cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Veri Hardinansyah Dja'far
Contact Email
admin@transpublika.co.id
Phone
+6281234560500
Journal Mail Official
admin@transpublika.co.id
Editorial Address
Jl. Kolonel Sugiono IIIC/438 RT 10/RW 04 Mergosono, , Malang, Provinsi Jawa Timur, 65134
Location
Kota malang,
Jawa timur
INDONESIA
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Published by Transpublika Publisher
ISSN : -     EISSN : 28099745     DOI : https://doi.org/10.55047/comorbid
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Nursing
About the Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) is an international, modern, general medical publication that publishes research on all aspects of medicine, from fundamental research to significant clinical trials and cost-effectiveness analyses. We generally publish human research that contribute to our understanding of medical epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; clinical trials that evaluate the efficacy of particular therapies and comparative trials; and systematic reviews. We want to encourage the conversion of fundamental research into clinical trials and clinical evidence into therapeutic practice. When studies in animal models produce remarkable research findings that are extremely clinically relevant, we publish them on occasion. The international medical community, as well as educators, policymakers, patient advocacy groups, and other interested parties, are among our target audiences. The online edition of COMORBID is updated on a regular basis. Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Articles from all branches of medicine and associated subjects are published in PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 89 Documents
 5   6   7   8   9 
THE FACTORS RELATED TO H. PYLORI INFECTION RESISTANCE AFTER ERADICATION OR ITS RECURRENCE IN SULAIMANI CITY Ahmad, Hazhan Nawzad; Abdulkareem, Makwan Mohammed; Alshekhani, Muhamad Abdularahman Muhamad
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1414

Abstract

Helicobacter pylori (H. pylori) infection can lead to peptic ulcers, chronic gastritis, lymphoma and gastric cancer. This study aimed to assess the factors related to H. pylori resistance after eradication and its recurrence after 6 months. 574 patients tested for H. pylori and those who positive has been assessed for recurrence after 6 months or resistance to treatment and factors related to recurrence in correlation with demographic data. 51% of men and 49% of women were still testing positive for H. pylori after receiving treatment.   The majority of patients who tested positive again for H. pylori were taking clarithromycin-based triple therapy, with only a small percentage being treated with levofloxacin, rate of resistance and recurrence were 23.54% and 8.7%, respectively. Most common symptoms after recurrence were epigastric pain and nausea (62.96%) and dyspepsia (55.55%). The highest rate of recurrence is related to O+ blood group, which is 47.82%. Recurrence rate after H. pylori eradication by standard therapy (clarithromycin triple treatment) or levofloxacin-based therapy is 8.7%. Poor sanitation, low income, and treatments regimens are independent risk factors for recurrence of H. pylori. Reducing the frequency of eating outdoors and treating family members may reduce H. pylori infection recurrence.
NARRATIVE REVIEW OF ADJUSTMENT DISORDERS AMONG FRESHMEN Edward, Sara Nabeel; Amin, Nazar Mohammad Mohammad; Abdulkareem, Makwan
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1445

Abstract

Adjustment disorders refer to the psychological reactions to adapt to new circumstances, including situations such as divorce, major work change, transition from school to university, or migration. This study aimed at summarizing adjustment disorders in a single short paper by using different recent sources and references. This review article was conducted by using deferent recently published articles considering adjustment disorders generally and its occurrence among first year student of colleges specifically. Adjustment disorders are very common mental health issues that arise in response to significant changes in life style and warrant proper assessment and evaluation in order to maximize daily functioning.
HOMOSEXUALITY: A SCIENTIFIC VIEW Ahmed, Jaafar Omer; Qasab, Zana Ahmad; Saeed, Sarhang Ibrahim
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1474

Abstract

Homosexuality has a long history. The public is exposed to scientific findings through media reports; there are many misunderstandings about homosexuality; and as a result, a person who has homosexual feelings suffers minor stress. Two different directions have emerged. One believes that homosexuals are responsible for the spread of diseases. The second one believes that homosexuality is a normal behavior. The main goal of this narrative review is to revisit this issue, emphasizing the need for consistent interpretation and ongoing research. This review is framed using insights from recent scientific resources. Four main terms related to homosexuality (sex, gender, gender identity, and sexual orientation) and their dimensions are discussed. Some data about homosexual orientations and behaviors are explained. Homosexuality in the past and present, its history as a mental disorder until its removal from textbooks, and its relationship with mental health are mentioned. The reasons why a person is homosexual are multifaceted, etiologically complex, and unclear. Both views—biological and environmental factors—are clarified. Changes in the understanding of homosexuality continue due to the influence of politics, society, and religion. We need more research to better understand the phenomenon, all aspects of the causes, and how to deal with them. These efforts must be free from political and religious directions.
PSYCHIATRIC COMORBIDY IN PATIENTS SUFFERING FROM CHRONIC MEDICAL DISEASES Faraj, Siba Sameer; Mohammad Amin, Nazar Mohammad; Abdulkareem, Makwan Mohammed
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1511

Abstract

Psychiatric symptoms are commonly distributed among general population and commonly comorbid with chronic medical diseases such as diabetes and thyroid diseases. This study aimed at discussing common mental health problems that are comorbid with chronic medical diseases in a single short paper by using different recent sources and references. This review article was conducted by using different recently published articles considering common mental health issues that are comorbid with chronic medical diseases such as diabetes mellitus, ischemic heart diseases, and thyroid diseases. Anxiety symptoms, depression, insomnia and somatization are commonly present among patients who have diabetes mellitus, thyroid disorders, hypertension, ischemic heart diseases, peptic ulcer and rheumatic illnesses.
The Effect of Brandt Daroff Exercise on the Balance of Vertigo Patients in the Cut Meutia Room of TK II Iskandar Muda Hospital Banda Aceh Sunita, Sunita; Mulfianda, Riyan; Desreza, Nanda
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 1 (2025): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i1.1530

Abstract

Vertigo is a disorder of balance against gravity with symptoms of dizziness, spinning like floating, the world seems to turn upside down. Vertigo can be brief or prolonged, lasting for hours or days. Complaints of vertigo come suddenly and are felt continuously until the patient cannot sleep. The Brandt-Daroff exercise is a treatment for vertigo that helps speed up recovery, prevent future episodes, and improve balance without needing medication. This vertigo exercise increases blood flow to the brain, allowing the body's balancing mechanism to operate better and the sensory system to do its job more efficiently. The goal of this study was to see how brandt daroff exercise affected the balance of vertigo patients at the Cut Meutia Room at Tk II Iskandar Muda Hospital in Banda Aceh. This type of research is a quasy experiment method with a one group pretest and postest design approach, this research was conducted in January-July 2024. The population and sample were all vertigo patients totaling 43 people and the sampling method used total sampling technique. Data collection using observation sheets and questionnaires. This study's data analysis methods include univariate and bivariate analysis, as well as statistical testing with the Wilcoxon signed rank test. The results of the study; there is an effect of brandt daroff exercise on the balance of vertigo patients with p-value = 0.007. Hence, Tk II Iskandar Muda Hospital is expected to train nurses on the importance of brandt daroff exercises to help reduce vertigo symptoms in patients.
MOLECULAR DOCKING OF CYMBOPOGON CITRATUS EXTRACTS AS POTENCY FOR DRUG FORMULATION TARGETING FUNGAL SPECIES CAUSING ONYCHOMYCOSIS IN BENUE STATE, NIGERIA Magdalene, Tyona Ngodoo
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1551

Abstract

Onychomycosis is a fungal infection of the nails, characterized by thickening, discoloration, and brittleness. It is caused by dermatophytes, non-dermatophyte molds, and yeasts and poses a significant public health challenge, particularly in tropical regions like Nigeria. Current antifungal treatments often show inconsistent efficacy, prompting the search for alternative therapies. This study explores the potential of Cymbopogon citratus (lemongrass) extracts as antifungal agents targeting key enzymes involved in fungal pathogenesis in onychomycosis in Benue State, Nigeria. Using ethical approval and rigorous laboratory protocols, fungal samples were cultured, and the Squalene Epoxidase (SQLE) gene was identified. Phytoconstituents in C. citratus extracts were analyzed via Gas Chromatography-Mass Spectrometry. Molecular docking using the Schrodinger Glide protocol predicted interactions with SQLE, a critical enzyme for fungal ergosterol biosynthesis. Dodecanoic acid-1,2,3-propane showed the highest docking score (-65.13 kcal/mol) and a molecular weight of 638 g/mol, outperforming terbinafine (-64.39 kcal/mol, 327.9 g/mol). The compounds exhibited strong binding to SQLE, suggesting a mechanism for disrupting fungal membrane synthesis. These findings emphasize the integration of computational predictions with in vitro studies in developing effective treatments for onychomycosis, addressing a significant medical need locally and globally.
Mathematical Model Transmission Dynamics of Onychomycosis with Cymbopogon Citratus Application as Control on Patients in Selected Hospitals in Benue State, Nigeria Magdalene, Tyona Ngodoo
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 1 (2025): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i1.1552

Abstract

Onychomycosis, a fungal nail infection, presents significant public health challenges, including in Benue State, Nigeria. Traditional plants like Cymbopogon citratus (lemon grass) have demonstrated antifungal properties. This study develops a mathematical model to analyze onychomycosis transmission dynamics and evaluate C. citratus extracts as a potential treatment. The model uses ordinary differential equations, categorizing individuals as susceptible (S), infected (I), and recovered (R) over time. Simulations show that reducing contact with infected individuals lowers transmission rates. Consistent treatment with C. citratus increases recovery, thereby decreasing susceptibility. Numerical simulations reveal that applying C. citratus extracts using a sterilized nail polish brush over two years resulted in reduced infection. The treatment regimen involved bi-weekly application for up to two years, with periodic monitoring of nail improvement. The study highlights that isolating infected individuals, combined with treatment and environmental precautions (such as avoiding shared nail equipment and walking barefoot in contaminated areas), significantly reduces transmission. These findings suggest that early detection, isolation, and consistent treatment with C. citratus are key to managing and potentially eradicating onychomycosis in the population.
Case Report: Acute Post-Streptococcal Glomerulonephritis with Renal Complications and Hemodialysis Siregar, Christine Bonuria; Indra, Ridha Mutiara; Amiranti, Nugrah Tri
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 1 (2025): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i1.1588

Abstract

Acute poststreptococcal glomerulonephritis (APSGN) is characterized by infections of the skin (impetigo) or throat (pharyngitis) caused by nephritogenic strains of group A beta-hemolytic Streptococcus. It is more commonly observed in school-aged children, with a mean presentation age between 6 and 8 years. Most studies report a higher prevalence among males, ranging from 54% to 87%. If left untreated, APSGN can lead to chronic kidney failure, hypertension, and recurrent proteinuria. Antibiotic therapy in patients with the primary infection is crucial to prevent the progression of complications. This report aims to describe a current case of APSGN, including its complications, management, and recommended follow-up strategies.
The Rapport of Health Education Through Brainstorming Methods on Students' Knowledge and Attitudes About Sexuality Issues at the State Junior High School Darussalam District Banda Aceh Desreza, Nanda; Muntaza, Anjana; Sartika, Dewi
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 2 (2025): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i2.1531

Abstract

Sexual conduct is an activity motivated by sexual desire. Teenagers' attitudes will be influenced by their lack of understanding about premarital sex. Brainstorming approaches can also be used to address problems based on the ideas presented by pupils. The purpose of this study was to determine students' knowledge and attitudes toward sexuality issues before and after giving health education using the brainstorming approach at the State Junior High School 8 Darussalam district Banda Aceh. This investigation was a quasi-experiment. Data was collected from March 7 to April 6, 2023. This study used a sample of 15 brainstorming groups from State Junior High School. Data was collected via primary sources. The Wilcoxon test was employed in the analysis, which included univariate and bivariate approaches. The findings revealed variations in knowledge (p-value 0.001) and attitudes (p-value 0.001) among the brainstorming groups. The researchers determined that brainstorming had a considerable impact on pupils' knowledge and attitudes.
THE POTENTIAL ACTIVITY OF ASIATICOSIDE FROM AKAR MANIS (Glycyrrhiza glabra) AS HYPOLIPEMIC Prasetyawan, Fendy; Saristiana, Yuneka; Salmasfattah, Novyananda; Mildawati, Ratna; Mayasari, Shinta
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1608

Abstract

Asiaticoside, a bioactive compound derived from Glycyrrhiza glabra (licorice root), has garnered attention for its potential as a hypolipemic agent. This study explores the lipid-lowering effects of asiaticoside, focusing on its mechanism of action and pharmacological properties. In silico analysis showed a high activation probability (pa=0.934) for asiaticoside, indicating its strong potential to interact with targets involved in lipid metabolism, such as PPAR-α, and reduce blood lipid levels. Additionally, its low inhibition probability (pi=0.003) suggests minimal risk for non-specific biological interference, making it a promising candidate for therapeutic use with a favorable safety profile. Asiaticoside’s antioxidant and anti-inflammatory properties further enhance its potential for cardiovascular protection by reducing oxidative stress, a key factor in atherosclerosis. While preliminary in silico results are promising, further in vitro and in vivo studies are required to confirm its efficacy, safety, and pharmacokinetics. Overall, asiaticoside represents a promising natural agent for managing hyperlipidemia and related metabolic disorders, offering an alternative to conventional synthetic therapies.

Page 7 of 9 | Total Record : 89

 5   6   7   8   9 

Filter by Year

2022 2025


Reset
Filter By Issues
All Issue Vol. 4 No. 4 (2025): OCTOBER Vol. 4 No. 3 (2025): JULY Vol. 4 No. 2 (2025): APRIL Vol. 4 No. 1 (2025): JANUARY Vol. 3 No. 4 (2024): OCTOBER Vol. 3 No. 3 (2024): JULY Vol. 3 No. 2 (2024): APRIL Vol. 3 No. 1 (2024): JANUARY Vol. 2 No. 4 (2023): OCTOBER Vol. 2 No. 3 (2023): JULY Vol. 2 No. 2 (2023): APRIL Vol. 2 No. 1 (2023): JANUARY Vol. 1 No. 4 (2022): OCTOBER Vol. 1 No. 3 (2022): JULY Vol. 1 No. 2 (2022): APRIL Vol. 1 No. 1 (2022): JANUARY More Issue