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The Avicenna Medical Journal
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27209563     EISSN : 2720 9563     DOI : 10.15408/avicenna.v1i1.15639
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
The Avicenna Medical Journal, the official journal of Faculty of Medicine Universitas Islam Negeri Syarif Hidayatullah Jakarta, presents multidisciplinary scientific papers which describe innovative research spanning the entire spectrum of medical aspects both basic science and clinical aspects. It addresses scientists and researchers to publish novel research that is mechanism-based, hypothesis-driven, and focus on significant issues include, but are not limited to: Basic research and biomedical approach on the disease Clinical research Social and other aspects in the integrated focus on solving medical problems Research may involve either in vitro or in vivo or in silico approaches. The Avicenna Medical Journal receives research articles, review articles, and case reports. Appearing 2 times in a year under peer review, The Avicenna Medical Journal actively participates in solving the medical problem and its related aspects.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 93 Documents
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The Relationship Between Nutritional Status with Malondialdehyde (MDA) and Vitamin D Level Anastasya, Karina Shasri; Faradilla, Meutia Atika; Satyasari, Daniella; Larasari, Andira
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.47151

Abstract

Background: Nutritional status has been found to be correlated with malondialdehyde (MDA) profiles in the blood. MDA is a marker of oxidative stress in the body and is the final product of lipid peroxidation chain reactions. The long-term undernutrition and excess status will be closely related to metabolic disorders and degenerative diseases. Street cleaning staff are often exposed to free radicals that will improve lipid peroxidation, which will also break down into MDA. Vitamin D serum levels have an inverse correlation with adipose tissue mass, where the higher the BMI and body fat mass of a person, the lower the levels of vitamin D serum. The purpose of this study was to determine the relationship of nutritional status with MDA and vitamin D levels in the blood. Methods: This research will be conducted from July 2024 to February 2025, using a cross-sectional design at the Faculty of Medicine, Trisakti University, with the target population being the street cleaning staff in Jakarta. The samples were taken by consecutive sampling for all street cleaning staff who met the inclusion and exclusion criteria, with a total of 76 samples. Results: The results showed that there was no significant relationship between nutritional status with MDA and vitamin D, but there was a significant relationship between vitamin D and MDA (r=0.190; p=0.047). Conclusion: Higher BMI is associated with a relative reduction in muscle mass percentage and a substantial increase in visceral adiposity, irrespective of sex. These findings suggest that BMI alone may not adequately represent body composition or metabolic risk and support the routine use of body composition assessment as a complementary tool in clinical obesity evaluation. Keywords: Nutritional status, MDA, vitamin D
Comparison of the Effectiveness of Ringer’s Lactate and 0.9% NaCl on Mortality in Adult Sepsis Patients: An Evidence-Based Case Report Ridwan, Muhammad Rafif; Ridwan, Faras Khairunnisa; Ridwan, Muhammad Ijlal; Surianty Susilo
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.47192

Abstract

Background: The selection of crystalloid fluid in sepsis resuscitation affects acid-base balance, organ perfusion, and mortality. 0.9% NaCl (normal saline, NS) is the standard fluid, but its high chloride content has the potential to cause physiological disturbances. In contrast, balanced crystalloids such as Ringer's Lactate (RL) have an electrolyte composition closer to physiological plasma and are thought to provide better clinical outcomes. Recent evidence suggests a possible role for RL in reducing mortality in patients with sepsis, although some studies report mixed results. This study aims to evaluate the effectiveness of Ringer's Lactate compared to 0.9% NaCl on mortality in adult patients with sepsis, using an evidence-based case report approach to inform fluid resuscitation decisions. Methods: A literature search was conducted in October 2025 through PubMed NCBI, Medline EBSCO, ScienceDirect, and Google Scholar. Four studies met the inclusion criteria (3 RCTs, 1 SR/MA of RCTs) and were subsequently screened according to the Centre for Evidence-Based Medicine (CEBM) guidelines for critical appraisal, relative to validity, relevance, and practicality to the clinical scenario. Results: Across the included studies, the direction of effect generally favored RL over NS with respect to mortality outcomes. However, effect estimates were reported using different measures, including risk ratios and hazard ratios, and not all observed differences reached statistical significance. Given methodological heterogeneity and identified risks of bias, quantitative pooling of results was not performed, and findings were interpreted qualitatively. Conclusion: The use of Ringer’s Lactate in adult patients with sepsis appears to be associated with a favorable direction of effect on mortality compared with 0.9 NaCl. Nevertheless, the certainty of this evidence is limited, and definitive conclusions regarding superiority cannot be drawn. Keywords: NaCl, balanced crystalloid, normal saline, mortality, Ringer’s lactate, sepsis
Aggressiveness of Indonesia Triple Negative Breast Cancer Driven by Programmed Death Ligand-1 and Tumor Microenvironment Sari, Dianidya Kumandang; Fitri Hapsari , Rr. Ayu; Ariany, Devy; Sakaraga, Deamon
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.48991

Abstract

Background: Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes in Indonesia. The expression of PD-L1 1 and TME characteristics play essential roles in both immune system avoidance and medical treatment results. The Indonesian medical field lacks a comprehensive analysis of local TNBC research data because new studies continue to emerge.  Methods: The research followed PRISMA guidelines and PECO framework for analysis. A total of 22 records were identified; 10 studies met eligibility, and 6 studies were included in the final synthesis.  Results: The studies showed a wide range of PD-L1 expression in tumor cells, from 21% to 93.5%, depending on antibody clone (SP142, SP263, 22C3) and scoring threshold. The studies showed that most tumors had high-grade characteristics between 42% and 88% while displaying high proliferative rates with Ki-67 ≥20% in more than 80% of cases. The three most common metastasis locations in patients were the lungs, bones and then the brain. The survival rates of patients improved when their CD8/CD163 and CD4/FOXP3 ratios increased. The survival outcomes of patients worsened when their PD-L1 expression levels or mRNA expression increased.  Conclusion: Indonesian TNBC shows aggressive pathological characteristics with variable PD-L1 expression and diverse tumor microenvironments. PD-L1 alone does not provide consistent prognostic value and is best interpreted together with immune-cell ratios and TIL density. Establishing standardized biomarker evaluation and adopting immune-based molecular classification could improve the precision of immunotherapy strategies in Indonesia. Keywords:Triple-negative breast cancer, PD-L1, tumor microenvironment, immune ratios, metastasis, Indonesia

Page 10 of 10 | Total Record : 93

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