOI : https://doi.org/10.52447/scpij.v7i1
Core Subject : Health, Social,
Health Professions Medicine & Pharmacology Public Health Social Sciences
Social Clinical Pharmacy Indonesia Journal (SCPIJ) is a scientific journal managed by the Faculty of Pharmacy Universitas 17 Agustus 1945 Jakarta, which is published twice a year (April and October). SCPIJ is a scientific research journal in the field of community service with articles that have never been published online or in print before. SCPIJ aims to disseminate conceptual thoughts or ideas and research results that have been achieved in the fields of pharmacy and health, Regulatory Affairs and Pharmaceutical Marketing Research, Pharmaceutical Care,Pharmacotheraphy, Pharmacoepydemology, Pharmacogenetic, Rational Therapeutics, Evidence-Based Practice, Health Services Research, Medication Management, Drug Interactions, Drug Utilization, Drug Prescribing, Drug Information. The results of the service published in this journal are in the form of experimental and non-experimental service.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 10 Documents
 1 
Search results for , issue "Vol 10, No 2 (2025)" : 10 Documents clear
EVALUATION OF DRUG INTERACTION RISK AND PATTERNS IN HYPERTENSIVE PATIENTS WITH COMORBIDITIES IN A HOSPITAL SETTING Putri Nurhidayah, Eka
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9038

Abstract

Hypertension is a chronic condition with a high prevalence and is frequently accompanied by comorbidities that require polypharmacy, thereby increasing the risk of drug–drug interactions (DDIs). This study aimed to evaluate the risk and patterns of DDIs among hypertensive inpatients with comorbidities using a retrospective observational design based on medical record data from 2023–2024. Descriptive analysis was performed on patient characteristics, antihypertensive regimens, and potential DDIs using scientific literature and standardized interaction-checking tools (Medscape, DrugBank, Drugs.com). Validation was conducted independently by a clinical pharmacy practitioner and a clinical pharmacy researcher. Of the 182 medical records reviewed, 65 met the inclusion criteria. Most patients were aged ≥60 years (56.9%) and female (55.4%). A total of 56.9% of patients experienced potential DDIs. Moderate-risk interactions most frequently involved pharmacodynamic mechanisms, particularly aspirin–furosemide, nifedipine–alprazolam, valsartan–insulin glargine, and candesartan–meloxicam. Major interactions were identified in combinations such as valsartan–spironolactone and ramipril–spironolactone, which may increase the risk of hyperkalemia, as well as diltiazem–bisoprolol, which has an additive effect on SA/AV nodal conduction.These findings highlight that hypertensive patients with comorbidities are at high risk for DDIs. Regular clinical monitoring and systematic medication review by clinical pharmacists are essential to enhance therapeutic safety and effectiveness in hospital settings.
ROLE OF ANTIBIOTIC STEWARDSHIP PROGRAM IN IMPROVING RATIONAL THIRD-LINE ANTIBIOTIC USE IN TYPE-2 DM INPATIENTS AT FATMAWATI HOSPITAL Budiastuti, Rizky Farmasita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8397

Abstract

Type-2 diabetes mellitus (T2DM) is the most common metabolic disorders, caused by a combination of two factors: damaged insulin secretion by pancreatic β-cell and the inability of insulin-sensitive tissues to respond appropriately to insulin. Epidemiological data reveal alarming values that predict a concerning future for T2DM. According to the International Diabetes Federation (IDF), in 2019, diabetes caused 4.2 million deaths, and 463 million adults aged between 20-79 years old were living with diabetes, a number that is projected to increase up to 700 million by 2045. Based on data from RISKESDAS in 2018, the prevalence of DM in Indonesia has increased from 6.9% in 2013 to 8.5% in 2018. The Antimicrobial Resistance Control Program (PPRA) team is essential in the development and implementation of evidence-based guidelines and policies. The purpose of this study was to determine the profile of patients receiving antibiotic therapy and the use of third-line antibiotics in T2DM patients at Fatmawati Hospital during the July-December 2021 period. This research used a retrospective descriptive design with a non-experimental approach. The sample size consisted of 52 medical records that met the inclusion criteria. The results showed that patients receiving the most antibiotic treatment were between the ages of 55-64 years (38.5%), women (52%), and those with diabetic foot complications (51.8%). The single and most used combination antibiotics were ampicillin-sulbactam (34.7%) and ampicillin-sulbactam+metronidazole (29.2%). 28.8% of the patients were recommended to receive third-line antibiotics and received considerations from the PPRA team, of which 73.33% obtained approval.
PENGARUH KONDISI KELEMBABAN LEMBAB DAN KERING TERHADAP JUMLAH DAN VIABILITAS SEL PUNCA MESENKIMAL PADA PASASE 6-9 Budiastuti, Rizky Farmasita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8960

Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh kondisi kelembaban inkubator terhadap jumlah dan viabilitas sel punca mesenkimal (Mesenchymal Stem Cell, MSC) pada pasase 6 hingga 9. Dua kondisi fisiologis diuji, yaitu kultur dalam inkubator dengan kelembaban tinggi (RH ±95%) dan kelembaban rendah (RH <80%) pada kondisi normoksia (37°C, 5% CO₂). Sel yang digunakan merupakan MSC manusia yang diperoleh dari jaringan lemak donor dewasa dan telah dikarakterisasi positif terhadap penanda CD73, CD90, dan CD105. Proses kultur dilakukan secara aseptis dengan media a-MEM yang diperkaya Human Platelet Lysate (HPL) serta antibiotik 1% penicillin-streptomycin. Parameter yang diukur meliputi jumlah total sel, viabilitas sel menggunakan pewarnaan Trypan Blue, dan Population Doubling Time (PDT). Hasil menunjukkan bahwa kelembaban tinggi memberikan hasil yang signifikan terhadap peningkatan jumlah sel dan viabilitas (p<0,05). Rata-rata jumlah sel akhir pada kondisi lembab mencapai 23,36×10⁶ dengan viabilitas 90,23%, sedangkan pada kondisi kering hanya 5,56×10⁶ dengan viabilitas 81,13%. Perbedaan kelembaban juga memengaruhi PDT, di mana kondisi lembab menghasilkan pertumbuhan lebih cepat (0,33 hari⁻¹) dibandingkan kondisi kering (0,54 hari⁻¹). Dengan demikian, kelembaban tinggi berperan penting dalam menjaga stabilitas fisiologis dan mempercepat proliferasi MSC in vitro.
Hubungan Antara Rasionalitas dengan Efektivitas Antihipertensi pada Pasien Hipertensi Dewasa di RSUP Dr. R. Soetijono Blora PRESTICASARI, HARDIYANI
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8987

Abstract

Hipertensi merupakan penyakit dengan prevalensi tinggi di Indonesia, termasuk di Kabupaten Blora. Penelitian ini bertujuan untuk mengevaluasi hubungan antara rasionalitas terapi antihipertensi dengan efektivitasnya pada pasien hipertensi dewasa di RSUD Dr. R. Soetijono Blora. Metode penelitian menggunakan desain cross-sectional dengan pengambilan data dilakukan secara retrospektif dari rekam medis pasien periode 1 Mei 2023–30 April 2024. Sampel terdiri dari 75 pasien yang memenuhi kriteria inklusi dan ekslusi. Rasionalitas terapi dinilai berdasarkan terpenuhinya kriteria tepat obat, dosis, dan pasien sedangkan efektivitas terapi dilihat dari penurunan tekanan darah setelah satu bulan pengobatan. Hasil penelitian menunjukkan bahwa 36% pasien termasuk dalam kategori rasional efektif. Analisis statistik dengan uji Chi-square menunjukkan tidak ada hubungan yang bermakna antara rasionalitas dengan efektivitas antihipertensi pada pasien hipertensi dewasa (p>0,05).
PROFIL DRUG UTILIZATION (DU) 90% DAN KESESUAIAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID DI RS X KABUPATEN WONOGIRI Kusumaningrum, Yunita Dyah; Rachmawati, Ema; Firandi, Adelia; Norcahyanti, Ika
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8821

Abstract

Demam Tifoid merupakan infeksi bakteri Salmonella thypi yang memerlukan terapi dengan antibiotik. Penggunaan antibiotik perlu dilakukan dengan bijak supaya efektif untuk penyembuhan infeksi dan mencegah terjadinya resistensi. World Health Organization (WHO) merekomendasikan penggunaan metode Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) untuk menilai kuantitas penggunaan antibiotik dan dapat dikombinasikan dengan metode Drug utilization (DU) 90% untuk menilai segmen obat dengan penggunaan tinggi. Penelitian ini bertujuan untuk menganalisis penggunaan antibiotik dengan metode DU 90% pada pasien demam tifoid pada tahun 2020-2022 di RS X Wonogiri dan menganalisis kesesuaian pemilihan antibiotik berdasarkan panduan klinik rumah sakit. Penelitian ini merupakan penelitian observasional menggunakan metode cross sectional dengan pengambilan data secara retrospektif. Data penggunaan antibiotik dianalisis dengan menghitung nilai DDD/100 patient-days dan dilanjutkan menghitung segmen DU 90%. Untuk analisis kesesuaian pemilihan antibiotik dihitung dalam persentase kesesuaian terhadap panduan praktik klinik RS X Wonogiri. Hasil penelitian menunjukkan penggunaan antibiotik untuk demam tifoid paling tinggi yaitu tiamfenikol dan seftriakson. Antibiotik dengan nilai DDD/100 patient-days tertinggi tahun 2020-2022 adalah tiamfenikol, berturut-turut sebesar 50,80; 56,63; dan 50,95 DDD/100 patient-days. Antibiotik yang masuk ke dalam segmen DU 90% pada tahun 2020-2022 yaitu tiamfenikol, sefriakson, kloramfenikol, sefoperazon, sefotaksim, levofloksasin, dan seftazidim. Kesesuaian penggunaan antibiotik berdasarkan panduan praktik klinik rumah sakit yaitu 76,39% pada tahun 2020, 58,73% pada tahun 2021, dan 71,28% pada tahun 2022
DRUG THERAPY IN PATIENTS WITH GRADE 4 DEXTRA HIP OSTEOARTHRITIS WITH COMORBID HYPERTENSION AND TYPE 2 DIABETES MELLITUS Astiani, Rangki; Piter, Piter; Anggraeni, Ria; Luthfiana, Farisa; Sari, Dini Permata; Ramatillah, Diana Laila; Khan, Khasif
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8977

Abstract

Osteoarthritis (OA) is a chronic degenerative disease that affects the joints, especially heavy joints such as the knees and hips. OA often causes chronic pain and limited mobility, which is even more complex when accompanied by comorbid hypertension and type 2 diabetes mellitus. These comorbidities increase the risk of pharmacotherapy side effects and drug interactions, requiring a multidisciplinary approach and careful clinical pharmacy monitoring. The purpose of this report is to review the pharmacotherapy management of grade 4 OA Hip Dextra with comorbid HT and DMT2, assessing the safety, effectiveness, and role of clinical pharmacists in therapy optimization. A retrospective case study was conducted by analyzing the patient's medical records, including anamnesis, physical examination, laboratory, pharmacological therapy, and clinical response. The analysis was conducted based on the national guidelines of the Indonesian Ministry of Health, the 2021 National Formulary, PERKENI 2023, and PAPDI 2021. The patient was given combination therapy of NSAIDs, analgesics, prophylactic antibiotics, muscle relaxants, gastric protection, and supplementation for anemia. Therapeutic adjustments were made according to the patient's response and laboratory parameters. Clinical pharmacy monitoring ensures pain control, mobility, hemoglobin, and blood sugar. A multidisciplinary approach based on national guidelines has been shown to improve the safety and effectiveness of OA therapy with multiple comorbidities.
EVALUASI PEMANTAUAN TERAPI OBAT PADA PASIEN GERIATRI DENGAN TIA, SINDROMA DISPEPSIA, DISLIPIDEMIA, DIABETES MELITUS TIPE 2 DI RUMAH SAKIT “X” DI JAKARTA melasari, wulan panduwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9022

Abstract

Pemantauan terapi obat (PTO) dilakukan untuk memastikan keamanan, efektivitas, dan ketepatan penggunaan obat pada pasien. Pelaksanaan pemantauan terapi obat terlihat pada kasus seorang pasien yang datang ke Poli Saraf dengan keluhan tidak ada nafsu makan, bicara pelo, begah, mual, muntah, dan keluarga mengatakan pasien tidak mau makan sejak pulang perawatan dari Unit Stroke. Pasien didiagnosa Transient ischemic attack (TIA), sindroma dispepsia, dislipidemia, dan diabetes melitus tipe 2.  Tujuan pemantauan terapi obat adalah untuk mengidentifikasi Drug Related Problems (DRPs) pada pasien geriatri dengan diagnosa Transient ischemic attack (TIA), sindroma dispepsia, dislipidemia, dan diabetes melitus tipe 2. Metode yang dilakukan dalam pemantauan terapi obat ini adalah secara observasional dengan pengambilan data melalui catatan perkembangan pasien terintergrasi dari Sistem Informasi Manajemen Rumah Sakit (SIMRS), analisis data menggunakan format SOAP, identifikasi Drug Related Problems (DRPs) berdasarkan klasifikasi PCNE (Pharmaceutical Care Network Europe) V9.1, dan melakukan visite secara langsung serta koordinasi profesional pemberi asuhan terkait intervensi pengobatan. Berdasarkan pemantauan terapi obat diperoleh drug related problems berupa adanya interaksi obat dengan kategori mayor antara Donepezil HCl dengan Risperidone yang dapat mengakibatkan meningkatnya risiko perpanjangan interval QT dan torsade de pointes. Setiap intervensi telah dicantumkan di catatan perkembangan pasien terintegrasi dan telah didiskusikan dengan dokter sehingga hasil intervensi dapat diimplementasikan.Kata kunci: Pemantauan terapi obat, Transient ischemic attack, Sindroma dispepsia, Dislipidemia, Diabetes melitus tipe 2
Determinan Dan Pola Konsumsi Antibiotik Pada Balita Dengan Diare di Indonesia: Analisis Data Demographic Health Survey 2017 Maylinda, Tashya Dhela; Yulianto, Rivai Endra Dwi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9258

Abstract

Diarrhea is still the second leading cause of death for children under five years of age. Deaths of children under five years due to diarrhea are caused by unsafe water, inadequate sanitation, and hygiene. Socio-demographic characteristics, environment, behavior, and parenting practices are factors associated with diarrhea in children under five years in Indonesia. The use of antibiotics in the treatment of diarrhea needs more attention. Antibiotic resistance can occur if its use is not based on a proper diagnosis. This study was conducted to examine the factors that influence the incidence of diarrhea in children under five years of age. This study also looked at the prevalence of treatment centers for diarrhea patients and the use of antibiotics for the treatment of diarrhea in children under five years of age. The data used is cross-sectional data on children under five living in households in Indonesia taken from the 2017 DHS survey through data collections and survey reports. Descriptive analyzes were performed on survey reports and datasets related to demographics, the prevalence of diarrheal diseases, and the use of antibiotics for the treatment of diarrhea. Significance analysis was conducted to see whether the selected variables had an effect on the incidence of diarrhea in children under five years of age. Gender, age, location of residence (urban or rural), wealth level, mother's education level and the main material of the house floor are significant factors influencing the incidence of diarrhea in children under five years. Puskesmas is a place to seek treatment for diarrhea which is most frequently visited by children under five years old (20.99%). 10.9% of pediatric patients with diarrhea visited more than one health facility. Private hospitals are the places that most often give antibiotics to children under five years of age who have diarrhea (25%). Antibiotics were given not only by licensed health care facilities but also by other places visited by respondents, namely traditional birth attendants, grocery stores, and other sources.
ANALYSIS OF CHEMOTHERAPY COSTS IN BREAST CANCER PATIENTS PARTICIPATING BPJS AT DHARMAIS CANCER HOSPITAL JAKARTA Piter, Piter; Astiani, Rangki; Monica, Kristin; Permatasari, Yuri
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.7773

Abstract

This study aims to find out how much chemotherapy costs for inpatient breast cancer chemotherapy patients participating in BPJS and whether there is a difference in real hospital costs compared to INA-CBGs rates. This research is a descriptive, observational study taken from secondary data, in the form of medical record data, laboratory data, INA-CBGs e-claim data and financial data on patient medical costs in accordance with the inclusion and exclusion criteria totaling 100 patient data. Data analysis uses One Sample T-test to see whether there is a significant difference between real costs and INA-CBGs rates. Based on the results of the One Sample T-test, it shows that there is a significant difference. According to the statistical results, a significance of p<0.005 was obtained in class 3 and there was no significant difference in class 1 or class 2. The average cost that breast cancer patients have to pay for each procedure chemotherapy, severity level I Rp. 7,129,348, severity level II Rp. 9,323,275 and severity level III Rp. 9,037,426.
REVIEW ARTIKEL: WAWASAN FARMAKOGENOMIK DAN BIOINFORMATIKA VARIAN GEN ACE DAN PENGARUHNYA TERHADAP RESPONS INHIBITOR ACE PADA HIPERTENSI Anggraeni, Ria; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9109

Abstract

Respons terhadap terapi antihipertensi berbasis angiotensin-converting enzyme inhibitors (ACEIs) bervariasi antar individu, yang sebagian besar dipengaruhi oleh faktor genetik. Gen ACE memiliki sejumlah polimorfisme yang dapat memengaruhi kadar enzim dan efektivitas terapi. Penelitian ini bertujuan mengeksplorasi hubungan antara variasi genetik pada gen ACE dan respons terhadap kaptopril, lisinopril, ramipril, dan enalapril pada pasien hipertensi. Penelitian ini menggunakan pendekatan bioinformatika dan farmakogenomik dengan menganalisis data dari PharmGKB, Ensembl, dan GTEx Portal. Polimorfisme genetik dianalisis untuk mengevaluasi keterkaitannya dengan efektivitas ACEI menggunakan pendekatan statistik deskriptif. Empat polimorfisme nukleotida tunggal (SNP) pada gen ACE ditemukan berasosiasi dengan respons terhadap ACEI. Varian rs4291 dan rs1799752 dikaitkan dengan efikasi kaptopril, di mana genotipe AA menunjukkan penurunan keparahan gagal ginjal. Varian rs1799752 juga terkait dengan lisinopril dan enalapril, dengan genotipe DD memberikan penurunan tekanan darah yang lebih besar. Selain itu, rs4359 dan rs4344 berkorelasi dengan efektivitas ramipril, terutama pada genotipe CC+TT dan AA+GG. Kesimpulan: Variasi genetik pada gen ACE berperan dalam menentukan respons terhadap terapi ACEI. Pendekatan farmakogenetik berpotensi meningkatkan efikasi dan keamanan pengobatan antihipertensi

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