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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 9 Documents
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Search results for , issue "Articles in Press" : 9 Documents clear
The Nature of Processes Affecting the Solubility, Viscosity, and Density Characteristics of Aqueous Electrolyte Systems Kambarova, Galiya; Nazarbek, Ulzhalgas; Nazarbekova, Saule; Abdurazova, Perizat; Raiymbekov, Yerkebulan
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.281

Abstract

This study investigates the key factors influencing the solubility, viscosity, and density of aqueous electrolyte systems. Model solutions of types 1-1, 1-2, 2-1, and 2-2 electrolytes were examined across a wide concentration range. The results show that solubility increases with temperature due to a higher proportion of free water molecules, while greater electrolyte concentrations lead to a rise in viscosity and density. It was found that ion radius and charge density strongly impact solution properties: larger ion radii and lower charge densities decrease viscosity and increase density, whereas smaller radii and higher charge densities have the opposite effect. The findings offer new insights into the relationship between ionic parameters and macroscopic solution behavior, supported by mathematical modeling and graphical analysis.
Biosynthesis of Silver Nanoparticles from Callistephus chinensis Flower Waste: Evaluation of Antibacterial, Anticancer, and Contaminated Water Remediation Applications Kakodkar, Shruti; Dhawal, Pranjali; Kadam, Janvi; Khan, Rumanna; Shewale, Pradnya; Chaukekar, Tejaswi
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.282

Abstract

The present study explored antibacterial and anticancer properties of silver nanoparticles (AgNPs) uniquely synthesized using aster (Callistephus chinensis) flower waste (AFW) via a microwave-assisted approach. The nanoparticles were also tested for their effectiveness in treating coliform-contaminated borewell water. The AFW extract was characterized using LC-HRMS and quantitatively analysis using TPC and TFC assays. Nanoparticle characterization was performed using UV-spectroscopy, FT-IR, SEM, EDX, TEM, SAED and XRD instruments. The AFW extract showed 1.6687 mg of gallic acid equivalent (GAE) and 9.71 mg quercetin equivalent TPC and TFC, respectively. The LC-HRMS profile also revealed the presence of various polyphenols followed by organic acids and alkaloids. The minimum inhibitory concentration required to inhibit 90% of bacterial growth (MIC90) was determined against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The cytotoxic activity of AgNPs was analyzed against cervical cancer cell line HeLa and normal human dermal fibroblast (HDF) cells. AgNPs exhibited a strong antibacterial activity, with MIC90 of 0.0625 mg/mL against E. coli and P. aeruginosa, and 0.125 mg/mL against S. aureus. Nanoparticle treatment did not alter the physicochemical parameters of borewell water beyond their permissible limits. According to MPN analysis, untreated borewell water contained 1600 coliforms/100 mL, which were eliminated following nanoparticle treatment (0 coliforms/100mL). AgNPs displayed anticancer activity against HeLa cell lines with an inhibitory concentration (IC50) of 0.21 mg/mL. The IC50 of AgNPs against normal HDF cells was 0.414 mg/mL — higher than that observed against HeLa cell lines and the bacterial MIC90, thus indicating selective cytotoxicity. To conclude, the study demonstrated the promising use of AFW in the green synthesis of AgNPs, which exhibited potent antibacterial and anticancer properties, along with low toxicity to HDF cell lines. These AgNPs also demonstrated promising applications in treating coliform-contaminated borewell water.
Design of Hydroxyxanthone Derivatives as Breast Cancer Inhibitors: A QSAR Modeling, Molecular Docking, Molecular Dynamics, MM-PBSA and ADMET Prediction Fatmasari, Nela; Hermawan, Faris; Jumina, Jumina; Kurniawan, Yehezkiel Steven; Pranowo, Harno Dwi; Puspitasari, Anita Dwi; Hastuti, Lathifah Puji; Marlina, Lala Adetia; Putra, Nicky Rahmana
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.283

Abstract

A comprehensive QSAR analysis, in conjunction with molecular docking, molecular dynamics simulations, MM-PBSA binding energy estimations, and ADMET profiling, was conducted to facilitate the development of novel anticancer agents based on hydroxyxanthone derivatives. Molecular and electronic descriptors were calculated using the DFT method with the 3-21G basis set. The best QSAR model identified several descriptors that significantly influence anticancer activity, including the atomic charges at positions C1, C3, C4a, and C7, as well as the highest occupied molecular orbital (HOMO), surface area (SA), molecular volume (VOL), and molecular weight (MW). This model was used to design novel hydroxyxanthone derivatives (X27 to X47). The docking result showed that compounds 7-bromo-3-hydroxy-1-(methylamino)-9H-xanthen-9-one (X43), 6-hydroxy-8-(methylamino)-9-oxo-9H-xanthene-2-carbonitrile (X44), and 3-hydroxy-7-mercapto-1-(methylamino)-9H-xanthen-9-one (X45) had stronger binding energy values than gefitinib as a native ligand. Gefitinib had a binding energy of -6.84 kcal/mol, while those compounds had values of -6.92, -7.12, and -6.92 kcal/mol, respectively. In a molecular dynamics simulation of 100 ns, compounds X43, X44, and X45 exhibited stability comparable to that of gefitinib against the EGFR protein. Additionally, the binding energy MM-PBSA of compound X43 was the lowest (-29.18 kcal/mol), followed by X44 (-27.11 kcal/mol), gefitinib (-26.06 kcal/mol), and X45 (-25.21 kcal/mol). Furthermore, these compounds met Lipinski's rule parameters and the minimal standard parameters in terms of ADMET characteristics, as predicted by physicochemical properties. In conclusion, compounds X43, X44, and X45 are potential anticancer agents for MDA-MB-231 breast cancer cells.
Phytochemical Profiling, Antibacterial Properties and Toxicity of Amla Fruit Tea (Phyllanthus emblica L.): An In Vitro and In Silico Study Cahyaningrum, Putu Lakustini; Sudaryati, Ni Luh Gede; Bogoriani, Ni Wayan; Asih, Ida Ayu Raka Astiti; Adnyana, I Made Dwi Mertha; Jenar, Putut Dewantha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.284

Abstract

Antimicrobial resistance represents a critical global health challenge, necessitating the exploration of alternative therapeutic agents. This study investigated the antimicrobial potential of amla fruit tea (Phyllanthus emblica L.) through comprehensive phytochemical characterization, antibacterial assessment, and computational modeling to identify potential mechanisms of action. LC-HRMS analysis was employed for phytochemical profiling, antibacterial activity was evaluated via disk diffusion method against Staphylococcus aureus and Escherichia coli, and molecular docking studies were conducted against tyrosyl-tRNA synthetase and FimH adhesin proteins. Analysis identified 89 bioactive compounds, with oxidized hydroxytetrahydrofuranyl acetate, L-α-palmitin, and ellagic acid predominating. Antibacterial activity against S. aureus and E. coli was evaluated via the disk diffusion method, revealing that moderate inhibition increased at higher concentrations (25%) and with extended exposure, with E. coli exhibiting greater susceptibility than S. aureus. Molecular docking studies against tyrosyl-tRNA synthetase (S. aureus) and FimH adhesin protein (E. coli) identified the W-18 benzenesulfonamide derivative as the most promising compound, which demonstrated strong binding affinities of -11.01 and -7.48 kcal/mol, respectively. While all five principal compounds met Lipinski's drug-likeness criteria, toxicological assessment revealed varying safety profiles, with two compounds classified as "possibly hazardous" and two as "toxic when swallowed." These findings suggest that amla fruit tea has antibacterial properties through two mechanisms: disruption of protein synthesis and bacterial adhesion. However, its efficacy remains considerably lower than that of conventional antibiotics, suggesting potential applications as complementary therapy rather than antibiotic replacement.
Addressing Awareness and Affordability of Generic Medicines in India: A Data Driven Strategic Framework Banerjee, Saurabh Kumar; Lahiri, Moon Moon; Agarwal, Devika; Agrawal, Happy
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.285

Abstract

Access to quality and affordable generic medicines is vital to address the challenging situation which the country is currently facing in the present context. Less than 50% of medications are prescribed in India under their generic (INPN) names, despite the country being one of the leading suppliers of generic medications globally. Up to 90% of the money that impoverished people spend on healthcare can be attributed to medications. Thus, affordability of medications is essential for achieving desired treatment outcome since high drug costs lead to a reduction in access to healthcare. There is a lack of scientific data concerning the understanding of generic medicines among various stakeholders, including physicians, pharmacists, the general public, and health policy advocates, hence a need was felt to do an in-depth introspection of the scientific data centered around awareness and affordability of generic medicines in India and propose a conceptual framework for developing a strategic roadmap for popularizing generic medicines in India. Extensive literature search of research papers with high citations published between 2011–2024 were retrieved and investigated using PRISMA 2020 Flow diagram. In context to physicians the study suggested that physicians should choose less expensive brands of antibiotics and there is a need to design interventions at the fresh graduate level at medical colleges centered around the efficacy of generic drugs over the branded drugs. In context to Govt health policymakers the study suggested that policies towards opening Fair Price Medicine Shop (FPMS) taking the Government of West Bengal model could be taken into consideration and Pradhan Mantri Bhartiya Jan Aushadhi Pariyojana (PMBJP) drug policies on medicine distribution and procurement must be revisited with reference to the NELM. In context to pharmacists, community chemists regulatory agencies and educational institutions should work together to raise the level of generic drugs expertise among community chemists and drug store employees. Finally in context to patients, patient centric educational and awareness programs should be developed at the primary care level related to awareness and misconceptions of generic drugs in the public.
Optimization of In Vitro Microcloning of Lagochilus inebrians Bunge Sultonova, Kumush; Alikulov, Begali; Xasanov, Normat; Abdullayeva, Yulduz; Sharopova, Shahnoza; Jabborov, Baxtiyor; Hotamova, Hulkar; Dilshoda, Mamadiyarova; Khusniddin, Boymurodov
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.286

Abstract

In the following years, introduction (in situ) of rare and promising medicinal plants, determination of morphological and ecological adaptability to selected soil and climate conditions, and obtaining pathogen-free seedlings through microclonal (in vitro) reproduction in areas affected by environmental stress factors creation of plantations are gaining importance. This research aimed at choosing the optimal conditions for obtaining pathogen-free seedlings of Lagochilus inebrians in vitro and acclimatization in arid conditions. The optimal amounts of added phytohormones were chosen to increase the efficiency of the nutrient media used in the microconal propagation of L. inebrians, based on the possibility of acclimatization in arid conditions. The obtained results serve to multiply L. inebrians in vitro and create plantations in arid regions based on the obtained seedlings.
Alginate as A Natural Coagulant-Aid: Advances, Challenges, and Applications Kristianto, Hans; Prasetyo, Susiana; Sugih, Asaf Kleopas
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.287

Abstract

Coagulation is a critical step in water and wastewater treatments that is essential for the removal of suspended solids, organic matters, and colloidal particles. Conventional metal-based coagulants such as aluminium sulphate, ferric chloride, and polyaluminium chloride and synthetic polymer such as polyacrylamide are widely used due to their proven efficiency. However, concerns over their environmental impact, including the generation of non-biodegradable sludge, potential health risks, and negative impact on the water ecosystem, have driven the search for alternative, eco-friendly coagulants. Natural coagulants derived from plants, animals, or microorganisms have emerged as promising alternatives, offering advantages like biodegradability, non-toxicity, and lower sludge production. Among these, polysaccharide-based coagulants such as alginate, a biopolymer sourced from brown seaweed and bacteria, have gained significant attention. Alginate's biodegradability, non-toxicity, low cost, and versatile gelation properties make it a potential substitute for synthetic coagulants. This review focuses on the use of alginate as a coagulant-aid, providing an overview of its sources, characteristics, coagulation mechanisms, and variables that affect the coagulation performance. The review also highlights the benefits, challenges, and future research directions for improving the efficiency and scalability of alginate in sustainable water/wastewater treatment processes.
Optimization of a Mixture of Curcuma Dye Mixture with SiO₂ (Rice Husk Waste) to the Energy Efficiency of TiO₂ -based Solar Cells Subagyo, Tulus; Widhiyanuriyawan, Denny; Widodo, Agung Sugeng; Wardana, I Nyoman Gede
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.288

Abstract

Global energy challenges and environmental problems encourage the search for sustainable energy solutions, with TiO₂-based solar cells that are still limited to its efficiency due to low light absorption and charge recombination. This study aims to examine the synergistic effect of curcuma and SiO₂ dye from rice husk waste in improving the energy efficiency of TiO₂ solar cells. The research methodology involves the fabrication of sensitive solar cells with different layer compositions: TiO₂ only, TiO₂ with one layer of SiO₂ (1L-SiO₂), two layers (2L-SiO₂), and three layers (3L-SiO₂). The TiO₂ photoanode is prepared using the screen printing method, followed by loading coloring through immersion in the curcuma coloring solution. The performance of solar cells is evaluated using the current voltage measurement (I-V) and electrochemical impedance spectroscopy (EIS) to analyze efficiency, charge transportation, and recombination processes. The results show that the addition of SiO₂ increases the efficiency of solar cells, with 1L-SiO₂ producing the highest compilation of short circuit (JSC) 0.37 mA/cm², showing an increase in cargo transportation. However, 1L-SiO₂ shows a decrease in performance due to excessive thickness, which leads to an increase in charge recombination and internal resistance. Impedance analysis confirms that 1L-SiO₂ optimizes cargo transportation but also increases recombination resistance, which affects overall efficiency. Adding SiO₂ from rice husk waste increases the efficiency of TiO₂-based solar cells, with curcuma coloring increases light absorption and charge transfer. However, excessive SiO₂ layers reduce performance due to higher recombination and resistance. Further research is needed to optimize the thickness of the layer and dye stability.
Preparation and Characterization of Cellulose-clay Composite using Indonesian Natural Bentonite for Cr(VI) Adsorption Julinawati, Julinawati; Nadia, Eka; Mustafa, Irfan; Suryati, Suryati
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.289

Abstract

Contamination of Cr(VI) is of global concern, whereas the innovation in wastewater treatment is required. Combination of bentonite and cellulose could produce an effective adsorbent to treat Cr(VI)-containing wastewater. The aim of this study was to investigate the use of composite bentonite/cellulose (B/Cell) to remove Cr(VI) in the aqueous media, in which the bentonite was collected from local sources. The Na-bentonite was firstly prepared before proceeding to cellulose embedment. The resultant B/Cell was characterized for its functional groups, morphology, and crystallinity. The Cr(VI) adsorption capacity and removal efficiency were determined based on batch adsorption. Our findings revealed that the B/Cell composite with a 4:1 bentonite-to-cellulose mass ratio exhibited the highest removal efficiency (85.68%) among tested formulations. Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction analyses confirmed the successful integration of cellulose and structural modification of bentonite. Optimal adsorption was achieved at pH 3, 180-min contact time, and 10 g/L adsorbent dosage. Isotherm modeling showed excellent fits for Sips (R2 = 0.9992) model, with maximum adsorption capacity reaching 192.56 mg/g. Kinetic analysis indicated pseudo-second-order kinetics (R2 = 0.959, qe = 1.018 mg/g), suggesting a chemisorption mechanism. These results highlight the potential of the B/Cell composite as an efficient and low-cost adsorbent for Cr(VI) removal from aqueous environments.

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